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The Crop Journal 2024年第2期12卷 482-492页

作者： Jiayuan Guo Yiling Wu Jianqiang Huang Kaihui Yu Meilian chen Yijuan Han Zhenhui Zhong Guodong Lu Yonghe Hong Zonghua Wang xiaofeng chen Fujian Universities Engineering Research Center of Marine Biology and Drugs Fuzhou Institute of OceanographyCollege of Geography and OceanographyMinjiang UniversityFuzhou 350108FujianChina Rice Research Institute Fujian Academy of Agricultural SciencesFuzhou 350018FujianChina Ministerial and Provincial Joint Innovation Center for Safety Production of Cross-Strait Crops Minjiang UniversityFuzhou 350108FujianChina State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Avirulence effectors(Avrs),encoded by plant pathogens,can be recognized by plants harboring the corresponding resistance proteins,thereby initiating effector-triggered immunity(ETI).In susceptible plants,however,Avrs can function as effectors,facilitating infection via effector-triggered susceptibility(ETS).Mechanisms of Avr-mediated ETS remain largely *** we report that the Magnaporthe oryzae effector Avr-PikD enters rice cells via the canonical cytoplasmic secretion pathway and suppresses rice basal ***-PikD interacts with an LSD1-like transcriptional activator AKIP30 of rice,and AKIP30 is also a positive regulator of rice immunity,whereas Avr-PikD impedes its nuclear localization and suppresses its transcriptional *** summary,*** delivers Avr-PikD into rice cells to facilitate ETS by inhibiting AKIP30-mediated transcriptional regulation of immune response against ***.

关键词： Magnaporthe oryzae Avirulence effector Avr-PikD Effector-triggered susceptibility Rice immunity Transcriptional activator

Green Synthesized Liquid-like Dynamic Polymer Chains with Decreased Nonspecific Adhesivity for High-Purity Capture of Circulating Tumor Cells

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CCS Chemistry 2024年第2期6卷 507-517页

作者： Feng Wu xiaofeng chen Shuli Wang Ruimin Zhou Chunyan Wang Lejian Yu Jing Zheng Chaoyong Yang Xu Hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005 College of Physical Science and Technology Xiamen UniversityXiamenFujian 361005 College of Physics and New Energy Xuzhou University of TechnologyXuzhouJiangsu 221018 Fujian Engineering Research Center for Solid-State Lighting Department of Electronic ScienceSchool of Electronic Science and EngineeringXiamen UniversityXiamenFujian 361005 Institute of Artificial Intelligence Xiamen UniversityXiamenFujian 361005 Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) XiamenFujian 361102 State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdaoShandong 266071

The capture of circulating tumor cells(CTCs)is of great significance in reducing cancer mortality and ***,the nonspecific binding of proteins and white blood cells(WBCs)weakens the targeting capabilities of the capture surfaces,which critically hampers the efficiency and purity of the captured ***,we propose a liquid-like interface design strategy that consists of liquid-like polymer chains and anti-EpCAM modification processes for high-purity and high-efficiency capture of *** dynamic flexible feature of the liquid-like chains endows the modified surfaces with excellent antiadhesion property for proteins and blood *** liquid-like surfaces can capture the target CTCs and show high cell viability due to the environmentfriendly surface modification *** liquid-like surface designs were introduced in the deterministic lateral displacement(DLD)-patterned microfluidic chip,the nonspecific adhesion rate of WBCs was reduced by more than fivefold compared to that in the DLD chip without liquid-like interface design,while maintaining comparable capture ***,this strategy provides a novel perspective on surface design for achieving high purity and efficient capture of CTCs.

关键词： green synthesis dynamic polymer chains liquid-like interface nonspecific adsorption capture of circulating tumor cells microfluidics

Histological and single-nucleus transcriptome analyses reveal the specialized functions of ligular sclerenchyma cells and key regulators of leaf angle in maize

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Molecular Plant 2024年第6期17卷 920-934页

作者： Qibin Wang Qiuyue Guo Qingbiao Shi Hengjia Yang Meiling Liu Yani Niu Shuxuan Quan Di Xu xiaofeng chen Laiyi Li Wenchang Xu Fanying Kong Haisen Zhang Pinghua Li Bosheng Li Gang Li State Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai’an 271018China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agriculture Sciences in WeifangWeifangShandong 261325China State Key Laboratory of Wheat Improvement College of AgronomyShandong Agricultural UniversityTai’an 271018China

