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Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease

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Journal of Pharmaceutical Analysis 2024年第4期14卷 552-561页

作者： Panpan chen Zihan Zhu Haoyuan Geng xiaoqing Cui Yuhao Han Lei Wang Yaqi Zhang Heng Lu xiao Wang yun Zhang chenglong Sun Key Laboratory for Natural Active Pharmaceutical Constituents Research in Universities of Shandong Province School of Pharmaceutical SciencesQilu University of Technology(Shandong Academy of Sciences)Jinan250014China Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan250014China School of Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China Biology Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan250103China

Eclipta prostrata *** been used in traditional medicine and known for its liver-protective properties for ***(WEL)and demethylwedelolactone(DWEL)are the major coumarins found in *** ***,the comprehensive characterization of these two compounds on non-alcoholic fatty liver disease(NAFLD)still remains to be *** a well-established zebrafish model of thioacetamide(TAA)-induced liver injury,the present study sought to investigate the impacts and mechanisms of WEL and DWEL on NAFLD through integrative spatial metabolomics with liver-specific transcriptomics *** results showed that WEL and DWEL significantly improved liver function and reduced the accumulation of fat in the *** biodistributions and metabolism of these two compounds in whole-body zebrafish were successfully mapped,and the discriminatory endogenous metabolites reversely regulated by WEL and DWEL treatments were also *** on spatial metabolomics and transcriptomics,we identified that steroid biosynthesis and fatty acid metabolism are mainly involved in the hepatoprotective effects of WEL instead of *** study unveils the distinct mechanism of WEL and DWEL in ameliorating NAFLD,and presents a“multi-omics”platform of spatial metabolomics and liver-specific transcriptomics to develop highly effective compounds for further improved therapy.

关键词： Spatial metabolomics Transcriptomics Non-alcoholic fatty liver disease Wedelolactone Demethylwedelolactone

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Mesoscale Mechanical Properties and Influencing Factors of Concrete under Uniaxial Tension

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1156-1168页

作者： chen Tao LI Kungang xiao Shiyun State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

Monte Carlo simulations were carried out to generate a mesoscale model of concrete with randomly packed aggregates with different shapes and *** mechanical properties of concrete specimens under uniaxial tensile loads were studied using statistical *** results indicated that the entire process of damage and failure of specimens exhibited mainly two failure types:fracture patternsⅠandⅡ.Furthermore,the influences of the aggregate content ratio,aggregate shape,aggregate size,interfacial transition zone(ITZ)strength,and porosity ratio on the concrete specimens were *** numerical simulation results showed that the elastic modulus of the concrete specimens increased approximately linearly with the aggregate volume ratio but decreased linearly with the porosity and was not affected by the ITZ *** tensile strength decreased with the increases in the aggregate content and porosity of the sample,but increased linearly with the ITZ *** addition,the aggregate shape led to a difference in the tensile strength of the concrete.

关键词： concrete mechanical behavior aggregate interfacial transition zone pore

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Neuronomodulation of Excitable Neurons

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Neuroscience Bulletin 2024年第1期40卷 103-112页

作者： Yizhang chen Lin xiao Jian Qiu Institute of Neuroscience Second Military Medical UniversityShanghai 200433China Institute for Brain Research and Rehabilitation Key Laboratory of BrainCognition and Education Sciences of Ministry of EducationSouth China Normal UniversityGuangzhou 510631China Department of Chemical Physiology and Biochemistry Oregon Health and Science UniversityPortlandOR 97239USA

Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in response to chemical substances,from spillover neuro-transmitters to paracrine or endocrine hormones circulating in the *** can be direct or indirect,depending on the transduction pathways from the ligand binding site to the ion pore,either on the same molecule,*** ion channel,or through an intermediate step on different *** major players in direct neurono-modulation are ligand-gated or voltage-gated ion *** key process of direct neuronomodulation is the binding and chemoactivation of ligand-gated or voltage-gated ion channels,either orthosterically or allosterically,by various *** neuronomodulation involves metabotropic receptor-mediated slow potentials,where steroid hormones,cytokines,and chemokines can implement these *** neuronomodulation is of great significance for understanding the physiological mechanisms of brain function,and the occurrence and treatment of diseases.

