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Unveiling the mechanisms of Fe(Ⅲ)-loaded chitosan composite(CTS-Fe)in enhancing anaerobic digestion of waste activated sludge

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Journal of Environmental sciences 2024年第4期138卷 200-211页

作者： Boaiqi Zhang Ziwen Zhao RuiMa Nan chen Zhe Kong Zhongfang Lei Zhenya Zhang graduate school of Life and Environmental sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8572Japan The Key Laboratory of Water and Sediment sciences Ministry of Education/State Environmental Protection Key Laboratory of All Material Fluxes in River Ecosystems/College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China South china.Institute of Environmental sciences Ministry of Ecology and EnvironmentGuangzhou 510345China school of Water Resources and Environment China University of Geosciences(Beijing)Beijing 100083China school of Environmental science and Engineering Suzhou University of Science and TechnologySuzhou 215009China

Anaerobic digestion(AD)of waste activated sludge(WAS)is usually limited by the low generation efficiency of ***(Ⅲ)-loaded chitosan composite(CTS-Fe)have been reported to effectively enhanced the digestion of WAS,but its role in promoting anaerobic sludge digestion remains *** present study,the effects of CTS-Fe on the hydrolysis and methanogenesis stages of WAS anaerobic digestion were *** addition of CTSFe increased methane production potential by 8%-23%under the tested conditions with the addition of 5-20 g/L ***,the results demonstrate that the addition of CTS-Fe could effectively promote the hydrolysis of WAS,evidenced by lower protein or polysaccharides concentration,higher soluble organic carbon in rector adding CTS-Fe,as well as the increased activity of extracellular hydrolase with higher CTS-Fe ***,the enrichment of Clostridia abundance(iron-reducing bacteria(IRBs))was observed in CTS-Fe adding reactor(8.9%-13.8%),which was higher than that in the control reactor(7.9%).The observation further suggesting the acceleration of hydrolysis through dissimilatory iron reduction(DIR)process,thus providing abundant substrates for ***,the presence of CTS-Fe was inhibited the acetoclastic and hydrogenotrophic methanogenesis process,which could be ascribed to the Fe(Ⅲ)act as electron acceptor coupled to methane for anaerobic ***,coenzyme F420 activity in the CTS-Fe added reactor was 34.9% lower than in the blank,also abundance of microorganisms involved in hydrogenotrophic methanogenesis was *** from this study could provide theoretical support for the practical applications of CTS-Fe.

关键词： Chitosan-Fe(Ⅲ)composite Methanogenesis Dissimilatory iron reduction Enzyme activity Microbial community structure

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CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy

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Journal of Genetics and Genomics 2024年第2期51卷 184-196页

作者： Yan Shi Chunyan Cao Yiheng Zeng Yuanliang Ding Long chen Fuze Zheng Xuejiao chen Fanggui Zhou Xiefeng Yang Jinjing Li Liuqing Xu Guorong Xu Minting Lin Hiroyuki Ishiura Shoji Tsuji Ning Wang Zhiqiang Wang Wan-Jin chen Kang Yang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Department of Neurology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350212China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan 471000China Department of Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujian 363000China Department of Neurology Jian'ou Municipal Hospital of Fujian ProvinceJian'ouFujian 353100China Department of Radiology First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Department of Neurology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Neurology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Institute of Medical Genomics International University of Health and WelfareChiba 286-0048Japan

CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with ***,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/***,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal *** CGG repeat expansions range from 161 to 669 repeat *** of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle *** one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance *** biopsies from three patients show a myopathic pattern and rimmed *** of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to *** study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers.

关键词： Oculopharyngeal myopathy with leukoencephalopathy Oculopharyngodistal myopathy CGG repeat expansion Rimmed vacuoles

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Design,synthesis,antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives

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Acta Pharmacologica Sinica 2007年第1期28卷 140-152页

作者： Hai-hong LI~2 Xiu-hua ZHANG~3 Jin-zhi TAN~2 Li-li chen~2 Hong LIU~(2,5) Xiao-min LUO~(2,5) Xu SHEN~(2,4) Li-ping LIN~(3,5) Kai-xian chen~2 Jian DING~3 Hua-liang JIANG~(2,4)2 Center for Drug Discovery and Design,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological sciences,and graduate school,Chinese Academy of sciences,Shanghai 201203,china.3 Division of Anti-tumor Pharmacology,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological sciences,Chinese Academy of sciences,Shanghai 201203,china.4 school of Pharmacy,East china.university of science and technology,Shanghai 200237,china CenterforDrugDiscoveryandDesign StateKeyLaboratoryofDrugResearchShanghaiInstituteofMateriaMedicaShanghaiInstitutesforBiologicalSciencesandGraduateSchoolChineseAcademyofSciencesShanghai201203China

Aim:To design and synthesize a novel class of antitumor agents,featuring the 3,5-substituted indolin-2-one ***:Based on enzyme binding fea-tures of（Z）-SU5402,introducing a β-pyrrole group at the 3-position of the indolin-2-one core,a series of novel 3,5-substituted indolin-2-ones were designed *** human carcinoma cell lines of A-43l,A-549,MDA-MB-468,and Autosomal Dominant Polycystic Kidney disease were chosen for the cellproliferation ***:Twenty new compounds（1a-t）with E configurationhave been designed,synthesized and *** structural features weredetermined by nuclear magnetic resonance（NMR）spectra,low-and high-resolu-tion mass spectra,and confirmed by X-ray *** the enzymeassay showed a weak inhibition effect against the epidermal growth factor receptor,vascular endothelial growth factor receptor,fibroblast growth factor receptor andplatelet-derived growth factor receptor tyrosine kinases,the cell-based antitumoractivity was *** 1 g and lh showed higher inhibitory activitytoward the A-549 and MDA-MB-468 cell lines with IC50of 0.065-9.4 μmol/***:This study provides a new template for further development ofpotent antitumor drugs.

关键词： protein-tyrosine kinase indolin-2-one antitumor drug screening assays drug design molecular models

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YBa_2Cu_3O_7超导管内磁场与外磁场的关系

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物理学报 1989年第6期38卷 1016-1020页

作者：徐凤枝杨沛然陈烈陈肖兰柴璋李碧钦中国科学院物理研究所中国科学技术大学研究生院

本文报道了当外磁场H_e较低时(H_eH_(rm)时,这几个量增加较大。当直流外磁场He<1/2H_(rm)时,超导管可将其完全屏蔽,对交流场不能完全屏蔽,但其屏蔽效果仍优于最好的金属屏蔽筒。

关键词：超导合金超导管磁场

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Boosting Adversarial Training with Learnable Distribution

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Computers, Materials & Continua 2024年第3期78卷 3247-3265页

作者： Kai chen Jinwei Wang James Msughter Adeke Guangjie Liu Yuewei Dai school of Electronics and Information Engineering Nanjing University of Information Science and TechnologyNanjing210044China Key Laboratory of Intelligent Support technology for Complex Environments Ministry of EducationNanjing210044China school of Computer and Software Nanjing University of Information Science and TechnologyNanjing210044China Nanjing Center for Applied Mathematics Nanjing211135China

In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural *** training is one of the most potent methods to defend against adversarial ***,the difference in the feature space between natural and adversarial examples hinders the accuracy and robustness of the model in adversarial *** paper proposes a learnable distribution adversarial training method,aiming to construct the same distribution for training data utilizing the Gaussian mixture *** distribution centroid is built to classify samples and constrain the distribution of the sample *** natural and adversarial examples are pushed to the same distribution centroid to improve the accuracy and robustness of the *** proposed method generates adversarial examples to close the distribution gap between the natural and adversarial examples through an attack algorithm explicitly designed for adversarial *** algorithm gradually increases the accuracy and robustness of the model by scaling ***,the proposed method outputs the predicted labels and the distance between the sample and the distribution *** distribution characteristics of the samples can be utilized to detect adversarial cases that can potentially evade the model *** effectiveness of the proposed method is demonstrated through comprehensive experiments.

关键词： Adversarial training feature space learnable distribution distribution centroid

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A Novel Quantization and Model Compression Approach for Hardware Accelerators in Edge Computing

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Computers, Materials & Continua 2024年第8期80卷 3021-3045页

作者： Fangzhou He Ke Ding DingjiangYan Jie Li Jiajun Wang Mingzhe chen State Key Laboratory of Intelligent Vehicle Safety technology Chongqing401133China Foresight technology Institute Chongqing Changan Automobile Co.Ltd.Chongqing400023China school of Computer science and Engineering Chongqing University of Science and TechnologyChongqing401331China

Massive computational complexity and memory requirement of artificial intelligence models impede their deploy-ability on edge computing devices of the Internet of Things(IoT).While Power-of-Two(PoT)quantization is pro-posed to improve the efficiency for edge inference of Deep Neural Networks(DNNs),existing PoT schemes require a huge amount of bit-wise manipulation and have large memory overhead,and their efficiency is bounded by the bottleneck of computation latency and memory *** tackle this challenge,we present an efficient inference approach on the basis of PoT quantization and model *** integer-only scalar PoT quantization(IOS-PoT)is designed jointly with a distribution loss regularizer,wherein the regularizer minimizes quantization errors and training ***,two-stage model compression is developed to effectively reduce memory requirement,and alleviate bandwidth usage in communications of networked heterogenous learning *** product look-up table(P-LUT)inference scheme is leveraged to replace bit-shifting with only indexing and addition operations for achieving low-latency computation and implementing efficient edge ***,comprehensive experiments on Residual Networks(ResNets)and efficient architectures with Canadian Institute for Advanced Research(CIFAR),ImageNet,and Real-world Affective Faces Database(RAF-DB)datasets,indicate that our approach achieves 2×∼10×improvement in the reduction of both weight size and computation cost in comparison to state-of-the-art methods.A P-LUT accelerator prototype is implemented on the Xilinx KV260 Field Programmable Gate Array(FPGA)platform for accelerating convolution operations,with performance results showing that P-LUT reduces memory footprint by 1.45×,achieves more than 3×power efficiency and 2×resource efficiency,compared to the conventional bit-shifting scheme.

关键词： Edge computing model compression hardware accelerator power-of-two quantization

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Continuous near-complete photocatalytic degradation of toluene by V/N-doped TiO_(2)loade d on honeycomb ceramics under UV irradiation

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Journal of Materials science & technology 2024年第7期174卷 188-194页

作者： Gang Liu Lijuan Han Jingwei Wang Yongqiang Yang Zuoyan chen Bilu Liu Xingcai An Gansu Natural Energy Institute Lanzhou 730046China Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen Institute&Institute of Materials ResearchTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Shenyang National Laboratory for Materials science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Photocatalytic degradation of volatile organic compounds(VOCs)is a significant applying aspect of *** the modulation of photocatalysts and the rational dispersion of them on supports are key for solar-driven VOC *** batch-type photoreactors have low efficiency while continuous-flow photoreactors suffer from the problem of incomplete removal of ***,aiming for continuous and complete degradation of toluene gas as the target contaminant,continuous-flow pho-tocatalytic degradation reactors were made by adhering the vanadium and nitrogen codoped TiO_(2)on honeycomb ceramics(V/N-TiO_(2)@HC)by a simple sol-gel *** such a reactor,the rich ordered pores in the HC accelerate mass transport of toluene,and the introduction of V/N dopants narrows the bandgap and widens the light absorption range of TiO_(2),together resulting in continuous and nearly-complete pho-tocatalytic degradation of *** unique and stable structure of HC allows the photocatalysts to be *** degradation rate of toluene gas can reach 97.8%,and after 24 rounds of photocatalytic degra-dation,there is still a degradation rate of 96.7%.The impacts of loading times and gaseous flow rate on the photocatalytic performance of V/N-TiO_(2)@HC are studied in *** study provides a practical so-lution for the continuous and complete photocatalytic degradation of VOCs and opens a new application field for HC.

关键词： Honeycomb ceramics V/N co-doped TiO_(2) Photocatalytic degradation Toluene gas Continuous and complete degradation

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Ripple Knowledge Graph Convolutional Networks for Recommendation Systems

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Machine Intelligence Research 2024年第3期21卷 481-494页

作者： chen Li Yang Cao Ye Zhu Debo cheng chengyuan Li Yasuhiko Morimoto graduate school of Informatics Nagoya UniversityChikusaNagoya 464-8602Japan Centre for Cyber Resilience and Trust Deakin UniversityBurwood 3125Australia science TechnologyEngineering and Mathematics(STEM)University of South AustraliaAdelaide 5000Australia graduate school of Engineering Hiroshima UniversityHigashi-hiroshima 10587Japan

Using knowledge graphs to assist deep learning models in making recommendation decisions has recently been proven to effectively improve the model′s interpretability and *** paper introduces an end-to-end deep learning model,named representation-enhanced knowledge graph convolutional networks(RKGCN),which dynamically analyses each user′s preferences and makes a recommendation of suitable *** combines knowledge graphs on both the item side and user side to enrich their representations to maximize the utilization of the abundant information in knowledge *** is able to offer more personalized and relevant recommendations in three different *** experimental results show the superior effectiveness of our model over 5 baseline models on three real-world datasets including movies,books,and music.

关键词： Deep learning recommendation systems knowledge graph graph convolutional networks(GCNs) graph neural networks(GNNs)

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Gamma Approximation Based Multi-Antenna Covert Communication Detection

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china.Communications 2024年第9期21卷 90-97页

作者： Wan Pengwu chen Dongrui Wang Danyang Hui Xi Peng Kang school of Communications and Information Engineering&school of Artificial Intelligence Xi’an University of Posts and TelecommunicationsXi’an 710121China Key Laboratory of Integrated Service Networks School of Telecommunications EngineeringXidian UniversityXi’an 710071China

Covert communication technology makes wireless communication more secure,but it also provides more opportunities for illegal users to transmit harmful *** order to detect the illegal covert communication of the lawbreakers in real time for subsequent processing,this paper proposes a Gamma approximation-based detection method for multi-antenna covert communication ***,the Gamma approximation property is used to calculate the miss detection rate and false alarm rate of the monitor *** the optimization problem to minimize the sum of the missed detection rate and the false alarm rate is *** optimal detection threshold and the minimum error detection probability are solved according to the properties of the Lambert W ***,simulation results are given to demonstrate the effectiveness of the proposed method.

关键词： covert communication detection Gamma approximation Lambert W function multi-antenna technique

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Delineation of urban growth boundary based on FLUS model under the perspective of land use evaluation in hilly mountainous areas

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Journal of Mountain science 2024年第5期21卷 1647-1662页

作者： ZHANG Yunping LIN Jianping HUANG Yimin chen Zebin ZHU chenhui YUAN Hao school of Geography and Environmental Engineering Gannan Normal UniversityGanzhou 341000China Key Laboratory of Low Carbon Recycling technology for Municipal Solid Waste in Jiangxi Province Ganzhou 341000China

With rapid economic development,the size of urban land in china.is expanding *** Urban Growth Boundary(UGB)is an expandable spatial boundary for urban construction in a certain period in order to control the urban *** delineation of UGB can inhibit the disorderly spread of urban space and guide the normal development of the *** is of practical significance for the construction of green urban *** study utilizes GIS technology to establish a land construction suitability evaluation system for Nankang city,which is experiencing rapid urban expansion,and outlines the preliminary UGB under the future land use simulation(FLUS)*** the same time,considering the coupled coordination of"Production-Living-Ecological Space",and based on the suitability evaluation,we revised the preliminary UGB by combining the advantages of the patch-generating land use simulation(PLUS)model and the convex hull model to delineate the final *** results show that:1)the comprehensive score of the evaluation of the suitability of the construction of land from high to low shows the distribution of the center of the city to the surrounding circle type spread,the center of the city has the highest suitability *** results of convex hull model show that the urban expansion type of Nankang is *** the future,the urban expansion will mainly occur in the northern part of the *** PLUS model predicts an increase of 3359.97 hm^(2)of construction land in Nankang by 2035,of which 2022.97 hm^(2)is urban construction land.2)The FLUS model has a prediction accuracy of 86.3%and delineates a preliminary UGB area of 9215.07 hm^(2).3)We used the results of the construction suitability evaluation,PLUS model simulation results,and convex hull model predictions to revise the originally delineated *** final delineated UGB area is 8895.67 hm^(2)and it is capable of meeting the future development of the study *** results of the delineation can promote

关键词： Urban sprawl FLUS model Spatial correction Urban growth boundary Sustainable development

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