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Can statins reduce risk of lung cancer,especially among elderly people? A meta-analysis

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Chinese Journal of Cancer Research 2013年第6期25卷 679-688页

作者： Zhantao Deng Shu Zhang Long Yi shilin chen Department of Thoracic Surgery Jiangsu Cancer Hospital Affliated to Nanjing Medicinal University Key Laboratory of Medical Molecular Technology Medical School of Nanjing University Nanjing Drum Tower Hospital

Objective： As the most common cause of cancer mortality throughout the world, lung cancer has drawn people＇s attention on how to reduce the risk with chemopreventive ways. Many epidemiological studies have shown inconsistent effects of statins on lung cancer, but some observational studies have showed that statins had protective effect on lung cancer among elderly people. So we preformed this meta-analysis to find whether statins were chemopreventive. Methods： We searched MEDLINE, EMBASE and Web of Science databases from inception to September, 2013. A total of 23 studies were selected, including 15 observational studies and 8 randomized controlled trials （RCTs）. Both fixed and random-effects models were used to calculate pooled estimates in primary and sensitivity analyses. We used Q and 12 statistics to assess statistical heterogeneity, and evaluated publication bias by Begg＇s test and Egger＇s test. Results： No association between statins and lung cancer risk was identified either in the meta-analysis among RCTs [relative risk （RR）： 0.95, 95% confidence interval （95% CI）： 0.85-1.06] or observational studies （RR： 0.89, 95% CI： 0.77-1.04）. We also selected 6 observational studies that all researched on elderly people. The result of meta-analysis showed that there was still no protective effect between statins and lung cancer among elderly people （RR： 1.03, 95% CI： 0.96-1.11）. Conclusions： Our results did not support a protective effect of statins on the overall lung cancer risk and the lung cancer risk among elderly people. More well-designed RCTs are needed to enhance our understanding of the chemopreventive effect of statins on lung cancer.

关键词： Statins lung cancer meta-analysis elderly people risk

Letter to the editor: Comment on the Regulatios of the Simplified Registration and Approval Management for Compound Recipe of Classical Prescription of Traditional Chinese Medicine

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Acta Pharmaceutica Sinica B 2018年第1期8卷 127-129页

作者： shilin chen Aihua Liang Boli Zhang China Academy of Chinese Medical Sciences

To the Editor:On Oct 9,2017,China Food and Drug Administration announced1~ the Regulations of the Simplified Registration and Approval Management for Compound Recipe of Classical Prescription of Traditional Chinese Medicine(Exposure Draft)which has been stirring up intense debate in the *** article China to Roll Back Regulations for Traditional Medicine Despite Safety Concerns lately

关键词： In Letter to the editor Comment on the Regulatios of the Simplified Registration and Approval Management for Compound Recipe of Classical Prescription of Traditional Chinese Medicine

Editorial of Special Column “Research on Emerging COVID-19(Target, Mechanism, and Therapeutics)”

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1146-1148页

作者： Hai-Bin Luo shilin chen Peiqing Liu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Laboratory of Pharmacology&Toxicology and New Drug R&D Center School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou 510006China

Coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has become a global crisis1,*** from SARS-Co V-2 can result in severe lymphopenia,prolonged coagulation profiles,lethal acute respiratory distress syndrome(ARDS),watery diarrhea,cardiac disease,multiorgan dysfunction,and sudden death3,4.

关键词： acute respiratory distress

Safety issues and new rapid detection methods in traditional Chinese medicinal materials

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Acta Pharmaceutica Sinica B 2015年第1期5卷 38-46页

作者： Lili Wang Weijun Kong Meihua Yang Jianping Han shilin chen Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

The safety of traditional Chinese medicine(TCM) is a major strategic issue that involves human health. With the continuous improvement in disease prevention and treatment, the export of TCM and its related products has increased dramatically in China. However, the frequent safety issues of Chinese medicine have become the ‘bottleneck' impeding the modernization of TCM. It was proved that mycotoxins seriously affect TCM safety; the pesticide residues of TCM are a key problem in TCM international trade; adulterants have also been detected, which is related to market circulation. These three factors have greatly affected TCM safety. In this study, fast, highly effective, economically-feasible and accurate detection methods concerning TCM safety issues were reviewed, especially on the authenticity, mycotoxins and pesticide residues of medicinal materials.

关键词： Traditional Chinese medicine Safety issue Rapid detection Mycotoxins Pesticide residues Authentication 2D DNA barcodes Traceability

Progress and prediction of multicomponent quantification in complex systems with practical LC-UV methods

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Journal of Pharmaceutical Analysis 2023年第2期13卷 142-155页

作者： Xi chen Zhao Yang Yang Xu Zhe Liu Yanfang Liu Yuntao Dai shilin chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China Key Lab of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu611137China

Complex systems exist widely,including medicines from natural products,functional foods,and biological *** biological activity of complex systems is often the result of the synergistic effect of multiple *** the quality evaluation of complex samples,multicomponent quantitative analysis(MCQA)is usually *** overcome the difficulty in obtaining standard products,scholars have proposed achieving MCQA through the“single standard to determine multiple components(SSDMC)”*** method has been used in the determination of multicomponent content in natural source drugs and the analysis of impurities in chemical drugs and has been included in the Chinese *** on a convenient(ultra)high-performance liquid chromatography method,how can the repeatability and robustness of the MCQA method be improved?How can the chromatography conditions be optimized to improve the number of quantitative components?How can computer software technology be introduced to improve the efficiency of multicomponent analysis(MCA)?These are the key problems that remain to be solved in practical ***,this review article summarizes the calculation methods of relative correction factors in the SSDMC approach in the past five years,as well as the method robustness and accuracy ***,it also summarizes methods to improve peak capacity and quantitative accuracy in MCA,including column selection and twodimensional chromatographic analysis ***,computer software technologies for predicting chromatographic conditions and analytical parameters are introduced,which provides an idea for intelligent method development in *** paper aims to provide methodological ideas for the improvement of complex system analysis,especially MCQA.

