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Human influence on the duration of extreme temperature events in Asia's hotspot regions

Advances in Climate Change Research 2024年第2期15卷 312-326页

作者： Zi-Meng WANG Hong-Yun MA Wei LI Hai-shan chen Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)/Key Laboratory of Meteorological Disaster Ministry of Education(KLME)Nanjing University of Information Science and TechnologyNanjing 210044China

Observations and models indicate that human activities exert a considerable impact on the frequency and intensity of extreme temperature events,which are associated with global warming.However,changes in the duration of extreme temperature events and their association with human influence have not been considered in most studies.Thus,the possible relationship between the observed changes in the warm and cold spell duration(WSDI and CSDI)in hotspot regions during 1960-2014 and human influence was investigated based on the NCEP/NCAR reanalysis version 1 and Coupled Model Inter-comparison Project Phase 6(CMIP6)data.Constraint projection based on these attribution results was also performed.The optimal fingerprinting technique was used to compare observed changes in WSDI and CSDI to simulated changes averaged across eight CMIP6 models.Results show that anthropogenic(ANT)forcing contributed to the observed increase in WSDI in the three hotspot regions(West Asia,South Asia and Southeast Asia),with the majority of the changes being attributed to greenhouse gas forcing.However,a generally weak ANT signal can be observed in the decreasing trend of CSDI and can be detected in South and Southeast Asia.The influence of aerosol forcing remains undetected in either WSDI or CSDI,which differs from the results for frequency and intensity of extreme temperatures.The attribution results revealed that the constrained projection of WSDI is lower than the raw projection for 2015-2100 in West Asia and Southeast Asia.However,no differences in future CSDI changes are found in Southeast Asia between the constrained and raw projections.

关键词： Extreme temperature events Duration Detection attribution Constraint projection Hotspot regions

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Persistent greening against drying in northeast Asian semiarid grasslands:Asymmetrical responses of direct and legacy effects to intensified drought

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Advances in Climate Change Research 2024年第1期15卷 9-20页

作者： Yu-Tong MA Hai-shan chen Yao-Ming SONG Bo-Tao ZHOU shan-Lei SUN Xin-Guan DU Yue SUN Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

Despite experiencing a decadal shift towards drought conditions at the end of the 2Oth century,semiarid grasslands in northeast Asia(NEA)exhibited an evident greening trend from 1982 to 2020.However,the mechanism behind this phenomenon remains unclear.Hence,we analysed the interdecadal changes in vegetation response to drought on the basis of the standardised precipitation evapotranspiration index(SPEI)and Global Inventory Modelling and Mapping Studies LAI4g datasets,with an emphasis on the differences between direct and legacy effects(as measured by resilience),to explore the mechanism of persistent grassland greening.Results revealed that during the post-drought shift period(2000-2020),the sudden decrease in the water content of the intermediate soil layer triggered an intensified vegetation response to drought.Specifically,although direct effects and resilience were amplified,they exhibited asymmetric changes.Resilience was stronger than direct effects,and this difference increased with increasing drought(drought recovery)levels.These combined effects may account for persistent greening against intensified drying in the semiarid grasslands in NEA.Given the projected exacerbation of future droughts,this study holds notable importance for comprehending the long-term change dynamics of dryland ecosystems.

关键词： Semiarid grassland Drought decadal shift Direct effect Legacy effect(resilience) Northeast Asia

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Enhanced cyclic stability of partially disordered spinel cathodes through direct fluorination with gaseous fluorine

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Rare Metals 2024年第4期43卷 1635-1646页

作者： Yong-Nian Ma Ling-chen Kong Shao-shan chen Yong Wang Li-Dong Sun Cong Peng Meng-Meng Qin Yu Li Wei Feng Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin University Institute of Advanced Technology and Equipment Beijing University of Chemical Technology

Spinel-type cathodes are considered an optimal substitute for conventional layered oxide cathodes owing to their use of inexpensive and earth-abundant manganese as the redox-active element.Moreover,the introduction of cation disorder can effectively suppress the detrimental two-phase reaction to realize high capacities in a wide voltage range.However,the continuous capacity decay during cycles has hindered the widespread application of these cathode materials.Inorganic fluorides exhibit excellent electrochemical stability at high voltage;therefore,in this study,the direct F2 gas reaction with a partially disordered spinel cathode(Li1.6Mn1.6O3.7F0.3,LMOF1.6) was initially applied to investigate the impacts of fluorination on the surface structure and electrochemical performances.The inorganic fluorinated layer,mainly containing LiF,was distributed uniformly on the surface of LMOF1.6nanoparticles after fluorination for an appropriate time without the turbulence caused by the valency of manganese cation,which improved the capacity retention and rate capability by the suppression of structural damage,parasitic reaction,and cation dissolution.The LMOF1.6cathode fluorinated for 0.5 h exhibited a capacity of283.6 mAh·g-1at 50 mA·g-1and an enhanced capacity retention of 29.6% after 50 cycles in the voltage range of1.5-4.8 V,as compared to the pristine LMOF1.6 with only27.9% capacity retention.

