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China CDC weekly 2024年第39期6卷 1011-1016页

作者： Hao lin Meijun chen Yuhui shi Ying Ji Yuting lin Wangnan Cao Chun Chang Department of Social Medicine and Health Education School of Public HealthPeking University Health Science CenterBeijingChina Center for Healthy Aging Peking University Health Science CenterBeijingChina School of Public Health The University of Hong KongHong Kong Special Administrative RegionChina

What is already known about this topic?The proportion of elderly living alone in China is approximately 10%.Living away from family poses enormous challenges for older *** is added by this report?Compared to those living with family,elderly individuals living alone exhibit a lower registration rate with general practitioners and have less social *** are the implications for public health practice?While the current health service system for elderly people living alone is working relatively well,there is a need for additional programs to enhance social support and improve their social well-being.

关键词： alone elderly service

Enhancing Safety in Autonomous Vehicle Navigation:An Optimized Path Planning Approach Leveraging Model Predictive Control

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Computers, Materials & Continua 2024年第9期80卷 3555-3572页

作者： shih-lin lin Bo-chen lin Graduate Institute of Vehicle Engineering National Changhua University of EducationChanghua50007TaiwanChina

This paper explores the application of Model Predictive Control(MPC)to enhance safety and efficiency in autonomous vehicle(AV)navigation through optimized path *** evolution of AV technology has progressed rapidly,moving from basic driver-assistance systems(Level 1)to fully autonomous capabilities(Level 5).Central to this advancement are two key functionalities:Lane-Change Maneuvers(LCM)and Adaptive Cruise Control(ACC).In this study,a detailed simulation environment is created to replicate the road network between Nantun andWuri on National Freeway No.1 in *** MPC controller is deployed to optimize vehicle trajectories,ensuring safe and efficient *** onboard sensors,including vehicle cameras and millimeterwave radar,are used to detect and respond to dynamic changes in the surrounding environment,enabling real-time decision-making for LCM and *** simulation resultshighlight the superiority of the MPC-based approach in maintaining safe distances,executing controlled lane changes,and optimizing fuel ***,the MPC controller effectively manages collision avoidance,reduces travel time,and contributes to smoother traffic flow compared to traditional path planning *** findings underscore the potential of MPC to enhance the reliability and safety of autonomous driving in complex traffic *** research will focus on validating these results through real-world testing,addressing computational challenges for real-time implementation,and exploring the adaptability of MPC under various environmental *** study provides a significant step towards achieving safer and more efficient autonomous vehicle navigation,paving the way for broader adoption of MPC in AV systems.

关键词： Autonomous driving model predictive control(MPC) lane change maneuver(LCM) adaptive cruise control(ACC)

ITS2 barcoding DNA region combined with high resolution melting(HRM) analysis of Hyoscyami Semen, the mature seed of Hyoscyamus niger

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Chinese Journal of Natural Medicines 2016年第12期14卷 898-903页

作者： XIONG Chao HU Zhi-Gang TU Yuan LIU He-Gang WANG Ping ZHAO Ming-Ming shii Yu-Hua WU Lan SUN Wei chen shi-lin College of Pharmacy Hubei University of Chinese Medicine Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Traditional Chinese Medicine Resources Research Center Tianjin Tasly Pharmaceutical Co. Ltd.

Hyoscyami Semen, the mature dried seed of Hyoscyamus niger L., has long been used as a traditional Chinese medicine to treat human diseases. Hyoscyami Semen is found in local markets in China. In markets, sellers and buyers commonly inadvertently mix the seeds of H. niger with the seeds of related species such as Hygrophila salicifolia(Vahl) Nees, Astragalus complanatus R. Br., Cuscuta australis R. Br., Cuscuta chinensis Lam., and Impatiens balsamina L. because of their similar morphologies or similar names. Thus, developing a reliable method for discriminating H. niger seeds from its adulterants is necessary to reduce confusion and ensure the safe use of Hyoscyami Semen. The present study was designed to evaluate the efficiency of high-resolution melting analysis combined with DNA barcoding(Bar-HRM) with internal transcribed spacer 2 to discriminate H. niger. Our results show that Bar-HRM successfully identified the adulterants and detected the proportion of H. niger DNA extract within an admixture. In particular, HRM detected H. niger DNA extract in A. complanatus DNA extract at concentrations as low as 1%. In conclusion, the Bar-HRM method developed in the present study for authenticating H. niger is rapid and cost-effective. It can be used in the future to guarantee the purity of Hyoscyami Semen for the clinical use.

