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LEVITIN-POYAK WELL-POSEDNESS OF GENERALIZED VECTOR EQUILIBRIUM PROBLEMS WITH FUNCTIONAL CONSTRAINTS

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Acta Mathematica Scientia 2010年第5期30卷 1400-1412页

作者：王刚黄学祥张杰陈光亚 school of Management Fudan University Institute of Applied Mathematics Chongqing University of Posts and Telecommunications Academy of Mathematics and Systems Science CAS

In this article, we study Levitin-Polyak type well-posedness for generalized vector equilibrium problems with abstract and functional constraints. Criteria and characterizations for these types of well-posednesses are... 详细信息

关键词： generalized vector equilibrium problems well-posedness set-valued map approximating solution sequence

Housing Wealth, Financial Wealth and Consumption in china

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china & World Economy 2009年第3期17卷 57-74页

作者： Jie chen Feng Guo Aiyong Zhu Associate Professor,school of Management,fudan university,shanghai,china. Senior Research Economist and Economics Lecturer,Haile/US Bank College of Business,Northern Kentucky university,Highland Heights,USA. Master Student,school of Economics,fudan university,shanghai,china. Associate Professor School of Management Fudan University Shanghai China. Email: jiech@*** Senior Research Economist and Economics Lecturer Haile/US Bank College of Business Northern Kentucky University Highland Heights USA. Email: guof1@nku.edu Master Student School of Economics Fudan University Shanghai China. Email: zhudayong_cn@***.

The paper investigates the relationship between changes in asset wealth and the trend movements of household consumption in urban china. Using the vector error correction cointegration model we demonstrate that there is a unique long-run cointegrating relationship between household consumption, disposable income, financial wealth and housing wealth in urban china. We find that housing wealth is the only factor that restores the long-run equilibrium relationship when the cointegrated system is disturbed by an external shock. In addition, our permanent-transitory variance decomposition analysis indicates that nearly all variance in the movement of consumption is permanent, supporting the classical random walk hypothesis of consumption behavior. However, a large proportion of variance in the short-run movements of housing wealth is found to be transitory.

关键词： consumption disposable income financial wealth housing wealth

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广告频率和品牌成熟度对信息加工模式的影响

心理学报 2001年第5期33卷 448-452页

作者：陈宁复旦大学管理学院上海200433

广告可以通过受众的自动化加工和控制性加工两条途径为品牌价值的建立作出贡献。该研究运用加工分离程序 ,探讨了在不同的呈现频率下 ,受众对不同成熟度商品的广告的信息加工模式。结果发现 :(1)在非注意条件下 ,与新品牌相比 ,成熟品... 详细信息

广告可以通过受众的自动化加工和控制性加工两条途径为品牌价值的建立作出贡献。该研究运用加工分离程序 ,探讨了在不同的呈现频率下 ,受众对不同成熟度商品的广告的信息加工模式。结果发现 :(1)在非注意条件下 ,与新品牌相比 ,成熟品牌会引起更多的自动化加工 ,控制性加工在各种成熟度的商品之间差异不显著 ;(2 )在低卷入学习状态下 ,重复既提高了广告的自动影响 ,也提高了控制性加工的影响。因此 ,重复播放是提高广告有效性的一条途径。

关键词：广告呈现频率品牌成熟度信息加工

In vivo and in vitro chondrotoxicity of ciprofloxacin in juvenile rats

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Acta Pharmacologica Sinica 2004年第10期 22-26页

作者： Ping LI, Neng-neng chenG, Bin-yan chen, Yong-ming WANG Department of Pharmacology, school of Pharmacy, fudan university, shanghai 200032, china

AIM: To study the relationship between chondrotoxicity and toxicokinetics of ciprofloxacin (CPFX). METHODS: Rats, 4-week old, were treated with CPFX 0, 400, 800, and 1200 mg/kg ig once daily on seven consecutive days. The knee joint cartilage was examined histopathologically. The concentration of CPFX in venous blood and knee joint cartilage samples were determined by a microbioassay using Escherichia coli 44102. The effects of CPFX on proliferation of chondrocytes and secretion of soluble proteoglycans were determined with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 1,9-dimethylmethylene blue (DMB) assay, respectively. RESULTS: Cartilage was severely lesioned after treatment with CPFX 800 or 1200 mg/kg for 7 d, such as matrix swelling and loss of chondrocytes. The thickness of cartilage was significantly decreased compared with the control group. The maximum serum concentration (Cmax), the area under the plasma concentration-time curve (AUC0-∞2), and concentration in cartila

关键词： ciprofloxacin knee joints articular cartilage glycosaminoglycans cell survival toxicokinetics juvenile rats

