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Food Science and Human Wellness 2024年第2期13卷 659-667页

作者： Lanlan Gui Shaokang Wang Jing Wang Wang Liao Zitong chen Da Pan Hui xia Guiju Sun Su Tian Department of Nutrition and Food Hygiene School of Public HealthSoutheast UniversityNanjing 210009China Nanjing Municipal Center for Disease Control and Prevention Nanjing 210003China Department of Nutrition and Food Hygiene School of Public HealthHebei Medical UniversityShijiazhuang 050017China

Forsythia suspensa,belonging to the deciduous shrubs of the Luteaceae family,a traditional Chinese medicine,has effects of alleviating swelling,clearing heat,detoxification and promoting blood *** leaves of *** contain multiple chemical components and have a long history of use in folk medicines and health *** purpose of this study was to explore the effects of forsythin extract from *** leaves on intestinal microbiota and short-chain fatty acid(SCFA)content in rats with obesity induced by a high-fat *** extract in *** leaves increased the abundance of the intestinal microbiota,ameliorated intestinal microbiota disorders and inhibited the increase in total SCFA content in the intestinal tract in rats with obesity induced by a high-fat *** results suggested that forsythin extract in *** leaves may slow the development of obesity induced by a high-fat diet;thus,its active components and efficacy are worthy of further study.

关键词： Forsythin High-fat diet Intestinal microbiota Short-chain fatty acid(SCFA)

Regulated reaction pathway of CO_(2)photoreduction into CH_(4)by metal atom pair sites

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Rare Metals 2024年第9期43卷 4620-4627页

作者： Dong-Po He Guang-Bing Huang Jun Hu Yang Wu xiao-Dong Li Qing-xia chen Shan Zhu Wen-Sheng Yan Jun-Fa Zhu Yang Pan Xing-chen Jiao Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Hefei National Research Center for Physical Sciences at Microscale National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230026China Max Planck Institute of Microstructure Physics Weinberg 206120 HalleGermany State Grid Anhui Electric Power Research Institute Hefei 230601China

The carbon dioxide(CO_(2))reduction process involves complex protonation,making the resulting product often *** achieve the desired product,it is crucial to manipulate the reaction ***,we build the metal atom pair sites for selective CO_(2)photoreduction into *** a prototype,Ni atom pair sites loaded on the Mo S_(2)nanosheets were synthesized and verified by highresolution transmission electron microscopy(HRTEM),X-ray photoelectron spectroscopy(XPS)and X-rayabsorption near edge structure spectra(XANES).In-situ Fourier transform infrared spectroscopy(FTIR)monitors the*CHO group,a crucial intermediate in CH_(4)production,during CO_(2)photoreduction on the Ni-Mo S_(2)nanosheets,whereas this monitoring is not observed for the Mo S_(2)***,theoretical calculations disclose that over the Ni-Mo S_(2)nanosheet slab,the formation energy of*CHO intermediates is determined to be lower(0.585 e V)than the desorption energy of*CO intermediates for CO production(0.64 e V),implying the higher selectivity of CH_(4)production.

关键词： steps dioxide desired

A neural m^(6)A pathway regulates behavioral aggregation in migratory locusts

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Science china(Life Sciences) 2024年第6期67卷 1242-1254页

作者： xianliang Huang Qing Li Yanan Xu Ang Li Shanzheng Wang Yusheng chen Chunrui Zhang xia Zhang Hailin Wang Cong Lv Baofa Sun Shaoqin Li Le Kang Bing chen school of Life Science Institutes of Life Science and Green DevelopmentHebei UniversityBaoding 071002China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Health Sciences Anhui UniversityHefei 230601China Beijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100101China

RNA N6-methyladenosine(m^(6)A),as the most abundant modification of messenger RNA,can modulate insect behaviors,but its specific roles in aggregation behaviors remain ***,we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta *** results demonstrated that METTL3,METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or *** individual knockdown of methyltransferases(i.e.,METTL3 and METTL14)promoted locust movement and conspecific attraction,whereas ALKBH5 knockdown induced a behavioral shift toward the solitary ***,global transcriptome profiles revealed that m^(6)A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of *** summary,our in vivo characterization of the m^(6)A functions in migratory locusts clearly demonstrated the crucial roles of the m^(6)A pathway in effectively modulating aggregation behaviors.

