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初诊弥漫大B细胞淋巴瘤患者外周血B细胞计数与临床特征及预后的相关性分析

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中国实验血液学杂志 2024年第2期32卷 458-465页

作者：陆天米浩赵丹丹杨水个步云文张芳陈文明孙道萍济宁医学院临床医学院山东济宁272013 济宁市第一人民医院血液内科山东济宁272011 济宁市第一人民医院肿瘤科山东济宁272011

目的:探讨外周血B细胞计数与初诊弥漫性大B细胞淋巴瘤(DLBCL)患者临床特征及预后的相关性。方法:回顾性分析67例初诊DLBCL患者治疗前外周血B细胞计数与其临床特征、实验室指标、治疗疗效及预后的关系。结果:按照B细胞计数中位值将患者... 详细信息

目的:探讨外周血B细胞计数与初诊弥漫性大B细胞淋巴瘤(DLBCL)患者临床特征及预后的相关性。方法:回顾性分析67例初诊DLBCL患者治疗前外周血B细胞计数与其临床特征、实验室指标、治疗疗效及预后的关系。结果:按照B细胞计数中位值将患者分为低B细胞计数组(B细胞<0.1×10^(9)/L,n=34)和高B细胞计数组(B细胞≥0.1×10^(9)/L,n=33)。与高B细胞计数组相比,低B细胞计数组中有更高比例的Lugano分期III-IV期、LDH升高、β2-MG升高及IPI评分3-5的患者(P值分别为0.033、0.000、0.023、0.001),且CRP升高更多见(P=0.033)。低B细胞计数组的外周血CD3^(+)和CD4^(+)细胞计数显著低于高B细胞计数组(P=0.010,0.017)。高B细胞计数组患者初始治疗后总缓解率(ORR)及完全缓解(CR)率均显著高于低B细胞计数组(P=0.032,0.013)。中位随访时间为23(2-77)个月,高B细胞计数组患者的无进展生存(PFS)率及总生存(OS)率均明显优于低B细胞计数组(P=0.001,P=0.002)。单因素分析显示,初诊外周血低B细胞计数与PFS和OS缩短相关(HR=4.108,P=0.002;HR=8.218,P=0.006)。多因素分析显示,低B细胞计数是导致PFS缩短(HR=3.116,P=0.037)的独立预后因素。结论:初诊DLBCL患者外周血B细胞计数降低与高危临床特征相关,并可能影响免疫化疗的疗效,与较差的临床预后有关。

关键词：弥漫大B细胞淋巴瘤 B细胞外周血预后

关节镜下经皮微创钢板内固定术治疗胫骨平台骨折患者的疗效及对膝关节功能的影响

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川北医学院学报 2024年第7期39卷 913-915,940页

作者：滕加文陈文明李宝锋山东中医药大学附属医院显微骨科山东济南250014

目的:分析关节镜下经皮微创钢板内固定术(MIPPO)治疗胫骨平台骨折患者的疗效及对膝关节功能的影响。方法:选取90例胫骨平台骨折患者为研究对象,根据术式分为切开复位内固定术(ORIF)组和MIPPO组,每组各45例。比较两组患者围术期指标、愈... 详细信息

目的:分析关节镜下经皮微创钢板内固定术(MIPPO)治疗胫骨平台骨折患者的疗效及对膝关节功能的影响。方法:选取90例胫骨平台骨折患者为研究对象,根据术式分为切开复位内固定术(ORIF)组和MIPPO组,每组各45例。比较两组患者围术期指标、愈合时间、术后并发症总发生率及术后3个月膝关节活动度、膝关节功能。结果:相较于ORIF组,MIPPO组患者围术期指标、愈合时间、术后并发症总发生率均更低(P<0.05)。术后3个月时,相较于ORIF组,MIPPO组患者膝关节活动度、膝关节功能评分均更高(P<0.05)。结论:相较于ORIF,MIPPO治疗胫骨平台骨折患者疗效更优,有利于患者骨折预后,改善其膝关节功能。

