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Paclitaxel-lipid prodrug liposomes for improved drug delivery and breast carcinoma therapy

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Chinese Chemical Letters 2024年第2期35卷 335-340页

作者： Xin Wu Xinmei chen Xinyu Wang Haisheng He Jianming chen Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Department of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China shanghai Wei Er Lab Shanghai 201707China shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Paclitaxel(PTX)is widely applied for the treatment of unresectable and metastasis breast carcinoma as well as other cancers,whereas its efficacy is always impeded by poor *** are one kind of the most successful drug carriers which are capable of solubilizing PTX and improving patients’tolerance owing to excellent biocompatibility and ***,poor compatibility between PTX and liposomes compromises the stability,drug loading and anti-tumor capacity of liposomal *** address this issue,three lipids with various chain lengths,namely,myristic acid(MA,14C),palmitic acid(PA,16C)and stearic acid(SA,18C),were conjugated to PTX via ester bonds and the synthesized prodrugs with high lipophilicity were further formulated into liposomes,*** liposomes show high stability and drug loadings,as well as sustained drug *** chain lengths of lipids are negatively correlated with drug release and enzymatic conversion rates,which further impact the pharmacokinetics,tumor accumulation,and anti-tumor efficacy of liposomal *** rapid nor slow drug release facilitates high tumor accumulation as well as anti-tumor efficacy of *** all liposomes,PTX-PA-loaded liposomes show the longest circulation and highest tumor accumulation of PTX and exert the most potent anti-tumor capacities in vivo,owing to its moderate drug release and enzymatic conversion *** its superior safety,PTX-PA liposomes hold potential for further clinical translation.

关键词： Paclitaxel Lipids Prodrugs Liposomes Drug release Chemotherapy

Generalized Riemann problem for Euler system Dedicated to Professor LI TaTsien on the Occasion of His 80th Birthday

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Science china Mathematics 2017年第4期60卷 581-592页

作者： chen shuxing LI DeNing school of mathematical sciences Fudan University Department of Mathematics West Virginia University

This article is a survey on the progress in the study of the generalized Riemann problems for MD Euler system. A new result on generalized Riemann problems for Euler systems containing all three main nonlinear waves(s... 详细信息

关键词： Euler system Riemann problem shock rarefaction wave contact discontinuity or vortex sheet

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广告频率和品牌成熟度对信息加工模式的影响

心理学报 2001年第5期33卷 448-452页

作者：陈宁复旦大学管理学院上海200433

广告可以通过受众的自动化加工和控制性加工两条途径为品牌价值的建立作出贡献。该研究运用加工分离程序 ,探讨了在不同的呈现频率下 ,受众对不同成熟度商品的广告的信息加工模式。结果发现 :(1)在非注意条件下 ,与新品牌相比 ,成熟品... 详细信息

广告可以通过受众的自动化加工和控制性加工两条途径为品牌价值的建立作出贡献。该研究运用加工分离程序 ,探讨了在不同的呈现频率下 ,受众对不同成熟度商品的广告的信息加工模式。结果发现 :(1)在非注意条件下 ,与新品牌相比 ,成熟品牌会引起更多的自动化加工 ,控制性加工在各种成熟度的商品之间差异不显著 ;(2 )在低卷入学习状态下 ,重复既提高了广告的自动影响 ,也提高了控制性加工的影响。因此 ,重复播放是提高广告有效性的一条途径。

关键词：广告呈现频率品牌成熟度信息加工

Advanced nano-based strategies for mRNA tumor vaccine

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Acta Pharmaceutica Sinica B 2024年第1期14卷 170-189页

作者： Yangqi Qu Jingjing Xu Tong Zhang Qinjun chen Tao Sun chen Jiang Key Laboratory of Smart Drug Delivery(Ministry of Education) Minhang HospitalState Key Laboratory of Medical NeurobiologyDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China

Tumor vaccine is a promising strategy for cancer immunotherapy by introducing tumor antigens into the body to activate specific anti-tumor immune *** with the technological breakthroughs in genetic engineering and delivery systems,messenger ribonucleic acid(mRNA)technology has achieved unprecedented development and application over the last few years,especially the emergency use authorizations of two mRNA vaccines during the COVID-19 pandemic,which has saved countless lives and makes the world witness the powerful efficacy of mRNA technology in ***,unlike infectious disease vaccines,which mainly induce humoral immunity,tumor vaccines also need to activate potent cellular immunity to control tumor growth,which creates a higher demand for mRNA delivery to the lymphatic organs and antigen-presenting cells(APCs).Here we review the existing bottlenecks of mRNA tumor vaccines and advanced nano-based strategies to overcome those challenges,as well as future considerations of mRNA tumor vaccines and their delivery systems.

关键词： mRNA vaccine Nanoparticle Tumor vaccine Delivery system Stability Targeting Transfection Immunogenicity

Evidence for the Projections from the Basal Nucleus of the Amygdala to the Primary Visual Cortex in the Cat

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生物物理学报 2009年第S1期25卷 250-250页

作者： Yuanxin chen, Bin Zhu and Tiande Shou school of Life sciences, fudan university, shanghai, P.R.china

The amygdaloid complex receives information from all sensory systems, especially from vision. Some researches (Amaral DG, 2003) show that in the primate brain, the amygdala

关键词： Amygdaloid complex Basal nucleus Area 17 FluoroGold Evoked Potentials(EPs)

An Analytical Method for Oligosaccharides by High Performance Liquid Chromatography

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An Analytical Method for Oligosaccharides by High Performanc...

