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股骨大转子截骨联合Kocher-Langenbeck入路治疗髋臼高位后壁骨折

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中国骨伤 2024年第7期37卷 706-712页

作者：王晓盼陈笑天李仁杰刘乐予代秀松官建中吴敏陈晓东蚌埠医科大学第一附属医院创伤骨科组织移植安徽省重点实验室安徽蚌埠233004

目的:评价股骨大转子截骨技术联合Kocher-Langenbeck入路治疗髋臼高位后壁骨折的临床疗效。方法:回顾分析2020年1月至2022年12月收治的髋臼高位后壁骨折患者20例,其中男12例,女8例;年龄18~75岁。根据手术方式的不同分为两组,10例采用股... 详细信息

目的:评价股骨大转子截骨技术联合Kocher-Langenbeck入路治疗髋臼高位后壁骨折的临床疗效。方法:回顾分析2020年1月至2022年12月收治的髋臼高位后壁骨折患者20例,其中男12例,女8例;年龄18~75岁。根据手术方式的不同分为两组,10例采用股骨大转子截骨联合Kocher-Langenbeck入路为观察组,男5例,女5例,年龄18~75岁;10例单纯Kocher-Langenbeck入路为对照组,男7例,女3例,年龄18~71岁。使用Matta复位标准评价两组骨折的复位质量,末次随访时采用Harris评分比较两组患者髋关节功能。分析两组患者手术时间、失血量、术后并发症情况。结果:两组患者均获得随访,时间10~24个月。根据Matta骨折复位质量评价标准,观察组获解剖复位6例,满意复位3例,不满意复位1例;而对照组仅3例获解剖复位,满意复位3例,不满意复位4例。末次随访时,观察组髋关节Harris评分为71.4~96.6分,对照组为65.3~94.5分。根据Harris评分结果,观察组髋关节功能优6例,良3例,可1例;对照组,优2例,良3例,可3例,差2例。观察组术中出血量300~700 ml,手术时间120~180 min;对照组术中出血量300~650 ml,手术时间100~180 min。观察组创伤性关节炎1例,异位骨化1例;对照组创伤性关节炎3例,异位骨化3例,髋外展无力1例。结论:通过对结果数据的分析,与单纯采用Kocher-Langenbeck入路相比,将股骨大转子截骨技术用于高位后壁骨折的治疗,能够有效提高骨折解剖复位率,提升髋关节功能优良率,同时降低手术并发症的发生,值得临床应用。但因样本量较少,未进行相关统计学分析,结论仍需要进一步的临床验证。

关键词：髋臼骨折高位后壁骨折大转子截骨 Kocher-Langenbeck入路

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巴西酒神菊乙酸乙酯部位化学成分研究

中成药 2024年第6期46卷 1906-1913页

作者：梁勇周小青唐琍萍高雪梅颜冬梅陈笑天徐典李斌刘宏栋江西中医药大学院士工作站江西南昌330004

目的对巴西酒神菊Baccharis trimera(Less.)DC乙酸乙酯部位的化学成分进行研究。方法巴西酒神菊乙酸乙酯部位采用大孔树脂D101、Sephadex LH-20凝胶、硅胶等多种色谱技术进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结... 详细信息

目的对巴西酒神菊Baccharis trimera(Less.)DC乙酸乙酯部位的化学成分进行研究。方法巴西酒神菊乙酸乙酯部位采用大孔树脂D101、Sephadex LH-20凝胶、硅胶等多种色谱技术进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到23个化合物,分别鉴定为15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oicacid(1),13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid(2),methyltrineracetal(3),epimethyltrineracetal(4),trinerolide(5),15-epitrinerolide(6),18-methylmalonyl-7α-hydroxy-methyltrineracetal(7),18-methylmalonyl-7α-hydroxy-epimethyltriner-acetal(8),18-methylmalonyl-methyltrineracetal(9),18-methylmalonyl-epi-methyltrineracetal(10),methy 3,5-dicaffeoylquinate(11),8-dimetho-xyflavone(12),4′,7-dihydroxy-5-methoxyflavanone(13),4-(3′,4′-dihydroxycinnamoyl)-oxy-methylcinnamate(14),3′,7-dihydroxy-4′,6,8-trimethoxy-flavone(15),erigeroflavanone(16),nepetin(17),4,2′,4′,β-tetrahydroxy-6′-methoxy-α,β-dihydrochalcone(18),eugenyl-O-β-D-glucoside(19),7-hydroxyl-5,6,3′,4′-tetramethoxylflavone(20),phomoxanthone J(21),18-acetyl-7α-hydroxy-methyltrineracetal(22),18-acetyl-7α-hydroxy-epimethyltrineracetal(23)。结论化合物3~10,22~23为首次从巴西酒神菊中分离的差向异构体,化合物11~16,18~21为首次从酒神菊属植物中分离得到。