关键词：关节镜下经皮微创钢板内固定术胫骨平台骨折骨折愈合膝关节功能

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国内共建园区标准化现状与思考

中国标准化 2024年第5期 76-80页

作者：王鹏刘婷婷陈文明程永红中国标准化研究院长三角分院

标准化是促进共建园区高质量建设的有效途径,是提升共建园区运营管理水平的重要保证。本文以国内共建园区为研究对象,系统梳理了国内共建园区的发展历程、政策要素及标准化发展现状,并提出问题及建议,以期为国内共建园区标准化工作的持... 详细信息

标准化是促进共建园区高质量建设的有效途径,是提升共建园区运营管理水平的重要保证。本文以国内共建园区为研究对象,系统梳理了国内共建园区的发展历程、政策要素及标准化发展现状,并提出问题及建议,以期为国内共建园区标准化工作的持续完善提供参考借鉴。

关键词：共建园区园区发展标准化

Regulated polarization degree of upconversion luminescence and multiple anti-counterfeit applications

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Rare Metals 2024年第5期43卷 2172-2183页

作者： Dong-Ping wen Ping chen Yi Liang Xiao-ming Mo Cao-Feng Pan Center On Nanoenergy Research Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China Key Laboratory of Micronano Energy and Sensor CAS Center for Excellence in NanoscienceBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100140China

Polarization upconversion luminescence(PUCL)of lanthanide ions(Ln^(3+))has been widely used in single particle tracking,microfluidics detection,three-dimensional displays,and so ***,no effective strategy has been developed for modulating *** we report a strategy to regulate PUCL in Ho^(3+)-doped NaYF4single nanorods based on the number of upconversion *** constructing a multiphoton upconversion system for Ho^(3+),we regulate the degree of polarization(DOP)of PUCL from 0.590 for two-photon luminescence to 0.929 for three-photon upconversion luminescence(UCL).Furthermore,our strategy is verified from cross-relaxation between Ho^(3+)and Yb^(3+),excitation wavelength,excitation power density,and local site *** this regulation strategy of PUCL has also been achieved in Tm^(3+),with the DOP ranging from 0.233 for two-photon luminescence to 0.925 for four-photon UCL Besides,multi-dimensional anti-counterfeiting display has been explored with *** work provides an effective strategy for regulating PUCL and also provides more opportunities for the development of polarization display optical encoding,anti-counterfeiting,and integrated optical devices.

关键词： Polarization upconversion luminescence Degree of polarization Population density of excited state Number of upconversion photons Polarization anti-counterfeitingdisplay

数字经济领域对标达标提升对策研究——以嘉兴市为例

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标准科学 2024年第1期 78-82,95页

作者：陈文明傅洁璐程永红刘婷婷中国标准化研究院长三角分院

对标达标是一种认识质量和标准差距,寻求最有效管理方案的相对性评价与改进方法。开展数字经济领域对标达标提升活动是推动数字经济产业和企业高质量发展的重要途径。本文以浙江省数字经济和标准化发展重点城市——嘉兴市为例,具体描述... 详细信息

对标达标是一种认识质量和标准差距,寻求最有效管理方案的相对性评价与改进方法。开展数字经济领域对标达标提升活动是推动数字经济产业和企业高质量发展的重要途径。本文以浙江省数字经济和标准化发展重点城市——嘉兴市为例,具体描述嘉兴市数字经济领域的标准化现状,系统探讨其面临的问题和需求,最终聚焦于数字经济领域对标达标的问题识别、重点产业对标技术方案与标准制定、标准数字化支持、服务体系培育构建、典型案例总结与宣传,提出多方面对策建议,也为其他地区展开数字经济领域对标达标提升行动提供经验借鉴。

关键词：数字经济对标达标标准化

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The centrosymmetric to non-centrosymmetric transformation induced by alkaline-earth cations producing infrared nonlinear optical AeMn_(6)Ga_(6)S_(16)(Ae=Ca,Sr)

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Science China Chemistry 2024年第9期67卷 2941-2948页

