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Prognostic value of high-sensitivity cardiac troponin T in patients with en-domyocardial-biopsy proven cardiac amyloidosis

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Journal of Geriatric Cardiology 2014年第2期11卷 136-140页

作者： Geng QIAN chen WU Yang ZHANG Yun-Dai chen wei DONG yi-Hong REN Department of Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China

Objective To investigate prognostic predictors of long-term survival of patients with cardiac amyloidosis （CA）, and to determine predictive value of high-sensitivity cardiac troponin T （hs-cTnT） in CA patients. Methods We recruited 102 consecutive CA cases and followed these patients for 5 years. We described their clinical characteristics at presentation and used a new, high-sensitivity assay to determine the concentration of cTnT in plasma samples from these patients. Results The patients with poor prognosis showed older age （56 ±12 years vs. 50 ±15 years, P=0.022）, higher incidences of heart failure （36.92%vs. 16.22%, P=0.041）, pericardial effusion （60.00%vs. 35.14%, P=0.023）, greater thickness of interventricular septum （IVS）（15 ±4 mm vs. 13 ±4 mm, P=0.034）, higher level of hs-cTnT （0.186 ±0.249 ng/mL vs. 0.044 ±0.055 ng/mL, P=0.001） and higher NT-proBNP （N-terminal pro-B-type natriuretic pep-tide） levels （11,742 ± 10,464 pg/mL vs. 6,031 ± 7,458 pg/mL, P=0.006）. At multivariate Cox regression analysis, heart failure （HR：1.78, 95%CI：1.09-2.92, P=0.021）, greater wall thickness of IVS （HR：1.44, 95%CI：1.04-3.01, P=0.0375） and higher hs-cTnT level （HR：6.16, 95%CI：2.20-17.24, P=0.001） at enrollment emerged as independent predictors of all-cause mortality. Conclusions We showed that hs-cTnT is associated with a very ominous prognosis, and it is also the strongest predictor of all-cause mortality in multivariate analysis. Examination of hs-cTnT concentrations provides valuable prognostic information concerning long-term outcomes.

关键词： Cardiac amyloidosis Long-term survival Troponin T

Automated Identification of Ordered Phases for Simulation Studies of Block Copolymers

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Chinese Journal of Polymer Science 2024年第5期42卷 683-692,I0011页

作者： Yu-chen Zhang wei-Ling Huang yi-Xin Liu State Key Laboratory of Molecule Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

In unit cell simulations,identification of ordered phases in block copolymers(BCPs)is a tedious and time-consuming task,impeding the advancement of more streamlined and potentially automated research *** this study,we propose a scattering-based automated identification strategy(SAIS)for characterization and identification of ordered phases of BCPs based on their computed scattering *** approach leverages the scattering theory of perfect crystals to efficiently compute the scattering patterns of periodic morphologies in a unit *** the first stage of the SAIS,phases are identified by comparing reflection conditions at a sequence of Miller *** confirm or refine the identification results of the first stage,the second stage of the SAIS introduces a tailored residual between the test phase and each of the known candidate ***,our strategy incorporates a variance-like criterion to distinguish background species,enabling its extension to multi-species BCP *** has been demonstrated that our strategy achieves exceptional accuracy and robustness while requiring minimal computational ***,the approach allows for real-time expansion and improvement to the candidate phase library,facilitating the development of automated research workflows for designing specific ordered structures and discovering new ordered phases in BCPs.

关键词： Block copolymer Phase identification Scattering function

Dynamic Crosslinked Phosphorescent Poly(vinyl alcohol)-Terpyridine Films with Enhanced Mechanical Properties and Tunable Shape Memory

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Chinese Journal of Polymer Science 2024年第10期42卷 1595-1601,I0015页

作者： Meng wei wei-Hao Feng chen Yu Zhen-yi Jiang Guang-Qiang yin wei Lu Tao chen Key Laboratory of Advanced Marine Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China School of Materials Science and Chemical Engineering Ningbo UniversityNingbo315211China

