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Mass spectrometry analysis of melanoma related O-glycans in sera

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Science china Chemistry 2010年第4期53卷 807-811页

作者： BAI chen1,4, WU Gang1 & ZHAO Liang2,3 1Department of Life Science, fudan university, shanghai 2.0433, china 2Department of Chemistry, fudan university, shanghai 2.0433, china 3Institutes of Biomedical sciences, fudan university, shanghai 2.0433, china 4Department of Food Science, shanghai Business school, shanghai 200235, china Department of Life Science Fudan University Shanghai China Department of Food Science Shanghai Business School Shanghai China Department of Chemistry Fudan University Shanghai China Institutes of Biomedical sciences Fudan University Shanghai China

Glycomics comparison was carried out by screening melanoma serum biomarkers between C57 mice with and without B16 implanted. O-glycans were released from 10 μL sera by β-elimination, purified by Graphitized Carbon Cartridge Solid Phase Extraction (GCC-SPE) and analyzed by MALDI-QIT-TOF-MS. MS raw data were acquired and exported by Launchpad software. MATLAB was then applied for further data analysis. 10 Glycans were considered to have stable changes after B16 implantation and 5 of them were under structural analysis via MS/MS.

关键词： mass spectrometry glycomics melanoma biomarkers

Hydrogen sulfide:third gaseous transmitter,but with great pharmacological potential

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Acta Pharmacologica Sinica 2007年第11期28卷 1709-1716页

作者： Chang-qing chen Hong XIN Yi-zhun ZHU Department Of Pharmacology,school of Pharmacy,fudan university shanghai 200032,china Department of Pharmacology School of Pharmacy Fudan University Shanghai China

Hydrogen sulfide (H2S),which is well known traditionally as a toxic gas,has beenproven to be produced endogenously by 3 enzymes in mammalian tissues andplays important roles in physiological and pathophysiological *** thecentral nervous system,H2S functions as not only a neuromodulator,but also aneuroprotectant against oxidative *** the cardiovascular system,H2S re-laxes vascular smooth muscles by the activation of KATPchannels and inhibitssmooth muscle cell proliferation via the mitogen-activated protein kinase signal-ing *** effects are important for maintaining blood pressure andpreventing vessel structural remodeling,and identifies H2S as an important factorin the development of some vascular diseases,such as hypertension.H2S alsoshows cardioprotective effects in ischemic myocardium and septic and *** studies have demonstrated a new mechanism to explain the motoreffect of H2S on the rat detrusor muscle,which is through the activation of thecapsaicin-sensitive primary *** review focuses on the recent researchachievements on H2S and discloses the great potential of H2S as the third gaseoustransmitter in cardiac protection.

关键词： hydrogen sulfide cystathionine β-synthetase cystathionine γ-lyase KATP channels capsaicin

A characterization of solvability for a class of networks

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Science china(Information sciences) 2012年第4期55卷 747-754页

作者： YUAN chen & KAN HaiBin shanghai Key Lab of Intelligent Information Processing,school of Computer Science,fudan university,shanghai 2.0433,china shanghai Key Lab of Intelligent Information Processing School of Computer Science Fudan University Shanghai China

In this paper,we find that Property P can be generalized to characterize the solvability of a kind of networks with any number of sources,thus partially answering the open problem as to whether there are properties similar to Property P to characterize the solvability of some *** an application,for a given integer n,we construct such a solvable network that has no solvable solution if its alphabet size is less than n.

关键词： capacity coding capacity network coding solvability

Artificial pulmonary surfactant as a carrier for intratracheally instilled insulin

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Acta Pharmacologica Sinica 2007年第5期28卷 744-750页

作者： Ying JI,chen LIU,Yuan-ying PEI~2Department of Pharmaceuties,school of Pharmacy,fudan university,shanghai 200032,china Department of Pharmaceutics School of Pharmacy Fudan University Shanghai China

Aim:The relative bioavailabilities and effects on lung injury alleviation of 4 insu-lin-artificial pulmonary surfactant (INS-APS) preparations were studied in *** relationship between the minimal surface tension (γmin) of INS-APS andthe absorption of insulin was also ***:Four formulations ofAPS[1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)/lecithin/palmitic acid(PA),DPPC/1-hexadecanol (Hex)/tyloxapol (Tyl),DPPC/L-α-phosphatidyl-DL-glyc-erol sodium salt (PG),DPPC/Tyl]were prepared by thin-film sonication methodand direct *** γminof 4 APS dispersions was examined with andwithout INS by pulsating with a bubble surface *** vivo experimentswere performed in which serum glucose change and the insulin level were mea-sured by an enzymatic glucose reagent kit and a radioimmunology assay kit afterIT to *** reduction in lung injury by INS-APS following 7 d of consecutiveadministration was evaluated by the pulmonary edema index (the weight ratio ofwet lung to dry lung) and histopathology ***:The γminof allAPS dispersions were below 10 mN/*** was no significant difference (P>0.05) between the γ(min)of APS and the corresponding *** vivo experi-ments showed a significant glucose level decrease and insulin absorptionincrease (P0.05) between INS/DPPC/Tyl,INS/DPPC/PG,and the control *** pulmonary edema indices and histopatho-logical observation indicated that INS-APS could alleviate lung ***:The most potent hypoglycemic effect and insulin absorption increase in this studywere obtained with INS/DPPC/*** to the results,there was a linearcorrelation between the γminand relative bioavailability of INS-

关键词： pulmonary drug delivery system pharmacokinetics pharmacodynamics hypoglycemic effect minimal surface tension absorption pulmonary edema index histopathology examination

Decay Rate of Solutions to Hyperbolic System of First Order

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Acta Mathematica Sinica,English Series 1999年第4期15卷 471-484页

作者： shuxing chen Yi Zhou Institute of Mathematics,fudan university,shanghai 2.0433,P.R.china E-mail:sxchen@*** Fax:021-65646073 Institute of Mathematics Fudan University Shanghai P. R. China

In this paper we generalize the global Sobolev inequality introduced by Klainerman in studying wave equation to the hyperbolic system *** obtain several decay estimates of solutions of a hyperbolic system of first order by different norms of initial *** particular,the result mentioned in Theorem 1.5 offers an optimal decay rate of solutions,if the initial data belongs to the assigned weighted Sobolev *** the proof of the theorem we reduce the estimate of solutions of a hyperbolic system to the corresponding case for a scalar pseudodifferential equation of the first order,and then establish the required estimate by using microlocal analysis.

