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空空导弹越肩发射全向攻击区计算

飞行力学 2007年第3期25卷 26-29,33页

作者：姜欢刘彦邢晓岚陈万春北京航空航天大学宇航学院北京100083 空军装备研究院总体所北京100076

越肩发射是空空导弹攻击后半球目标,实现全向攻击的新型攻击方式。采用程序转弯和空间比例导引复合制导以实现导弹越肩发射,并设计了相应的简单自动驾驶仪,分析了攻击区影响因素以及攻击区搜索算法,最后计算出了空空导弹的全向攻击区,... 详细信息

越肩发射是空空导弹攻击后半球目标,实现全向攻击的新型攻击方式。采用程序转弯和空间比例导引复合制导以实现导弹越肩发射,并设计了相应的简单自动驾驶仪,分析了攻击区影响因素以及攻击区搜索算法,最后计算出了空空导弹的全向攻击区,验证了制导方法的正确性。

关键词：越肩发射全向攻击攻击区

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拱梁组合结构体系桥梁质量检验评定标准研究

广西大学学报（自然科学版） 2009年第2期34卷 150-153页

作者：邹存俊徐岳陈万春任更锋长安大学旧桥检测与加固技术交通行业重点实验室陕西西安710064

针对特殊结构桥梁质量检验评定标准缺乏的现状,以《公路工程质量检验评定标准》为基础,根据拱梁组合结构体系桥梁的特性,运用对比分析的方法,提出针对拱梁组合结构体系桥梁的结构分项工程、分部工程及单位工程划分原则;补充部分质量检... 详细信息

针对特殊结构桥梁质量检验评定标准缺乏的现状,以《公路工程质量检验评定标准》为基础,根据拱梁组合结构体系桥梁的特性,运用对比分析的方法,提出针对拱梁组合结构体系桥梁的结构分项工程、分部工程及单位工程划分原则;补充部分质量检验评定标准内容,编制了适用于拱梁组合结构体系桥梁质量检验评定的专项标准,以及相应质量检验评定用表.成果应用表明,该评定标准方便可行.

关键词：拱梁组合结构桥梁检验评定标准

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen chen Xiaolin Zeng Le wang Wenwu Zhang Gang Li Xing cheng Peiqiang Su Yong wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang Wu Yi-Sheng chen Yu-chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity