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Association of Estimated Pulse Wave Velocity and the Dynamic Changes in Estimated Pulse Wave Velocity with All-Cause Mortality among Middle-Aged and Elderly Chinese

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Biomedical and Environmental Sciences 2022年第11期35卷 1001-1011页

作者： LIU Han Rui LI chen Yang XIA Xue chen shu feng LU Xiang feng GU Dong feng LIU Fang Chao HUANG Jian feng Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China Department of Epidemiology and Health Statistics School of Public HealthCapital Medical UniversityBeijing 100069China Medical School Southern University of Science and TechnologyShenzhen 518055GuangdongChina

Objective We aimed to clarify the association between estimated pulse wave velocity(ePWV)and the changes in ePWV with all-cause mortality among middle-aged and elderly *** Data were obtained from the China Health and Retirement Longitudinal Study(CHARLS)from *** ePWV was calculated using an equation that included age and mean blood pressure(MBP).The ΔePWV was assessed as the difference in ePWV between the first two *** proportional hazard models were used to determine the association between ePWV and ΔePWV with all-cause mortality after adjustment for potential *** Of 13,116 participants during a median follow-up of 7.0 years,1,356 deaths *** increased ePWV was independently associated with all-cause *** hazard ratio[95% confidence interval(CI)]for participants from the 1^(st)-4^(th) quartile groups was 1.00,1.69(1.31-2.18),3.09(2.44-3.91),and 8.54(6.78-10.75),*** standard deviation(SD)increment of ePWV increased the risk of all-cause mortality by 132%.Furthermore,theΔePWV was significantly associated with a 1.28-fold(95%CI,1.18-1.38)risk of all-cause mortality per SD *** This cohort study provided novel evidence from a Chinese population that an increased ePWV or progression of the ePWV was independently associated with all-cause mortality,which highlighted the importance of mitigating ePWV progression in clinical practice.

关键词： Arterial stiffness Estimated pulse wave velocity Mortality Cohort

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Association between Fruit and Vegetable Intake and Arterial Stiffness: The China-PAR Project

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Biomedical and Environmental Sciences 2023年第12期36卷 1113-1122页

作者： LIU shuai LIU Fang Chao LI Jian Xin HUANG Ke Yong YANG Xue Li chen Ji Chun CAO Jie chen shu feng HUANG Jian feng SHEN Chong LU Xiang feng GU Dong feng Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijing 100730China School of Medicine Southern University of Science and TechnologyShenzhen 518055GuangdongChina

Objective This study aimed to investigate the association between fruit and vegetable intake and arterial *** We conducted a cohort-based study comprising 6,628 participants with arterial stiffness information in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project. A semi-quantitative food-frequency questionnaire was used to assess baseline(2007–2008) and recent(2018–2021) fruit and vegetable intake. We assessed changes in fruit and vegetable intake from2007–2008 to 2018–2021 in 6,481 participants. Arterial stiffness was measured using the arterial velocity–pulse index(AVI) and arterial pressure-volume index(API). Elevated AVI and API values were defined according to diverse age reference *** Multivariable-adjusted linear regression models revealed that every 100 g/d increment in fruit and vegetable intake was associated with a 0.11 decrease in AVI(B =-0.11;95% confidence interval [CI]:-0.20,-0.02) on average, rather than API(B = 0.02;95% CI:-0.09, 0.13). The risk of elevated AVI(odds ratio [OR] = 0.82;95% CI: 0.70, 0.97) is 18% lower in individuals with high intake(≥ 500 g/d) than in those with low intake(< 500 g/d). Furthermore, maintaining a high intake in the past median of 11.5years of follow-up was associated with an even lower risk of elevated AVI compared with a low intake at both baseline and follow-up(OR = 0.64;95% CI: 0.49, 0.83).Conclusion Fruit and vegetable intake was negatively associated with arterial stiffness, emphasizing recommendations for adherence to fruit and vegetable intake for the prevention of arterial stiffness.

关键词： Fruit Vegetable Arterial stiffness Cardiovascular disease

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Variations in the calpain-10 gene are associated with the risk of type 2 diabetes and hypertension in northern Han Chinese population

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Chinese Medical Journal 2007年第24期120卷 2218-2223页

作者： chen shu-feng LU Xiang-feng YAN Wei-li HUANG Jian-feng GU Dong-feng Department of Evidence Based Medicine and Division ofPopulation Genetics Fuwai Hospital Chinese Academy ofMedical Sciences and Peking Union Medical College Beijing100037 China National Human Genome Center at Beijing Beijing 100176 China Division of Environmental Health School of Public HealthXinjiang Medical University Urumqi 830054 China

Background Calpain-10 （CAPNIO） has been identified as a susceptibility gene in type 2 diabetes mellitus （T2DM） and insulin resistance. The present study aimed to identify the effects of genetic variations in the CAPNIO gene on the development of type 2 diabetes and hypertension in northern Han Chinese population. Methods We performed a case-control study and genotyped single nucleotide polymorphism （SNP）-44, -43, -19 and -63 of CAPNIO gene in 1046 subjects from the northern China, including 493 patients with T2DM and hypertension and 553 age- and gender-matched normal healthy controls. Results Univariate analysis showed that the four polymorphisms were not independently associated with T2DM and hypertension. However, the frequency distributions of SNP-44 allele C （allele 2）（17.89% vs 9.80%, P=-0.0016） and genotype CC （22）（4.21% vs 1.01%, P=-0.0059） in obese patients （body mass index 〉 30 kg/m2） were different from those in non-obese patients. Logistic regression analyses revealed that carriers of the 1112/1221 diplotype had a significantly lower odds ratio for diabetes and hypertension （OR=0.399, 95% CI, 0.196-0.814, P=-0.0115）. The 1112/1121 diplotype associated with significantly increased risk of type 2 diabetes in Mexican-American was not associated with the increased risk in Chinese. Conclusion These results suggested that CAPNIO gene variations might play roles in the risk of diabetes and hypertension in northern Han Chinese population.

关键词： calpain-10 type 2 diabetes mellitus hypertension genetics association study

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Association study of the endothelial nitric oxide synthase gene polymorphisms with essential hypertension in northern Han Chinese

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Chinese Medical Journal 2006年第13期119卷 1065-1071页

作者： ZHAO Qi SU Shao-yong chen shu-feng LI Biao GU Dong-feng Division of Population Genetics and Prevention Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China National Human Genome Center at Beijing Beijing 100176 China Institute of Biophysics Chinese Academy of Sciences Beijing100101 China

Background Nitric oxide （NO） synthesized by endothelial nitric oxide synthase （eNOS） plays an important role in both the regulation of endothelial function and the control of blood pressure. Up to now, there has been conflicting data regarding the association between three clinically relevant polymorphisms （T-786C, intron4b/a and G894T） of the eNOS gene and essential hypertension.

关键词： case-control studies endothelial nitric oxide synthase haplotype hypertension single nucleotide polymorphism

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Influences of MoS2 contents on sintering process and properties of Cu-MoS2 composites

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材料科学与工程（中英文版） 2008年第12期2卷 7-12,18页

作者： chen shu-xian feng Yi LI shu XIE Yu-juan Department of Materials Science and Engineering Hefei University of Technology Hefei 230009 China

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Relationship between cystathionine γ-lyase gene polymorphism and essential hypertension in Northern Chinese Han population

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Chinese Medical Journal 2008年第8期121卷 716-720页

作者： LI Yun ZHAO Qi LIU Xiao-li WANG Lai-yuan LU Xiang-feng LI Hong-fang chen shu-feng HUANG Jian-feng GU Dong-feng Department of Evidence Based Medicine and Division of Population Genetics Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China National Human Genome Center at Beijing Beijing 100176 China