作者： Yang-Ping Zhang Shao-Min Pei wen-Fa chen Bin-wen Liu Xiao-ming Jiang Guo-Cong Guo State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China

Non-centrosymmetric(NCS)structure is an indispensable prerequisite for second-order nonlinear optical(NLO)***,the mainstream approach for designing new NCS structures still relies on chemical substitution,necessitating an urgent infusion of fresh *** this work,two isomorphic sulfides AeMn_(6)Ga_(6)S_(16)(Ae=Ca,1;Sr,2)are afforded by modifying the skeleton of centrosymmetric(CS)Mn_(2)Ga_(2)S_(5) via introducing strong electropositive alkaline-earth ***,the incorporation of Ca^(2+)/Sr^(2+)cations allows the elementary[MnGaS_(9)]_(∞)chains to reconfigure into bumpy[MnS_(6)]-[GaS_(4)]layers in a new engagement manner,thus enabling the conversion from CS to NCS *** modifications cause not only strong second-harmonic generation(SHG)responses(~1.5×benchmark AgGaS_(2)@1,700 nm),but also significantly feasible bandgaps(2.60-2.64 e V)compared to the sulfide Mn_(2)Ga_(2)S_(5)(1.36 e V),which ultimately facilitate ultrahigh laser-induced damage thresholds(4.4-6.6×AgGaS_(2)@1,064 nm for compounds 1 and 2).The present study offers an ingenious approach for the transformation of CS to NCS structure.

关键词： second-harmonic generation non-centrosymmetrical structure NLO functional motif solid-state method

Isolation of Human Antibodies Against Hepatitis E Virus From Phage Display Library by Immobilized Metal Affinity Chromatography

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Biomedical and Environmental Sciences 2007年第6期20卷 488-494页

作者： YING-WEI chen wen-XIN LUO ming-QIAO WANG JIN WANG LI-FENG LI QUAN YUAN JUN ZHANG NING-SHAO XIA National Institute of Diagnostic and Vaccine Development for infectious diseases The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering School of Life Sciences Xiamen University Xiamen 361005 Fujian China

Objective To isolate human antibodies against hepatitis E virus from phage display library by a new method of panning phage antibody library based on immobilized metal affinity chromatography （1MAC）. Methods Phage antibody library was allowed to mix with hex-His tagged expressed HEV specific antigen, NE2, in solution for adequate binding before affinity resin for hex-His was added. The non-specific phage antibodies were removed by extensive washing and the specific bound phage antibodies could then be eluted to infect TG1 or repeat the binding process for subsequent rounds of purification. The specificity of the selected human antibodies were tested by antigen competitive ELISA, human sera blocking ELISA, scFv expression, and sequence analysis. Results His-NE2 specific recombinant phages were successfully enriched after panning procedure. Two individual phage clones, 126 and 138, showed 50% inhibition in NE2 antigen competition ELISA and obvious blocking effect by HEV positive serum in blocking ELISA. Soluble scFv of 126, 138 bound to NE2 specifically. Conclusion Two specific human phage antibodies against hepatitis E virus （HEV） from phage display library were isolated by immobilized metal affinity chromatography. The immobilized metal affinity chromatography applied to phage antibody selection was a helpful supplement to the selection in solution.

关键词： HEV antibodies Phage antibody library Affinity chromatography Panning

Using Copula functions to predict climatic change impacts on floods in river source regions

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Advances in Climate Change Research 2024年第3期15卷 406-418页

作者： Ting-Xing chen Hai-Shen LYU Robert HORTON Yong-Hua ZHU Ren-Sheng chen ming-Yue SUN ming-wen LIU Yu LIN The National Key Laboratory of Water Disaster Prevention College of Hydrology and Water ResourcesHohai UniversityNanjing 2098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China Departmentof Agronomy lowa State UniversityAmes IA5oollUSA Qilian Alpine Eology and Hydrology Research Station Northwest Instiuteof Eco-Environmentand ReourcesChinese Academy of SciencesLanzhou0000 China