Leaf angle(LA)is a crucial factor that affects planting density and yield in ***,the regulatory mechanisms underlying LA formation remain largely *** this study,we performed a comparative histological analysis of the ligular region across various maize inbred lines and revealed that LA is significantly influenced by a two-step regulatory process involving initial cell elongation followed by subsequent lignification in the ligular adaxial sclerenchyma cells(SCs).Subsequently,we performed both bulk and single-nucleus RNA sequencing,generated a comprehensive transcriptomic atlas of the ligular region,and identified numerous genes enriched in the hypodermal cells that may influence their specialization into ***,we functionally characterized two genes encoding atypical basic-helix-loop-helix(bHLH)transcription factors,bHLH30 and its homolog bHLH155,which are highly expressed in the elongated adaxial *** analyses revealed that bHLH30 and bHLH155 positively regulate LA expansion,and molecular experiments demonstrated their ability to activate the transcription of genes involved in cell elongation and lignification of *** findings highlight the specialized functions of ligular adaxial SCs in LA regulation by restricting further extension of ligular cells and enhancing mechanical *** transcriptomic atlas of the ligular region at single-nucleus resolution not only deepens our understanding of LA regulation but also enables identification of numerous potential targets for optimizing plant architecture in modern maize breeding.

关键词： planting specialized angle

First-line camrelizumab(a PD-1 inhibitor)plus apatinib(an VEGFR-2 inhibitor)and chemotherapy for advanced gastric cancer(SPACE):a phase 1 study

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1760-1767页

作者： xiaofeng chen Hao Xu Xiaobing chen Tongpeng Xu Yitong Tian Deqiang Wang Fen Guo Kangxin Wang Guangfu Jin Xiao Li Rong Wang Fengyuan Li Yongbin Ding Jie Tang Yueyu Fang Jing Zhao Liang Liu Ling Ma Lijuan Meng Zhiguo Hou Rongrong Zheng Yang Liu Ni Guan Bei Zhang Shuang Tong Shiqing chen Xing Li Yongqian Shu Department of Oncology The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Gusu School Nanjing medical UniversitySuzhouChina Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingChina Department of General surgery The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of Oncology Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhouChina Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer&Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer ZhengzhouChina Department of Oncology Digestive Disease Institute&Cancer Institute of Jiangsu UniversityAffiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology Suzhou Hospital of Nanjing Medical UniversitySuzhouChina Department of Oncology Nanjing PuKou People’s HospitalNanjingChina Department of Epidemiology School of Public HealthNanjing Medical UniversityNanjingChina Department of Pathology The First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of general surgery Jurong Branch hospital of Jiangsu Province People HospitalJurongChina Department of Medical Oncology Liyang People’s HospitalLiyangChina Department of radiology Nanjing PuKou People’s HospitalNanjingChina Jiangsu Hengrui Pharmaceuticals ShanghaiChina Department of Medical Affairs 3D Medicines Inc.ShanghaiChina Shanghai OrigiMed Co. Ltd.ShanghaiChina

Patients with advanced gastric cancer typically face a grim *** phase 1a(dose escalation)and phase 1b(dose expansion)study investigated safety and efficacy of first-line camrelizumab plus apatinib and chemotherapyfor advanced gastric or gastroesophageal junction *** primary endpoints included maximum tolerated dose(MTD)in phase 1a and objective response rate(ORR)across phase 1a and *** 1a tested three dose regimens of camrelizumab,apatinib,oxaliplatin,and *** regimen 1:camrelizumab 200 mg on day 1,apatinib 250 mg every other day,oxaliplatin 100 mg/m^(2) on day 1,and S-140 mg twice a day on days *** regimen 2:same as dose regimen 1,but oxaliplatin 130mg/*** regimen3:same as dose regimen 2,but apatinib 250 mg ***-four patients were included(9 in phase 1a,25 in phase 1b).No dose-limiting toxicities occurred so no MTD was *** 3 was set for the recommended phase 2 doses and administered in phase *** confrmed ORR was 76.5%(95%CI 58.8-89.3).The median progression-free survival was 8.4 months(95%CI 5.9-not evaluable[NE]),and the median overall survival(OS)was not mature(11.6-NE).Ten patients underwent surgery after treatment and the multidisciplinary team *** 24 patients without surgery,the median OS was 19.6 months(7.8-NE).Eighteen patients(52.9%)developed grade≥3 treatment-emergent adverse *** plus apatinib and chemotherapy showed favorable clinical outcomes and manageable safety for untreated advanced gastric cancer(ChiCTR2000034109).

