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A Review of Type 1 and Type 2 Intraductal Papillary Neoplasms of the Bile Duct

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Current Medical Science 2024年第3期44卷 485-493页

作者： Xia-hui HUANG Tian-xiang chen Hong-liang LIU ming-wen HUANG Department of General Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang330006China

Intraductal papillary neoplasm of the bile duct(IPNB)is a heterogeneous disease similar to intraductal papillary mucinous neoplasm of the *** lesions have been recognized as one of the three major precancerous lesions in the biliary tract since *** 2018,Japanese and Korean pathologists reached a consensus,classifying IPNBs into type l and type 2 *** are more prevalent in male patients in East Asia and are closely related to diseases such as cholelithiasis and *** a molecular genetic perspective,IPNBs exhibit early genetic variations,and different molecular pathways may be involved in the tumorigenesis of type 1 and type 2 *** histological subtypes of IPNBs include gastric,intestinal,pancreaticobiliary,or oncocytic subtypes,but type 1 IPNBs typically exhibit more regular and well-organized histological features than type 2 IPNBs and are more commonly found in the intrahepatic bile ducts with abundant *** to the rarity of these lesions and the absence of specific clinical and laboratory features,imaging is crucial for the preoperative diagnosis of IPNB,with local bile duct dilation and growth along the bile ducts being the main imaging *** resection remains the optimal treatment for IPNBs,but negative bile duct margins and the removal of lymph nodes in the hepatic hilum significantly improve the postoperative survival rates for patients with IPNBs.

关键词： intraductal papillary neoplasm of the bile duct subclassification neoplasms precancerous tissue prognosis

Electrochemical Reduction of Benzo[b]thiophene 1,1-Dioxides with HFIP as Hydrogen Donor

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Chinese Journal of Chemistry 2024年第6期42卷 585-591页

作者： ming-Zhong Guo Mei-Jin Mou Zhuo chen Shao-Fei Ni ming Li Li-Rong wen Lin-Bao Zhang State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science & TechnologyQingdaoShandong266042 China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantouGuangdong515063 China

A straightforward electrochemical reduction of benzo[b]thiophene 1,1-dioxides with HFIP as the hydrogen donor has been reported in an undivided cell under metal-free ***,the tolerance of various functional groups and ... 详细信息

关键词： Electrochemistry Reduction Benzo[b]thiophene 1,1-dioxides Deuterium Hydrogen source

Surface Modification of AB_2 and AB_5 Hydrogen Storage Alloy Electrodes by the Hot-Charging Treatment

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Journal of Materials Science & Technology 2001年第2期17卷 247-251页

作者： Bo YU, Lian chen, mingfen wen, ming TONG and Demin chen Institute of Matel Research, Chinese Academy of Sciences, Shenyang 110015, China Yanwen TIAN and Yuchun ZHAI The Northeastern University, Shenyang 110006, China Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110015 China

The effect of the hot-charging treatment on the performance of AB(2) and AB(5) hydrogen storage alloy electrodes was investigated. The result showed that the treatment can markedly improve the voltage plateau ratio (VPR), the high rate discharge ability (HRDA), the diffusion coefficient of hydrogen DH and the discharge capacity of the AB2 hydrogen storage alloy electrode. The SEM analysis showed that the hot-charging treatment brings about a Ni-rich surface due to the dissolution of Zr oxides. It is also very helpful for the improvement of the kinetic properties of AB2 hydrogen storage alloy electrode because the microcracking of the surface results in fresh surface. This can be the basic modification treatment for NiMH battery used in electric vehicles (EVs) in the future. But for AB(5) type alloys, the treatment has the disadvantage of impairing the comprehensive electrochemical properties, because the surface of the alloy may be corroded during the treatment. The mechanism of the surface modification of the electrode is also proposed.