Flood frequency in river source regions is significantly affected by rainfall and snowmelt as part of climatic changes.A traditional univariate flood frequency analysis cannot reflect the complexity of floods,and when used in isolation,it can only underestimate flood *** effective flood prevention and mitigation,it is essential to consider the combined effects of precipitation and *** functions can effectively quantify the joint distribution relationship between floods and their associated variables without restrictions on their distribution *** study uses copula functions to consider a multivariate probability distribution model of flood peak flow(Q)with cumulative snowmelt(CSm)and cumulative precipitation(CPr)for the Hutubi River basin located in northern Xinjiang,*** joint frequencies of rainfall and snowmelt floods are predicted using copula models based on the Coupled Model Intercomparison Project Phase 6 *** results show that Q has a significant positive correlation with 24-d CSm(r=0.559,p=0.002)and 23-d CPr(r=0.965,p<0.05).Flood frequency will increase in the future,and mid-(2050e2074)and long-term(2075e2099)floods will be more severe than those in the near-term(2025e2049).The probability of flood occurrence is higher under the SSP2-4.5 and SSP1-2.6 scenarios than under *** during the historical period(1990e2014)led to extreme floods,and increasing future precipitation trends are found to be *** increases with rising temperatures and occurs earlier than estimated,leading to an earlier flood period in the basin and more frequent snowmelt *** Q under the joint return period is larger than that during the same univariate return *** difference indicates that neglecting the interaction between precipitation and snowmelt for floods leads to an underestimation of the flood risk(with underestimations ranging from 0.3%to 22%).The underestimations decrease with an increase

关键词： Climate change Flood frequency Copula CMIP6 River source regions

Microfluidic thermotaxic selection of highlymotile sperm and in vitro fertilization

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Bio-Design and Manufacturing 2024年第5期7卷 687-700页

作者： Sihan chen Jiemin chen Zihan Qin Jibo Wang Yuwen Wang Rong Liu wen Zhao ming Zhang Yuanzhen Zhang Mengcheng Luo Pu chen Tissue Engineering and Organ Manufacturing(TEOM)Lab Department of Biomedical EngineeringTaiKang Medical School(School of Basic Medical Sciences)Wuhan UniversityWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease TaiKangMedical School(School of Basic Medical Sciences)Wuhan UniversityWuhan 430071China Reproductive Medicine Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhan 430071China

The selection of the most motile and functionally competent sperm is an essential basis for in vitro fertilization(IVF)and normal embryonic *** adopted clinical approaches for sperm sample processing intensely rely on centrifugation and wash steps that may induce mechanical damage and oxidative stress to *** a few microfluidic sperm sorting devices may avoid these adverse effects by exploiting intrinsic guidance mechanisms of sperm swimming,none of these approaches have been fully validated by clinical-grade assessment *** this study,a microfluidic sperm sorting device that enables the selection of highly motile and functional sperm via their intrinsic thermotaxis is *** by the temperature microenvironment in the fallopian tube during natural sperm selection,a microfluidic device with controllable temperature gradients along the sperm separation channel was designed and *** study investigated the optimal temperature conditions for human sperm selection and fully characterized thermotaxis-selected sperm with 45 human sperm *** indicated that a temperature range of 35–36.5℃along the separation channel significantly improves human sperm motility rate((85.25±6.28)%vs.(60.72±1.37)%;P=0.0484),increases normal sperm morphology rate((16.42±1.43)%vs.(12.55±0.88)%;P<0.0001),and reduces DNA fragmentation((7.44±0.79)%vs.(10.36±0.72)%;P=0.0485)compared to the nonthermotaxis *** thermotaxis is species-specific,and selected mouse sperm displayed the highest motility in response to a temperature range of 36–37.5℃ along the separation ***,IVF experiments indicated that the selected sperm permitted an increased fertilization rate and improved embryonic development from zygote to *** microfluidic thermotaxic selection approach will be translated into clinical practice to improve the IVF success rate for patients with oligozoospermia and asthenozoospermia.

关键词： Microfluidic device Thermotaxis Sperm sorting Assisted reproductive technology In vitro fertilization