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Characteristics and demographic factors of traditional Chinese medicine constitution types among elderly individuals in china:A national multistage cluster random study Author links open overlay panel

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 257-263页

作者： Jing xia Minghua Bai Huirong Song Houqin Li Dayan Zhang Mary Y.Jiang Ran chen Feiyu He cheng Ni Center for Studies in Constitution and Reproductive Sciences of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese MedicineBeijing 100029China Huangsi Comprehensive Outpatient Department Beijing Tongrentang Healthcare Industry Investment Group CompanyBeijing 100032China Zhangjiakou Second Traditional Chinese Medicine Hospital Zhangjiakou 076250China Faculty of Medicine The Chinese University of Hong KongHong Kong 999077China

Objective To reveal the distribution characteristics and demographic factors of traditional Chinese medicine(TCM)constitution among elderly individuals in *** Elderly individuals from seven regions in china were selected as samples in this study using a multistage cluster random sampling *** basic information questionnaire and Constitution in Chinese Medicine Questionnaire(Elderly Edition)were *** statistical analysis,chi-squared tests,and binary logistic regression analysis were *** The single balanced constitution(BC)accounted for 2..9%.The results of the major TCM constitution types showed that BC(43.2.)accounted for the largest proportion and unbalanced constitutions ranged from 0.9%to 15.7%.East china region(odds ratio[OR]=2.097;95%confidence interval[CI],1.912.to 2.301),married status(OR=1.341;95%CI,1.2.5 to 1.457),and managers(OR=1.2.4;95%CI,1.044 to 1.505)were significantly associated with ***>70 years was associated with qi-deficiency constitution and blood stasis constitution(BSC).Female sex was significantly associated with yang-deficiency constitution(OR=1.646;95%CI,1.52.to 1.782..Southwest region was significantly associated with phlegm-dampness constitution(OR=1.809;95%CI,1.569 to 2.086).North china region was significantly associated with inherited special constitution(OR=2.52.;95%CI,1.569 to 4.05).South china region(OR=2.741;95%CI,1.997 to 1.3.763),Central china region(OR=8.889;95%CI,6.676 to 11.835),senior middle school education(OR=2.442.95%CI,1.932.to 3.088),and managers(OR=1.804;95%CI,1.2. to 2.69)were significantly associated with *** This study defined the distribution characteristics and demographic factors of TCM constitution in the elderly *** and improving unbalanced constitutions,which are correlated with diseases,can help promote healthy aging through the scientific management of these demographic factors.

关键词： Constitution in Chinese Medicine Questionnaire(Elderly Edition) Body constitution Multistage cluster random sampling Demographic factors Elderly individuals

Synergistic effects of three traditional herbs green tea,mulberry leaf and corn silk on glucose uptake level of L6 myoblasts and the hypoglycemic mechanism

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Traditional Medicine Research 2024年第7期9卷 1-12页

作者： Jing-Na Zhou Ming-Yue Li Ting-Ting Zhang Jing-Yang Lu Min Zhang Peng-Wei Zhuang Hai-xia chen Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China. school of Food Science and Bioengineering Tianjin Agricultural UniversityTianjin 300384China. State Key Laboratory of Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China. Haihe Laboratory of Modern Chinese Medicine Chinese Materia Medica CollegeTianjin University of Traditional Chinese MedicineTianjin 301617China.

Background:Green tea,mulberry leaf and corn silk are traditional herbs used in the prevention and treatment of diabetes in china for a long time,but their synergistic hypoglycemic effects and mechanisms remain ***:The effective components of green tea,mulberry leaf and corn silk were extracted and *** design of experiments was used to study the influences of different combinations on the cell viability and glucose uptake level of L6 myoblasts,so as to determine the optimal synergistic hypoglycemic *** possible hypoglycemic mechanism of the optimal synergistic combination was explored by cytotoxicity assay,glucose uptake assay,and western ***:Three polyphenol enrichment fractions of the herbs,30%ethanol elution fraction of green tea(GT),50%ethanol elution fraction of mulberry leaf(ML)and 60%ethanol elution fraction of corn silk(CS)were *** antioxidant activities of GT-30%,ML-50%and CS-60%were superior to those of crude extracts,and showed strong potential inα-amylase andα-glucosidase inhibition *** optimal synergistic combination of crude extracts G7(crude extract of green tea:crude extract of mulberry leaf:crude extract of corn silk=1:5:3),polyphenol enrichment fractions R3(GT-30%:ML-50%:CS-60%=1:7:1)and monomers X2.epigallocatechin gallate:morusin:formononetin=3:1:2.were selected,respectively.G7,R3,and X2.showed promoting effects on the cell viability and glucose uptake of L6 myoblasts within the detected concentration *** addition,G7,R3,and X2.could increase the expression levels of p-PI3K/PI3K and p-Akt/Akt in L6 myoblasts,and promote the translocation of Glut4,but G7 and R3 showed more significant ***:The synergistic hypoglycemic effects of green tea,mulberry leaf and corn silk had the characteristics of multiple-components and multiple-targets with p-PI3K/PI3K,p-Akt/Akt and the translocation of Glut4 signal pathways *** three traditional herbs might have the potential