关键词： Hyoscyami Semen Bar-HRM Identification Clinical safe medication

Insights into plant salt stress signaling and tolerance

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Journal of Genetics and Genomics 2024年第1期51卷 16-34页

作者： Huapeng Zhou Haifan shi Yongqing Yang Xixian Feng Xi chen Fei Xiao Honghui lin Yan Guo Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengduSichuan 610064China State Key Laboratory of Plant Environmental Resilience China Agricultural UniversityBeijing 100193China College of Grassland Science Nanjing Agricultural UniversityNanjingJiangsu 210095China Xinjiang Key Laboratory of Biological Resources and Genetic Engineering College of Life Science and TechnologyXinjiang UniversityUrumqiXinjiang 830046China

Soil salinization is an essential environmental stressor,threatening agricultural yield and ecological security *** soils accumulate excessive soluble salts which are detrimental to most plants by limiting plant growth and *** is of great necessity for plants to efficiently deal with the adverse effects caused by salt stress for survival and successful *** determinants of salt tolerance have been identified in plants,and the cellular and physiological mechanisms of plant salt response and adaption have been intensely *** respond to salt stress signals and rapidly initiate signaling pathways to re-establish cellular homeostasis with adjusted growth and cellular *** review summarizes the advances in salt stress perception,signaling,and response in plants.A better under-standing of plant salt resistance will contribute to improving crop performance under saline conditions using multiple engineering *** rhizosphere microbiome-mediated plant salt tolerance as well as chemical priming for enhanced plant salt resistance are also discussed in this review.

关键词： Salt stress Salt perception Salt response and signaling Plant salt tolerance Chemical priming Rhizosphere microbiome

Genome-wide identifcation of the histone acetyltransferase gene family in Citrus clementina and its potential roles in citrate metabolism

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Food Quality and Safety 2024年第1期8卷 201-211页

作者： Xiahui lin Yanna shi Shengchao Liu Xincheng Liu Minglei Zhang Bo Zhang Shaojia Li Kunsong chen College of Agriculture and Biotechnology Zhejiang UniversityZijingang CampusHangzhouChina Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang UniversityZijingang CampusHangzhouChina The State Agriculture Ministry Laboratory of Horticultural Plant Growth Development and Quality ImprovementZhejiang UniversityZijingang CampusHangzhouChina Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina Institute of Horticulture Jiangxi Academy of Agricultural SciencesNanchangChina

Histone acetyltransferase(HAT)catalyzes histone acetylation and is involved in plant growth and development and stress ***,37 CitHAT genes were identifed in Citrus *** physicochemical properties,chromosomal location,gene structure,conserved domain and motif,and cis-acting elements were *** were classifed into four subfamilies based on protein sequence homology,which was strongly supported by gene structure,conserved domain,and motif *** cis-acting elements in gene promoter regions were predicted to be associated with the regulation of plant growth,stress resistance,and response to *** and transcriptomic analyses of citrus callus with mock treatment and HAT inhibitor treatment revealed that increased citric acid content in inhibitor treatment may be attributed to differential expression of CitPEPCK2 and CitGS2,which may be due to the hypo-acetylation of histone *** expression patterns of CitHATs in citrus fruit development stages showed that CitHAG11 and CitHAG28 exhibited a negative correlation with citric acid *** study associates the potential function of histone acetyltransferases in citrate metabolism and extends the molecular mechanism of citrate metabolism in fruits.

关键词： Citrus histone acetyltransferases citric acid citrate metabolism histone acetylation.

A compact X-band backward traveling-wave accelerating structure

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Nuclear Science and Techniques 2024年第5期35卷 13-29页

作者： Xian-Cai lin Hao Zha Jia-Ru shi Qiang Gao Fang-Jun Hu Qing-Zhu Li Huai-Bi chen Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

Very high-energy electrons(VHEEs)are potential candidates for FLASH radiotherapy for deep-seated *** proposed a compact VHEE facility based on an X-band high-gradient high-power *** this study,we investigated and realized the first X-band backward traveling-wave(BTW)accelerating structure as the buncher for a VHEE facility.A method for calculating the parameters of single cell from the field distribution was introduced to simplify the design of the BTW ***-domain circuit equations were applied to calculate the transient beam parameters of the buncher in the unsteady state.A prototype of the BTW structure with a thermionic cathode-diode electron gun was designed,fabricated,and tested at high power at the Tsinghua X-band high-power test *** structure successfully operated with 5-MW microwave pulses from the pulse compressor and outputted electron bunches with an energy of 8 MeV and a pulsed current of 108 mA.

关键词： Backward traveling-wave accelerating structure Equivalent circuit model High-power test Very high-energy electron radiotherapy

Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441

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Research 2024年第1期2023卷 181-197页

作者： Wen-Juan lin Wen-Pu shi Wan-Yi Ge Liang-Liang chen Wei-Hong Guo Peng Shang Da-Chuan Yin Key Laboratory for Space Bioscience and Biotechnology School of Life SciencesNorthwestern Polytechnical University127 Youyixi RoadXi'an 710072ShaanxiPR China