关键词： RNA methylation N^(6)-methyladenosine transcriptional orchestration aggregation behavior Locusta migratoria

Synergistic effect of carbon nanotube and encapsulated carbon layer enabling high-performance SnS_2-based anode for lithium storage

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Journal of Energy Chemistry 2024年第10期97卷 700-709,I0015页

作者： Chunwei Dong Yongjin xia Zhijiang Su Zhihua Han Yang Dong Jingyun chen Fei Hao Qiyao Yu Qing Jiang Jiaye Ye National Instituteof Clean-and-Low-Carbon Energy Beijing 102209China Key Laboratory of Automobile Materials Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022JilinChina State Key Laboratory of Explosion Science and Technology School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China school of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Tin disulfide(SnS_(2)),due to large interlayer spacing and high theoretical capacity,is regarded as a prospective anode material for lithium-ion ***,the poor electron conductivity of SnS_(2) and huge volumetric change during the lithiation/delithiation process lead to a rapid capacity decay of the battery,hindering its *** address these issues,herein,SnS_(2) is in-situ grown on the surface of carbon nanotubes(CNT)and then encapsulated with a layer of porous amorphous carbon(CNT/SnS_(2)@C)by simple solvothermal and further carbonization *** synergistic effect of CNT and porous carbon layer not only enhances the electrical co nductivity of SnS_(2) but also limits the huge volumetric change to avoid the pulverization and detachment of SnS_(2).Density functional theo ry calculations show that CNT/SnS_(2)@C has high Li^(+)adsorption and lithium storage capacity achieving high reaction ***,cells with the CNT/SnS_(2)@C anode exhibit a high lithium storage capacity of 837mAh/g after 100 cycles at 0.1 A/g and retaining a capacity of 529.8 mAh/g under 1.0 A/g after 1000 *** study provides a fundamental understanding of the electrochemical processes and beneficial guidance to design high-performance SnS_(2)-based anodes for LIBs.

关键词： Lithium-ion batteries Porous amorphous carbon Carbon nanotubes SnS_(2)-based anode Density functional theory calculations

Maize ZmSRO1e promotes mesocotyl elongation and deep sowing tolerance by inhibiting the activity of ZmbZIP61

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Journal of Integrative Plant Biology 2024年第8期66卷 1571-1586页

作者： Lumin Qin Fangfang Kong Lin Wei Minghan Cui Jianhang Li chen Zhu Yue Liu Guangmin xia Shuwei Liu Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life ScienceShandong UniversityQingdao 266237China Crop Research Institute Anhui Academy of Agricultural SciencesHefeiAnhui Province 230031China

Deep sowing is a traditional method for drought resistance in maize production,and mesocotyl elongation is strongly associated with the ability of maize to germinate from deep ***,little is known about the functional genes and mechanisms regulating maize mesocotyl *** the present study,we identified a plant-specific SIMILAR TO RCD-ONE(SRO) protein family member,ZmSRO1e,involved in maize mesocotyl *** expression of ZmSRO1e is strongly inhibited upon transfer from dark to white *** loss-of-function zmsro1e mutant exhibited a dramatically shorter mesocotyl than the wild-type in both constant light and darkness,while overexpression of ZmSRO1e significantly promoted mesocotyl elongation,indicating that ZmSRO1e positively regulates mesocotyl *** showed that ZmSRO1e physically interacted with Zmb ZIP61,an ortholog of Arabidopsis ELONGATED HYPOCOTYL 5(HY5) and showed a function similar to that of HY5 in regulating *** found that ZmSRO1e repressed the transcriptional activity of Zmb ZIP61 toward target genes involved in the regulation of cell expansion,such as ZmEXPB4 and ZmEXPB6,by interfering with the binding of ZmbZIP61 to the promoters of target *** results provide a new understanding of the mechanism by which SRO regulates photomorphogenesis and highlight its potential application in deep sowing-resistant breeding.

关键词： deep sowing HY5 maize Mesocotyl SRO

Characteristics of perfluoromethyl vinyl ether:A new eco-friendly alternative gas for SF_(6)

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High Voltage 2024年第3期9卷 509-517页

作者： Song xiao Yijiang chen Mingjun Tang Shuangshuang Tian Haoran xia Yifan Wang Ju Tang Yi Li xiaoxing Zhang State Key Laboratory of Power Grid Environmental Protection School of Electrical Engineering and AutomationWuhan UniversityHubeiChina Key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System School of Electrical and Electronic EngineeringHubei University of TechnologyWuhanChina

The exploration of eco-friendly insulating gas to substitute the most potent greenhouse gas sulphur hexafluoride(SF6)has consistently garnered significant ***,the au-thors evaluated the feasibility of utilising perfluoromethyl vinyl ether(PMVE,C_(3)F_(6)O)as a new branch of eco-friendly insulating gas for the first *** primary dielectric and stability characteristics of PMVE regarding AC breakdown,partial discharge,dielectric recovery,and decomposition properties were revealed under various gas pressure and electrical field *** was found that PMVE demonstrated superior dielectric strength,with the AC breakdown and PD inception voltage(PDIV)1.10 and 1.14 times that of pure SF_(6).Furthermore,the dielectric strength of PMVE exhibits stability even after undergoing 100 cycles of AC breakdowns,and there is no observable formation of solid precipitation on the electrode *** discharge decomposition of PMVE mainly generates fluorocarbon(CF_(4),C_(2)F_(6),C_(3)F_(6),C_(3)F_(8),etc.)and ***,the exceptional insulation stabilityandno absence of solidprecipitation featuresendow PMVE tobe utilised as a new eco-friendly gas for SF_(6)-free gas-insulated equipment.

关键词： surface dielectric vinyl

RHA2b-mediated MYB30 degradation facilitates MYB75-regulated,sucrose-induced anthocyanin biosynthesis in Arabidopsis seedlings

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Plant Communications 2024年第3期5卷 62-76页

作者： Huapeng Zhou Jiaxian He Yiyi Zhang Hongyun Zhao xia Sun Xi chen Xinrui Liu Yuan Zheng Honghui Lin Key Laboratory of Bio-resource and Eco-environment of the Ministry of Education College of Life SciencesSichuan UniversityChengdu 610064China Innovative Center of Molecular Genetics and Evolution School of Life SciencesGuangzhou UniversityGuangzhou 510642China State Key Laboratory of Cotton Biology Department of BiologyHenan UniversityKaifeng 475004China

Anthocyanins play diverse roles in plant physiology and stress *** Arabidopsis,the MYB–bHLH–WD40(MBW)complex has a crucial role in the regulation of anthocyanin ***,we report that the R2R3-MYB transcription factor MYB30 and the ubiquitin E3 ligase RHA2b participate in anthocyanin biosynthesis through regulation of the MBW ***30 was found to negatively regulate sucrose-induced anthocyanin biosynthesis in Arabidopsis *** of multiple genes involved inflavo-noid or anthocyanin biosynthesis was affected in the myb30 mutant,and MYB30 directly repressed the expression of MYB75,which encodes a core component of the MBW complex,by binding to its ***,MYB30 physically interacted with MYB75 to inhibit its activity by repressing MBW complex *** addition,sucrose treatment signicantly promoted MYB30 degradation via the action of *** ubiquitination and degradation of MYB30 were signicantly attenuated in the rha2b mutant un-der high-sucrose treatment,and further analysis showed that MYB75 directly promoted RHA2b expression in response to high *** work thus reveals an anthocyanin biosynthetic regulatory module,RHA2b–MYB30,that controls the function of the MBW complex via *** repression of MYB75 by MYB30 is released by MYB75-induced RHA2b expression,thus ensuring the self-activation of MYB75 when anthocy-anin synthesis is needed.