关键词： green tea mulberry leaf corn silk synergistic effect type 2.diabetes mellitus mechanism

Impact of gradient microstructure on strain hardening via activation of multiple deformation mechanisms in CoCrNi medium entropy alloy

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Materials Futures

Materials Futures 2024年第4期3卷 11-21页

作者： Jiaqi Meng Yonghao Zhao Yi Liu Zongyao Li Bo Gao Mengning Xu Weiheng xia Xuefei chen Hao Zhou Yuntian Zhu Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094People’s Republic of China school of Materials Science and Engineering Hohai UniversityChanazhou 213200People’s Republic of China Liaoning Academy of Materials Shenyang 110167People’s Republic of China Department of Materials Science and Engineering City University of Hong KongHong Kong Special Administrative Region of China 999077People’s Republic of China

Face centered cubic(FCC)structural medium/high entropy alloys(MEAs),characterized by excellent strength and ductility,have attracted significant attention by the research *** incorporation of gradient structures(GSs)further can enhance their mechanical *** the present research,we employ the rotation acceleration shot peening technique to introduce a GS within the CoCrNi FCC MEA to investigate underlying mechanisms governing the physical deformation processes during the generation of GSs through processing,which the primary goal is mitigating the intrinsic trade-off between strength and *** the microstructures analysis along the depth direction,both pre and post uniaxial tensile plastic deformation,we unveiled that the low stacking fault(SF)energy characteristic of the CoCrNi MEA triggered the emergence of diverse defects in the core *** presence of nanoscale deformation twins,SFs,Lomer–Cottrell dislocation locks and phase transformation from FCC to hexagonal close-packed at twin boundaries synergistically enhanced the strain hardening capacity of the material.

关键词： CoCrNi MEA heterogeneous structure twinning phase transformation strain hardening

A Necessary Condition for the Consistency of LAD Estimate

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Acta Mathematica Sinica,English Series 1996年第3期12卷 292-297页

作者： chen xiru, Department of {2. Graduate school, Academia Sinica Beijing 100039, chinaWu Yuehua, Department of {2. York university, TorontoZhao Lincheng, Department of {2. university of Science and Technology of china Heifei 2.002., china Department of mathematics Graduate School Academia Sinica Beijing China Department of mathematics York University Toronto Department of mathematics University of Science and Technology of China Heifei China

If in the linear model （1）the random errors e1, e2....satisfy assumption （B）（See Section 1）, then a necessary condition for the consistency of the LAD estimate of βo is sum from i=1 to∞‖xi‖2.∞.

If in the linear model （1）the random errors e1, e2./sub>,...satisfy assumption （B）（See Section 1）, then a necessary condition for the consistency of the LAD estimate of βo is sum from i=1 to∞‖xi‖2./sup>=∞.

关键词： Linear model LAD estimates Consistency

Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke

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Stroke & Vascular Neurology 2024年第4期9卷 367-379,I0022-I0031页

作者： Tianchi Tang Li-bin Hu Chao Ding Zhihua Zhang Ning Wang Tingting Wang Hang Zhou Siqi xia Linfeng Fan Xiong-jie Fu Feng Yan xiangnan Zhang Gao {2. Jianru Li Department of Neurosurgery Zhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina 2NeurosurgeryZhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiangChina 3Zhejiang University School of MedicineHangzhouZhejiangChina 4Zhejiang University Department of PharmacologyHangzhouZhejiangChina