The biological effects of magnetic fields(MFs)have been a controversial ***,in recent years,there has been increasing evidence that MFs do affect biological ***,the physical mechanism remains ***,we show that MFs(16 T)reduce apoptosis in cell lines by inhibiting liquid–liquid phase separation(LLPS)of Tau-441,suggesting that the MF effect on LLPS may be one of the mechanisms for understanding the“mysterious”magnetobiological *** LLPS of Tau-441 occurred in the cytoplasm after induction with *** phase-separated droplets of Tau-441 recruited hexokinase(HK),resulting in a decrease in the amount of free HK in the *** cells,HK and Bax compete to bind to the voltage-dependent anion channel(VDAC I)on the mitochondrial membrane.A decrease in the number of free HK molecules increased the chance of Bax binding to VDAC I,leading to increased Bax-mediated *** the presence of a static MF,LLPS was marked inhibited and HK recruitment was reduced,resulting in an increased probability of HK binding to VDAC I and a decreased probability of Bax binding to VDAC I,thus reducing Bax-mediated *** findings revealed a new physical mechanism for understanding magnetobiological effects from the perspective of *** addition,these results show the potential applications of physical environments,such as MFs in this study,in the treatment of LLPS-related diseases.

关键词： inhibited Apoptosis finding

Control of highly pathogenic avian influenza through vaccination

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Journal of Integrative Agriculture 2024年第5期23卷 1447-1453页

作者： Xianying Zeng Jianzhong shi Hualan chen State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin150069China

The stamping-out strategy has been used to control highly pathogenic avian influenza viruses in many countries,driven by the belief that vaccination would not be successful against such viruses and fears that avian influenza virus in vaccinated birds would evolve more rapidly and pose a greater risk to *** this review,we summarize the successes in controlling highly pathogenic avian influenza in China and make suggestions regarding the requirements for vaccine selection and *** addition,we present evidence that vaccination of poultry not only eliminates human infection with avian influenza virus,but also significantly reduces and abolishes some harmful characteristics of avian influenza virus.

关键词： avian influenza control highly pathogenic vaccination

GC-MS Analysis on Volatile Oil from Branches of Picrasma quassioides

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Chinese Herbal Medicines 2013年第1期5卷 73-76页

作者： HUANG lin-fang WANG Zeng-hui chen shi-lin Institute of Medicinal Plant Development Chinese Academy of Medical Sciences College of Pharmacy Hunan University of Chinese Medicine

Objective To analyze the volatile oil from the branches of Picrasma quassioides. Methods Volatile oil was extracted from the branches of P. quassioides by steam distillation. GC-MS method was used to analyze the components. Results A total of 49 compounds were isolated, and 46 compounds were successfully identified, which represented over 98% of the total oil composition. The major components of the volatile oil in the branches of P. quassioides included caryophyllene (12.83%), 12-oxabicyclo[9.1.0]dodeca-3,7-diene,1,5,5,8-tetramethyl-[1R-(1R*,3E,7E,11-R*)] (12.29%), 1-hexanol (9.96%), naphthalene, 1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methyletheyl)-[1S-(1a,7a,8aa)] (7.32%), aromadendrene oxide-(2) (6.69%), and α-caryophyllene (3.88%). Conclusion The major components in volatile oil are terpenoids, hydroxy compounds, and other acyclic alkane compounds.

关键词： GC-MS hydroxy compounds Picrasma quassioides terpenoids volatile oil

A novel fused bi-macrocyclic host for sensitive detection of Cr_(2)O_(7)^(2-)based on enrichment effect

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Chinese Chemical Letters 2024年第7期35卷 291-295页

作者： Ting-Ting Huang Jin-Fa chen Juan Liu Tai-Bao Wei Hong Yao Bingbing shi Qi lin Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission Gansu Provincial Biomass Function Composites Engineering Research CenterCollege of Chemical EngineeringNorthwest Minzu University(Northwest University for Nationalities)Lanzhou 730000China

Improving the highly selective and sensitive binding of chemosensor to target guest is always very *** order to solve this issue,herein,the enrichment effect was introduced into the design of chemosensor molecule.A novel bi-fused-macrocyclic host molecule BPN1 was synthesized by bridging a pillar[5]arene and a naphthalene diimide(NDI)group through hydrogen-bond-rich *** the BPN1,the naphthalimide side ring is outside the cavity of the pillar[5]*** addition,Cr(VI)greatly threat human health and the environment due to its severe toxicity,and it is very important to develop effective chemosensor for sensitive and selective detection of Cr_(2)O_(7)^(2-)or its ion *** this paper,the novel bi-fused-macrocyclic host molecule BPN1 can recognize Cr_(2)O_(7)^(2-)with high selectivity and *** mechanism of BPN1 recognition of Cr_(2)O_(7)^(2-)was studied through experiments and density functional theory(DFT),the results show that BPN1 could supply enrichment effect to bind Cr_(2)O_(7)^(2-)through multiple weak interactions such as hydrogen bonds and anion-π,and achieve highly sensitive and selective detection of Cr_(2)O_(7)^(2-).It is a significant and feasible strategy for improve high selectivity and sensitivity of host to specific objects by using the enrichment effect of fused bi-macrocyclic.

关键词： Pillararene Bi-macrocyclic Detection of Cr_(2)O_(7)^(2−) DFT The enrichment effect