关键词： Hyperbolic system Decay rate Asymptotic behaviour Microlocal analysis

Impact of Long-term Exposure to Air Particulate Matter on Life Expectancy and Survival Rate of shanghai Residents

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Biomedical and Environmental sciences 2002年第3期15卷 209-214页

作者： KAN HAI-DONG1 AND chen BING-HENG Department of Environmental Health, school of Public Health, fudan university, shanghai 200032, china Department of Environmental Health School of Public Health Fudan University 上海 200032

Objective To evaluate the impact of long-term air particulate matter exposure on the life expectancy and survival rate of shanghai residents. Methods Epidemiology - based exposure-response function was used for the calculation of attributable deaths to air particulate matter in shanghai, and the effect of long-term exposure to particulate matter on life expectancy and survival rate was estimated using the life table of shanghai residents in 1999. Results It was shown that in 1999, the long-term air particulate matter exposure caused 1.34-1.69 years reduction of life expectancy and a decrease of survival rate for each age group of shanghai residents. Conclusion The effect of long-term exposure to air particulate matter on life expectancy is substantial in shanghai.

关键词： Particulate matter Life expectancy Survival rate shanghai

The maximal rates and minimal decoding delay of more general complex orthogonal designs

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Science china(Information sciences) 2010年第9期53卷 1826-1832页

作者： LI Yuan,KAN HaiBin*,YUAN chen & MA HuanFei The shanghai Key Lab of Intelligent Information Processing,school of Computer Science,fudan university,shanghai 2.0433,china The shanghai Key Lab of Intelligent Information Processing School of Computer Science Fudan University Shanghai China

Space-time block codes based on complex orthogonal design have been widely investigated for their remarkable *** this paper,we propose a definition of more general complex orthogonal designs,which permits arbitrary complex factor with unit modulus in each *** prove that the maximal rate is still (m+1)/2m for n = 2m or 2m-1 antennas and minimal delay is also lower-bounded by(2m/(m-1)).Thus,allowing complex factor with unit modulus in each entry will not improve the main performance criterion of space-time block codes.

关键词： space-time block codes complex orthogonal design more general complex orthogonal design maximal rates minimal delays

A HYPERBOLIC SYSTEM OF CONSERVATION LAWS FOR FLUID FLOWS THROUGH COMPLIANT AXISYMMETRIC VESSELS

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Acta Mathematica Scientia 2010年第2期30卷 391-427页

作者： Gui-Qiang G.chen school of mathematical sciences,fudan university,shanghai 2.0433,china mathematical Institute,university of Oxford,24-29 St Giles,Oxford,OX1 3LB,UK Department of Mathematics,Northwestern university,Evanston,IL 60208-2730,USA Weihua Ruan Department of Mathematics,Computer Science and Statistics,Purdue university Calumet,Hammond,IN 46323-2094,USA school of mathematical sciences Fudan University Shanghai 200433 China mathematical Institute University of Oxford 24-29 St Giles Oxford OX1 3LB UK Department of Mathematics Northwestern University Evanston IL 60208-2730 USA Department of Mathematics Computer Science and Statistics Purdue University Calumet Hammond IN 46323-2094 USA

We are concerned with the derivation and analysis of one-dimensional hyperbolic systems of conservation laws modelling fluid flows such as the blood flow through compliant axisyminetric vessels. Early models derived are nonconservative and/or nonho- mogeneous with measure source terms, which are endowed with infinitely many Riemann solutions for some Riemann data. In this paper, we derive a one-dimensional hyperbolic system that is conservative and homogeneous. Moreover, there exists a unique global Riemann solution for the Riemann problem for two vessels with arbitrarily large Riemann data, under a natural stability entropy criterion. The Riemann solutions may consist of four waves for some cases. The system can also be written as a 3 × 3 system for which strict hyperbolicity fails and the standing waves can be regarded as the contact discontinuities corresponding to the second family with zero eigenvalue.

关键词： conservation laws hyperbolic system fluid flow blood flow vessel hyper-bolicity Riemann problem Riemann solution wave curve shock wave rarefaction wave standing wave stability

Thompson's Group and the Linear Group GL∞（Z）

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Chinese Annals of Mathematics,Series B 2011年第6期32卷 863-884页

作者： Yan WU 1 Xiaoman chen 21 College of Mathematics Physics and Information Engineering,Jiaxing university,Jiaxing 314033,Zhejiang,china.2 school of mathematical sciences,fudan university,shanghai 2.0433,china.

The authors study the finite decomposition complexity of metric spaces of H,equipped with different metrics,where is a subgroup of the linear group GL∞ (Z).It is proved that there is an injective Lipschitz mapφ:(F,ds) → (H,d),where is the Thompson's group,the word-metric of with respect to the finite generating set and a metric of *** it is not a proper ***,it is proved that:φ(F,ds) → (H,d1) is not a Lipschitz map,where d1 is another metric of H.

关键词： Finite decomposition complexity Thompson’s group Word-metric Lipschitz map Reduced tree diagram