检索结果-南通市图书馆

Establishment of a prognostic scoring model for regional recurrent nasopharyngeal carcinoma after neck dissection

Cancer Biology & Medicine 2020年第1期17卷 227-236页

作者： Xiaoyun Li Chao Lin Jinjie Yan Qiuyan chen Xuesong Sun Sailan Liu Shanshan Guo Liting Liu haojun Xie Qingnan Tang Yujing Liang Ling Guo hao Li Xuekui Liu Xiang Guo Linquan Tang Haiqiang Mai State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou 510060China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Head and Neck Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China

Objective:The main aim of this study was to establish a scoring model to predict risk of progression and survival in patients with regionally recurrent nasopharyngeal carcinoma(NPC).Methods:Three hundred and forty-eight patients subjected to neck dissection from 2003 to 2017 were included for *** information for each patient was *** prognostic factors were selected using the Cox proportional hazards model and incorporated into the scoring *** index(C-index)and calibration curves were used to verify discrimination and calibration,respectively and the results validated using bootstrap ***:Microscopic positive lymph node>2[hazard ratio(HR),2.19;95%confidence interval(CI),1.30–3.68;P=0.003],extranodal extension(HR,2.75;95%CI,1.69–4.47;P<0.001),and lower neck involvement(HR,1.78;95%CI,1.04–3.04;P=0.034)were identified from multivariate analysis as independent factors for overall survival(OS).A qualitative 4-point scale was generated to stratify patients into 4 risk groups for predicting OS and progression-free survival(PFS).The novel scoring model demonstrated enhanced discrimination(C-index=0.69;95%CI,0.62–0.76)relative to the original recurrent tumor-node-metastasis(rTNM)staging system(C-index=0.56;95%CI,0.50–0.62),and was internally validated with a bootstrap-adjusted C-index of *** calibration curve showed good agreement between predicted probabilities and actual ***:The scoring system established in this study based on a large regionally recurrent NPC cohort fills a gap regarding assessment of risk and prediction of survival outcomes after neck dissection in this population and could be further applied to identify high-risk patients who may benefit from more aggressive intervention.

关键词： Nasopharyngeal carcinoma recurrence lymphatic metastasis operation prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructure and physical properties of Cu-2.3Ni-0.5Si alloy with thermo-mechanical treatment

引用

Rare Metals 2023年第1期42卷 64-69页

作者： Dong-Mei Liu Cong-shuai Yin Yan-Hong Hua Dong-Lin Zhang Yu-Ao Li Bo-Jie Ma Xiu-chen Zhao hao-Feng Xie Li-Jun Peng Guo-Jie Huang Xu-Jun Mi State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.LtdBeijing100088China GRIMAT Engineering Institute Co. Ltd.Beijing101407China General Research Institute for Nonferrous Metals Beijing100088China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China

For Cu-Ni-Si alloys,cold rolling is usually performed after solution treatment to enhance physical properties such as strength and electrical conductivity during the aging *** paper reports the variation in microstructure and physical properties during the aging process of Cu-2.3Ni-0.5Si alloy cold-rolled at room temperature(RT) and cryogenic temperature(CT).When aged at 450℃ for 2 h,RT-rolled samples exhibited a maximum hardness of HV5234 with an electric conductivity of 39.9% *** CTrolled samples,the peak hardness was achieved when the samples were aged at 450% for 1 h.

关键词： alloy Microstructure microstructure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A dendritic Cu/Cu_(2)O structure with high curvature enables rapid and efficient reduction of carbon dioxide to C_(2) in an H-cell

引用

Chinese Journal of Catalysis 2024年第8期63卷 144-153页

作者： Lei shao Bochen Hu Jinhui hao Junjie Jin Weidong Shi Min chen School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

Electrocatalytic reduction of CO_(2)(CO_(2)RR)to multicarbon products is an efficient approach for ad-dressing the energy crisis and achieving carbon *** H-cells,achieving high-current C_(2)products is challenging because of the inefficient mass transfer of the catalyst and the presence of the hydrogen evolution reaction(HER).In this study,dendritic Cu/Cu_(2)O with abundant Cu^(0)/Cu^(+)interfaces and numerous dendritic curves was synthesized in a CO_(2)atmosphere,resulting in the high selectivity and current density of the C_(2)*** Cu/Cu_(2)O achieved a C_(2)Faradaic efficiency of 69.8%and a C_(2)partial current density of 129.5 mA cm^(-2)in an *** element simulations showed that a dendritic structure with a high curvature generates a strong electric field,leading to a localized CO_(2)***,DRT analysis showed that a dendritic struc-ture with a high curvature actively adsorbed the surrounding high concentration of CO_(2),enhancing the mass transfer rate and achieving a high current *** the experiment,the impact of the electronic structure on the performance of the catalyst was investigated by varying the atomic ratio of Cu^(0)/Cu^(+) on the catalyst surface,which resulted in improved ethylene *** the optimal atomic ratio of Cu^(0)/Cu^(+),the charge transfer resistance was minimized,and the desorption rate of the intermediates was low,favoring C_(2) *** functional theory calculations indicated that the Cu^(0)/Cu^(+) interfaces exhibited a lower Gibbs free energy for the rate-determining step,enhancing C_(2)H_(4) *** Cu/Cu_(2)O catalyst also exhibited a low Cu d-band center,which enhanced the adsorption stability of *CO on the surface and facilitated C_(2)*** observa-tion explained the higher yield of C_(2) products at the Cu^(0)/Cu^(+) interface than that of H_(2) under rapid mass *** results of the net present value model showed that the H-c

关键词： Reduction of CO_(2) High current Dendritic structure Cu/Cu_(2)O H-cell

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于广义模糊集、粗糙集的医学图像三维区域提取

引用

西北工业大学学报 2008年第3期26卷 377-381页

作者：陈世浩王毅郝重阳西北工业大学电子与信息工程研究所陕西西安710072

文章通过研究直接从三维医学图像中提取感兴趣区域的问题,提出了一种基于广义模糊集、粗糙集的三维区域提取方法,以解决医学图像的对比度低,组织边缘难以区分的问题。使用双线性广义模糊增强算子对三维医学图像增强,运用粗糙集理论将基... 详细信息

文章通过研究直接从三维医学图像中提取感兴趣区域的问题,提出了一种基于广义模糊集、粗糙集的三维区域提取方法,以解决医学图像的对比度低,组织边缘难以区分的问题。使用双线性广义模糊增强算子对三维医学图像增强,运用粗糙集理论将基于多种信息的粗糙描述进行综合,实现对感兴趣区域的三维提取。实验证明,这是一种可对三维感兴趣区域提取的有效方法。

关键词：双线性广义模糊集图像增强粗糙集三维区域提取

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simultaneous incorporation of PTH(1-34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration

引用

Bioactive Materials 2021年第6期6卷 1839-1851页

作者： Zhiyuan Zou Le Wang Zhifei Zhou Qing Sun Delong Liu Yan chen hao Hu Yu Cai Sixiong Lin Zhengran Yu Bizhi Tan Wei Guo Zemin Ling Xuenong Zou Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology Department of Spine SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Functional Polymer Materials Ministry of EducationInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China Department of Pathology Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhou 510120China Department of Orthopaedics Hunan Provincial People’s HospitalChangsha 410002China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen518132China

Tissue regeneration based on the utilization of artificial soft materials is considered a promising treatment for bone-related ***,we report cranial bone regeneration promoted by hydrogels that contain parathyroid hormone(PTH)peptide PTH(1-34)and nano-hydroxyapatite(nHAP).A combination of the positively charged natural polymer chitosan(CS)and negatively charged sodium alginate led to the formation of hydrogels with porous structures,as shown by scanning electron *** characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1-34).In vitro experiments showed that the hydrogel containing nHAP and PTH(1-34)exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells(rBMSCs)via the Notch signaling pathway,as shown by the upregulated expression of osteogenic-related *** found that increasing the content of PTH(1-34)in the hydrogels resulted in enhanced osteogenic differentiation of *** of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP,indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment *** the in vitro and in vivo results demonstrated that simultaneously incorporating nHAP and PTH into hydrogels shows promise for bone regeneration,suggesting a new strategy for tissue engineering and regeneration in the future.

