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Particle distributions in Lamb wave based acoustofluidics

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Nanotechnology and Precision Engineering 2024年第2期7卷 60-68页

作者： Chuanchao Zhang xian chen Wei Wei Xuejiao chen Quanning Li Xuexin Duan Key Laboratory of Precision Measuring Technology and Instruments College of Precision Instrument and Optoelectronics EngineeringTianjin UniversityTianjin300072China

Acoustic streaming enabled by a Lamb wave resonator(LWR)is efficient for particle trapping and enrichment in microfluidic ***,because Lamb waves combine the features of bulk acoustic waves and surface acoustic waves,the resulting acoustic streaming in the LWR occurs in multiple planes,and the particle flow behavior in this acoustofluidic system is largely *** here are numerical simulations and laboratory experiments conducted to investigate the boundary conditions for particle motion inside a microvortex induced by an *** dynamic capture,the particles’trajectories become orbital paths within an acoustic *** suspended particles encounter two distinct acoustic phenomena,i.e.,the drag force resulting from acoustic streaming and the acoustic radiation force,which exert forces in various directions on the *** the acoustic radiation force and the fluid drag force are dominant for large and small particles in a mixed solution,respectively,the large particles reside within the vortex while the small particles remain at its ***,when the acoustic radiation force is dominant for both types of particles,the distribution pattern is reversed.

关键词： Acoustofluidics Lamb wave resonator Particle manipulation Microvortex

Engineered extracellular vesicles: A new approach for targeted therapy of tumors and overcoming drug resistance

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Cancer Communications 2024年第2期44卷 205-225页

作者： chen Ming-Kun chen Zi-xian Cai Mao-Ping chen Hong chen Zhuang-Fei Zhao Shan-Chao Department of Urology The Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdongP.R.China The Third Clinical College Southern Medical UniversityGuangzhouGuangdongP.R.China Luoyang Key Laboratory of Organic Functional Molecules College of Food and DrugLuoyang Normal UniversityLuoyangHenanP.R.China Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China

Targeted delivery of anti-tumor drugs and overcoming drug resistance in malig-nant tumor cells remain significant clinical ***,there are only few effective methods to address these *** vesicles(EVs),actively secreted by cells,play a crucial role in intercellular information transmis-sion and cargo *** studies have demonstrated that engineered EVs can serve as drug delivery carriers and showed promising application ***,there is an urgent need for further improvements in the isolation and purification of EVs,surface modification techniques,drug assem-bly processes,and precise recognition of tumor cells for targeted drug delivery *** this review,we summarize the applications of engineered EVs in cancer treatment and overcoming drug resistance,and current challenges asso-ciated with engineered EVs are also *** review aims to provide new insights and potential directions for utilizing engineered EVs as targeted delivery systems for anti-tumor drugs and overcoming drug resistance in the near future.

关键词： drug delivery drug resistance extracellular vesicles nanoparticles

A topology approach to overcome the pore size/volume trade-offs for autonomous indoor humidity control

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Science China Chemistry 2024年第9期67卷 2968-2974页

作者： Zhi-Shuo Wang Xue-Wen Zhang Kai Zheng Xiao-xian chen Dong-Dong Zhou Jie-Peng Zhang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular EngineeringSchool of ChemistryIGCMESun Yat-Sen UniversityGuangzhou 510275China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515021China

Autonomous indoor humidity control is gaining more and more attention but is limited by the trade-offs among pore volume,pore size and water stability of water *** solve this problem by using a unique coordination network topology combined with hydrolytically stable M(Ⅲ)carboxylate *** extending the ligand length from 9.0 to 11.2 and 13.7?,the pore volume significantly increases from 0.99 to 1.40 and 1.78 cm^(3)g^(-1),which proportionally increases the saturated water adsorption ***,the pore size slightly increases from 10.4 to 11.0 and 13.5A,which restricts the isotherm inflection pressure and hysteresis width to meet the requirement of indoor humidity *** single-crystals suitable for Xray diffraction studies were obtained by using Fe(Ⅲ)salts,while isostructural frameworks with sufficiently high water stabilities were synthesized by using Cr(Ⅲ)salts,which offer record working capacity of 0.90 and 1.10 g g^(-1)for indoor humidity control.

