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阿司匹林和氯吡格雷联合应用对小鼠脑缺血损伤后骨髓及脑内炎症反应的影响

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中国卒中杂志 2022年第6期17卷 605-610页

作者：董雯姜鸣钰陈文涛刘文倩陈青芳赵顺英叶维贞温少红刘向荣首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心北京100070

目的探讨小鼠脑缺血损伤后阿司匹林和氯吡格雷联合应用21 d对骨髓中性粒细胞炎症因子及脑内小胶质细胞极化的影响。方法雄性C57BL/6小鼠随机分为对照组、阿司匹林联合氯吡格雷组(双抗组)2组,每组10只。通过结扎大脑中动脉远端制作脑缺... 详细信息

目的探讨小鼠脑缺血损伤后阿司匹林和氯吡格雷联合应用21 d对骨髓中性粒细胞炎症因子及脑内小胶质细胞极化的影响。方法雄性C57BL/6小鼠随机分为对照组、阿司匹林联合氯吡格雷组(双抗组)2组,每组10只。通过结扎大脑中动脉远端制作脑缺血再灌注模型(缺血60 min,解开结扎实现再灌注),再灌注即刻通过灌胃给予饮用水100μL(对照组)和阿司匹林(剂量12 mg/kg,每只实际用量0.3 mg)与氯吡格雷(剂量12 mg/kg,每只实际用量0.3 mg)混悬液100μL(双抗组),每日1次,连续21 d。21 d后处死小鼠,分离骨髓中性粒细胞,通过实时荧光定量PCR检测骨髓中性粒细胞相关炎症因子,包括IL-1β、IL-6、IL-10、诱导型一氧化氮合酶(inducible nitric-oxide synthase,iNOS)、TNFα、精氨酸酶1(arginase1,Arg1)、转化生长因子β(transforming growth factorβ,TGFβ)、CD206、CD32、几丁质酶样蛋白(chitinase-like 3,Chil3/YM1)的表达情况。脑组织行冰冻切片,免疫荧光染色标记离子化钙结合适配分子1(ionized calcium binding adapter molecule 1,Iba1)、CD16和CD206,观察小胶质细胞数量、形态变化与极化状态。结果与对照组相比,治疗21 d后双抗组小鼠骨髓中性粒细胞IL-1β的相对表达下降(0.703±0.124 vs.1.000±0.203,P=0.019);YM1(2.173±0.968 vs.1.000±0.282,P=0.019)和CD206(1.361±0.203 vs.1.000±0.260,P=0.048)的相对表达上调。治疗21 d后双抗组与对照组梗死周边区的小胶质细胞数量差异无统计学意义,但双抗组CD16阳性(M1型)小胶质细胞数量降低(119.4±37.43个/平方毫米vs.220.2±63.07个/平方毫米,P<0.001),CD206阳性(M2型)小胶质细胞数量增加(198.2±40.16个/平方毫米vs.122.8±29.88个/平方毫米,P<0.001),且双抗组小胶质细胞形态上呈多分支网状结构。结论阿司匹林与氯吡格雷联合应用可能通过抑制骨髓中性粒细胞炎症反应,增加脑内小胶质细胞分支,并激活小胶质细胞向抗炎表型(M2型)转化,从而发挥神经保护作用。

关键词：缺血性脑损伤阿司匹林氯吡格雷中性粒细胞小胶质细胞

毛柳苷在脑缺血再灌注后抑制神经元自噬及神经保护作用研究

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中国卒中杂志 2022年第9期17卷 991-1001页

作者：温少红刘宽赵顺英董雯陈青芳陈文涛叶维贞姜鸣钰刘向荣首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心北京100070 湖南省人民医院星沙院区神经外科

目的通过动物模型和体外细胞培养探索毛柳苷(salidroside,SAL)对脑缺血再灌注损伤的神经保护作用及其可能机制。方法36只雄性C57BL/6J小鼠随机分为假手术组(12只)、溶剂组(12只)和SAL组(12只)。线栓法制作小鼠右侧大脑中动脉闭塞模型,缺... 详细信息

