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NOX2参与适应性免疫反应及其与慢性肉芽肿病伴随性自身免疫病的联系

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现代免疫学 2024年第2期44卷 165-169页

作者：苏晓亚洪莉陈同辛上海交通大学医学院附属上海儿童医学中心风湿免疫科上海200127 上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所上海200127 上海交通大学医学院附属上海儿童医学中心临床营养科上海200127

吞噬细胞还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶又称NOX2,是一种多组分酶复合物,在宿主免疫防御和免疫调节中发挥重要作用。NOX2组分功能缺陷会导致慢性肉芽肿病(chronic granulomatous disease,CGD)。NOX2缺陷引起的固有免疫反应改变是... 详细信息

吞噬细胞还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶又称NOX2,是一种多组分酶复合物,在宿主免疫防御和免疫调节中发挥重要作用。NOX2组分功能缺陷会导致慢性肉芽肿病(chronic granulomatous disease,CGD)。NOX2缺陷引起的固有免疫反应改变是CGD感染性疾病发生的主要原因。随着对CGD发病机制的深入研究,发现NOX2缺陷能够影响T、 B细胞介导的免疫应答,进而影响CGD患者自身免疫病的发生、发展。该文将对NOX2缺陷引起的适应性免疫的改变及其与CGD患者伴随性自身免疫病的关系进行综述。

关键词：吞噬细胞还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶慢性肉芽肿病适应性免疫自身免疫病

A Novel Mutation of Notch homolog protein 2 gene in a Chinese Family with Hajdu-cheney Syndrome

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Chinese Medical Journal 2017年第23期130卷 2883-2884页

作者： Ruo-Lan Gong Jing Wu tong-xin chen Department of Allergy and Immunology Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Division of Immunology Institute of Pediatric Translational Medicine Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Hajdu-cheney syndrome （HCS） is a rare disorder which is characterized by developmental delay, craniofacial anomalies, congenital heart defects, hearing deficit, polycystic kidneys, and bone abnormalities, including ... 详细信息

关键词： Acroosteolysis Hajdu-cheney Syndrome Notch homolog protein 2 gene Osteoporosis

EZH2参与TLR介导的B细胞增殖和抗体分泌

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现代免疫学 2024年第3期44卷 214-220页

作者：苏晓亚吴静陈同辛洪莉上海交通大学医学院附属上海儿童医学中心过敏免疫科上海200127 上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所上海200127 上海交通大学医学院附属上海儿童医学中心临床营养科上海200127

TLR属于模式识别受体家族中的一员,能够识别多种类型的PAMP。TLR信号通路在B细胞分化和激活过程中起着多种作用。为研究zeste基因的增强子同源物2(enhancer of zeste homolog 2,EZH2)在B细胞TLR介导的免疫反应中的作用,调取国家基因组... 详细信息

TLR属于模式识别受体家族中的一员,能够识别多种类型的PAMP。TLR信号通路在B细胞分化和激活过程中起着多种作用。为研究zeste基因的增强子同源物2(enhancer of zeste homolog 2,EZH2)在B细胞TLR介导的免疫反应中的作用,调取国家基因组科学数据中心与人类B细胞TLR信号通路有关的转录组数据,初步分析多梳抑制复合体2(polycomb repressive complex 2,PRC2)亚基的表达改变。随后分离人PBMC中的B细胞,用qRT-PCR和Western blotting的方法从转录水平和蛋白水平检测B细胞TLR通路激活后EZH2的表达水平。结果显示B细胞TLR激活后EZH2的表达增加。接着用EZH2抑制剂3-去氮腺嘌呤(3-deazaneplanocin A,DZNep)预处理人PBMC细胞,用流式细胞术和ELISA检测TLR介导的B细胞增殖和抗体分泌的改变。结果显示抑制B细胞中EZH2的功能后,TLR9介导的B细胞增殖和抗体分泌减少。综上,EZH2能够参与B细胞TLR介导的免疫反应,抑制B细胞中EZH2的表达后,TLR介导的B细胞增殖和抗体分泌减少。

关键词： Toll样受体 Zeste基因增强子同源物2 B淋巴细胞增殖抗体分泌

Cyclic Variability in Chemical Composition and Swelling-Shrinkage Properties of the Xiashu Loess Stratum near Nanjing,China

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Pedosphere 2007年第5期17卷 666-672页

作者： XIA Jia HUANG Guang-Long LIU Zi-tong chen xin-Min Institute of Geotechnical Engineering Nanjing University of Technology Nanjing 210009 （China）

Xiashu loess strata are widely distributed along the middle-lower reaches of the Yangtze River in East China with the stratum near Nanjing,Jiangsu Province being *** cyclic variability of the stratum was investigated through comparison of geological features,chemical composition,and swelling-shrinkage properties between the loess and the paleosol *** on the investigation of such a cyclic variability,soil behavior associated with the unsaturated state of the Xiashu loess stratum and its usefulness for geotechnical design and construction in the Nanjing area was analyzed. The stratum consisted of two types of cyclically alternating soil layers,namely the loess and the paleosol layers,which was the major cause for its cyclic *** loess and the paleosol layers were formed in different sedimentary *** order to avoid detrimental results from the differential engineering properties between them,this study suggested for the practitioners the importance of inspecting the variation of water content and controlling the downward net fluxes during geotechnical construction in the Nanjing area.

关键词： chemical composition cyclic variability swelling-shrinkage properties unsaturated state Xiashu loessstratum

Deep learning for joint channel estimation and feedback in massive MIMO systems

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Digital Communications and Networks 2024年第1期10卷 83-93页

作者： Jiajia Guo tong chen Shi Jin Geoffrey Ye Li xin Wang Xiaolin Hou National Mobile Communications Research Laboratory Southeast UniversityNanjing210096China Department of Electrical and Electronic Engineering Imperial College LondonLondonSW72AZUK DOCOMO Beijing Communications Laboratories Co. LtdBeijingChina

The great potentials of massive Multiple-Input Multiple-Output(MIMO)in Frequency Division Duplex(FDD)mode can be fully exploited when the downlink Channel State Information(CSI)is available at base ***,the accurate CsI is difficult to obtain due to the large amount of feedback overhead caused by massive *** this paper,we propose a deep learning based joint channel estimation and feedback framework,which comprehensively realizes the estimation,compression,and reconstruction of downlink channels in FDD massive MIMO *** networks are constructed to perform estimation and feedback explicitly and *** explicit network adopts a multi-Signal-to-Noise-Ratios(SNRs)technique to obtain a single trained channel estimation subnet that works well with different SNRs and employs a deep residual network to reconstruct the channels,while the implicit network directly compresses pilots and sends them back to reduce network *** module is also designed to generate data-bearing *** results show that the two proposed networks exhibit excellent performance of reconstruction and are robust to different environments and quantization errors.

关键词： Channel estimation CSI feedback Deep learning Massive MIMO FDD

A novel hypomorphic ζ-chain-associated protein tyrosine kinase 70 kDa mutation with normal CD8+ T cells count

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Chinese Medical Journal 2020年第14期133卷 1759-1760页

作者： Yue Li Jing Wu tong-xin chen Division of Immunology Pediatric Translational Medicine InstituteShanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Rheumatology and Immunology Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China

To the Editor:The z-chain-associated protein tyrosine kinase 70 kDa(ZAP70)deficiency is a rare autosomal recessive primary immunodeficiency characterized by absent CD8+T cells and non-functional CD4+T cells.[1]According to current reports,approximately 18 pathogenic ZAP70 mutations have been identified in less than 30 patients.[1-4]ZAP70 deficiency always results in recurrent bacterial,viral,and opportunistic infections,diarrhea,and autoimmune ***,ZAP70 hypomorphic mutations appear to have observable clinical heterogeneity,such as Epstein-Barr virus-associated lymphoproliferative disorder/lymphoma,late-onset immunodeficiency,[3]and silent brain infarcts.[5]Hence,next-generation sequencing technology might be the predominant diagnostic approach.