Background Ischaemic stroke triggers neuronal mitophagy,while the involvement of mitophagy receptors in ischaemia/reperfusion(I/R)injury-induced neuronal mitophagy remain not fully ***,we aimed to investigate the involvement of mitophagy receptor FUN14 domain-containing 1(FUNDC1)and its modulation in neuronal mitophagy induced by I/R *** Wild-type and FUNDC1 knockout mice were generated to establish models of neuronal I/R injury,including transient middle cerebral artery occlusion(tMCAO)in vivo and oxygen glucose deprivation/reperfusion in *** outcomes of mice with two genotypes were *** mitophagy was analysed both in vivo and in *** of FUNDC1 and its regulator Src were *** impact of Src on FUNDC1-mediated mitophagy was assessed through administration of Src antagonist *** To our surprise,FUNDC1 knockout mice subjected to tMCAO showed stroke outcomes comparable to those of their wild-type *** neuronal mitophagy could be activated by I/R injury,FUNDC1 deletion did not disrupt neuronal *** activation of FUNDC1,represented by dephosphorylation of Tyr18,was detected in the early stages(within 3hours)of neuronal I/R injury;however,phosphorylated Tyr18 reappeared and even surpassed baseline levels in later stages(after 6hours),accompanied by a decrease in FUNDC1-light chain 3 *** inactivation of FUNDC1 was associated with Src activation,represented by phosphorylation of Tyr416,which changed in parallel with the level of phosphorylated FUNDC1(Tyr18)during neuronal I/R ***,FUNDC1-mediated mitophagy in neurons under I/R conditions can be rescued by pharmacological inhibition of *** FUNDC1 is inactivated by Src during the later stage(after 6hours)of neuronal I/R injury,and rescue of FUNDC1-mediated mitophagy may serve as a potential therapeutic strategy for treating ischaemic stroke.

关键词： FUNDC1 involvement injury

Composition analysis of Compound Shenhua Tablet,a seven-herb Chinese medicine for IgA nephropathy:evaluation of analyte-capacity of the assays

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Chinese Journal of Natural Medicines 2024年第2期22卷 178-192页

作者： ZHANG Haiyan WANG Qiuyue WANG Jianan ZHANG Sichao JIA Weiwei HE Ning xia xiaoyan WANG Ting LAI Liyu LI Jiaying DU Jing OLALEYE Olajide E {2. xiangmei YANG Junling LI Chuan Graduate school Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China school of Pharmacy University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100049China Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China Zhongshan Institute for Drug Discovery Zhongshan 528400China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China

Compound Shenhua Tablet,a medicine comprising seven herbs,is employed in treating IgA *** study aimed to meticulously analyze its chemical *** on a list of candidate compounds,identified through extensive literature review pertinent to the tablet’s herbal components,the composition analysis entailed the systematic identification,characterization,and quantification of the *** analyte-capacity of LC/ESI-MS-based and GC/EI-MS-based assays was *** identified and characterized constituents were quantified to determine their content levels and were ranked based on the constituents’daily doses.A total of 2.3 constituents,classified into 12.distinct categories,were identified and characterized in the Compound Shenhua *** constituents exhibited content levels of 1−10982.g·g^(−1),with daily doses of 0.01−395μmol·d^(−1).The predominant constituents,with daily doses of≥10μmol·d^(−1),include nine organic acids(citric acid,quinic acid,chlorogenic acid,cryptochlorogenic acid,gallic acid,neochlorogenic acid,isochlorogenic acid C,isochlorogenic acid B,and linoleic acid),five iridoids(specnuezhenide,nuezhenoside G13,nuezhenidic acid,secoxyloganin,and secologanoside),two monoterpene glycosides(paeoniflorin and albiflorin),a sesquiterpenoid(curzerenone),a triterpenoid(oleanolic acid),and a phenylethanoid(salidroside).Additionally,there were 83,12.,and 55 constituents detected in the medicine with daily doses of 1–10,0.1–1,and 0.01–0.1μmol·d^(−1),*** combination of the LC/ESI-MS-based and GC/EI-MS-based assays demonstrated a complementary relationship in their analyte-capacity for detecting the constituents present in the *** comprehensive composition analysis establishes a solid foundation for further pharmacological research on Compound Shenhua Tablet and facilitates the quality evaluation of this complex herbal medicine.

关键词： Compound Shenhua Tablet Composition analysis Analyte-capacity

A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2.replication

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3112-3129页

作者： Yuzheng Zhou Zongpeng chen Sijie Liu Sixu Liu Yujie Liao Ashuai Du Zijun Dong Yongxing Zhang Xuan chen Siyi Tao Xin Wu Aroona Razzaq Gang Xu De-an Tan Shanni Li Youwen Deng Jian Peng Shuyan Dai Xu Deng {2.nwen Zhang Taijiao Jiang Zheng Zhang Gong cheng Jincun Zhao Zan{2.n {2. Department of Cell Biology School of Life SciencesCentral South University410013 ChangshaChina Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and Technology518112 ShenzhenChina Department of Basic Medicine School of MedicineHunan Normal University410081 ChangshaChina Department of spine surgery The Third Xiangya HospitalCentral South University410013 ChangshaChina school of Basic Medical Sciences Anhui Medical University230032 HefeiChina Hunan Key Laboratory of Neurorestoratology 921 Hospital of Joint Logistics Support Force People’s Liberation Army of China(The Second Affiliated Hospital of Hunan Normal University)410003 ChangshaHunanChina Department of Geriatric Surgery Xiangya HospitalCentral South University410008 ChangshaChina xiangya school of Pharmaceutical Sciences Central South University410013 ChangshaChina Institute of Infectious Diseases Shenzhen Bay Laboratory518132 ShenzhenChina Guangzhou Laboratory 510005 GuangzhouChina Tsinghua university-Peking university Joint Center for Life Sciences School of MedicineTsinghua University100084 BeijingChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouChina Hunan Key Laboratory of Animal Models for Human Diseases Hunan Key Laboratory of Medical Genetics&Center for Medical GeneticsSchool of Life SciencesCentral South University410008 ChangshaChina

