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Role of basic studies in expanding the donor pool for liver transplantation

Hepatobiliary & Pancreatic Diseases International 2008年第6期7卷 571-580页

作者： chen, hao Zhang, Ying Zhou, Lin Xie, Hai-Yang Zheng, shu-Sen Zhejiang Univ Sch Med Affiliated Hosp 1Minist Publ Hlth Key Lab Combined Multiorgan Transplantat Hangzhou 310003 Zhejiang Peoples R China Zhejiang Univ Sch Med Affiliated Hosp 1 State Key Lab Diag & Treatment Infect Dis Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: Liver transplantation is an effective treatment for end-stage liver disease, but a huge gap remains between the number of people who need a liver transplant and the number of organs available. In order to maximize donor organ access for adult and pediatric recipients, novel surgical and liver replacement procedures have evolved. Newer surgical techniques include split cadaveric liver transplantation and living donor liver transplantation (LDLT). With marginal and abnormal donor livers, despite tremendous advances in surgical technology, individual surgical procedure can not be completely brought into play unless effective measurements and basal studies are undertaken. DATA SOURCES: A literature search of MEDLINE and the Web of Science database using 'liver transplantation' and 'expanding donor pool' was conducted and research articles were reviewed. RESULTS: Therapies directed toward scavenging O(2-), inhibiting nicotinamide adenine dinucleotide phosphate oxidase, and/or immuno-neutralizing tumor necrosis factor-alpha may prove useful in limiting the liver injury induced by surgical procedures such as split liver transplantation or LDLT. Improved donor organ perfusion and preservation methods, modulation of inflammatory cytokines, energy status enhancement, microcirculation amelioration, and antioxidant usage can improve non-heart beating donor liver transplantation. Effective measures have been taken to improve the local conditions of donor cells with steatosis, including usage of fat-derived hormone and inflammatory mediators, ischemic preconditioning, depletion of Kupffer cells, and cytokine antibody and gene therapy. Double-filtration plasmapheresis can effectively reduce HCV viremia and prevent HCV recurrence in patient with high HCV RNA levels after LDLT. CONCLUSIONS: Shortage of grafts and poor function of marginal and abnormal donor grafts put many patients at risk of death in waiting for liver transplantation. Advances in surgical technology, co

关键词： liver transplantation split liver transplantation living donor liver transplantation non-heart beating donor expanding donor pool

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2009-2013年佛山市男男性行为者艾滋病哨点监测结果分析

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华南预防医学 2015年第1期41卷 33-36页

作者：隋丹丹陈抒豪宫艳华钟崚峭曾琪佛山市疾病预防控制中心广东佛山528051

目的分析佛山市男男性行为者(MSM)艾滋病知识、行为、HIV感染状况及接受艾滋病相关服务情况,为该市开展MSM人群艾滋病防治工作提供参考依据。方法收集2009—2013年佛山市MSM艾滋病哨点监测数据,采用描述性流行病学方法进行分析。结果 2... 详细信息

目的分析佛山市男男性行为者(MSM)艾滋病知识、行为、HIV感染状况及接受艾滋病相关服务情况,为该市开展MSM人群艾滋病防治工作提供参考依据。方法收集2009—2013年佛山市MSM艾滋病哨点监测数据,采用描述性流行病学方法进行分析。结果 2009—2013年共监测MSM 1 522人,艾滋病知识总知晓率为85.1%(1 295/1 522)。最近6个月与同性发生过肛交性行为的比例为81.1%(1 235/1 522),每次都使用安全套的比例为45.0%(556/1 235);HIV抗体总阳性率为10.4%(159/1 522),HIV抗体阳性率呈上升趋势(P<0.01),从2009年的2.9%上升到2013年的12.7%,上升了337.9%。单因素分析结果显示,HIV抗体阳性率与年龄、文化程度、安全套使用频率、吸毒史、性病史及是否接受过安全套宣传和发放/艾滋病咨询与检测服务有关(P<0.05或P<0.01)。结论佛山市MSM人群安全套使用率偏低,HIV抗体阳性呈上升趋势,今后应大力开展安全套推广使用促进工作,以降低该人群的HIV感染率。

关键词：获得性免疫缺陷综合征男男性行为流行病学

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Mapping the landscape of gastric signet ring cell carcinoma:Overcoming hurdles and charting new paths for advancement

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World Journal of Clinical Oncology 2025年第2期16卷 94-109页

作者： shu-Yuan Wang Jing-Hang Wang Run-Kai chen Zhen Yuan hao Cui Bo Wei Jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND In recent years,the global prevalence of gastric cancer(GC)has witnessed a progressive decrease,accompanied by a step-growth in the incidence of gastric signet ring cell carcinoma(GSRCC).As precision medicine concepts progress,GSRCC,a distinct sub-type of GC,has drawn considerable attention from ***,there still persist some controversies regarding the associated research *** To summarize the current obstacles and potential future directions for research on *** To begin with,all literature related to GSRCC published from January 1,2004 to December 31,2023 was subjected to bibliometric analysis in this ***,this paper analyzed the research data using CiteSpace,GraphPad Prism v8.0.2,and VOSviewer,which was obtained from the Web of Science Core Collection *** analysis results were visually *** This study provided a comprehensive overview of the statistical characteristics of the 995 English articles related to GSRCC,including cited references,authors,journals,countries,institutions,and *** popular keywords and clusters contain"prognosis","survival","expression","histology",and"chemotherapy".CONCLUSION The prognosis,precise definition and classification,as well as chemoresistance of GSRCC,continue to be crucial areas of ongoing research,whose directions are closely tied to advancements in molecular biology research on GSRCC.

关键词： Gastric cancer Signet ring cell carcinoma Bibliometric analysis CiteSpace VOSviewer

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Highly anti-corrosive NiFe LDHs–NiFe alloy hybrid enables long-term stable alkaline seawater electrolysis

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Rare Metals 2024年第9期43卷 4321-4332页

作者： Jia-Hong Li hao chen Si-Hang You Gan-Xin Yang Peng Liu Meng-Qi Gao shu-Guang chen Fei-Fei Zhang School of Materials Science and Engineering Changsha University of Science and TechnologyHunan 410114China Department of Materials Science and Engineering Faculty of EngineeringNational University of SingaporeSingapore 117576Singapore School of Materials Science and Engineering Jilin UniversityJilin 130022China

Owing to the significant potential of alkalin seawater electrolysis for converting surplus power into eco friendly hydrogen fuel,we developed bifunctional elec trodes that integrate low-crystalline NiFe LDHs and amorphous NiFe alloy on a Ni foam(NF)substrate to enhance this *** by the battery-like charac teristics of NiFe LDHs,an anti-corrosive and active oute layer of NiFe^(vac)OOH continuously forms over time in th hybrid on the anode for the oxygen evolution reaction(OER),effectively mitigating powder shedding caused by corrosion induced by multiple anions in *** while,the strong bond between the hybrid and the NF substrate maintains intact hybrid coatings to ensure a rel atively high overall conductivity of the electrodes,signif icantly reducing the negative effects of structura degradation during the OER and hydrogen evolution reaction(HER),as well as the accumulation of contami nants on the electrode *** long-term tests,thes bifunctionalhybridelectrodesmaintained stable performance,even at a high current density o500 mA·cm^(-2).The cell voltage increased by only 88 m V over 1000 h to 1.970 V during saline electrolysis and by103 mV over 500 h to 2.062 V during seawater electroly ***,this study provides valuable insights into efficient and stable seawater electrolysis using NiFe LDHs–NiFe alloy hybrids.

关键词： NiFe LDHs Bifunctional Corrosion Stability Seawater electrolysis

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Gold self-relay catalysis for accessing functionalized cyclopentenones bearing an allcarbon quaternary stereocenter

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Organic Chemistry Frontiers 2022年第1期9卷 140-146页

作者： Fan-Tao Meng Jing-Long chen Xiao-Yan Qin Tian-shu Zhang shu-Jiang Tu Bo Jiang Wen-Juan hao School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhou221116P.R.China School of Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou 221018P.R.China

A new gold(I)self-relay catalysis consisting of a 3,3-rearrangement,Nazarov cyclization and Michael addition cascade of 1,3-enyne acetates with aurones and their derived azadienes is reported,and used to produce a series of densely functionalized cyclopentenones bearing a cyclic quaternary stereocenter in moderate to good yields under mild *** tandem protocol demonstrates high regioselectivity,broad substrate flexibility and good functional group tolerance of substrates without inert atmosphere protection,providing a catalytic and convergent approach for creating all-carbon stereoscopic centers.

关键词： catalysis quaternary functional

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Patient satisfaction and follow-up adherence to glaucoma case management clinic in China

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 73-81页

作者： hao Lin Hu-Jie Lu Wen-Zhe Zhou shu-shu Zuo Yan-Yan chen Shao-Dan Zhang National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina School of Ophthalmology and Optometry Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To assess glaucoma patient satisfaction and follow-up adherence in case management and identify associated predictors to improve healthcare quality and patient ***:In this cross-sectional study,a total of 119 patients completed a Patient Satisfaction Questionnaire-18 and a sociodemographic *** data was obtained from the case management ***-up adherence was defined as completing each follow-up within±30d of the scheduled time set by ophthalmologists during the study ***:Average satisfaction scored 78.65±7,with an average of 4.39±0.58 across the seven *** negatively correlated with satisfaction(P=0.008),whilst patients with follow-up duration of 2 or more years reported higher satisfaction(P=0.045).Multivariate logistics regression analysis revealed that longer follow-up durations were associated with lower follow-up adherence(OR=0.97,95%CI,0.95-1.00,P=0.044).Additionally,patients with suspected glaucoma(OR=2.72,95%CI,1.03-7.20,P=0.044)and those with an annual income over 100000 Chinese yuan demonstrated higher adherence(OR=5.57,95%CI,1.00-30.89,P=0.049).CONCLUSION:The case management model proves effective for glaucoma patients,with positive adherence *** implementation of this model can be optimized in the future based on the identified factors and extended to glaucoma patients in more hospitals.

关键词： glaucoma patient satisfaction follow-up adherence case management

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Research progress of catalysts for direct coal liquefaction

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Journal of Energy Chemistry 2025年第1期 481-497页

作者： Wei Song Penggao Liu Xinyue chen Ting Wang Chunrong He Rui hao Kaiyu Liu State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of Chemistry Xinjiang University College of Chemistry and Chemical Engineering Henan Polytechnic University Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical Engineering Central South University

Coal direct liquefaction technology is a crucial contemporary coal chemical technology for efficient and clean use of coal resources. The development of direct coal liquefaction technology and the promotion of alternative energy sources are important measures to guarantee energy security and economic security. However, several challenges need to be addressed, including low conversion rate, inadequate oil yield, significant coking, demanding reaction conditions, and high energy consumption. Extensive research has been conducted on these issues, but further exploration is required in certain aspects such as pyrolysis of macromolecules during the liquefaction process, hydrogen activation, catalysts' performance and stability, solvent hydrogenation, as well as interactions between free radicals to understand their mechanisms better. This paper presents a comprehensive analysis of the design strategy for efficient catalysts in coal liquefaction, encompassing the mechanism of coal liquefaction, catalyst construction,and enhancement of catalytic conversion efficiency. It serves as a comprehensive guide for further research endeavors. Firstly, it systematically summarizes the conversion mechanism of direct coal liquefaction, provides detailed descriptions of various catalyst design strategies, and especially outlines the catalytic mechanism. Furthermore, it addresses the challenges and prospects associated with constructing efficient catalysts for direct coal liquefaction based on an understanding of their action mechanisms.