Achieving versatile room temperature phosphorescence(RTP)materials,especially with tunable mechanical properties and shape memory is attractive and essential but rarely ***,a strategy was reported to realize multi-functional RTP films with multicolor fluorescence,ultralong afterglow,adjustable mechanical properties,and shape memory through the synergistic dynamic interaction of lanthanide(Ln~Ⅲ)-terpyridine coordination,borate ester bonds,and hydrogen bondings in a poly(vinyl alcohol)(PVA)*** varying the amount of borax,the mechanical properties of the films could be finely controlled due to the change of crosslinking degree of dynamic borate ester bonds in *** assembly and disassembly of borate ester bonds upon the trigger of borax and acid were applied as reversible linkage to achieve programmable shape memory *** addition,the films displayed both fascinating multicolor fluorescence and ultralong afterglow characteristics due to the presence of Ln III doping and confinement of terpyridine in *** study provides a new avenue to impart modulable mechanical strength and shape memory to RTP materials.

关键词： Room temperature phosphorescence materials Dynamic bonds Multicolor fluorescent Tunable mechanical properties Shape memory

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教研融合提升有机化学教学策略

广州化工 2024年第15期52卷 179-181页

作者：买热牙木古丽·阿吉陈维一苏州大学苏州医学院江苏苏州215123 苏州大学东吴学院江苏苏州215006

以氟化钾为催化剂,固相法研究α,α-二氰基烯烃化合物和N-苄基马来酰亚胺的Michael加成反应,高收率合成产物;把相关领域的理论知识、实验操作技能和社会关注热点结合起来,形成“教研融合”的教学和实验方案;在实验中引入适合学生的新颖... 详细信息

以氟化钾为催化剂,固相法研究α,α-二氰基烯烃化合物和N-苄基马来酰亚胺的Michael加成反应,高收率合成产物;把相关领域的理论知识、实验操作技能和社会关注热点结合起来,形成“教研融合”的教学和实验方案;在实验中引入适合学生的新颖反应和操作单元,对产物进行核磁共振法和X-射线衍射法表征,增强了教学内容的前瞻性和新颖性,增加了学生对有机化学课程学习的愿望和兴趣。

关键词：教研融合有机化学迈克尔加成反应教学改革绿色化学

Evaluation on cutting performance of novel PDC cutter for pipe jacking machine

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Underground Space 2024年第1期14卷 34-52页

作者： Long-Chuan Deng yi-Xiang Yuan Xiao-Zhao Li Qian-wei Zhuang Chi Zhang yi-wei chen School of Earth Sciences and Engineering Nanjing UniversityNanjingJiangsu 210023China Shanghai Tunnel Engineering Co.Ltd. Shanghai 200232China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhouJiangsu 221116China School of Mechanics and Engineering Science Shanghai UniversityShanghai 200444China

It is inevitable to cut reinforced concrete(RC)appeared in cross passage of city metro by cutting tools when constructing in densely populated *** previous cutters employed to cut RC are insufficient and easily damaged,so a new polycrystalline diamond compact(PDC)cutter is used to solve this *** on the theoretical analysis of cutting mechanism,both circular and tapered PDC cutters with cutting edge angle of 90and negative front rack angle of 10are used to cut *** peeling and breaking patterns of cutting concrete are proposed,the nodular and grainy chips are the preferred modes in cutting steel *** LS-DYNA is employed to investigate the cutting performance in *** simulation results show that the average and peak cutting forces increase with the growth of penetration depth,cutting speed,and roundness,and subsequently the recommended penetration depth less than 1.2 mm is obtained to cut RC due to the existence of steel ***,the linear cutting platform is adopted to investigate the force ability and damage state of PDC *** is concluded that the cutting force increases abruptly and fluctuates heavily when cutting the coarse *** patterns occurred in both numerical and experimental results are generally ***,the steel bar is pulled out and the PDC cutter is damaged at the penetration depth of 0.8 mm,while a good cut occurs at the penetration depth of 0.3 *** tapered PDC cutter with a relatively low cutting force is prone to be broken compared with circular PDC *** is suggested that the circular PDC cutter at the penetration depth of 0.3 mm should be used to cut RC in practical engineering.