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不同年龄广告名人效应的心理加工机制研究

心理科学 2003年第1期26卷 37-40页

作者：陈宁复旦大学管理学院上海200433

本研究从自动化加工和控制性加工这个视角研究了名人效应的心理加工机制。实验运用加工分离程序 ,探讨了不同年龄阶段的受众对名人广告的信息加工模式。结果发现 :( 1 )名人效应是一个普遍存在的现象 ,与用一般消费者做代言人相比 ,青... 详细信息

本研究从自动化加工和控制性加工这个视角研究了名人效应的心理加工机制。实验运用加工分离程序 ,探讨了不同年龄阶段的受众对名人广告的信息加工模式。结果发现 :( 1 )名人效应是一个普遍存在的现象 ,与用一般消费者做代言人相比 ,青少年、成年人 (大学生 )以及老年人对名人广告均明显存在更多的自动化加工 ,且加工水平没有年龄差异。但是 ,老年人的控制性加工明显低于其他两组 ;( 2 )在非注意条件下 ,代言人的专业化程度明显地影响了大学生组的控制性加工 ,但与各组被试的自动化加工都关系不大。

关键词：老年人控制性不同年龄机制研究成年人心理发现名人效应名人广告加工水平

Reversal of hyperglycemia by protein transduction of NeuroD in vivo

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Acta Pharmacologica Sinica 2007年第8期28卷 1181-1188页

作者： Yin HUANG Jing chen Ge LI Tian-yue chenG Ming-hong JIANG Shu-yu ZHANG Jun LU Shi YAN Wei-wei FAN Da-ru LU~1 State Key Laboratory of Genetic Engineering,Institute of Genetics,school of Life Science,fudan university,shanghai 200433,china State Key Laboratory of Genetic Engineering Institute of Genetics School of Life Science Fudan University Shanghai China

Aim:To test whether the neurogenic differentiation(NeuroD)protein could alle-viate symptoms of diabetes mellitus by its transduction activity in ***:Type 1 diabetes mellitus in mice was induced by ip(intraperitoneal)injection ofstreptozotocin(150 mg/kg).One group of diabetic mice were intravenouslyinjected with the NeuroD-EGFP(Enhanced Green Fluorescent Protein)(5 mg/kg,n=6)and the other group with EGFP(5 mg/kg,n=5).After the transduction ofNeuroD-EGFP,the distribution of the protein was examined by means of frozensection under fluorescent microscope *** conducted RT-PCR andReal-time quantitative PCR to measure the transcription levels of insulin *** was utilized to detect the insulin ***-noassay was conducted to determine the serum insulin *** glucoselevels and body weights were regularly recorded after the protein ***:The NeuroD protein can be transduced into cells in vivo with a highefficiency of nearly 100%.Insulin mRNA was highly expressed in NeuroD-treateddiabetic mice,38-fold higher than that of control group(P<0.05).Immunohis-tochemistry revealed enteric insulin expression in the NeuroD-treated *** fasting serum insulin level of the NeuroD-EGFP group(n=6)was 337±39pg/mL,significantly higher than that of the control diabetic mice(n=5)which was84+23 pg/mL(P<0.01,t-test).Records of blood glucose level also displayed alle-viation of hyperglycemia after NeuroD administration(P<0.01,t-test,n=6).Conclusion:In vivo-transduced NeuroD in the small intestine remained function-ally active and could ameliorate the non-fasting glucose levels of streptozotocin-induced,diabetic mice by inducing enteric insulin expression.

关键词： neurogenic differentiation 1 type 1 diabetes mellitus intestines insulin

Amino acid 1-209 is essential for PDX-1-mediated repression of human CMV IE promoter activity

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Acta Pharmacologica Sinica 2006年第11期27卷 1495-1503页

作者： Jing chen~1 Lei chen~2 Ge LI~1 Lu chenG~1 Yin HUANG~1 Jia-xin ZHANG~1 Wei-wei FAN~1 Da-ru LU~(1,3)1 State Key Laboratory of Genetic Engineering,Institute of Genetics,school of Life sciences,fudan university,shanghai 200433,china 2 International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Institute,Second Military Medical university,225 Changhai Road,shanghai 200438,china. State Key Laboratory of Genetic Engineering Institute of Genetics School of Life Sciences Fudan University Shanghai China International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery Institute Second Military Medical University Shanghai China