关键词： Neuron Membrane potential Excitability Chemoactivation Neuronomodulation

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Improved Flexible Triboelectric Nanogenerator Based on Tile-Nanostructure for Wireless Human Health Monitor

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Energy & Environmental Materials 2024年第4期7卷 386-395页

作者： Huamin chen Shujun Guo Shaochun Zhang Yu xiao Wei Yang Zhaoyang Sun Xu Cai Run Fang Huining Wang yun Xu Jun Wang Zhou Li Fujian Key Laboratory of Functional Marine Sensing Materials Minjiang University Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Institute of Semiconductors Chinese Academy of Sciences Beijing Key Laboratory of Inorganic Stretchable and Flexible Information Technology Faculty of Science and Engineering The University of Nottingham Ningbo China

Triboelectric nanogenerators (TENCs) have emerged as promising candidates for integrating with flexible electronics as self-powered systems owing to their intrinsic flexibility,biocompatibility,and *** this study,an improved flexible TENC with a tile-nanostructured MXene/polymethyl methacrylate (PMMA) composite electrode (MP-TENC) is proposed for use in wireless human health monitor.

关键词： flexible electrode MXene tile nanostructure triboelectric nanogenerator wireless monitor

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局部子空间聚类

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自动化学报 2016年第8期42卷 1238-1247页

作者：刘展杰陈晓云福州大学数学与计算机科学学院福州350116

现有子空间聚类方法通常以数据全局线性为前提,将每个样本点表示为其他样本点的线性组合,因而导致常见子空间聚类方法不能很好地应用于非线性数据.为克服全局线性表示的局限,借鉴流形学习思想,用k近邻局部线性表示代替全局线性表示,与... 详细信息

现有子空间聚类方法通常以数据全局线性为前提,将每个样本点表示为其他样本点的线性组合,因而导致常见子空间聚类方法不能很好地应用于非线性数据.为克服全局线性表示的局限,借鉴流形学习思想,用k近邻局部线性表示代替全局线性表示,与稀疏子空间聚类和最小二乘子空间聚类方法相结合,提出局部稀疏子空间聚类和局部最小二乘子空间聚类方法,统称局部子空间聚类方法.在双月形数据、6个图像数据集和4个基因表达数据集上进行实验,实验结果表明该方法是有效的.

关键词：局部线性 k近邻子空间聚类图像数据基因表达数据

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Bending Analysis of Circular Piezoelectric Semiconductor Plates Incorporating Flexoelectricity

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Acta Mechanica Solida Sinica 2024年第4期37卷 613-621页

作者： Liang Sun Zhengguang xiao Chunli Zhang Weiqiu chen Department of Engineering Mechanics Zhejiang UniversityHangzhou310027China Department of Basic Courses Naval University of EngineeringWuhan430033China Huanjiang Laboratory Zhuji311816China

Based on the three-dimensional(3D)basic equations of piezoelectric semiconductors(PSs),we establish a two-dimensional(2D)deformation-polarization-carrier coupling bending model for PS structures,taking flexoelectricity into *** analytical solutions to classical flexure of a clamped circular PS thin plate are *** the derived analytical model,we numerically investigate the distributions of electromechanical fields and the concentration of electrons in the circular PS thin plate under an upward concentrated *** effect of flexoelectricity on the multi-field coupling responses of the circular PS plate is *** obtained results provide theoretical guidance for the design of novel PS devices.

关键词： Piezoelectric semiconductor Plate model Flexoelectricity Multi-field coupling

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Communication-centric integrated sensing and communications with mixed fields

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Science China(Information Sciences) 2024年第11期67卷 369-370页

作者： yun xiao Enhao WANG yunfei chen Hongjian SUN Aissa IKHLEF Department of Engineering Durham University

Integrated sensing and communications(ISAC) is expected to play a vital role in the sixth-generation(6G) wireless networks [1]. By utilizing high frequencies, extremely largescale antenna arrays, and new antenna designs, the 6Gempowered ISAC faces several new challenges, one of which is the considerable near-field(NF) region [1]. Compared with far-field(FF) plane wave model, the NF model assumes spherical wave. This will affect beamforming(BF)designs in ISAC. Most previous works on ISAC beamforming assume the traditional FF model [2].