HPLC-ELSD法测定小百部中小百部苷B的含量

第八届全国复合糖生物化学与分子生物学学术会议

作者： ZHENG Xiao-Xun, BAI chen, LI Ze, DU Jia-Mu (school of Life sciences, fudan university, shanghai 2.0433, china)

The oligoglucose is taken as a model to establish a new method to analyze oligosaccharide structure bymethylated,AcCl/Hcl degradation,(S)-MNBCOOH fluorescent derivation and High performance liquidchromatography *** ca...

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复旦学报（医学版） 2004年第5期31卷 521-523页

作者：白桦冯举陈道峰复旦大学药学院生药学教研室上海200032

目的　建立测定小百部 (AsparagusfilicinusBuch . Ham)中小百部苷B含量的方法 ,评价不同产地药材的质量。方法　高效液相色谱法。色谱柱 :ZorbaxEclipseXDB C18柱 (5 μm ,15 0mm× 4 .6mm) ;流动相 :甲醇水(82∶18) ;流速 :1.0mL/mi... 详细信息

目的　建立测定小百部 (AsparagusfilicinusBuch . Ham)中小百部苷B含量的方法 ,评价不同产地药材的质量。方法　高效液相色谱法。色谱柱 :ZorbaxEclipseXDB C18柱 (5 μm ,15 0mm× 4 .6mm) ;流动相 :甲醇水(82∶18) ;流速 :1.0mL/min ;柱温 :35℃ ;ELSD参数 ;漂移管温度为 10 0℃ ,气体流量 1.5L/min。结果　小百部苷B在 1.0～ 10 .0 μg范围内呈良好的线性关系 ,r =0 .9997,平均加样回收率为 96 .74 % ,RSD =1.90 % (n =5 )。结论　以HPLC ELSD法测定小百部中小百部苷B含量的方法可行。

关键词： HPLC-ELSD法含量百部生药不同产地指标成分高效液相色谱法甲醇回收率色谱柱

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不同年龄广告名人效应的心理加工机制研究

心理科学 2003年第1期26卷 37-40页

作者：陈宁复旦大学管理学院上海200433

本研究从自动化加工和控制性加工这个视角研究了名人效应的心理加工机制。实验运用加工分离程序 ,探讨了不同年龄阶段的受众对名人广告的信息加工模式。结果发现 :( 1 )名人效应是一个普遍存在的现象 ,与用一般消费者做代言人相比 ,青... 详细信息

本研究从自动化加工和控制性加工这个视角研究了名人效应的心理加工机制。实验运用加工分离程序 ,探讨了不同年龄阶段的受众对名人广告的信息加工模式。结果发现 :( 1 )名人效应是一个普遍存在的现象 ,与用一般消费者做代言人相比 ,青少年、成年人 (大学生 )以及老年人对名人广告均明显存在更多的自动化加工 ,且加工水平没有年龄差异。但是 ,老年人的控制性加工明显低于其他两组 ;( 2 )在非注意条件下 ,代言人的专业化程度明显地影响了大学生组的控制性加工 ,但与各组被试的自动化加工都关系不大。

关键词：老年人控制性不同年龄机制研究成年人心理发现名人效应名人广告加工水平

Risk factors of adverse drug reaction from non-steroidal anti-inflammatory drugs in shanghai patients with arthropathy

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Acta Pharmacologica Sinica 2004年第3期25卷 103-111页

作者： Wen SHI2,Yong-ming WANG,Shao-li LI3,Min YAN3,Duan Li,Bin-yan chen,Neng-neng chenG Department of Pharmacology,school of Pharmacy,fudan university,shanghai 200032 The Center for Drug Reevaluation and 3 The Center for Adverse Drug Reaction Monitoring,State Food and Drug Administration,Beijing 100061,china Department of Pharmacology School of Pharmacy Fudan University The Center for Drug Reevaluation and The Center for Adverse Drug Reaction Monitoring State Food and Drug Administration Beijing 100061 China

AIM: The study was to screen the possible risk factors of adverse drug reaction (ADR) induced by non-steroidal anti-inflammatory drugs (NSAIDs) in shanghai patients with arthropathy. METHODS: The subjects were ran- domly selected from a database of outpatients with arthropathy from 9 main hospitals in shanghai. A door to door retrospective epidemiological survey was used to collect demographic information about the patients, both indi- vidual and familial. This included data on their medical histories, lifestyle and dietary habits, history of smoking and alcohol consumption, history of drug therapy, quality of life (QOL) prior to NSAIDs intake, history of NSAIDs therapy and its ADR events, etc. Descriptive statistical methods and univariate analysis were also used to identify possible risk factors for ADRs induced by NSAIDs. RESULTS: Of the 1002 patients surveyed, the average length of NSAIDs intake was 2 years. ADR incidence from different NSAIDs was high, in a range from 46.7 %-66.2 %. In general, the candidate risk factors for ADRs were different for each NSAID. Each of the candidate risk factors were defined and studied in order to evaluate its role in the determination of ADRs from NSAIDs. “Family history of ADRs caused by NSAIDs” was found to be a significant risk factor for the four commonly used NSAIDs: meloxicam, diclofenac, nimesulide, and nabumetone. CONCLUSION: A retrospective epidemiological survey was useful in detecting the risk factors for ADRs caused by NSAIDs. The study found that different NSAIDs might have different risk factors and that there is no single risk factor universally applicable to all NSAIDs.

关键词： non-steroidal anti-inflammatory drugs adverse drug reaction risk factors retrospective studies quality of life