关键词： metal-organic frameworks water adsorption indoor humidity control water stability pore engineering

A 28/56 Gb/s NRZ/PAM-4 dual-mode transceiver with 1/4 rate reconfigurable 4-tap FFE and half-rate slicer in a 28-nm CMOS

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Journal of Semiconductors 2024年第6期45卷 35-46页

作者： Yukun He Zhao Yuan Kanan Wang Renjie Tang Yunxiang He xian chen Zhengyang Ye Xiaoyan Gui School of Microelectronics Xi’an Jiaotong UniversityXi’an 710049China

A 28/56 Gb/s NRZ/PAM-4 dual-mode transceiver(TRx)designed in a 28-nm complementary metal-oxide-semiconduc-tor(CMOS)process is presented in this article.A voltage-mode(VM)driver featuring a 4-tap reconfigurable feed-forward equal-izer(FFE)is employed in the quarter-rate transmitter(TX).The half-rate receiver(RX)incorporates a continuous-time linear equal-izer(CTLE),a 3-stage high-speed slicer with multi-clock-phase sampling,and a clock and data recovery(CDR).The experimen-tal results show that the TRx operates at a maximum speed of 56 Gb/s with chip-on board(COB)*** 28 Gb/s NRZ eye diagram shows a far-end vertical eye opening of 210 mV with an output amplitude of 351 mV single-ended and the 56 Gb/s PAM-4 eye diagram exhibits far-end eye opening of 33 mV(upper-eye),31 mV(mid-eye),and 28 mV(lower-eye)with an output amplitude of 353 mV *** recovered 14 GHz clock from the RX exhibits random jitter(RJ)of 469 fs and deterministic jitter(DJ)of 8.76 *** 875 Mb/s de-multiplexed data features 593 ps horizontal eye opening with 32.02 ps RJ,at bit-error rate(BER)of 10-5(0.53 UI).The power dissipation of TX and RX are 125 and 181.4 mW,respectively,from a 0.9-V sup-ply.

关键词： transceiver(TRx) feed-forward equalizer(FFE) clock and data recovery(CDR) continuous time linear equalizer(CTLE)

WNT5A Regulated by miR154-5p is Associated with Angiopoiesis and Invasion of Placental Site Trophoblastic Tumor (PSTT)

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Biomedical and Environmental Sciences 2024年第4期37卷 423-427页

作者： ZHANG Sai chen Zhi xian ZHANG Mo DU Yan ZHOU Jia Yi WU Jing YU Yin Hua CAO Qi ZHAO Hong Bo Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China

Placental site trophoblastic tumor(PSTT),a rare gestational trophoblastic neoplasm(GTN),exhibits slow growth,late-onset metastasis,and chemotherapy insensitivity[1,2].The invasive capacity of trophoblasts induces angiogenesis in PSTT,yet the specific mechanism remains unclear[3].PSTT is typically resistant to chemotherapy and hysterectomy stands as the primary therapeutic choice for patients with an overall cure rate of approximately 75%-80%[4,5].Therefore,investigating the precise emergence and progression of PSTT is crucial,aiming to identify novel targets for diagnosis and therapy.

关键词： chemotherapy diagnosis metastasis

Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population:A prospective,multicenter,randomized,two-stage study

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World Journal of Gastroenterology 2024年第27期30卷 3304-3313页

作者： Xue-Ping Huang Zhi-Hui Lin Yi-Juan Liu Shao-Wei Lin Yan-Feng Shao Feng Qiu Qing-Wu Qiu Zhang-Kun Xu Jin-xian chen Liang-Huo chen Zhen-Qun Lin Wen-Hua Dai Ming-Qing Zhang Qi Jiang Zhong-Qin Xiao xian-Xing cheng xiang-Fei Zhang Wen-Bin You Wei chen Long-Qin Li Wei-Xing Lin Yong-Fu Wang Fu-Jin Lai Long-Qun chen Zhong-Hua Huang Wen-Qi Zheng Jin-Qi Wei Department of Gastroenterology Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina School of Public Health Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Third People’s Hospital of Fujian ProvinceFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial Hospital North Brance Fujian Provincial Geriatric HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Xiaoao HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The General Hospital of Fujian Energy GroupFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Second Hospital of ZhangzhouZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Anxi Country HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Zhangzhou Municipal Hospital of TCMZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Zhangpu HospitalZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology The Affiliated Dongnan Hospital of Xiamen UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology First Hospital of Nanping CityNanping 353000Fujian ProvinceChina Department of Gastroenterology Fujian Nanping Second HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Wuyishan Municipal HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Fuzhou Changle District HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Changle City Second HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Jinjiang Municipal HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Fuding Hospital Affiliated to Fuj

BACKGROUND The efficacy of Vonoprazan-amoxicillin dual therapy(VAT)in the treatment of Helicobacter pylori(***)is *** To evaluate the efficacy of VAT in the Chinese *** This prospective,multicenter,randomized,open-label,and two-stage study was conducted at 23 centers in Fujian,China(May 2021-April 2022).***-infected patients were randomized to bismuth quadruple therapy(BQT),BQT-Vonoprazan(BQT-V),seven-day VAT(VAT-7),ten-day VAT(VAT-10),and fourteen-day VAT(VAT-14)*** primary endpoint was the *** eradication *** secondary endpoint was the frequency of adverse *** study was registered with the Chinese Clinical Trial Registry,*** In the first stage,VAT-7 and BQT-V groups were selected for early termination because less than 23 among 28 cases were *** the second stage,the eradication rates for BQT,VAT-10,and VA-14 were 80.2%[95%confidence interval(95%CI):71.4%-86.8%],93.2%(86.6%-96.7%),92.2%(85.3%-96.0%)in the intention-to-treat(ITT)analysis,and 80.9%(95%CI:71.7%-87.5%),94.0%(87.5%-97.2%),and 93.9%(87.4%-97.2%)in the per-protocol *** ITT analysis showed a higher eradication rate in the VAT-10 and VAT-14 groups than in the BQT group(P=0.022 and P=0.046,respectively).The incidence of adverse events in the VAT-10 and VAT-14 groups was lower than in the BQT group(25.27%and 13.73%vs 37.62%,respectively;P<0.001).CONCLUSION VAT with a duration of 10 or 14 days achieves a higher eradication rate than the BQT,with a more tolerable safety profile in ***-infected patients in *** XP et *** for *** eradication.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Bismuth quadruple therapy

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可持续发展评估新思路:甜甜圈框架研究进展

自然资源学报 2024年第2期39卷 307-318页

作者：陈先鹏方恺浙大城市学院法学院杭州310015 浙江大学公共管理学院杭州310058 浙江大学民生保障与公共治理研究中心杭州310058

可持续发展是全人类普遍关注和热烈讨论的焦点议题。作为行星边界框架向社会经济领域的拓展,甜甜圈框架为全球范围内的可持续发展评估提供了新思路。本文对甜甜圈框架的概念内涵、理论基础、本地化拓展、存在的问题及改进方向进行了系... 详细信息

可持续发展是全人类普遍关注和热烈讨论的焦点议题。作为行星边界框架向社会经济领域的拓展,甜甜圈框架为全球范围内的可持续发展评估提供了新思路。本文对甜甜圈框架的概念内涵、理论基础、本地化拓展、存在的问题及改进方向进行了系统梳理和深入分析。研究表明:甜甜圈框架有机整合了环境边界和社会经济基本需求,进而将环境可持续性和社会经济发展纳入同一个分析框架。该框架以稳态经济理论为理论基础,强调既要一定的人造资本以满足人的社会经济需求,又要恒定的自然资本以维持环境的可持续性。甜甜圈框架的本地化拓展应用多以环境可持续性和社会经济发展的各自评估为主,缺乏对内在交互机制的深入阐释。为增强对环境边界与社会经济边界之间传导机制的科学认知,亟需加强基于生态系统单元的环境边界、生态系统服务和社会经济边界三者之间互动关系的研究。甜甜圈框架对全球和区域可持续发展的指导价值有待进一步提升。由于与中国兼顾生态保护红线和社会经济底线的发展理念高度契合,甜甜圈框架在中国可持续发展领域具有较大的应用潜力空间。

关键词：可持续发展甜甜圈框架行星边界社会经济边界生态系统服务

从诃梨勒到诃子:中印文化交流视域下的本草“中国化”

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陕西师范大学学报（哲学社会科学版） 2024年第4期53卷 53-65页

作者：陈宪良成都中医药大学中国出土医学文献与文物研究院四川成都610075

诃梨勒作为一味产自印度、伊朗等地的果药,经由丝绸之路上的胡商、胡僧从海陆两种途径进入中国。经过中医吸收与创新,来自域外的诃梨勒不仅化身为中医治病救人的常用方剂药诃子,而且还融进先民的宗教、饮食、染色等日常生活,丰富了中原... 详细信息

诃梨勒作为一味产自印度、伊朗等地的果药,经由丝绸之路上的胡商、胡僧从海陆两种途径进入中国。经过中医吸收与创新,来自域外的诃梨勒不仅化身为中医治病救人的常用方剂药诃子,而且还融进先民的宗教、饮食、染色等日常生活,丰富了中原地区人们的生活。就物质文化内涵而言,因为诃梨勒融入了历史、文化、宗教等诸多元素,所以其早已超越药材本身的价值,成为丝绸之路以及中印文化交流史上具有特别意义的物质文化符号,充分体现了中华优秀传统文化对外来事物强大的吸纳与创新能力,是为中印文化交流的一个缩影。

关键词：诃梨勒中医医药丝绸之路敦煌写卷佛教医学弘法僧医

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电磁不连续和缺陷结构表面波散射特性

航空学报 2024年第12期45卷 269-281页

作者：余龙舟黄江涛钟世东陈宪陈诚中国空气动力研究与发展中心空天技术研究所绵阳621000

对于隐身飞行器设计,当镜面和腔体等主要散射源被抑制后,表面波在电磁不连续和缺陷结构处产生的回波散射和空间散射成为重要的散射源。为研究电磁不连续和缺陷结构的表面波散射行为,通过平板波导激励,建立起表面波传输模型。基于该表面... 详细信息

对于隐身飞行器设计,当镜面和腔体等主要散射源被抑制后,表面波在电磁不连续和缺陷结构处产生的回波散射和空间散射成为重要的散射源。为研究电磁不连续和缺陷结构的表面波散射行为,通过平板波导激励,建立起表面波传输模型。基于该表面波传输模型,从飞行器表面结构出发,建立了曲面及二面倾角、缝隙和台阶3类电磁不连续或缺陷结构,并开展仿真研究,获得了关键结构参数与回波散射强度和空间散射效率的定量关系。研究表明:凸面不连续结构的表面波在传输过程中不断向空间散射而衰减,当凸面半径超过10倍波导波长时,衰减系数接近0,凹面不连续结构的表面波在传输过程中不衰减;二面倾角结构的倾角在30°范围内时,能够有效抑制表面波的空间散射效率在10%以内,且回波散射较弱;缝隙和台阶的表面波散射与结构尺寸之间存在半波谐振关系,且回波散射和空间散射抑制难以兼顾。研究结果可为隐身飞行器外形结构的表面波散射抑制设计提供指导。

关键词：电磁散射外形隐身设计表面波电磁不连续结构电磁缺陷结构