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brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng wei Tan Xingxing chen Shuyuan bai Qiong Wu Yushan chen Zhen wei Yufei Mei Yan Zeng brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase b signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,bDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Dynamic Characteristics of Touch-trigger Probe

Dynamic Characteristics of Touch-trigger Probe

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第三届国际仪器科学技术学术研讨会

作者： FEI Ye-tai a ZHAO Jing a chen wei-fang b LIN Shen-wang b aSchool of Instrumentation Hefei University of Technology Anhui China bDepartment of Mechanical Engineering Far East Institute of Technology Tainan China

Coordinate Measuring Machine (CMMs) are widely used in modern manufacturing industry. Fast probing now is a new trend for next generation CMMs. However, as the speed of CMMs increases, dynamic errors

关键词： Coordinate Measuring Machine (CMM) Touch-trigger probe Pre-travel Neural Network (NN)

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Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang chenyang Zhang Linlin Wu wei Sun Hongliang Zhang Jianhua chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen Menghua Li weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi Shi wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d b for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3b and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3b,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu chenrui Liu Xingxing fang Liangming Zhang bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-bV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa b Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou wei chen Aidong Wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κb,NRF2,bCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase b therapeutics

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu wei Huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng chen Xianxian Zhao Shihua Li Xiaojiang Li weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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On single particle breakage behavior of crushable weathered sands

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Journal of Mountain Science 2022年第12期19卷 3627-3644页

作者： YU fang-wei ZHAO Chuang LIU wei-chen Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610299China Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China China-Pakistan Joint Research Centeron Earth Sciences Islamabad 45320Pakistan Department of Civil Engineering The University of TokyoTokyo 113-8656Japan Department of Civil Engineering Zhejiang UniversityHangzhou 310058China

This paper presents an experimental study on single particle breakage behavior of crushable weathered sands by a number of single particle uniaxial compression tests to comprehensively investigate the characteristics of single particle breakage,the probability of survival of single particle,and the effects of particle size and weathering on single particle *** behavior of single particle under uniaxial compression falls into the mixed five phases:damage by chipping,elastic deformation,fragmentation by partial fracture,breakage by splitting,and the residuals,demonstrating the complexity and variability of the tensile strengths of single *** behavior of single particle breakage was quantified herein by the initial fracture and failure strengths of single *** probability of survival decreased as the characteristic stresses *** increase in the particle size or weathering number of single particle resulted in a reduction in the probability of survival of single *** a given probability of survival,the difference in the initial fracture characteristic stress and failure characteristic stress decreased with increasing particle size but showed a complex change with increasing weathering *** probability of survival showed greater variability for the normalized initial fracture characteristic stress than for the normalized failure characteristic stress,implying that the initial fracture stresses of single particles diverged more than the failure stresses of the *** average initial fracture and failure characteristic stresses,and the initial fracture and failure characteristic stresses corresponding to 1/e(37%)survival of single particles decreased while increasing particle size or weathering number,but the decrease showed a sharper rate for smaller single particles with a lower weathering *** ln-ln coordinates showed a linear representation of the failure characteristic stress and particle size,verifying th

关键词： breakage Compression Particle size Probability of survival Sands Weathering

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Highly sensitive glucose sensor based on hierarchical CuO

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Science China(Technological Sciences) 2021年第1期64卷 65-70页

作者： chen fang SHAO bo ZHAI wei MA XiaoYan MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions Northwestern Polytechnical UniversityXi’an 710129China

The fabrication of high performance CuO based glucose sensors remains a great challenge due to the "trade-off effect" between sensitivity and linear range. In this study, a hierarchical CuO nanostructure with a great number of firecracker-shaped nanorods along the ligament and three-dimensional interconnected nanoporous is obtained by dealloying and post oxidation process of Al-33.3 wt% Cu eutectic alloy ribbons. because of the precise structural design, not only the number of active sites for glucose electro-oxidation is significantly increased but also the glucose diffusion under high concentration is greatly accelerated, leading to a high sensitivity of 1.18 mA cm^(-2) mM^(-1) and a wider linear range up to 5.53 mM for glucose detection. This work provides a potential approach to design hierarchical nanostructure for other metal oxides with desirable properties for electrocatalytic applications.

关键词： hierarchical CuO nanostructure dealloying glucose sensor highly sensitive

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Optimal stopping time on discounted semi-Markov processes

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Frontiers of Mathematics in China 2021年第2期16卷 303-324页

作者： fang chen Xianping GUO Zhong-wei LIAO School of Mathematics Sun Yat-Sen UniversityGuangzhou 510275China College of Education for the Future Beijing Normal UniversityBeijing 100875China

This paper attempts to study the optimal stopping time for semi- Markov processes (SMPs) under the discount optimization criteria with unbounded cost rates. In our work, we introduce an explicit construction of the equivalent semi-Markov decision processes (SMDPs). The equivalence is embodied in the expected discounted cost functions of SMPs and SMDPs, that is, every stopping time of SMPs can induce a policy of SMDPs such that the value functions are equal, and vice versa. The existence of the optimal stopping time of SMPs is proved by this equivalence relation. Next, we give the optimality equation of the value function and develop an effective iterative algorithm for computing it. Moreover, we show that the optimal and ε-optimal stopping time can be characterized by the hitting time of the special sets. Finally, to illustrate the validity of our results, an example of a maintenance system is presented in the end.

关键词： Optimal stopping time semi-Markov processes(SMPs) value function semi-Markov decision processes(SMDPs) optimal policy iterative lgorithm

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