Background Hydrogen sulfide （H2S） plays an important role in the smooth muscle cell relaxation and thereby participates in the development of hypertension. Cystathionine γ-lyase is the key enzyme in the endogenous production of H2S. Up to now, the reports on the relationship between the polymorphisms of cystathionine γ-lyase gene （CTH） and essential hypertension （EH） are limited. This study was designed to assess their underlying relationship. Methods A total of 503 hypertensive patients and 490 age-, gender- and area-matched normotensive controls were enrolled in this study. Based on the FASTSNP, a web server to identify putative functional single nucleotide polymorphisms （SNPs） of genes, we selected two SNPs, rs482843 and rs1021737, in the CTH gene for genotyping. Genotyping was performed by the polymerase chain reaction and restriction fragment length polymorphism method （PCR-RFLP）. The frequencies of the alleles and genotypes between cases and controls were compared by the chi-square test. The program *** was used to investigate the relationship between the haplotypes and EH. Results These two SNPs were in Hardy-Weinberg Equilibrium in both cases and controls. The genotype distribution and allele frequencies of them did not significantly differ between cases and controls （all P〉0.05）. In the stepwise logistic regression analysis we failed to observe their association with hypertension. In addition, none of the four estimated haplotypes or diplotypes significantly increased or decreased the risk of hypertension before or after adjustment for several known risk factors. Conclusions The present study suggests that the SNPs rs482843 and rs1021737 of the CTH gene were not associated with essential hypertension in the Northern Chinese Han population. However, replications in other populations and further functional studies are still necessary to clarify the role of the CTH gene in the pathogenesis of EH.

关键词： cystathionine γ-lyase diplotype haplotype hypertension single nucleotide polymorphism

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Effect of elevated total cholesterol level and hypertension on the risk of fatal cardiovascular disease： a cohort study of Chinese steelworkers

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Chinese Medical Journal 2011年第22期124卷 3702-3706页

作者： YANG Ying LI Jian-xin chen Ji-chun CAO Jie LU Xiang-feng chen shu-feng WU Xi-gui DUAN Xiu-fang MO Xing-bo GU Dong-feng Department of Evidence Based Medicine Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background Increased blood pressure and elevated total cholesterol （TC） level are the two most important modifiable risk factors of cardiovascular disease （CVD） in the world. Hypertension and hypercholesterolemia co-exist more often than would be expected and whether there is a synergistic impact on fatal CVD between elevated TC and hypertension need to be further examined in Chinese population. Methods We conducted a cohort study which recruited 5092 Chinese male steelworkers aged 18-74 years in 1974-1980 and followed up for an average of 20.84 years. Totally 302 fatal CVD events were documented by the year of 2001. Cox proportional hazards regression models were undertaken to adjust for baseline variables with fatal CVD events as the outcome variable. Additive interaction model was used to evaluate the interaction between elevated TC and hypertension. Results Hypercholesterolemia and hypertension were significantly associated with an increased hazard ratio （HR） of fatal CVD （1.67 （95% CI 1.18-2.38） and 2.91 （95% CI 2.23-3.80） respectively. Compared to participants with normotension and TC 〈240 mg/dl, the HRs were 1.11 （95% CI 0.56-2.21）, 2.74 （95% CI 2.07-3.64） for hypercholesterolemia and hypertension respectively, and 5.51 （95% CI 3.58-8.46） for participants with both risk factors. There was an additive interaction with a 2.65 （95% CI 0.45-4.85） relative excess risk （RERI） between hypercholesterolemia and hypertension on CVD. Conclusion We found that the risk of fatal CVD was significantly associated with an additive interaction due to hypercholesterolemia and hypertension besides a conventional main effect derived from either of them, which highlights that the prevention and treatment of both risk factors might improve the individual risk profile thus reduce the CVD mortality.

关键词： cholesterol, cohort study cardiovascular disease hypertension hypercholesterolemia

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超固结粉质黏土水平应力释放特征与静止侧压力系数计算方法

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岩土力学 2022年第1期43卷 160-168页

作者：陈树峰孔令伟罗滔西京学院陕西省混凝土结构安全与耐久性重点实验室陕西西安710123 中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071 中国科学院大学北京100049

如何合理地描述超固结地层静止侧压力系数K_(0)分布规律对岩土工程有重要的理论意义和应用价值。通过超固结地层形成过程的应力发展分析,开展了侧应力松弛试验,研究了超固结粉质黏土水平应力释放规律,建立了残余超固结水平应力σ’_(hef... 详细信息