关键词： Spinel-type cathodes Direct fluorination Capacity retention ability High rate capability

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New recessive compound heterozygous variants of RP1L1 in RP1L1 maculopathy

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 107-112页

作者： Wen-Chao Cao Qing-shan chen Run Gan Tao Huang Xiao-He Yan The Second Clinical Medical College Jinan UniversityShenzhen 518040Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChin

AIM:To identify a maculopathy patient caused by new recessive compound heterozygous variants in RP1L1.METHODS:Comprehensive retinal morphological and functional examinations were evaluated for the patient with RP1L1 maculopathy.Targeted sequence capture array technique was used to screen potential pathologic variants.Polymerase chain reaction and Sanger sequencing were used to confirm the screening results.RESULTS:Fundus examination showed round macular lesions appeared in both eyes.Optical coherence tomography showed that the inner segment/outer segment continuity was disorganized and disruptive in the left eye,but it was uneven and slightly elevated in the right eye.Fundus autofluorescence showed patchy hyper-autofluorescence in the macula.Visual field examination indicates central defects in both eyes.Electroretinogram(ERG)and multifocal ERG showed no obvious abnormalities.Fundus fluorescein angiography in the macula showed obviously irregular hyper-fluorescence in the right eye and slightly hyper-fluorescence in the left eye.We found that the proband carried a missense variant(c.1972C>T)and a deletion variant(c.4717_4718del)of RP1L1,which were originated from the parents and formed compound heterozygous variants.Both variants are likely pathogenic according to the ACMG criteria.Multimodal imaging,ERG and detailed medical history are important diagnostic tools for differentiating between acquired and inherited retinal disorders.CONCLUSION:A maculopathy case with detailed retinal phenotype and new recessive compound heterozygous variants of RP1L1 is identified in a Chinese family,which expands the understanding of phenotype and genotype in RP1L1 maculopathy.

关键词： maculopathy recessive compound heterozygous variants RP1L1

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基于复合超材料的多种结构的太赫兹频率开关

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光谱学与光谱分析 2024年第2期44卷 331-335页

作者：陈姗姗张波太赫兹光电子学教育部重点实验室首都师范大学物理系北京100048

超材料可以应用于调制器,能够吸收特定频率的太赫兹波。然而当超材料的结构参数一旦确定,就只能在特定的共振频率产生完美吸收。设计了三种复合超材料结构探究复合超材料的共振,这三种结构的超材料均以石英为衬底,在该基底上加工一层具... 详细信息

超材料可以应用于调制器,能够吸收特定频率的太赫兹波。然而当超材料的结构参数一旦确定,就只能在特定的共振频率产生完美吸收。设计了三种复合超材料结构探究复合超材料的共振,这三种结构的超材料均以石英为衬底,在该基底上加工一层具有开口的金属谐振环。三种结构分别是单开口的金属谐振圆环,单开口的金属谐振方框和不对称双开口的金属谐振方框。在三种结构的开口中填入光敏材料氧化铟,改变氧化铟的电导率对这些复合超材料结构的太赫兹的调制特性进行了研究,同时对三种结构太赫兹频率开关的不同共振频率的电场分布进行了数值模拟。对于单开口不同形状的金属谐振环,共振频率不同,但都随着氧化铟电导率的增加,共振峰的吸收强度逐渐减小,从对应的电场分布图中可以看到,随着氧化铟电导率的增加,间隙边缘处的场强越来越弱,谐振峰吸收强度也就越来越弱,这个过程可以被认为是太赫兹波在共振频率的动态开关。对于不对称双开口的金属谐振方框,在偏离金属框中央处的开口填入氧化铟,这个结构可以看到两个谐振峰,随着电导率的增加,一个谐振峰吸收强度逐渐减弱,而另一个谐振峰吸收强度无明显变化,由此可得吸收强度随电导率增加而减弱的谐振峰为法诺共振,而另一个吸收强度一直无明显变化的谐振峰为偶极共振。从对应场分布图可以看到,法诺共振入射的太赫兹波的能量主要集中在金属谐振环的右侧金属臂上,而且随着电导率的增大,右侧金属臂的间隙处积累的电荷越来越多;而偶极共振入射的太赫兹波的能量主要集中在金属谐振环的左侧金属臂上,电导率增加,偶极共振的电场分布无明显变化。

关键词：太赫兹频率开关超材料

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Nanoindentation behavior and creep-induced cracking of long-term crept austenitic steel at 650℃

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Journal of Iron and Steel Research(International) 2024年第2期31卷 464-474页

作者： Zhen Zhang Yu-hang Duan Shuai Wang Jin-shan chen An-zhe Wang Xiang-yang Mao Yuan-ji Shi Jie Zhang Ming Liu Zheng-fei Hu School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing211167JiangsuChina Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing211167JiangsuChina Jiangsu Wind Power Engineering Technology Center Nanjing210023JiangsuChina Nanjing Vocational University of Industry Technology Nanjing210023JiangsuChina Baoshan Iron&Steel Co. Ltd.Shanghai201900China Fujian Provincial Key Laboratory of Terahertz Functional Devices and Intelligent Sensing School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou350116FujianChina School of Materials Science and Engineering Tongji UniversityShanghai201804China

The grain boundary(GB)damage of long-term crept HR3C(25Cr–20Ni–Nb–N)austenitic steel with solid solution state was investigated by nanoindentation test accompanied with in-situ electron back-scattered diffraction.The corresponding microstructure was characterized by scanning electron microscopy and transmission electron microscopy.Results show that the increase in nanoindentation hardness at the GBs and triple grain junctions may be related to the dislocation accumulation and carbide growth during the creep.Coarsened M23C6 and dislocations piling-up at the GB accelerate the nucleation and coalescence of creep cavity along the GB.The nanoindentation hardness in grains varies with orientation of the stress axis.The orientation difference of neighbor grains may induce local high geometrically necessary dislocation densities and strain gradients near the GB,consequently causing stress concentration and subsequent crack growth at specific GBs.

关键词： Austenitic steel Creep Nanoindentation Grain orientation Creep-induced cracking

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GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines

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World Journal of Stem Cells 2024年第5期16卷 538-550页

作者： Yang-Zhou Jiang Lan-Yue Hu Mao-shan chen Xiao-Jie Wang cheng-Ning Tan Pei-Pei Xue Teng Yu Xiao-Yan He Li-Xin Xiang Yan-Ni Xiao Xiao-Liang Li Qian Ran Zhong-Jun Li Li chen Laboratory of Radiation Biology Department of Blood TransfusionLaboratory Medicine CenterThe Second Affiliated HospitalThird Military Medical UniversityChongqing 400037China Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center Ministry of Education of the People’s Republic of ChinaChongqing 400037China

BACKGROUND Thrombocytopenia 2,an autosomal dominant inherited disease characterized by moderate thrombocytopenia,predisposition to myeloid malignancies and normal platelet size and function,can be caused by 5’-untranslated region(UTR)point mutations in ankyrin repeat domain containing 26(ANKRD26).Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1)have been identified as negative regulators of ANKRD26.However,the positive regulators of ANKRD26 are still unknown.AIM To prove the positive regulatory effect of GATA binding protein 2(GATA2)on ANKRD26 transcription.METHODS Human induced pluripotent stem cells derived from bone marrow(hiPSC-BM)INTRODUCTION Ankyrin repeat domain containing protein 26(ANKRD26)acts as a regulator of adipogenesis and is involved in the regulation of feeding behavior[1-3].The ANKRD26 gene is located on chromosome 10 and shares regions of homology with the primate-specific gene family POTE.According to the Human Protein Atlas database,the ANKRD26 protein is localized to the Golgi apparatus and vesicles,and its expression can be detected in nearly all human tissues[4].Moreover,UniProt annotation revealed that ANKRD26 is localized in the centrosome and contains coiled-coil domains formed by spectrin helices and ankyrin repeats[5,6].The most common disease related to ANKRD26 is thrombocytopenia 2(THC2),which is a rare autosomal dominant inherited disease characterized by lifelong mild-to-moderate thrombocytopenia and mild bleeding[7-9].Caused by the variants in the 5’-untranslated region(UTR)of ANKRD26,THC2 is defined by a decrease in the number of platelets in circulating blood and results in increased bleeding and decreased clotting ability[8,10].Due to the point mutations that occur in the 5’-UTR of ANKRD26,its negative transcription factors(TFs),Runt related transcription factor 1(RUNX1)and friend leukemia integration 1(FLI1),lose their repression effect[11].The persistent expression of ANKRD26 increases the activity of the mitogen activated protein kinase and e

关键词： Ankyrin repeat domain containing 26 GATA binding protein 2 Thrombocytopenia 2 Transcriptional regulation Myeloid-derived cell lines