关键词： regimen cancer doses

生成式人工智能重塑科技期刊产业的影响、挑战及应对策略研究

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中国科技期刊研究 2024年第7期35卷 890-898页

作者：陈晓峰沈锡宾湖北省科技信息研究院《科技进步与对策》编辑部湖北武汉430071 武汉理工大学计算机与人工智能学院湖北武汉430070 中华医学会杂志社新媒体部北京100052 国家新闻出版署医学期刊知识挖掘与服务重点实验室北京100052

【目的】探讨生成式人工智能给科技期刊业带来的影响与挑战,分析不同利益相关者的诉求与风险,提出科技期刊业应对生成式人工智能挑战的关键举措。【方法】基于文献综述梳理生成式人工智能在科技期刊业应用的最新进展,构建“需求—风险... 详细信息

【目的】探讨生成式人工智能给科技期刊业带来的影响与挑战,分析不同利益相关者的诉求与风险,提出科技期刊业应对生成式人工智能挑战的关键举措。【方法】基于文献综述梳理生成式人工智能在科技期刊业应用的最新进展,构建“需求—风险”二维分析框架,对不同应用场景进行分类评估;采用利益相关者分析法,多维解构生成式人工智能对作者、编辑、审稿人、读者等主体的影响;借鉴国内外经验教训,从前瞻政策、技术创新、服务升级、人才培养、伦理治理等方面系统提出推进科技期刊业智能化转型的对策建议。【结果】当前生成式人工智能已广泛应用于科技期刊选题策划、学术写作、同行评议、编辑出版、学术传播等环节,极大提升行业智能化水平,但也带来内容同质化、学术造假等问题隐患。不同利益相关者对生成式人工智能的诉求各异,既有效率提升、成本节约等普遍需求,也面临版权侵权、职业替代、伦理失范等风险挑战。【结论】生成式人工智能正驱动科技期刊业态重塑,亟须统筹布局、多管齐下,在加快关键技术创新应用的同时,注重人才培养和伦理规范,促进人机协同,构建开放共享、合作共赢的融合发展新生态,推动行业创新发展。

关键词：生成式人工智能科技期刊产业融合发展应用场景应对策略

网络体育传播中游戏表象的生成条件、内在机理与应对策略

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沈阳体育学院学报 2024年第2期43卷 131-137页

作者：杨赫陈晓峰复旦大学新闻传播学博士后流动站上海200433 上海商学院体育健康学院上海200235

智媒时代,游戏表象广泛地出现在网络体育传播中,深刻影响着人们的认知和体育运动参与。运用文献资料法、逻辑分析法,探究游戏表象在网络体育传播中的生成条件,剖析其内在机理,进而反思其所带来的社会影响,提出应对策略。研究认为,在现... 详细信息

智媒时代,游戏表象广泛地出现在网络体育传播中,深刻影响着人们的认知和体育运动参与。运用文献资料法、逻辑分析法,探究游戏表象在网络体育传播中的生成条件,剖析其内在机理,进而反思其所带来的社会影响,提出应对策略。研究认为,在现阶段的网络体育传播中,大叙事共享不足与拟像过剩为游戏表象的生成提供了必要条件,它以资本力量推动的资料库消费为核心运行模式,参照与现实共生的想象力环境,形成了基于角色独立性的媒介产品生产逻辑。针对游戏表象带来的挑战与负面影响,提出网络体育传播的应对策略:加快媒体转型升级,适应游戏表象带来的模式变化;创新游戏玩法与机制,缓解游戏表象引发的趋同效应;注重技术研发与应用,弥补游戏表象中用户身体实践的不足;培育新型游戏共同体,遏制游戏表象造成的过度娱乐化问题。

关键词：网络体育传播游戏表象游戏现实主义电子游戏体育媒介

严重急性呼吸综合征冠状病毒2感染后突发性耳聋发生机制研究进展

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中华耳科学杂志 2024年第1期22卷 150-153页

作者：陈晓奉谢兰丰上海市同仁医院感染科上海200336

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的新型冠状病毒感染(COVID-19)传播迅速,影响范围广,除了肺部并发症外还包括突发性耳聋。然而,其病理机制尚不清楚。可能的机制包括:病毒直接侵入并损伤耳蜗神经或耳蜗组织;耳蜗微血管血栓... 详细信息

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的新型冠状病毒感染(COVID-19)传播迅速,影响范围广,除了肺部并发症外还包括突发性耳聋。然而,其病理机制尚不清楚。可能的机制包括:病毒直接侵入并损伤耳蜗神经或耳蜗组织;耳蜗微血管血栓形成并导致耳蜗血管阻塞;病毒引起细胞因子风暴,导致耳蜗炎症。研究SARS-CoV-2作为突发性感音神经性听力损失病因的作用,可能为疾病的早期诊断、制定治疗策略以最大限度地提高临床恢复和避免不良反应提供机会。