关键词： Surface Modification of AB2 and AB5 Hydrogen Storage Alloy Electrodes by the Hot-Charging Treatment AB

Adhesive Contact of Elastic Solids with Self-Affine Fractal Rough Surfaces

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Acta Mechanica Solida Sinica 2024年第2期37卷 265-270页

作者： Xuan-ming Liang Shi-wen chen Si-He Wang Zhen-Yuan Gong Jun Feng Gang-Feng Wang Department of Engineering Mechanics SVL and MMMLXi’an Jiaotong UniversityXi’an710049China OPPO Mobile Telecommunications Corporation Ltd. Dongguan523860China

The elastic adhesive contact of self-affine fractal rough surfaces against a rigid flat is simulated using the finite element method. An array of nonlinear springs, of which the force-separation law obeys the Lennard–Jones potential, is introduced to account for the interfacial adhesion. For fractal rough surfaces, the interfacial interaction is generally attractive for large mean gaps, but turns repulsive as the gap continuously shrinks. The interfacial interactions at the turning point corresponding to the spontaneous contact are shown for various surfaces. For relatively smooth surfaces, the probability density distributions of repulsion and attraction are nearly symmetric. However, for rougher surfaces, the simulation results suggest a uniform distribution for attraction but a monotonously decreasing distribution with a long tail for repulsion. The pull-off force rises with increasing ratio of the work of adhesion to the equilibrium distance, whereas decreases for solids with a higher elastic modulus and a larger surface roughness. The current study will be helpful for understanding the adhesion of various types of rough solids.

关键词： Fractal rough surfaces Adhesion Contact mechanics Lennard-Jones potential

Gradient sparsification for efficient wireless federated learning with differential privacy

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Science China(Information Sciences) 2024年第4期67卷 272-288页

作者： Kang WEI Jun LI Chuan MA ming DING Feng SHU Haitao ZHAO wen chen Hongbo ZHU School of Electronic and Optical Engineering Nanjing University of Science and Technology Zhejiang Lab Key Laboratory of Computer Network and Information Integration(Southeast University) Ministry of Education Data61 Commonwealth Scientific and Industrial Research Organisation School of Information and Communication Engineering Hainan University School of Communications and Information Engineering Nanjing University of Posts and Telecommunications School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University

Federated learning(FL) enables distributed clients to collaboratively train a machine learning model without sharing raw data with each other. However, it suffers from the leakage of private information from uploading models. In addition, as the model size grows, the training latency increases due to the limited transmission bandwidth and model performance degradation while using differential privacy(DP)protection. In this paper, we propose a gradient sparsification empowered FL framework with DP over wireless channels, to improve training efficiency without sacrificing convergence performance. Specifically, we first design a random sparsification algorithm to retain a fraction of the gradient elements in each client’s local model, thereby mitigating the performance degradation induced by DP and reducing the number of transmission parameters over wireless channels. Then, we analyze the convergence bound of the proposed algorithm, by modeling a non-convex FL problem. Next, we formulate a time-sequential stochastic optimization problem for minimizing the developed convergence bound, under the constraints of transmit power, the average transmitting delay, as well as the client’s DP requirement. Utilizing the Lyapunov drift-plus-penalty framework, we develop an analytical solution to the optimization problem. Extensive experiments have been implemented on three real-life datasets to demonstrate the effectiveness of our proposed algorithm. We show that our proposed algorithms can fully exploit the interworking between communication and computation to outperform the baselines, i.e., random scheduling, round robin, and delay-minimization algorithms.

关键词： federated learning differential privacy gradient sparsification Lyapunov drift convergence analysis

Long non-coding RNA GATA6-AS1 is mediated by N6-methyladenosine methylation and inhibits the proliferation and metastasis of gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1019-1028页

作者： Jun-Jie Shen Min-Chang Li Shao-Qi Tian wen-ming chen Department of Oncology Jiangxi Hospital of Integrated Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Department of Hepatopancreatobiliary Surgery Jiangxi Hospital of Integrated Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Clinical Medical School Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Oncology Jining No.1 People’s HospitalJining 272011Shandong ProvinceChina

BACKGROUND Through experimental research on the biological function of GATA6-AS1,it was confirmed that GATA6-AS1 can inhibit the proliferation,invasion,and migration of gastric cancer cells,suggesting that GATA6-AS1 plays a role as an anti-oncogene in the occurrence and development of gastric *** experi-ments confirmed that the overexpression of fat mass and obesity-associated protein(FTO)inhibited the expression of GATA6-AS1,thereby promoting the occurrence and development of gastric *** To investigate the effects of GATA6-AS1 on the proliferation,invasion and migration of gastric cancer cells and its mechanism of *** We used bioinformatics methods to analyze the Cancer Genome Atlas(https://***/.The Cancer Genome Atlas)and download expression data for GATA6-AS1 in gastric cancer tissue and normal *** also constructed a GATA6-AS1 lentivirus overexpression vector which was transfected into gastric cancer cells to investigate its effects on proliferation,migration and invasion,and thereby clarify the expression of GATA6-AS1 in gastric cancer and its biological role in the genesis and development of gastric ***,we used a database(http://***/starbase2/)to analysis GATA6-AS1 whether by m6A methylation modify regulation and predict the methyltransferases that may methylate ***,RNA immunoprecipitation experiments confirmed that GATA6-AS1 was able to bind to the m6A methylation modification *** data allowed us to clarify the ability of m6A methylase to influence the action of GATA6-AS1 and its role in the occurrence and development of gastric *** Low expression levels of GATA6-AS1 were detected in gastric *** also determined the effects of GATA6-AS1 overexpression on the biological function of gastric cancer ***6-AS1 had strong binding ability with the m6A demethylase FTO,which was expressed at high levels in gastric cancer and negatively correlat