如何合理地描述超固结地层静止侧压力系数K_(0)分布规律对岩土工程有重要的理论意义和应用价值。通过超固结地层形成过程的应力发展分析,开展了侧应力松弛试验,研究了超固结粉质黏土水平应力释放规律,建立了残余超固结水平应力σ’_(hef)与超固结比OCR的联系,提出了基于水平应力释放的超固结土K_(0)计算方法,并用原位土体水平应力KSB试验和室内试验进行了验证。提出的超固结土K_(0)计算方法物理意义清晰,并在中高OCR条件下实现了与前人归纳经验公式的统一。结果表明:超固结水平应力σ’_(hef)经历回弹与松弛2个释放阶段后稳定于残余值σ’_(hef),粉质黏土σ’_(he)释放主要发生在回弹阶段;超固结水平应力残余值与初始值之比σ’_(hef)/σ’_(he0)随OCR增大而增大,但在OCR达到一定值OCRr后趋于稳定。研究成果可供超固结地层中的挡土结构物土压力计算和数值分析提供参考和借鉴。

关键词：静止侧压力系数超固结粉质黏土侧应力松弛原位测试

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低幅应变条件下粉质黏土泊松比的非线性特征

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岩土力学 2018年第2期39卷 580-588页

作者：陈树峰孔令伟黎澄生中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071 中国科学院大学北京100049

对哈尔滨原状粉质黏土进行共振柱试验,通过扭转及弯曲试验得出相应的弹性模量E、剪切模量G、泊松比ν,旨在分析低幅应变下粉质黏土泊松比随应变发展的非线性特征。试验结果表明:随着应变的增大,粉质黏土剪切模量与弹性模量均出现衰减,... 详细信息

对哈尔滨原状粉质黏土进行共振柱试验,通过扭转及弯曲试验得出相应的弹性模量E、剪切模量G、泊松比ν,旨在分析低幅应变下粉质黏土泊松比随应变发展的非线性特征。试验结果表明:随着应变的增大,粉质黏土剪切模量与弹性模量均出现衰减,但二者衰减并不同步,剪切模量先于弹性模量发生衰减;泊松比随着应变的增大而增大,并随着围压的升高而降低;在半对数坐标系下,泊松比与归一化剪切模量G/G_(max)近似呈线性关系,基于此提出低幅应变下泊松比预测模型。理论推导证明:低幅应变下ν-lgG/G_(max)曲线呈线性具有其必然性;随着应变的发展和G/G_(max)值的降低,ν-lgG/G_(max)曲线由斜率一定的线性段过渡到斜率逐渐降低的非线性段,并最终趋近于一定值。基于理论推导建立了泊松比预测模型参数与Hardin-Drnevich模型参数的关系,由此可依据低幅应变下ν-lgG/G_(max)曲线形态对较高应变下泊松比进行预测,实例验证表明该方法预测结果较好,具有一定应用价值。

关键词：泊松比弹性模量剪切模量阻尼比粉质黏土共振柱试验

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高校海外留学生安全应急管理研究——以云南财经大学案例为例

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黑龙江高教研究 2015年第10期33卷 60-63页

作者：陈树峰云南大学民族研究院云南昆明650091 云南财经大学东盟学院云南昆明650221

随着中国国际化进程加快,高校学生跨出国门接受优质教育的机会增多,海外留学生数量逐年攀升,面对陌生的国度学生难免会遭遇一些突发应急事件。文章以在2014年5月13日越南打砸抢烧事件中,云南财经大学对在越留学生应急管理进行个案分析,... 详细信息

随着中国国际化进程加快,高校学生跨出国门接受优质教育的机会增多,海外留学生数量逐年攀升,面对陌生的国度学生难免会遭遇一些突发应急事件。文章以在2014年5月13日越南打砸抢烧事件中,云南财经大学对在越留学生应急管理进行个案分析,总结其采取的主要措施,分析在应急管理过程中的经验与不足,最后对高校如何处理海外留学生安全应急事件给出对策和建议。

关键词：海外留学生合作办学应急管理突发事件

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