目的通过动物模型和体外细胞培养探索毛柳苷(salidroside,SAL)对脑缺血再灌注损伤的神经保护作用及其可能机制。方法36只雄性C57BL/6J小鼠随机分为假手术组(12只)、溶剂组(12只)和SAL组(12只)。线栓法制作小鼠右侧大脑中动脉闭塞模型,缺血1 h后再灌注,而后即刻尾静脉注射150μL SAL(剂量10 mg/kg,每只实际用量0.22 mg),溶剂组注射同等体积磷酸盐缓冲液,假手术组不给药。缺血再灌注后24 h进行小鼠神经功能缺损评分,神经元特异核蛋白(neuronal nuclei,NeuN)染色统计脑梗死率。取溶剂组小鼠全脑冰冻切片,自噬标记物微管相关蛋白1轻链3B(microtubule associated protein 1 light chain 3 beta,LC3B)分别与NeuN、胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)免疫荧光共染,观察LC3B与梗死周边区神经元、星形胶质细胞共定位情况,以明确缺血再灌注后24 h产生自噬活动的主要部位。自噬标记物苄氯素1(Beclin-1)、自噬相关蛋白3(autophagy related protein 3,Atg3)分别与NeuN免疫荧光共染,进一步观察梗死周边区神经元自噬水平变化情况,并统计Beclin-1^(+)/NeuN^(+)、Atg3^(+)/NeuN^(+)细胞在单位面积(1 mm^(2))内的个数。原代大鼠神经元培养10 d后进行氧糖剥夺(oxygen glucose deprivation,OGD),将细胞分为以下6组:对照(control,CON)组、OGD 1 h后复氧1 h(OGD 1 h)组、OGD 1 h后复氧4 h(OGD 4 h)组、SAL组、OGD 1 h后复氧1 h/全程SAL治疗(OGD^(+)SAL 1 h)组、OGD 1 h后复氧4 h/全程SAL治疗(OGD^(+)SAL 4 h)组,CON组和SAL组不进行OGD,SAL剂量50μmol/L。采用免疫印迹法检测各组细胞中自噬标记物LC3B、Beclin-1、Atg3、Atg5和Atg7的相对表达量;CON组、OGD 4 h组细胞进行LC3B、NeuN免疫荧光共染,观察OGD后神经元内LC3B表达变化情况,并统计LC3B^(+)/NeuN^(+)细胞在单位面积(1 mm^(2))内的个数。结果缺血再灌注后24 h,SAL组小鼠神经功能缺损评分(5.8±1.4分vs.7.1±1.4分,P=0.0332)和脑梗死率(28.7%±9.7%vs.39.9%±9.4%,P=0.0038)均低于溶剂组。溶剂组LC3B与梗死周边区神经元有共定位,与星形胶质细胞无共定位。SAL组Beclin-1^(+)/NeuN^(+)(312.4±45.6个/平方毫米vs.471.2±50.3个/平方毫米,P=0.0121)、Atg3^(+)/NeuN^(+)(322.5±26.5个/平方毫米vs.491.3±42.1个/平方毫米,P=0.0013)细胞数量少于溶剂组。大鼠原代神经元免疫印迹结果显示,OGD 1 h组(1.096±0.004 vs.1.000±0.000,P=0.0174)、OGD 4 h组(1.213±0.019 vs.1.000±0.000,P<0.0001)LC3B相对表达量高于CON组;OGD^(+)SAL 4 h组LC3B、Beclin-1、Atg3相对表达量低于OGD 4 h组(0.833±0.029 vs.1.213±0.019,P<0.0001,0.579±0.081 vs.1.152±0.144,P<0.0001,0.726±0.182 vs.1.091±0.177,P=0.0211);OGD^(+)SAL 4 h组LC3B、Beclin-1相对表达量低于OGD^(+)SAL 1 h组(0.833±0.029 vs.1.046±0.063,P<0.0001;0.579±0.081 vs.0.921±0.09,P=0.0030)。CON组LC3B^(+)/NeuN^(+)细胞数少于OGD 4 h组(51.9±18.7个/平方毫米vs.584.2±34.5个/平方毫米,P=0.0002)。结论SAL可能通过抑制神经元自噬在急性脑缺血再灌注损伤中发挥神经保护作用。

关键词：脑缺血再灌注神经元自噬毛柳苷神经保护

A Survey on Task Scheduling of CPU-GPU Heterogeneous Cluster

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ZTE Communications 2024年第3期22卷 83-90页

作者： ZHOU Yiheng ZENG Wei ZHENG qingfang LIU Zhilong chen Jianping University of Shanghai for Science and Technology Shanghai 200093China National Key Laboratory for Multimedia Information Processing School of Computer SciencePeking UniversityBeijing 100871China State Key Laboratory of Mobile Network and Mobile Multimedia Technology Shenzhen 518055China ZTE Corporation Shenzhen 518057China

This paper reviews task scheduling frameworks,methods,and evaluation metrics of central processing unit-graphics processing unit(CPU-GPU)heterogeneous *** scheduling of CPU-GPU heterogeneous clusters can be carried out on the system level,nodelevel,and device *** task-scheduling technologies are heuristic based on the experts’experience,while some technologies are based on statistic methods using machine learning,deep learning,or reinforcement *** metrics have been adopted to evaluate and compare different task scheduling technologies that try to optimize different goals of task *** statistic task scheduling has reached fewer research achievements than heuristic task scheduling,the statistic task scheduling still has significant research potential.