关键词： Long non-coding RNA GATA6-AS1 N6-methyladenine modification Fat mass and obesity-associated protein Gastric cancer

Autologous peripheral blood stem cell transplantation as front-line therapy for myeloma with double-hit and triple-hit in a real-world study

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Chinese Medical Journal 2021年第16期134卷 1991-1993页

作者： Guang-Zhong Yang Guo-Rong Wang Yan-chen Li Yin Wu wen Gao wen-ming chen Department of Hematology Multiple Myeloma Research Center of BeijingBeijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China.

Multiple myeloma(MM)is a plasmocytic malignancy which accounts for approximately 10%of all hematologic *** 2016,over 16,500 new cases were diagnosed in China,and approximately 10,300 patients died of the disease.[1]In novel-agent era,some patients had a poor prognosis with a median overall survival(OS)of<2 years although they received the therapy regimen containing novel agents and autologous peripheral blood stem cell transplantation(APBSCT)as front-line *** for Myeloma and Risk-Adapted Therapy 3.0(mSMART 3.0)from Mayo Clinic is a risk-stratification guideline revised in 2020.[2]This risk-stratification guideline proposed a novel point of view as having two of the above genetic abnormalities to be named as doublehit MM and having any three or more as triple-hit MM.

关键词： myeloma prognosis regimen

Highly Conductive Ag/pCF/MVQ Composite Rubber for Efficient Electromagnetic Interference Shielding

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Chinese Journal of Polymer Science 2024年第6期42卷 864-873页

作者： Yang chen Xiao-ming Shao Liang He Yi-Nuo Xu Qi-Yuan Yao Ding Feng wen-Cai Wang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Key Laboratory of Beijing City for Preparation and Processing of Novel Polymer Materials Beijing University of Chemical TechnologyBeijing100029China Sino-german School of Engineering Qingdao University of Science and TechnologyQingdao266400China

In this study,flexible and highly conductive composite rubber at low filler content was successfully prepared through polydopamine-assisted electroless silver plating plus mechanical ***,carbon fibers(CF)were activated by polydopamine(PDA)to improve the surface activity by self-polymerization ***,because of the metal chelating ability of PDA,silver layer was firmly deposited on the surface of CF through a facile electroless silver plating ***,flexible silver-plated carbon fibers(Ag/pCF)silicone rubber composites prepared by mechanical *** using X-ray photoelectron spectroscopy(XPS)and X-ray diffraction(XRD),the chemical composition and crystal structure of Ag/pCF were examined,and scanning electron microscopy(SEM)was used to assess the surface morphology of the Ag/*** results showed that a uniform and dense silver layer was formed on the surface of the CF,and the conductivity of the Ag/pCF could reach 7885 S/*** was noteworthy that the composite rubber filled with only 45 phr Ag/pCF had a high electromagnetic interference shielding effectiveness(100 dB)due to the low density and high aspect ratio of Ag/*** composite rubber has excellent potential for application in the field of electromagnetic interference shielding.

关键词： Carbon fibers Polydopamine Electroless plating Silver Electromagnetic interference shielding

Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system

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World Journal of Gastroenterology 2024年第6期30卷 607-609页

作者： Bai-Wei Zhao Ying-Jia chen Ruo-Peng Zhang Yong-ming chen Bo-wen Huang Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina Health Science Center Peking UniversityBeijing 100191China

The present letter to the editor is related to the study titled‘Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells’.Angiotensin-converting enzyme 2 can alleviate liver fibrosis by regulating autophagy of hepatic stellate cells and affecting the renin-angiotensin system.

关键词： Angiotensin-converting enzyme 2 Hepatic stellate cells Liver fibrosis Angiotensin II Angiotensin 1-7 Renin-angiotensin system