关键词：巴西酒神菊乙酸乙酯部位化学成分分离鉴定

Semiparametric Model Averaging for Ultrahigh-Dimensional Conditional Quantile Prediction

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Acta Mathematica Sinica,English Series 2023年第6期39卷 1171-1202页

作者： Chao Hui GUO Jing LV Hu YANG Jing Wen TU chen xiao tian School of Mathematical Sciences Chongqing Normal UniversityChongqing 401331P.R.China School of Mathematics and Statistics Southwest UniversityChongqing 400715P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China College of Finance University of International Business and EconomicsBeijing 100020P.R.China

In this paper,we develop a flexible semiparametric model averaging marginal regression procedure to forecast the joint conditional quantile function of the response variable for ultrahighdimensional ***,we approximate the joint conditional quantile function by a weighted average of one-dimensional marginal conditional quantile functions that have varying coefficient ***,a local linear regression technique is employed to derive the consistent estimates of marginal conditional quantile ***,based on estimated marginal conditional quantile functions,we estimate and select the significant model weights involved in the approximation by a nonconvex penalized quantile *** some relaxed conditions,we establish the asymptotic properties for the nonparametric kernel estimators and oracle estimators of the model averaging *** further derive the oracle property for the proposed nonconvex penalized model averaging ***,simulation studies and a real data analysis are conducted to illustrate the merits of our proposed model averaging method.

关键词： Kernel regression model averaging oracle property penalized quantile regression ultrahigh-dimension data

Synthesis of New 1,6-disubstituted Fulvenes

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Chinese Chemical Letters 1996年第10期7卷 881-883页

作者： Hu xiao Shu Feng chen and xiao tian LIANG(Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, 100050) Institute of Materia Medica Chinese Academy of Medical Sciences Beijing 100050

Sixteen new 1,6-disubstituted fulvenes have been prepared by acylation of cyclopentadienyl sodium and the result of preliminary pharmacological tests showed that several of them have antineoplastic activity.

关键词： Synthesis of New 1 6-disubstituted Fulvenes

A Cooperative Approach for the Extraction of Protein Motifs

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Chinese Chemical Letters 2006年第5期17卷 707-710页

作者： Chao chen Yuan Xin tian xiao Yong ZOU Pei Xiang CAI Jin Yuan MO School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275

By integrating the concept of cooperative approach, an extension of the fast annealing coevolutionary algorithm is presented in this paper. It outperformed the original algorithm in the domain of function optimization, especially in terms of convergence rate. It was also applied to a real optimization problem, protein motif extraction. And a satisfactory result has been obtained with the accuracy of prediction achieving 67.0%, which is in agreement with the result in the PROSITE database.

关键词： Cooperative approach global optimization protein motifs extraction.

A Hybrid Ant Colony Optimization for the Prediction of Protein Secondary Structure

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Chinese Chemical Letters 2005年第11期16卷 1551-1554页

作者： Chao chen Yuan Xin tian xiao Yong ZOU Pei Xiang CAI Jin Yuan MO School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275

Based on the concept of ant colony optimization and the idea of population in genetic algorithm, a novel global optimization algorithm, called the hybrid ant colony optimization （HACO）, is proposed in this paper to tackle continuous-space optimization problems. It was compared with other well-known stochastic methods in the optimization of the benchmark functions and was also used to solve the problem of selecting appropriate dilation efficiently by optimizing the wavelet power spectrum of the hydrophobic sequence of protein, which is the key step on using continuous wavelet transform （CWT） to predict a-helices and connecting peptides.

关键词： Ant colony algorithm global optimization wavelet power spectrum protein structure prediction.

Development and application of novel high‐efficiency composite ultrafine cement grouts for roadway in fractured surrounding rocks

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Deep Underground Science and Engineering 2024年第1期3卷 53-69页

作者： Maolin tian Shaojie chen Lijun Han Hongtian xiao Shandong Key Laboratory of Civil Engineering Disaster Prevention and Mitigation Shandong University of Science and TechnologyQingdaoChina College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdaoChina College of Energy and Mining Engineering Shandong University of Science and TechnologyQingdaoChina State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhouChina

The fractured surrounding rocks of roadways pose major challenges to safe *** has often been used to reinforce the surrounding rocks to mitigate the safety risks associated with fractured *** aim of this study is to develop highly efficient composite ultrafine cement(CUC)grouts to reinforce the roadway in fractured surrounding *** materials used are ultrafine cement(UC),ultrafine fly ash(UF),ultrafine slag(US),and additives(superplasticizer[SUP],aluminate ultrafine expansion agent[AUA],gypsum,and retarder).The fluidity,bleeding,shrinkage,setting time,chemical composition,microstructure,degree of hydration,and mechanical property of grouting materials were evaluated in this ***,a suitable and effective CUC grout mixture was used to reinforce the roadway in the fractured surrounding *** results have shown that the addition of UF and US reduces the plastic viscosity of CUC,and the best fluidity can be obtained by adding 40%UF and 10%*** UC and UF particles are small,the pozzolanic effect of UF promotes the hydration reaction,which is conductive to the stability of CUC *** addition,fine particles of UC,UF,and US can effectively fill the pores,while the volumetric expansion of AUA and gypsum decreases the pores and thus affects the microstructure of the solidified *** compressive test results have shown that the addition of specific amounts of UF and US can ameliorate the mechanical properties of CUC ***,the CUC22‐8 grout was used to reinforce the No.20322 belt *** results of numerical simulation and field monitoring have indicated that grouting can efficaciously reinforce the surrounding rock of the *** this research,high‐performance CUC grouts were developed for surrounding rock reinforcement of underground engineering by utilizing UC and some additives.

关键词： broken surrounding rock composite ultrafine cement(CUC)grouts grouting material grouting performance grouting reinforcement

Genome-Wide Association Studies Reveal New Genetic Targets for Five Panicle Traits of International Rice Varieties

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Rice science 2015年第5期22卷 217-226页

作者： ZHANG Ya-fang MA Yu-yin chen Zong-xiang ZOU Jie chen tian-xiao LI Qian-qian PAN Xue-biao ZUO Shi-min Jiangsu Key Laboratory of Crop Genetics and Physiology Co-innovation Center for Modern Production Technology of Grain Crops Key Laboratory of Plant Functional Genomics of the Ministry of Education Yangzhou University Department of Biochemical Engineering Yangzhou Polytechnic College

Narrow genetic background is a key limiting factor in breeding stable high-yielding rice. The introduction and utilization of international rice core germplasm is an important way to increase the genetic diversity of domestic rice varieties. We conducted a genome-wide association study on 5 panicle traits of 315 rice accessions introduced from the international rice micro-core germplasm bank. Based on the tests from Yangzhou of China and Arkansas of American, environment exhibited a significant impacts on panicle length and primary branch number, while grain length, grain width and grain length/width ratio were insensitive to environment changes. We discovered a total of 7, 5, 10, 8 and 6 chromosomal regions or single nucleotide polymorphism marker loci that were significantly associated with primary branch number, panicle length, grain length, grain width and grain length/width ratio, respectively. Among them, eleven regions were associated with grain shape and one region associated with primary branch number, showing the good consistence in two different environments. Significant linear correlation was discovered between the average trait value and the number of favorable alleles carried by the varieties in all associated loci. Among the associated loci, varieties in aromatic and tropical japonica sub-groups possessed most favorable alleles, while those in temperate japonica sub-group contained the least. The domestic varieties mainly harbored unfavorable alleles in six of the associated loci being detected. On the contrary, 15 varieties from 11 different countries harbored more favorable alleles （as many as 30 or more） than the others. Remarkably, all these 15 varieties belonged to the tropical japonica sub-group. In conclusion, our study demonstrates that varieties in the tropical japonica sub-group had high potentials for breeding stable high-yielding rice. Based on this discovery, we proposed a new approach for improving the panicle traits of domestic rice by

关键词： international rice core germplasm panicle trait genome-wide association study favorableallele breeding utilization

Recent progress in single crystal perovskite X-ray detectors

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Science China(Information Sciences) 2024年第3期67卷 5-19页

作者： xiao LIU Jun REN Yu-Ang chen Xiangshun GENG Dan XIE tian-Ling REN School of Integrated Circuits Tsinghua University Beijing National Research Center for Information Science and Technology (BNRist)

Perovskites have attracted extensive attention as radiation detection material due to their long carrier diffusion length and lifetime, high absorption coefficient, and flexible manufacturing process. Compared with polycrystalline structures, single crystal perovskites improve the performance of optoelectronic devices due to their low defect state density, better photoelectric characteristics, and chemical ***, we review the recent progress of single crystal perovskite X-ray detectors. First, we briefly introduced the basic concepts, detection mechanisms, figure of merits of perovskite X-ray detectors, and the preparation methods of single crystal perovskites. Then, we summarized the significant advancements in single crystal perovskite X-ray detectors in recent times. Finally, we discussed the critical challenges and some practicable solutions for developing high-performance X-ray detectors.

关键词： single crystal perovskites carrier transport radiation detection X-ray detectors X-ray imaging