Aim:To explore the different roles of pancreatic duodenal homeobox factors-1(PDX-1)domains in PDX-1 mediated repression of human cytomegalovirus imme-diately early(CMV IE)***:A series of truncated PDX-1 mutantswere *** binding of PDX-1 and CMV IE promoter was identified byelectrophoretic mobility shift assay(EMSA).The dual-reporter assay was ap-plied to examine the repression activities of PDX-1 mutants on CMV IE *** addition,RNAi technology was used to specifically knock down the endog-enous PDX-1 ***:The reporter assay indicated that compared tothe mock controls(pEGFP-N2),overexpression of PDX-1 resulted in a 41% de-crease of CMV IE promoter activity in the 293 cells(P<0.05)and 43% decrease inHeLa cells(P<0.05),and the repression levels of various truncated mutants playedon CMV IE promoter were *** knock down of the endogenousPDX-1 expression significantly restored the activity of CMV IE *** that domain 3 is necessary for nuclear localization and DNA bind-ing activity of ***,binding of PDX-1 alone to CMV IE promoter wasnot sufficient to inhibit its transcriptional activity,and other domains of PDX-1presented were also ***:Our data suggested that the DNAbinding activity of PDX-1 domain 3 and the cooperative binding of PDX-1 domain1/2 with other proteins were required for PDX-1 mediated repression of CMV IEpromoter.

关键词： CMV Immediately Early promoter pancreatic duodenal homeobox factors-Ⅰ down regulation

Effects of hypoxia,hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 in hepatic stellate cells

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World Journal of Gastroenterology 2001年第5期7卷 647-651页

作者： Ping-Sheng chen~(1,2) Wei-Rong Zhai~1 Xiao-Mei Zhou~3 Jin-Sheng Zhang~1 Yue-E Zhang~1 Yu-Qin Ling~1 Ying-Hong Gu~1 1 Department of Pathology,school of Basic Medical sciences,fudan university,shanghai 200032,china2 Ping-Sheng chen now works in the Department of Pathology,school of Basic Medical sciences the (former Nanjing Railway Medical College),Southeast university,Nanjing 210009,china3 Institute of Cancer Research,shanghai 200032,china Department of Pathology School of Basic Medical Sciences Fudan University 138 Yixueyuan Road Shanghai 200032 China.

AIM: To study the effects of hypoxia, hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 (MMP-2) in hepatic stellate cells (HSC). METHODS: The expressions of MMP-2, tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) and membrane type matrix metalloproteinase-1 (MT1-MMP) in cultured rat HSC were detected by immunocytochemistry (ICC) and in situ hybridization (ISH). The contents of MMP-2 and TIMP-2 in culture supernatant were detected with ELISA and the activity of MMP-2 in supernatant was revealed by zymography. RESULTS: In the situation of hypoxia for 12h, the expression of MMP-2 protein was enhanced (hypoxia group positive indexes: 5.7 +/- 2.0, n=10; control: 3.2 +/- 1.0, n = 7; P<0.05), while TIMP-2 protein was decreased in HSC (hypoxia group positive indexes: 2.5 +/- 0.7, n = 10; control: 3.6 +/- 1.0, n = 7; P < 0.05), and the activity (total A) of MMP-2 in supernatant declined obviously (hypoxia group: 7.334 +/- 1.922, n = 9; control: 17.277 +/- 7.424, n = 11; P < 0.01). Compared the varied duration of hypoxia, the changes of expressions including mRNA and protein level as well as activity of MMP-2 were most notable in 6h group. The highest value(A(hypoxia)-A(control)) of the protein and the most intense signal of mRNA were in the period of hypoxia for 6h, along with the lowest activity of MMP-2. In the situation of hyperoxia for 12h, the contents (A(450)) of MMP-2 and TIMP-2 in supernatant were both higher than those in the control, especially the TIMP-2 (hyperoxia group: 0.0499 +/- 0.0144, n = 16; control: 0.0219 +/- 0.0098, n = 14; P < 0.01), and so was the activity of MMP-2 (hyperoxia group: 5.252 +/- 0.771, n = 14; control: 4.304 +/- 1.083, n = 12; P < 0.05), and the expression of MT1-MMP was increased. CONCLUSION: HSC is sensitive to the oxygen, hypoxia enhances the expression of MMP-2 and the effect is more marked at the early stage; hyperoxia mainly raises the activity of MMP-2.

关键词： Animals Cell Division Cell Hypoxia Cells, Cultured Gelatinase A Gene Expression Regulation, Enzymologic Hepatocytes Hyperoxia Metalloendopeptidases RNA, Messenger Rats Rats, Sprague-Dawley Research Support, Non-U.S. Gov't Tissue Inhibitor of Metalloproteinase-2

An Analytical Method for Oligosaccharides by High Performance Liquid Chromatography

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An Analytical Method for Oligosaccharides by High Performanc...