关键词： Parathyroid hormone Hydrogels Bone regeneration Tissue engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distribution and Functional Characteristics of Voltage-Gated Sodium Channels in Immature Cochlear Hair Cells

引用

Neuroscience Bulletin 2020年第1期36卷 49-65页

作者： You Zhou chenchen Xia Manli Yi Xueling Wang hao Wu Yonghua Ji Department of Otolaryngology-Head and Neck Surgery Ninth People’s HospitalShanghai Jiaotong University School of MedicineShanghai 200125China Ear Institute Shanghai Jiaotong University School of MedicineShanghai 200125China Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases Shanghai 200125China Laboratory of Neuropharmacology and Neurotoxicology Shanghai UniversityShanghai 200444China Translational Institute for Cancer Pain Xinhua Hospital Chongming BranchShanghai 202150China

Voltage-gated sodium channels(VGSCs)are transiently expressed in cochlear hair cells before hearing onset and play an indispensable role in shaping spontaneous *** this study,we showed that Na^+currents shaped the spontaneous action potentials in developing mouse inner hair cells(IHCs)by decreasing the time required for the membrane potential to reach the action-potential *** immature IHCs,we identified 9 known VGSC subtypes(***-l.9ot),among which Navl.7a was the most highly expressed subtype and the main contributor to Na+currents in developing hair *** recordings of two cochlea-specific Navi.7 variants(CbmNavl.7a and CbmNavl.7b)revealed a novel loss-of-function mutation(C934R)at the extracellular linker between segments 5 and 6 of domain *** addition,post-transcriptional modification events,such as alternative splicing and RNA editing,amended the gating properties and kinetic features of CbmNavl.7a(C934).These results provide molecular and functional characteristics of VGSCs in mammalian IHCs and their contributions to spontaneous physiological activity during cochlear maturation.

关键词： Cochlear hair cell Spontaneous action potential Voltage-gated sodium channel Post-transcriptional modification Gating property Introduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种基于地形匹配的自适应道路建模方法

引用

系统仿真学报 2006年第10期18卷 2824-2826页

作者：王晨昊汤晓安陈敏陈鸿国防科技大学电子科学与工程学院长沙410073

道路建模是虚拟战场及数字城市等领域的重要研究内容之一。以横截面道路模型结构[1]为基础,给出了一种基于地形匹配的自适应道路模型的构建方法。通过引入道路控制点结构,为四种主要道路现象建立了模型,然后提出一种“预测-判断”匹配法... 详细信息

道路建模是虚拟战场及数字城市等领域的重要研究内容之一。以横截面道路模型结构[1]为基础,给出了一种基于地形匹配的自适应道路模型的构建方法。通过引入道路控制点结构,为四种主要道路现象建立了模型,然后提出一种“预测-判断”匹配法,用来在各个控制点之间实时生成地形匹配的非均匀截面串。算法可以较好的解决道路与地形的匹配问题,同时可以有效的降低道路模型的复杂度,提高渲染效率。

关键词：道路建模数字城市地形匹配几何建模

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intermittent fasting boosts antitumor immunity by restricting CD11b^(+)Ly6C^(low)Ly6G^(low) cell viability through glucose metabolism in murine breast tumor model

引用

Food Science and Human Wellness 2024年第4期13卷 2327-2345页

作者： chenghao Fu Zhehao Liang Zemiao Niu Ning chen Yuemin Li Zhenhua Liang Yanwei Huo hao Xi Rong Wang Yonghuan Yan Xiaoruo Gan Mengtian Wang Yun Huang Yan Zhang Mingming Gao Pin Lü Postdoctoral Station for Basic Medicine Cardiovascular Medical Science CenterDepartment of Cell BiologyKey Laboratory of Neural and Vascular Biology of Ministry of EducationHebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of Forensic Medicine College of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China Hebei Food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China Laboratory of Lipid Metabolism Department of Biochemistry and Molecular BiologyKey Laboratory of Medical Biotechnology of Hebei ProvinceShijiazhuang 050017China