关键词： diarrhea ZAP70 predominant

Sn-doped cobalt containing perovskite as the air electrode for highly active and durable reversible protonic ceramic electrochemical cells

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Journal of Advanced Ceramics 2024年第1期13卷 63-72页

作者： Min Fu Wenjing Hu Hua tong xin Ling Linggui Tan Fanglin chen Zetian Tao School of Resources Environment and Safety EngineeringUniversity of South ChinaHengyang 421001China Department of Mechanical Engineering University of South CarolinaColumbia 29208USA

One potential solution to the problems of energy storage and conversion is the use of reversible protonic ceramic electrochemical cells(R-PCEC),which are based on the solid oxide fuel cell(SOFC)technology and offer a flexible route to the generation of renewable ***,the R-PCEC development faces a range of significant challenges,including slow oxygen reaction kinetics,inadequate durability,and poor round-trip efficiency resulting from the inadequacy of an air *** address these issues,we report novel B-sites doped Pr_(0.5)Ba_(0.5)Co_(0.7)Fe_(0.3)O_(3−δ)(PBCF)with varying amounts of Sn as the air electrode for R-PCEC to further enhance electrochemical performance at lower *** 600℃,R-PCEC with an air electrode consisting of Pr_(0.5)Ba_(0.5)Co_(0.7)Fe_(0.25)Sn_(0.05)O_(3+δ)has achieved peak power density of 1.12 W∙cm^(−2) in the fuel cell mode and current density of 1.79 A∙cm^(−2) in the electrolysis mode at a voltage of 1.3 ***,R-PCECs have shown good stability in the electrolysis mode of 100 *** study presents a practical method for developing durable high-performance air electrodes for R-PCECs.

关键词： triple conducting oxide dual-element doping protonic ceramic electrochemical cells(PCECs) catalytic

Effects of interstitial cluster mobility on dislocation loops evolution under irradiation of austenitic steel

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Nuclear Science and Techniques 2024年第8期35卷 69-78页

作者： xin‑Hua Yan Lu Sun Du Zhou Teng Xie Chang Peng Ye‑xin Yang Li chen Zhen‑Feng tong North China Electric Power University Beijing 102206China China Nuclear Power Operations Co. LtdShenzhen 518000China

The evolution of dislocation loops in austenitic steels irradiated with Fe^(+)is investigated using cluster dynamics(CD)simulations by developing a CD *** CD predictions are compared with experimental results in the *** number density and average diameter of the dislocation loops obtained from the CD simulations are in good agreement with the experimental data obtained from transmission electron microscopy(TEM)observations of Fe~+-irradiated Solution Annealed 304,Cold Worked 316,and HR3 austenitic steels in the *** CD simulation results demonstrate that the diffusion of in-cascade interstitial clusters plays a major role in the dislocation loop density and dislocation loop growth;in particular,for the HR3 austenitic steel,the CD model has verified the effect of temperature on the density and size of the dislocation loops.

关键词： Cluster dynamics Dislocation loops In-cascade interstitial clusters Austenitic steels

Rice stripe mosaic virus hijacks rice heading‐related gene to promote the overwintering of its insect vector

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Journal of Integrative Plant Biology 2024年第9期66卷 2000-2016页

作者： Siping chen xinyi Zhong Zhiyi Wang Biao chen Xiuqin Huang Sipei Xu xin Yang Guohui Zhou tong Zhang Guangdong Province Key Laboratory of Microbial Signals and Disease Control College of Plant ProtectionSouth China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Green Pesticide South China Agricultural UniversityGuangzhou 510642China

Rice stripe mosaic virus(RSMV)is an emerging pathogen which significantly reduces rice yields in the southern region of *** is transmitted by the leafhopper Recilia dorsalis,which overwinters in rice *** field investigations revealed that RSMV infection causes delayed rice heading,resulting in a large number of green diseased plants remaining in winter rice *** creates a favorable environment for leafhoppers and viruses to overwinter,potentially contributing to the rapid spread and epidemic of the ***,we explored the mechanism by which RSMV manipulates the developmental processes of the rice plant.A rice heading‐related E3 ubiquitin ligase,Heading date Associated Factor 1(HAF1),was found to be hijacked by the RSMV‐encoded *** impairment of HAF1 function affects the ubiquitination and degradation of downstream proteins,HEADING DATE 1 and EARLY FLOWERING3,leading to a delay in rice *** results provide new insights into the development regulation‐based molecular interactions between virus and plant,and highlights the importance of understanding virus‐vector‐plant tripartite interactions for effective disease management strategies.

关键词： HAF1 heading leafhoppers overwintering RSMV