关键词： PDC cutter RC Pipe jacking machine Linear cutting tests Damage and wear LS-DYNA

Ant-nest-inspired porous structure for MXene composites with high-performance energy-storage and actuating multifunctions

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Nano Research 2024年第7期17卷 6673-6685页

作者： yi Wang Guanfeng Xue Zhiling Luo wei Zhang Luzhuo chen Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials College of Physics and EnergyFujian Normal UniversityFuzhou 350117China Fujian Provincial Collaborative Innovation Center for Advanced High-Field Superconducting Materials and Engineering Fuzhou 350117China

Integrating energy-storage devices(supercapacitors)and shape-deformation devices(actuators)advances the miniaturization and multifunctional development of soft ***,soft robots necessitate supercapacitors with high energy-storage performance and actuators with excellent actuation ***,inspired by ant nests,we present a porous structure fabricated by MXene-graphene-methylcellulose(M-GMC)composite,which overcomes the self-stacking of MXene nanosheets and offers a larger specific surface *** porous structure provides more channels and active sites for electrolyte ions,resulting in high energy storage *** areal capacitance of the M-GMC electrode reaches up to 787.9 mF·cm^(−2),significantly superior to that of the pristine MXene electrode(449.1 mF·cm^(−2)).Moreover,the M-GMC/polyethylene bilayer composites with energy storage and multi-responsive actuation functions are *** M-GMC is used as the electrode and the polyethylene is used as the encapsulation layer of the quasi-solid-state ***,the actuators fabricated by the bilayer composites can be driven by light or low voltage(≤9 V).The maximum bending curvature is up to 5.11 cm^(−1).Finally,a smart gripper and a fully encapsulated smart integrated circuit based on the M-GMC/polyethylene are *** smart gripper enables programmable control with multi-stage *** applications realize the intelligence and miniaturization of soft *** ant-nest-inspired M-GMC composites would provide a promising development strategy for soft robots and smart integrated devices.

关键词： MXene graphene ant nest supercapacitor actuator multi-functional

红外热成像技术在股静脉血流缓慢大鼠模型中的成像表达特性及其临床应用价值

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广东医学 2024年第8期45卷 946-950页

作者：陈伟毅张勇彬苏佳琪林伟国阮薇邓方阁广州医科大学附属第一医院、广州呼吸健康研究院、呼吸疾病全国重点实验室、国家呼吸系统疾病临床医学研究中心红外项目组广东广州510120 广州市干部和人才健康管理中心医学影像中心

目的探讨红外成像技术在股静脉血流缓慢大鼠模型中的成像表达特性及其临床应用价值。方法选取12只SD大鼠,随机分为两组:肾上腺素组(模型组)和生理盐水组(空白对照组)。模型组每次注射1mg/mL肾上腺素,空白对照组注射等量生理盐水,前后共2... 详细信息

目的探讨红外成像技术在股静脉血流缓慢大鼠模型中的成像表达特性及其临床应用价值。方法选取12只SD大鼠,随机分为两组:肾上腺素组(模型组)和生理盐水组(空白对照组)。模型组每次注射1mg/mL肾上腺素,空白对照组注射等量生理盐水,前后共2次,首次注射后2h,将大鼠置于冰水中游泳5min。建模前后使用红外热成像技术采集两组大鼠两侧股三角区域温度,建模完成后腹主动脉采血检测凝血指标及白细胞介素-6(IL-6),取右侧股静脉进行病理学检查。结果模型组大鼠活化部分凝血活酶时间(APTT)(P<0.01)、凝血酶时间(TT)(P<0.01)较空白对照组明显缩短;IL-6水平高于空白对照组(P=0.02)。两组大鼠股静脉切片血管形态结构正常,未见明确炎症细胞浸润及血栓形成。模型组大鼠股三角区域建模前最高温为(35.34±0.47)℃,建模后为(36.57±0.94)℃,模型组大鼠建模前后温度差异有统计学意义(P<0.01);模型组大鼠股三角区域建模后最高温高于空白对照组(P<0.01)。结论股静脉血流缓慢状态大鼠模型红外热成像表达特性为相对高温表达,具有无创无辐射优势的红外热成像技术可作为诊断血流缓慢状态的辅助手段。