关键词： Multicomponent quantification analysis Single standard to determine multiple components Predictive software

Rapid Authentication of the Poisonous Plant Gelsemium elegans by Combining Filter-Paper-Based DNA Extraction and RPA–LFD Detection

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Engineering 2021年第1期7卷 14-16页

作者： Xiasheng Zheng Wenli An Hui Yao Jiang Xu shilin chen National Engineering Research Center for Modernization of Traditional Chinese Medicine Mathematical Engineering Academy of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhou 510006China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Numerous plants and animals are edible and officinal,but some can be *** is sometimes confusion between poisonous and non-poisonous materials because of similarities in their ***,the unwitting intake of poisonous plant or animal material has resulted in poisoning cases and sometimes in death,especially for situation in the *** and accurate authentication of toxic species is essential for establishing and adopting optimal and urgent treatment for patients in such cases,and can be life-saving or can at least minimize the damage to ***,most of the current species authentication methods,including DNA barcoding,loop-mediated isothermal amplification(LAMP),chromatography technologies,and other methods,depend on professional equipment and a specialist laboratory,which are impracticable for real-time application in the *** is therefore crucial to develop a rapid,accurate,and specific authentication method for poisonous species that does not require any equipment.

关键词： intake establishing Plant

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低速双燃料柴油机奥托循环下的增压器配机

柴油机 2024年第3期46卷 8-13页

作者：陈世林邓高雄徐赵刚刘聪王璞上海中船三井造船柴油机有限公司上海201306

基于奥托循环的燃烧特点与需求,从柴油机空燃比和增压器特性两方面对低速双燃料柴油机奥托循环下的增压器配机进行分析。柴油机100%负荷处的压比流量应处于增压器的压力流量特性图的中心位置,在高负荷区域预估的增压器效率、扫气压力、... 详细信息

基于奥托循环的燃烧特点与需求,从柴油机空燃比和增压器特性两方面对低速双燃料柴油机奥托循环下的增压器配机进行分析。柴油机100%负荷处的压比流量应处于增压器的压力流量特性图的中心位置,在高负荷区域预估的增压器效率、扫气压力、扫气量尽可能稍大于设计要求,尽可能采用最小喷嘴环设计,增压器压气机工作线应处于高效区域。在此基础上对X92DF柴油机开展配机策划和试验验证。试验结果表明:该柴油机各项性能满足设计要求,增压器达到预期效果。

关键词：低速双燃料柴油机奥托循环空燃比增压器配机废气旁通

Herbgenomics: A stepping stone for research into herbal medicine

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Science China(Life Sciences) 2019年第7期62卷 913-920页

作者： Haoyu Hu Xiaofeng Shen Baosheng Liao Lu Luo Jiang Xu shilin chen Institute of Chinese Materia Medica China Academy of Chinese Medicinal Sciences

From the prehistoric era until the publishing of the Compendium of Materia Medica and the first scientific Nobel Prize in the Chinese mainland for Tu's discovery on anti-malarial tablets,each milestone and stepping stone in the developmental history of herbal medicine involved intrepid exploration,bold hypothesis formulation,and cautious *** thousands of years of discovery and development,herbal research has entered a new era—the era of *** combines herbal and genomic research,bridging the gap between traditional herbal medicine and cutting-edge omics ***,it provides a general picture of the genetic background of traditional herbs,enabling researchers to investigate the mechanisms underlying the prevention and treatment of human diseases from an omics perspective.

关键词： herbgenomics herbal medicines omics potential application

Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis

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Horticulture Research 2023年第9期10卷 306-320页

作者： Ziyan Xie Yaolei Mi Lingzhe Kong Maolun Gao Shanshan chen Weiqiang chen Xiangxiao Meng Wei Sun shilin chen Zhichao Xu Key Laboratory of Saline-alkali Vegetation Ecology Restoration(Northeast Forestry University) Ministry of EducationHarbin 150040China College of Life Science Northeast Forestry UniversityHarbin 150040China Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China

Is Cannabis a boon or bane?Cannabis sativa has long been a versatile crop for fiber extraction(industrial hemp),traditional Chinese medicine(hemp seeds),and recreational drugs(marijuana).Cannabis faced global prohibition in the twentieth century because of the psychoactive properties of △^(9)-tetrahydrocannabinol;however,recently,the perspective has changed with the recognition of additional therapeutic values,particularly the pharmacological potential of cannabidiol.A comprehensive understanding of the underlying mechanism of cannabinoid biosynthesis is necessary to cultivate and promote globally the medicinal application of Cannabis ***,we comprehensively review the historical usage of Cannabis,biosynthesis of trichome-specific cannabinoids,regulatory network of trichome development,and synthetic biology of *** review provides valuable insights into the efficient biosynthesis and green production of cannabinoids,and the development and utilization of novel Cannabis varieties.

关键词： comprehensive versatile globally