The ORF9b protein,derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2.serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune *** its significance,the precise regulatory mechanisms underlying its function remain *** the present study,we unveil that the ORF9b protein of SARS-CoV-2.including emerging mutant strains like Delta and Omicron,can undergo ubiquitination at the K67 site and subsequent degradation via the proteasome pathway,despite certain mutations present among these ***,our investigation further uncovers the pivotal role of the translocase of the outer mitochondrial membrane 70(TOM70)as a substrate receptor,bridging ORF9b with heat shock protein 90 alpha(HSP90α)and Cullin 5(CUL5)to form a *** this complex,CUL5 triggers the ubiquitination and degradation of ORF9b,acting as a host antiviral factor,while HSP90αfunctions to stabilize ***,treatment with HSP90 inhibitors such as GA or 17-AAG accelerates the degradation of ORF9b,leading to a pronounced inhibition of SARS-CoV-2.***-cell sequencing data revealed an up-regulation of HSP90αin lung epithelial cells from COVID-19 patients,suggesting a potential mechanism by which SARS-CoV-2.may exploit HSP90αto evade the host *** study identifies the CUL5-TOM70-HSP90αcomplex as a critical regulator of ORF9b protein stability,shedding light on the intricate host–virus immune response dynamics and offering promising avenues for drug development against SARS-CoV-2.in clinical settings.

关键词： stability modulator offering

Rational Design and Construction of a CdS QDs/lnVO_(4) Atomic-Layer(110)/(110)Facet S-Scheme Heterojunction for Highly Efficient Photocatalytic Degradation of C_(2.H_(4)

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Energy & Environmental Materials 2024年第3期7卷 211-218页

作者： Yuanpeng Dong Peizhu Ji Xinyue Xu Rong Li Yin Wang Kevin Peter Homewood xiaohong xia Yun Gao Xuxing {2. Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science&EngineeringHubei UniversityWuhan 430062China Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China United Water(xianning)Company Limited Xianning 437100China

Exploring high efficiency S-scheme heterojunction photocatalysts with strong redox ability for removing volatile organic compounds from the air is of great interest and ***,how to predict and regulate the transport of photogenerated carriers in heterojunctions is a great ***,density functional theory calculations were first used to successfully predict the formation of a CdS quantum dots/InVO_(4)atomic-layer(110)/(110)facet S-scheme ***,a CdS quantum dots/InVO_(4)atomic-layer was synthesized by in-situ loading of CdS quantum dots with(110)facets onto the(110)facets of InVO_(4)*** a result of the deliberately constructed built-in electric field between the adjoining facets,we obtain a remarkably enhanced photocatalytic degradation rate for *** rate is 13.8 times that of pure CdS and 13.2.times that of pure InVO_(4).In-situ irradiated X-ray photoelectron spectroscopy,photoluminescence and time-resolved photoluminescence measurements were carried *** experiments validate that the built-in electric field enhanced the dissociation of photoexcited excitons and the separation of free charge carriers,and results in the formation of S-scheme charge transfer *** reaction mechanism of the photocatalytic C_(2.H_(4)oxidation is investigated by in-situ electron paramagnetic *** work provides a mechanistic insight into the construction and optimization of semiconductor heterojunction photocatalysts for application to environmental remediation.

关键词： CdS QDs InVO_(4)atomic-layer photocatalysis S-scheme volatile organic compounds

IMpower2.0:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 103-113页

作者： Yi-Long Wu Shun Lu Gongyan chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang Amy Cai Lilian Bu Jane Shi Jinjing xia Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Respiration Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Department of Thoracic Oncology and Surgery the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Department of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Product Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: IMpower2.0(NCT02.13785) explored the efficacy and safety of single-agent atezolizumab *** as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian ***: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2.1 to receive either atezolizumab(1,2.0 mg) or docetaxel(75 mg/m^(2.). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT ***: Median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312. and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82.95% CI, 0.66-1.03]. Median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2. months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel ***: IMpower2.0 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.

关键词： Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody