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Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells

Cancer Biology & Medicine 2025年第1期22卷 48-66页

作者： renjie chen Jiahui Wang Shuoyu Huang Xuefeng Hu Xinran He Tiange Zhang Yunhan Hu Huijun Wei Sihui Nian Yushu Huang Zhihao Wu Research Laboratory of Tumor Microenvironment Wannan Medical College School of Laboratory Medicine Wannan Medical College School of Anesthesiology Wannan Medical College School of Medical Imageology Wannan Medical College School of Clinical Medicine Wannan Medical College Anhui Province Key Laboratory of Active Biological Macro-molecules Research Wannan Medical College Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui Wannan Medical College School of Pharmacy Wannan Medical College Anhui Province Key Laboratory of Non-coding RNA Basic and Clinical Transformation Wannan Medical College Anhui Provincial Engineering Research Center for Dental Materials and Application Wannan Medical College

Objective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer(NSCLC) but the effectiveness of chemotherapy is encumbered by drug resistance. Therefore, understanding the molecular mechanisms underlying chemotherapy resistance is crucial in improving treatment outcomes and ***: The cell viability assay and apoptosis were used to analyze chemoresistance. Western blot analysis and wound healing testing were used to evaluate the epithelial-to-mesenchymal transition(EMT). Immunoprecipitation was used for analysis of protein modification. Promoter activity was determined using the luciferase reporter assay. Immunofluorescence staining was used to determine reactive oxygen species levels. The expression patterns of EMT markers and carnitine palmitoyltransferase 1C(CPT1C) were determined by Western blot ***: CPT1C, which was shown to be highly expressed in lung cancer, is associated with cisplatin resistance in NSCLC cells. CPT1C depletion increased NSCLC cell sensitivity to cisplatin, while overexpression of CPT1C increased NSCLC cell resistance to cisplatin. Induction of EMT mediated CPT1C-induced cisplatin resistance. Ectopic expression of Snail reversed the increase in cisplatin sensitivity triggered by CPT1C knockdown. Moreover, CPT1C was shown to be regulated at the post-translational level and an E3-ubiquitin ligase, NEDD4L, was shown to be a major regulator of CPT1C stability and ***: These data provide evidence for the first time that the lipid metabolism enzyme, CPT1C, mediates resistance to chemotherapy. Therefore, the use of combination therapy with a CPT1C inhibitor may be a promising new avenue in lung cancer treatment.

关键词： CPT1C EMT NEDD4L NSCLC chemoresistance

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Effect of Nd-Ho-Al-Ga diffusion on coercivity and thermal stability of hot-deformed PrNd-Fe-B magnets

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Journal of Rare Earths 2025年第03期 578-583页

作者： Yuhang Cui Xu Tang renjie chen Yeyuan Du Ge Dai Yong Ouyang Yiping Huang Wenzong Yin Jinyun Ju Xianshuang Xia Aru Yan School of Materials Science and Chemical Engineering Ningbo University CISRI&NIMTE Joint Innovation Center for Rare Earth Permanent Magnets Ningbo Institute of Material Technology and EngineeringChinese Academy of Sciences University of Chinese Academy of Sciences

In this study,to enhance the coercivity and high-temperature stability of hot-deformed PrNd-Fe-B magnets,the NdHoAlGa alloy was utilized as a diffusion source and a dual-alloy diffusion process was employed to enhance the room temperature coercivity from 1.72 to 2.28 *** the magnet doped with7 wt% Nd72.3Ho13.8Al2.3Ga11.7,within the temperature range from 20 to 200℃,the remanence temperature coefficient a increases from-0.16%/℃ to-0.14%/℃,and the coercivity temperature coefficient βincreases from-0.49%/℃ to-0.43%/℃.By controlling grain boundary（GB） phases and optimizing the main phase simultaneously,Ga was induced to motivate the formation of non-ferromagnetic GB phases,reducing the size of grains and intergranular exchange ***,Ho was diffused into the main phase,forming（Pr,Nd,Ho）-Fe-B phase,which enhances the magnetic crystalline anisotropy field of the main phase grains at high temperatures.

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面向片区层面的空间规划交通碳排放测算方法研究

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交通节能与环保 2025年第1期21卷 57-62,112页

作者：陈人杰厦门市城市规划设计研究院有限公司福建厦门361000

本文通过溯源中观尺度下交通碳排放的结构特征,构建片区层面的基于交通活动的碳排放测算方法。并以交通碳排放测算为依据、以降低碳排放为目标,从推进交通设施与用地功能的协调耦合实现源头减排、优化出行结构实现前端减排、提升交通运... 详细信息

本文通过溯源中观尺度下交通碳排放的结构特征,构建片区层面的基于交通活动的碳排放测算方法。并以交通碳排放测算为依据、以降低碳排放为目标,从推进交通设施与用地功能的协调耦合实现源头减排、优化出行结构实现前端减排、提升交通运输管理水平实现过程减排三个方面提出交通减碳路径。

关键词：城市交通交通碳排放测算碳达峰碳中和空间规划

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Efficient fastest-path computations for road maps

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Computational Visual Media 2021年第2期7卷 267-281页

作者： renjie chen Craig Gotsman University of Science and Technology of China HefeiChina New Jersey Institute of Technology NewarkNJUSA

In the age of real-time online traffic information and GPS-enabled devices,fastest-path computations between two points in a road network modeled as a directed graph,where each directed edge is weighted by a“travel time”value,are becoming a standard feature of many navigation-related *** support this,very efficient computation of these paths in very large road networks is *** paths may be computed as minimal-cost paths in a weighted directed graph,but traditional minimal-cost path algorithms based on variants of the classical Dijkstra algorithm do not scale well,as in the worst case they may traverse the entire graph.A common improvement,which can dramatically reduce the number of graph vertices traversed,is the A*algorithm,which requires a good heuristic lower bound on the minimal *** introduce a simple,but very effective,heuristic function based on a small number of values assigned to each graph *** values are based on graph separators and are computed efficiently in a preprocessing *** present experimental results demonstrating that our heuristic provides estimates of the minimal cost superior to those of other *** experiments show that when used in the A*algorithm,this heuristic can reduce the number of vertices traversed by an order of magnitude compared to other heuristics.

关键词： shortest-path road map heuristic GPS navigation A^(*)search

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Fine particulate matter and cardiorespiratory health in China:A systematic review and meta-analysis of epidemiological studies

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Journal of Environmental Sciences 2023年第1期123卷 306-316页

作者： Huihuan Luo Qingli Zhang Yue Niu Haidong Kan renjie chen School of Public Health Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology AssessmentFudan UniversityShanghai 200032China

This review aimed to systematically summarize the epidemiological literature on the cardiorespiratory effects of PM_(2.5)published during the 13^(th) Five-Year Plan period(2016-2020)in *** articles published between January 1,2016 and June 30,2021 were searched in PubMed,Web of Science,the China National Knowledge Internet Database and Wanfang ***-or fixed-effects models were used to pool effect estimates where *** 8558 records identified,145 met the full eligibility criteria.A 10μg/m^(3) increase in short-term PM_(2.5)exposure was significantly associated with increases of 0.70%,0.86%,0.38%and 0.96%in cardiovascular mortality,respiratory mortality,cardiovascular morbidity,and respiratory morbidity,*** specific diseases with significant associations included stroke,ischemic heart disease,heart failure,arrhythmia,chronic obstructive pulmonary disease,pneumonia and allergic *** pooled estimates per 10μg/m^(3) increase in long-term PM_(2.5)exposure were 15.1%,11.9%and 21.0%increases in cardiovascular,stroke and lung cancer mortality,and 17.4%,11.0%and 4.88%increases in cardiovascular,hypertension and lung cancer incidence *** changes in blood pressure,heart rate variability,systemic infiammation,blood lipids,lung function and airway infiammation were observed for either short-term or long-term PM_(2.5)exposure,or ***,we summarized representative exposure-response relationships between short-and long-term PM_(2.5)exposure and a wide range of cardiorespiratory outcomes applicable to *** magnitudes of estimates were generally smaller in short-term associations and comparable in long-term associations compared with those in developed *** are helpful for future standard revisions and policy *** are still some notable gaps that merit further investigation in China.

关键词： Fine particulate matter Air pollution Cardiovascular system Respiratory system Mortality Morbidity Epidemiological studies

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Rational Design of MOF-Based Materials for Next-Generation Rechargeable Batteries

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Nano-Micro Letters 2021年第12期13卷 264-300页

作者： Zhengqing Ye Ying Jiang Li Li Feng Wu renjie chen Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081People’s Republic of China Advanced Technology Research Institute Beijing Institute of TechnologyJinan 250300People’s Republic of China

Metal–organic framework(MOF)-based materials with high porosity,tunable compositions,diverse structures,and versatile functionalities provide great scope for next-generation rechargeable battery ***,this review summarizes recent advances in pristine MOFs,MOF composites,MOF derivatives,and MOF composite derivatives for high-performance sodium-ion batteries,potassiumion batteries,Zn-ion batteries,lithium–sulfur batteries,lithium–oxygen batteries,and Zn–air batteries in which the unique roles of MOFs as electrodes,separators,and even electrolyte are ***,through the discussion of MOFbased materials in each battery system,the key principles for controllable synthesis of diverse MOF-based materials and electrochemical performance improvement mechanisms are discussed in ***,the major challenges and perspectives of MOFs are also proposed for next-generation battery applications.

关键词： Metal–organic frameworks MOF composites MOF derivatives MOF composite derivatives Batteries

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Lithium-Sulfur Batteries at Extreme Temperatures:Challenges,Strategies and Prospects

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Energy & Environmental Materials 2023年第4期6卷 297-311页

作者： Wenjia Qu Jingyi Xia Chong Luo chen Zhang renjie chen Wei Lv Quanhong Yang Nanoyang Group State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Beijing Key Laboratory of Environmental Science and Engineering School of Material Science and EngineeringBeijing Institute of TechnologyBeijing 10081China School of Marine Science and Technology Tianjin UniversityTianjin 300072China Shenzhen Geim Graphene Center Engineering Laboratory for Functionalized Carbon MaterialsTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

High-energy-density-batteries working at a wide-temperature range are urgently required in many performance-critical ***-sulfur batteries(LSB)are promising high-energy-density batteries that have the potential to maintain high performance at extreme ***,some problems like severe shuttling and safety issues at high temperatures or sluggish reaction kinetics and charge-transfer process at low temperatures decrease the performance and hinder their practical uses in extreme temperature ***,broadening the working temperature of LSB with stable electrochemical performance becomes a crucial *** this paper,the key stumbling blocks for high and low-temperature LSB are comprehensively *** solutions from the aspects of electrolyte and electrode materials are discussed to solve the aggravating shuttle effect and thermal safety issues under high temperature and the sluggish reaction kinetics under low ***,some specific promising solutions to extend the operating temperature range of LSB are also proposed and highlighted,which provide potential research directions on the practical LSB application in future.

关键词： high temperature lithium-sulfur batteries low temperature safety issue shuttle effect

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The RECEPTOR-LIKE PROTEIN53 immune complex associates with LLG1 to positively regulate plant immunity

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Journal of Integrative Plant Biology 2022年第9期64卷 1833-1846页

作者： renjie chen Pengwei Sun Guitao Zhong Wei Wang Dingzhong Tang State Key Laboratory of Ecological Control of Fujian-Taiwan Crop Pests Key Laboratory of Ministry of Education for GeneticsBreeding and Multiple Utilization of CropsPlant Immunity CenterFujian Agriculture and Forestry UniversityFuzhou350002 China Institute of Genetics and Developmental Biology the Chinese Academy of SciencesBeijing100101 China College of Life Sciences University of Chinese Academy of SciencesBeijing100049 China Ministerial and Provincial Joint Innovation Centre for Safety Production of Cross-Strait Crops Fujian Agriculture and Forestry UniversityFuzhou350002 China

Pattern recognition receptors(PRRs)sense ligands in pattern-triggered immunity(PTI).Plant PRRs include numerous receptor-like proteins(RLPs),but many RLPs remain functionally ***,we examine an Arabidopsis thaliana RLP,RLP53,which positively regulates immune *** forward genetic screen for suppressors of enhanced disease resistance1(edr1)identified a point mutation in RLP53 that fully suppresses disease resistance and mildewinduced cell death in edr1 *** rlp53 mutants showed enhanced susceptibility to virulent pathogens,including fungi,oomycetes,and bacteria,indicating that RLP53 is important for plant *** ectodomain of RLP53 contains leucine-rich repeat(LRR)***53 constitutively associates with the LRR receptorlike kinase SUPPRESSOR OF BRASSINOSTEROIDINSENSITIVE1-ASSOCIATEDKINASE(BAK1)-INTERACTINGRECEPTORKINASE1(SOBIR1)and interacts with the co-receptor BAK1 in a pathogen-induced *** double mutation sobir1-12 bak1-5 suppresses edr1-mediated disease resistance,suggesting that EDR1 negatively regulates PTI modulated by the RLP53–SOBIR1–BAK1 ***,the glycosylphosphatidylinositol(GPI)-anchored protein LORELEI-LIKE GPI-ANCHORED PROTEIN1(LLG1)interacts with RLP53 and mediates RLP53 accumulation in the plasma *** thus uncovered the role of a novel RLP and its associated immune complex in plant defense responses and revealed a potential new mechanism underlying regulation of RLP immune function by a GPI-anchored protein.

关键词： BAK1 EDR1 LLG1 plant immunity RLP53 SOBIR1

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THE GLASS TRANSITION TEMPERATURE AND MICROSTRUCTURE OF POLYURETHANE/EPOXY RESIN INTERPENETRATING POLYMER NETWORKS NANOCOMPOSITES

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Chinese Science Bulletin 2006年第3期51卷 293-298页

作者： JIA Qingming ZHENG Maosheng SHEN renjie chen Hongxiang School of Material Science and Engineering Xi'an Jiaotong UniversityXi'an 710049 China

Nanocomposites with various contents of organophilic montmorillonite (oMMT) have been prepared by adding oMMT to interpenetrating poly- mer networks (IPNs) of polyurethane and epoxy resin (PU/EP) which had been prepared by a sequential polymeric technique. DSC experiment indicates a novel phenomenon that the glass transition tem- perature (Tg) of the nanocomposites increases with the oMMT content up to 3 %, then decreases with further increasing oMMT content. In order to explain this phenomenon, crosslink density, hydrogen bond- ing in the hard segments, crystallization of the nanocomposites and the exfoliation degree of oMMT in the nanocomposites have been investigated by swelling method, FT-IR, XRD, SEM and TEM, re- spectively. The results indicate that the crosslink density and the hydrogen bonding index of the nanocomposites increase, but the crystallization de- gree of the nanocomposites decreases with increas- ing oMMT content. In addition, oMMT improves the network structure of PU/EP.

关键词：聚亚安酯环氧树脂有机蒙脱石纳米复合物玻璃态转化温度微观结构互穿聚合物网络

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A gradient solid electrolyte interphase with high Li+conductivity induced by bisfluoroacetamide additive for stable lithium metal batteries

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Nano Research 2023年第6期16卷 8425-8432页

作者： Zhaoyang Sun Ziyue Wen Yi chen Yue Ma Jinxiang Zhang Yuejiao Li Li Li renjie chen Beijing Key Laboratory of Environmental Science and Engineering School of Material Science&EngineeringBeijing Institute of TechnologyBeijing 100081China Institute of Advanced Technology Beijing Institute of TechnologyJinan 250300China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081China

Stable Li metal anodes have become the driving factor for high-energy-density battery ***,uncontrolled growth of Li dendrite hinders the application of rechargeable Li metal batteries(LMBs).Here,a multifunctional electrolyte additive bisfluoroacetamide(BFA)was proposed to facilitate high-performance *** uniform and dense deposition of Li^(+) was achieved due to the reduced nucleation and plateau overpotential by the addition of ***,X-ray photoelectron spectroscopy(XPS)tests reveal a gradient solid electrolyte interface(SEI)structure on the Li metal *** voltammetry(CV)curves at different sweep speeds prove the formation of pseudocapacitance at the electrode-electrolyte interface,which accelerates the Li+transport rate and protects the electrode *** low activation energy also indicates the ability of rapid Li^(+) transportation in electrolyte ***,the Li||Li symmetric cells with 1.0 wt.%BFA electrolyte exhibit good cycling performance at 0.5 mA·cm^(−2)for over 2000 h,and Li||LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622)full cells maintain a high capacity for 200 cycles at 1 C rate.

关键词： electrolytes additives solid electrolyte interphase Li dendrites Li metal batteries

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