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Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer

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World Journal of Clinical Oncology 2024年第4期15卷 531-539页

作者： De-Yi Geng Qing-shan chen Wan-Xian chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen chen Jia-Sheng chen Xiao-Ping Zhong Department of Plastic and Burns Surgery The Second Affiliated Hospital of Shantou University Medical CollegeShantou 515000Guangdong ProvinceChina Plastic Surgery Research Institute Ear Deformities Treatment Center and Cleft Lip and Palate Treatment Center of Shantou University Medical CollegeShantou 515000Guangdong ProvinceChina

Metastasis remains a major challenge in the successful management of malignant diseases.The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon,stomach,and pancreatic cancers,as well as melanoma,breast cancer,and sarcoma.As an important factor that influences the development of metastatic liver cancer,alternative splicing drives the diversity of RNA transcripts and protein subtypes,which may provide potential to broaden the target space.In particular,the dysfunction of splicing factors and abnormal expression of splicing variants are associated with the occurrence,progression,aggressiveness,and drug resistance of cancers caused by the selective splicing of specific genes.This review is the first to provide a detailed summary of the normal splicing process and alterations that occur during metastatic liver cancer.It will cover the role of alternative splicing in the mechanisms of metastatic liver cancer by examining splicing factor changes,abnormal splicing,and the contribution of hypoxia to these changes during metastasis.

关键词： Alternative splicing Carcinoma Hepatocellular Metastasic Liver neoplasms Prognosis

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数智时代劳动的存在特征、发生原因与发展导向——基于马克思主义政治经济学的分析

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经济学家 2024年第7期 35-44页

作者：陈兴山天津师范大学马克思主义学院

数智时代是当前世界历史的时代方位,数字劳动是当前人类劳动的存在形态。随着物联网、大数据、云计算,特别是人工智能技术的飞速发展与广泛应用,数字、数据、代码和流量等成为劳动资料。数字劳动资料的赋能使劳动呈现出劳动工具去物化... 详细信息

数智时代是当前世界历史的时代方位,数字劳动是当前人类劳动的存在形态。随着物联网、大数据、云计算,特别是人工智能技术的飞速发展与广泛应用,数字、数据、代码和流量等成为劳动资料。数字劳动资料的赋能使劳动呈现出劳动工具去物化、劳动过程去人化以及劳动产品去实化的存在特质。数智化工具是科技进步、资本逐利、劳动发展以及劳动解放要求的结果。而抛开资本制度层面,科学技术的发展、智化工具的实现使得劳动解放成为可能。谛视数字智能赋能下的劳动,它不童是一种“人为的”创造,更要操持“为人的”定向。为此,在发展数字经济之时,要完善数智基础设施,缩小数字鸿沟,共有数字技术;坚持人民立场,制定数智技术红线,共建数字体系;规避数智技术垄断,构建数字公域,共享数字成果。以新时代劳动创新理论指导数智时代的数字劳动实践是中国式现代化的重大现实任务,决定着新质生产力的发展,关系着经济社会发展的质量。

关键词：数智时代劳动变化数字赋能劳动解放以人为本

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代际支持背景下老年人社区服务设施需求特征研究——以深圳公共住房为例

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南方建筑 2024年第2期 82-93页

作者：陈珊刘嘉陈春一亚热带建筑与城市科学全国重点实验室深圳大学建筑与城市规划学院深圳市珠江投资发展有限公司华东建筑设计研究院有限公司

深圳市老年人非户籍人口占比大,提供代际支持的随迁老年人构成了常住老龄人口主力。立足于深圳公共住房建设现状及老年人特征,通过问卷调研多维度探析老年人设施使用需求;采用活动日志调研探析老年人日常社区服务设施使用的时间规律及... 详细信息

深圳市老年人非户籍人口占比大,提供代际支持的随迁老年人构成了常住老龄人口主力。立足于深圳公共住房建设现状及老年人特征,通过问卷调研多维度探析老年人设施使用需求;采用活动日志调研探析老年人日常社区服务设施使用的时间规律及行为链特征;结合典型案例定点行为观察,探析老年人时间-行为-设施使用场景。研究结果表明老年人社区活动设施需求显著,农贸菜市场及连锁超市的需求较大,教育设施成为老年人使用的重要设施,社康中心需求大于综合医院,养老设施需求较低等特征;各类社区服务设施使用的时间规律及设施组合使用规律明显等。研究结果可为深圳公共住房社区服务设施适老性优化提供有益的参考。

关键词：代际支持深圳公共住房社区服务设施老年人需求

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