关键词：严重急性呼吸综合征冠状病毒2 突发性感音神经性听力损失发生机制临床意义

新型农村集体经济推进乡村治理现代化的机理与现实路径

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当代经济研究 2024年第1期 46-56页

作者：陈晓枫钱翀福建师范大学经济学院福州350117

乡村治理是国家治理体系的基石,没有乡村治理现代化,就没有国家治理现代化。当前乡村社会诸多问题的根源在于农村集体经济的弱化以致支撑乡村治理的内生性资源匮乏,农民处于松散状态,组织化水平低,“乡政村治”遂演变为“乡政浮,村治虚... 详细信息

乡村治理是国家治理体系的基石,没有乡村治理现代化,就没有国家治理现代化。当前乡村社会诸多问题的根源在于农村集体经济的弱化以致支撑乡村治理的内生性资源匮乏,农民处于松散状态,组织化水平低,“乡政村治”遂演变为“乡政浮,村治虚”。新发展阶段,只有创新发展农村集体经济才能夯实物质基础、重塑基层组织,并有效弥合“自治”、“法治”和“德治”之间长期存在的实践隔层,进而切实推进乡村治理现代化。

关键词：新型农村集体经济乡村治理 “三治”融合

中国手工艺设计研究进展与趋势——基于Citespace计量分析

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包装工程 2024年第10期45卷 291-301页

作者：齐瑞文陈晓凤南昌大学文化资源与产业研究院南昌330031 南昌大学建筑与设计学院南昌330031

目的分析中国手工艺设计研究的现状与进展,为今后本领域研究的推进提供一定的参考。方法利用CiteSpace可视化文献分析工具,对1995—2023年CNKI总库中文核心期刊数据库中手工艺设计研究领域的相关文献进行知识结构图谱分析。结论我国手... 详细信息

目的分析中国手工艺设计研究的现状与进展,为今后本领域研究的推进提供一定的参考。方法利用CiteSpace可视化文献分析工具,对1995—2023年CNKI总库中文核心期刊数据库中手工艺设计研究领域的相关文献进行知识结构图谱分析。结论我国手工艺设计的研究进程,可分为萌芽阶段、初步发展、波动上升、蓬勃发展、热度持续五个阶段;研究机构主要集中在一线及新一线城市的院校,研究团队呈小集聚、大分散的状态分布;现阶段研究的局限是学术合作不够紧密,学科交叉有待加强;研究热点集中在协同设计、传统手工技艺、传承与开发、产品设计这四个方向;注重品牌建设与知识产权保护,与时尚产业深度融合,强化中国文化IP,借助数字化和智能化工具跨学科领域推进设计,基于互联网技术促进产品的销售和技艺的保护与传承,手工艺人才培养与社会传习更趋便利,深化乡村手工艺生产性保护,因地制宜开发文旅产品,政策导向下乡村手工艺设计研究的精细化、广泛化与多样化是该领域研究的趋势。

关键词：手工艺设计 CiteSpace 研究热点研究趋势文献计量分析

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数字技术赋能乡村文化产业高质量发展的内涵、作用机理与路径选择

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中共福建省委党校（福建行政学院）学报 2024年第3期 143-150页

作者：陈晓枫陈瑞旭裴文霞福建师范大学经济学院福建省习近平新时代中国特色社会主义思想研究中心福建医科大学马克思主义学院福建中医药大学马克思主义学院

随着数字技术在乡村文化产业中的不断深入与融合应用,数字技术已成为推动乡村文化产业高质量发展的重要动力。数字技术可以在思维、动能、要素以及市场等方面为乡村文化产业全方位赋能,并从产业业态、产业模式、产业体系、产业生态等方... 详细信息

随着数字技术在乡村文化产业中的不断深入与融合应用,数字技术已成为推动乡村文化产业高质量发展的重要动力。数字技术可以在思维、动能、要素以及市场等方面为乡村文化产业全方位赋能,并从产业业态、产业模式、产业体系、产业生态等方面助推乡村文化产业高质量发展。目前,依然存数字技术基础构建乡村文化产业新业态不足、乡村要素市场困境限制了数字技术赋能效应、乡村文化产业数字化融合发展程度不高以及乡村文化产业治理机制不健全等问题。为应对这些挑战,应采取措施加强乡村数字技术基础设施建设、促进数字技术同乡村文化产业的充分融合和完善乡村文化产业治理机制。

关键词：数字技术乡村文化产业乡村振兴高质量发展

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