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Risk Assessment for Hybrid AC/DC Systems Based on Transient Energy Function

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1654-1663页

作者： Peng Sun yun Teng Mingli Zhang Zhe chen Shenyang University of Technology Shenyang 110870China Liaoning Electric Power Co.Ltd.Economic Research Institute Shenyang 110000China Department of Energy Technology Aalborg UniversityAalborgDK DK 9220

In order to accurately assess the risk of the hybrid AC/DC network under fault,a risk assessment method for the hybrid AC/DC system based on the transient energy function is ***,based on the energy transfer relationship of the hybrid AC/DC power system,the transient energy function model of the hybrid AC/DC system is *** on the operating data of the power grid,the energy function is used as an efficiency variable,and the efficiency variable is integrated into the prior risk probability calculation of nodes in the network,and a Bayesian network-based risk assessment model of hybrid AC/DC system is *** the dynamic update model of network cascading failures,the clique tree propagation algorithm is used to dynamically calculate the posterior risk probability of the node to realize the dynamic assessment of the network ***,the improved IEEE-39 node hybrid AC/DC system is used as an example for *** results show that the proposed model can not only effectively evaluate the overall safety of the network,but also has feasibility in predicting faults,which can provide a theoretical basis for the stability control of the hybrid AC/DC system.

关键词： Cascading failure energy function hybrid AC-DC system risk assessment

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Frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 374-379页

作者： Jie Cai Wen-Wen Fan yun-Hui Zhong Cai-Lan Wen xiao-Dan Wei Wan-chen Wei Wan-Yan Xiang Jin-Mao chen Department of Ophthalmology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Digital and Intelligent Technology Transformation and Application Research Institute of Visual Function Tianjin 300000China Guangxi Medical University Nanning 530021Guangxi Zhuang Autonomous RegionChina

AIM:To investigate the frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university ***:Totally 158 student volunteers underwent routine vision examination in the optometry clinic of Guangxi Medical *** data were used to identify the different types of accommodation and nonstrabismic binocular vision dysfunction and to determine their *** analysis and logistic regression were used to examine the factors associated with these ***:The results showed that 36.71%of the subjects had accommodation and non-strabismic binocular vision issues,with 8.86%being attributed to accommodation dysfunction and 27.85%to binocular *** insufficiency(CI)was the most common abnormality,accounting for 13.29%.Those with these abnormalities experienced higher levels of eyestrain(χ2=69.518,P<0.001).The linear correlations were observed between the difference of binocular spherical equivalent(SE)and the index of horizontal esotropia at a distance(r=0.231,P=0.004)and the asthenopia survey scale(ASS)score(r=0.346,P<0.001).Furthermore,the right eye's SE was inversely correlated with the convergence of positive and negative fusion images at close range(r=-0.321,P<0.001),the convergence of negative fusion images at close range(r=-0.294,P<0.001),the vergence facility(VF;r=-0.234,P=0.003),and the set of negative fusion images at far range(r=-0.237,P=0.003).Logistic regression analysis indicated that gender,age,and the difference in right and binocular SE did not influence the emergence of these ***:Binocular vision abnormalities are more prevalent than accommodation dysfunction,with CI being the most frequent *** binocular refractive disparity leads to more severe eyestrain symptoms.

关键词： optometry clinic non-strabismic binocular vision dysfunction college students convergence insufficiency

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Revolution in thermoelectric cooling using PbSe thermoelectrics by grid plainification

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Science China Materials 2024年第5期67卷 1672-1673页

作者： xiao-Lei Shi Qingfeng Liu Zhi-Gang chen School of Chemistry and Physics ARC Research Hub in Zero-emission Power Generation for Carbon Neutralityand Centre for Materials ScienceQueensland University of TechnologyBrisbaneQueensland4000Australia State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing211816China

Thermoelectric materials and devices enable direct conversion between heat and electricity,holding potential applications in thermoelectric power generation,localized cooling,and electronic thermal management[1].Howev... 详细信息

关键词： enable thermoelectric constrained

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