Intermittent fasting can benefit breast cancer patients undergoing chemotherapy or ***,it is still uncertain how to select immunotherapy drugs to combine with intermittent *** we observed that two cycles of fasting treatment significantly inhibited breast tumor growth and lung tissue metastasis,as well as prolonged overall survival in mice bearing 4T1 and 4T07 breast *** this process,both the immunosuppressive monocytic-(M-)and granulocytic-(G-)myeloid-derived suppressor cell(MDSC)decreased,accompanied by an increase in interleukin(IL)7R^(+)and granzyme B^(+)T cells in the tumor ***,we observed that Ly6G^(low)G-MDSC sharply decreased after fasting treatment,and the cell surface markers and protein mass spectrometry data showed potential therapeutic *** investigation revealed that glucose metabolism restriction suppressed the splenic granulocytemonocyte progenitor and the generation of colony-stimulating factors and IL-6,which both contributed to the accumulation of *** the other hand,glucose metabolism restriction can directly induce the apoptosis of Ly6G^(low)G-MDSC,but not Ly6G^(high)*** summary,these results suggest that glucose metabolism restriction induced by fasting treatment attenuates the immune-suppressive milieu and enhances the activation of CD3^(+)T cells,providing potential solutions for enhancing immune-based cancer interventions.

关键词： Intermittent fasting Ly6G^(low)myeloid-derived suppressor cell apoptosis Extramedullary hematopoiesis Colony stimulating factor Glucose metabolism restriction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy——lysosomal pathway

引用

Acta Pharmaceutica Sinica B 2022年第6期12卷 2869-2886页

作者： Xiliang Du Chiara Di Malta Zhiyuan Fang Taiyu Shen Xiaodi Niu Meng chen Bo Jin hao Yu Lin Lei Wenwen Gao Yuxiang Song Zhe Wang Chuang Xu Zhijun Cao Guowen Liu Xinwei Li Key Laboratory of Zoonosis Ministry of EducationCollege of Veterinary MedicineJilin UniversityChangchun 130062China Telethon Institute of Genetics and Medicine(TIGEM)Via Campi Flegrei 34 PozzuoliNA 80078Italy Medical Genetics Unit Department of Medical and Translational ScienceFederico Ⅱ UniversityNaples 80131Italy College of Food Science and Engineering Jilin UniversityChangchun 130062China College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural UniversityDaqing 163319China State Key Laboratory of Animal Nutrition Beijing Engineering Technology Research Center of Raw Milk Quality and Safety ControlCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Nonalcoholic fatty liver disease(NAFLD) is characterized by hepatic steatosis and insulin resistance and there are currently no approved drugs for its *** of mTOR complex1(mTORCl) and subsequent impairment of the transcription factor EB(TFEB)-mediated autophagy-lysosomal pathway(ALP) are implicated in the development of ***,agents that augment hepatic TFEB transcriptional activity may have therapeutic potential against *** objective of this study was to investigate the effects of nuciferine,a major active component from lotus leaf,on NAFLD and its underlying mechanism of *** we show that nuciferine activated ALP and alleviated steatosis,insulin resistance in the livers of NAFLD mice and palmitic acid-challenged hepatocytes in a TFEB-dependent *** investigation revealed that nuciferine interacts with the Ragulator subunit hepatitis B X-interacting protein and impairs the interaction of the Ragulator complex with Rag GTPases,thereby suppressing lysosomal localization and activity of mTORC1,which activates TFEB-mediated ALP and further ameliorates hepatic steatosis and insulin *** present results indicate that nuciferine may be a potential agent for treating NAFLD and that regulation of the mTORCl-TFEB-ALP axis could represent a novel pharmacological strategy to combat NAFLD.

关键词： Autophagy Fatty liver Lotus leaf Lysosome MiT/TFE mTORC1 Ragulator TFEB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simultaneous prediction of rock matrix modulus and critical porosity

引用

Applied Geophysics 2019年第1期16卷 14-24页

作者： Li Nuo chen hao Zhang Xiu-Mei Han Jian-Qiang Wang Jian Wang Xiu-Ming State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Engineering Research Center of sea deep drilling and exploration Beijing 100190China

The matrix modulus and critical porosity in rocks are two critical parameters to seismic rock physics models;however, the critical porosity is diffi cult to obtain. Based on the linear relation between the effective bulk modulus and porosity, we propose a fast method for calculating the matrix modulus and critical porosity by least square fi tting of effective bulk modulus and porosity data measured in laboratory or fi eld. The proposed method is well suited for samples with wide porosity range. The calculation results accurately refl ect the differences in clay content, pressure, and saturation state. Samples with high clay content have low matrix modulus and critical porosity. The matrix modulus is independent of pressure, whereas the critical porosity increases with increasing pressure. The calculated matrix modulus for watersaturated samples is higher than that for dry rock samples.

关键词： modulus porosity clay content pressure saturation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：