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LightGCNet:基于轻量化卷积网络的深度色域压缩算法

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计算机科学与探索 2025年第1期19卷 196-210页

作者：杨晨徐昊朱佳伟吴秦柴志雷江南大学人工智能与计算机学院江苏无锡214122 江苏省模式识别与计算智能工程实验室江苏无锡214122

色域压缩是大色域向小色域进行转换时保持色彩信息的关键技术。经典算法虽计算快速,但处理结果缺乏细节且没有考虑人眼的感知特性,难以满足人们对色彩品质不断提升的要求。迭代算法处理效果更佳,但极其耗时,无法投入实际应用。针对上述... 详细信息

色域压缩是大色域向小色域进行转换时保持色彩信息的关键技术。经典算法虽计算快速,但处理结果缺乏细节且没有考虑人眼的感知特性,难以满足人们对色彩品质不断提升的要求。迭代算法处理效果更佳,但极其耗时,无法投入实际应用。针对上述问题,提出了轻量化的深度色域压缩方法,该方法可在逼近迭代算法计算效果的同时保持接近经典算法的速度。为色域压缩算法设计了LightGCNet模型,该网络中的双层卷积由DSC与DW卷积组合而成,相比常规U-Net,参数量与计算复杂度急剧降低。为进一步提高模型先验性,将预训练得到的DW卷积中多个核通道进行重聚焦操作以建立联系,最终权重由重聚焦权重和预训练权重组成。针对色相、明度、彩度这三个色彩属性,设计了色域压缩专用的损失函数。该函数不仅考虑了像素级损失,而且融合了图像感知损失,并联合色彩属性的多尺度信息进行加权,解决了深度色域压缩过程中细节丢失的问题。基于迭代算法生成标签以训练网络,联合学习目标色域特征与图像信息,实现了与迭代算法相当的效果。实验结果表明:该方法与业界经典的SGCK算法相比,iCID值降低了17.08%,SSIM值提高了5.30%。相比常规U-Net模型,LightGCNet参数量减少了82.96%,乘加次数从8.5GFLOPs大幅下降至2.2GFLOPs,使改良模型更适于低端设备部署。该模型在CPU上处理单幅512×512图像仅需0.208s,计算时间比迭代类算法减少99.92%。

关键词：色域压缩轻量化深度学习色彩管理

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A high-precision hydrodynamic model coupled with the hydrological habitat suitability model to reveal estuarine vegetation distribution

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Journal of Hydrodynamics 2022年第3期34卷 451-466页

作者： Qiao-feng Ma shu-xiu Liang Zhao-chen Sun Wen-hao Hou Xin-yue Hu Rui-jin Zhang State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian116024China School of Marine Science and Environment Engineering Dalian Ocean UniversityDalian116023China Operational Oceanographic Institution Dalian Ocean UniversityDalian116023China

In this paper,based on the finite volume method,a high-precision hydrodynamic model coupled with the habitat suitability model is established,and the computational efficiency of the coupled model is improved by a graphics processing unit(GPU)-accelerated *** coupled model is used to solve the problem of the non-conservation of mass that may be caused by the nearshore hydrodynamic model in the processing of wetting and drying,while avoiding the unphysical high velocities at the wetting and drying *** coupled model is applied to simulate the high-precision hydrodynamic process of the Liao River estuary(LRE)and the hydrological habitat suitability of the estuarine vegetation(Suaeda heteroptera)growing in the *** simulated values of the hydrological variables(the water level,the water depth,the current velocity and direction)are highly consistent with the measured *** root mean square errors(RMSE)of the hydrological variables are 0.10m,0.12m/s and 17.24°,***,the simulated combined suitability index(CSI)distribution of Suaeda heteroptera(***)matches with the distribution of *** obtained from the high-resolution remote sensing satellite images during the same time *** ratio of the simulated weighted usable area(WUA)of *** to the area obtained from the remote sensing satellite images during the same period is 81.9%.This study reveals the phenomenon that the distribution of *** in the LRE is highly correlated with the high-precision hydrodynamic processes,and provides a scientific basis and a valuable reference for the conservation and the restoration of the estuarine vegetation.

关键词： High-precision hydrodynamic model habitat suitability model conversation of mass weighted usable area vegetation distribution

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Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan Zhixing Ling Yong chen Nanda Rea Arne Rau Zhiming Cai Huaqing cheng Francesco Coti Zelati Lixin Dai Jingwei Hu shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang chen Zhang shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu Yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng chen Houlei chen Tianxiang chen Wei chen Yehai chen Yifan chen chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

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