关键词： anthocyanin biosynthesis high sucrose MBW complex MYB30 MYB75 RHA2b

B-cell-specific signatures reveal novel immunophenotyping and therapeutic targets for hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第34期30卷 3894-3925页

作者： Ke-Quan Xu Zheng Gong Jia-Ling Yang Chu-Qi xia Jian-Yi Zhao Xi chen Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina school of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina Department of General Surgery Second People’s Hospital of Jiaozuo CityJiaozuo 454001Henan ProvinceChina

BACKGROUND Immunotherapy presents both promises and challenges in treating hepatocellular carcinoma(HCC)due to its complex immunological *** role of B cells,a key part of the immune system,remains uncertain in *** To identify B-cell-specific signatures and reveal novel immunophenotyping and therapeutic targets for *** Using the Tumor Immune Single-cell Hub 2 database,we identified B-cell-related genes(BRGs)in *** enrichment analysis was performed to explore the possible collaboration between B cells and T cells in *** conducted univariate Cox regression analysis using The Cancer Genome Atlas liver HCC collection dataset to find BRGs linked to HCC ***,least absolute shrinkage and selection operator regression was utilized to develop a prognostic model with 11 *** model was validated using the International Cancer Genome Consortium dataset and *** The risk score derived from the prognostic model emerged as an independent prognostic factor for *** of the immune microenvironment and cell infiltration revealed the immune status of various risk groups,supporting the cooperation of B and T cells in suppressing *** BRGs model identified new molecular subtypes of HCC,each with distinct immune *** sensitivity analysis identified targeted drugs effective for each HCC subtype,enabling precision therapy and guiding clinical *** We clarified the role of B cells in HCC and propose that the BRGs model offers promising targets for personalized immunotherapy.

关键词： B cell Hepatocellular carcinoma Immune microenvironment Immunotherapy Molecular subtype

LSM6 promotes cell proliferation and migration regulated by HMGB1 in laryngeal squamous cell carcinoma

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Engineered Regeneration 2024年第2期5卷 247-254页

作者： Dengbin Ma Jiayi Li Hui Li Yao Tang xia Gao Hong chen xiaoyun Qian xiaohui Shen Department of Otolaryngology Head and Neck Surgery Research Institute of OtolaryngologyNanjing Drum Tower HospitalJiangsu Provincial Key Medical DisciplineAffiliated Hospital of medical SchoolNanjing UniversityNanjing210008China Department of Otorhinolaryngology Minda Hospital of Hubei Minzu UniversityEnshi445000China Nanjing Drum Tower Hospital Clinical College of Nanjing Medical university 321 Zhongshan RoadNanjing210008China

Elevated levels of high mobility group protein B1(HMGB1)play a significant role in the pathogenesis of many diseases,but is particularly important for the formation of malignant ***,the function of HMGB1 and the underlying mechanism of laryngeal squamous cell carcinoma(LSCC)remain incompletely understood,causing *** we found immunohistochemistry from 97 LSCC tissues showed HMGB1 was upreg-ulated,which was associated with poor ***1 knockdown could significantly inhibit wound closure and colony *** full-genome gene expression microarray was performed to investigate the *** knockdown of HMGB1 by siRNA,among the expressed differential genes,10 genes were ran-domly selected for ***,shRNA lentivirus targeting these genes were constructed to explore their role in LSCC by cell proliferation ***6 downregulation was dramatically promoted by HMGB1 knockdown,resulting in higher expression in LSCC ***,downregulation of LSM6 could significantly suppress cell proliferation,migration and colony *** study indicated that HMGB1 promoted LSCC cell malig-nant phenotypes through regulation of *** anticipate that HMGB1-LSM6 could be a putative therapeutic target for LSCC.

关键词： HMGB1 LSM6 Laryngeal squamous cell carcinoma Cell proliferation Migration

Existence of unbiased estimate of regression parameters in simple linear EV models

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Science china mathematics 2005年第7期48卷 915-928页

作者： LIU Jixue & chen xiru Department of statistics and Finance, university of Science and Technology of china, Hefei 230026, china Department of mathematics, Graduate school of Chinese Academy of Sciences, Beijing 100049, china Department of statistics and Finance University of Science and Technology of China Hefei 230026 China Department of mathematics Graduate School Chinese Academy of Sciences Beijing 100049 China

It is well known that for one-dimensional normal EV regression model X = x+ u,Y =α+βx+e, where x, u, e are mutually independent normal variables and Eu=Ee=0, the regression parameters a and β are not identifiable without some restriction imposed on the parameters. This paper discusses the problem of existence of unbiased estimate for a and β under some restrictions commonly used in practice. It is proved that the unbiased estimate does not exist under many such restrictions. We also point out one important case in which the unbiased estimates of a and β exist, and the form of the MVUE of a and β are also given.

关键词： EV regression model unbiased estimate identiflability.