关键词：血流缓慢动物模型红外热成像表达特性血液高凝

土壤CO_(2)排放对微咸水与淡水交替灌溉的响应

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节水灌溉 2024年第8期 102-109页

作者：陈艺伟管瑶贺兴宏李会文王剑王育强范德宝塔里木大学水利与建筑工程学院新疆阿拉尔843300

为揭示微咸水与淡水交替灌溉模式对土壤CO_(2)排放通量变化规律的影响,研究极端干旱区棉田3种灌溉水质(矿化度分别为2、3、5 g/L)和3种不同配比咸淡水交替[微咸水∶淡水=1∶1(W1);微咸水∶淡水=1∶4(W2);微咸水∶淡水=1∶0(W3)]灌溉对土... 详细信息

为揭示微咸水与淡水交替灌溉模式对土壤CO_(2)排放通量变化规律的影响,研究极端干旱区棉田3种灌溉水质(矿化度分别为2、3、5 g/L)和3种不同配比咸淡水交替[微咸水∶淡水=1∶1(W1);微咸水∶淡水=1∶4(W2);微咸水∶淡水=1∶0(W3)]灌溉对土壤CO_(2)排放通量的影响。结果表明:①以2 g/L为对照,3 g/L微咸水与淡水交替灌溉处理CO_(2)累积排放通量减少了6.03%~7.19%;5 g/L微咸水与淡水交替灌溉处理CO_(2)累积排放通量减少了9.83%~10.15%;②在相同矿化度条件下,土壤CO_(2)累积排放通量为W2处理>W1处理>W3处理,淡水灌水量多的处理CO_(2)排放通量较大。③以2 g/L为对照,3 g/L和5 g/L处理产量平均提高了1.25%和3.64%,W1处理产量相较于W2、W3处理平均提高了24.02%和14.12%。随着灌溉水矿化度的增大,土壤CO_(2)排放通量减小,所有不同配比下矿化度为5 g/L的处理CO_(2)排放量均小于2、3 g/L的处理;在微咸水与淡水交替灌溉条件下,矿化度为3 g/L且微咸水∶淡水=1∶1的灌水处理,土壤CO_(2)排放通量降低且棉花产量最大,能够为合理利用微咸水及保护干旱区灌区农田生态环境提供理论依据。

关键词：咸淡水交替灌溉土壤CO_(2)排放通量

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Equilibrium Reinsurance Strategy and Mean Residual Life Function

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 758-777页

作者： Dan-ping LI Lv chen Lin-yi QIAN wei WANG School of Statistics Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOEEast China Normal UniversityShanghai 200062China Academy of Statistics and Interdisciplinary Sciences Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOEEast China Normal UniversityShanghai 200062China School of Mathematics and Statistics Ningbo UniversityNingbo 315211China

In this paper,we analyze the relationship between the equilibrium reinsurance strategy and the tail of the distribution of the *** Mean Residual Life(MRL)has a close relationship with the tail of the distribution,we consider two classes of risk distributions,Decreasing Mean Residual Life(DMRL)and Increasing Mean Residual Life(IMRL)distributions,which can be used to classify light-tailed and heavy-tailed distributions,*** assume that the underlying risk process is modelled by the classical CramérLundberg model *** the mean-variance criterion,by solving the extended Hamilton-Jacobi-Bellman equation,we derive the equilibrium reinsurance strategy for the insurer and the reinsurer under DMRL and IMRL,***,we analyze how to choose the reinsurance premium to make the insurer and the reinsurer agree with the same reinsurance *** find that under the case of DMRL,if the distribution and the risk aversions satisfy certain conditions,the insurer and the reinsurer can adopt a reinsurance premium to agree on a reinsurance strategy,and under the case of IMRL,the insurer and the reinsurer can only agree with each other that the insurer do not purchase the reinsurance.

关键词： mean residual life excess-of-loss reinsurance insurer reinsurer stochastic control

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