关键词： CPU-GPU heterogeneous cluster task scheduling heuristic task scheduling statistic task scheduling parallelization

Enhancement of terbium efficiency by gallium and copper co-doping in(Pr,Nd)-Fe-B sintered magnets

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Journal of Rare Earths 2023年第4期41卷 572-577页

作者： qingfang Huang Qingzheng Jiang Yao Shi Sajjad Ur Rehman Xing Wei Ruoshu Wang Yongjian Zhang Deqin Xu Dakun chen Zhenchen Zhong Jiangxi Key Laboratory for Rare Earth Magnetic Materials and Devices&College of Rare Earth Jiangxi University of Science and TechnologyGanzhou 341000China Institute of Rare Earth Magnetic Material Xiamen Tungsten Co.Ltd.Xiamen 361010China Fujian Key Laboratory for Rare Earth Functional Materials Longyan 366300China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China

It is well known that Tb substitution for(Pr,Nd)in(Pr,Nd)-Fe-B based sintered magnetic materials is an effective way to increase intrinsic coercivity,but it is not quite clear whether the increment depends on the different matrix phases with various doping ingredient or not,which is essential to develop high quality magnets with high coercivity more efficiently and effectively with economic consumption of expensive Tb and other costly heavy rare *** this paper,we investigated the efficiency of Tb substitution for magnetic property in(Pr,Nd)-Fe-B sintered permanent magnets by co-doping Ga and Cu *** is shown that Ga and Cu co-doping can effectively improve the efficiency of Tb substitution to increase the thermal stability and the *** intrinsic coercivity increases up to 549 and 987 kA/m respectively by 1.5 wt%and 3.0 wt%Tb substitution in Ga and Cu co-doped magnets while the intrinsic coercivity increases up to only 334 and 613 kA/m respectively by the same amounts of Tb substitution in non-Ga and low-Cu *** other words,it demonstrates that there is about 329-366 kA/m linear equivalent enhancement of intrinsic coercivity by 1.0 wt%Tb substitution for(Pr,Nd)in Ga and Cu co-doped *** temperature coefficients of both intrinsic coercivityβand remanenceαat 20-150℃by 3.0 wt%Tb substitution for the magnets with Ga and Cu co-doping are-0.47%/K and-0.109%/K respectively,and in contrast those values are-0.52%/K and 0.116%/K respectively for the non-Ga and low-Cu *** is the principal reason for more efficient enhancement of magnetic property by Tb substitution in the Ga and Cu co-doped magnets in which Tb atoms are expelled from triple junction phases(TJPs)to penetrate into the grain boundary phases(GB phases)and thus modify the grain *** is prospected that the efficiency of Tb substitution would rely on different matrix phases with various doping constituents.

关键词： (Pr Nd)-Fe-B magnet Magnetic properties Microstructure Efficiency of Tb substitution Ga and Cu co-doping Rare earths

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儿童尖锐湿疣光动力疗法的治疗及护理

中国性科学 2011年第12期20卷 35-36页

作者：陈琴芳杨夕芳张小华李奇许南周亚男曹宁校中国医学科学院北京协和医学院皮肤病研究所(医院) 江苏南京210042

目的:观察儿童尖锐湿疣光动力治疗的疗效,探讨最佳护理方法。方法:28例6岁以下患儿疣体处外敷ALA 3小时,照射前20分钟给予10%水合氯醛口服,待患儿熟睡后采用635nm半导体激光器局部照射,光斑直径2.5cm,能量密度100J/CM2,时间20分钟。结果... 详细信息

目的:观察儿童尖锐湿疣光动力治疗的疗效,探讨最佳护理方法。方法:28例6岁以下患儿疣体处外敷ALA 3小时,照射前20分钟给予10%水合氯醛口服,待患儿熟睡后采用635nm半导体激光器局部照射,光斑直径2.5cm,能量密度100J/CM2,时间20分钟。结果:28例患儿服药后10～20分钟均能很好入睡,经1～3次治疗后25例患儿疣体完全清除,清除率89.3%。结论:儿童ALA-PDT时配合应用10%水合氯醛能很好入睡,采用综合护理方法能顺利完成治疗,获得疗效,并无不良反应。

关键词：儿童尖锐湿疣光动力疗法护理

Extraordinary simultaneous enhancement of the coercivity and remanence of dual alloy HRE-free Nd-Fe-B sintered magnets by post-sinter annealing

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Journal of Materials Science & Technology 2022年第11期106卷 236-242页

作者： qingfang Huang Qingzheng Jiang Jifan Hu Sajjad Ur Rehman Gang Fu Qichen Quan Jixiang Huang Deqin Xu Dakun chen Zhenchen Zhong Jiangxi Key Laboratory for Rare Earth Magnetic Materials and Devices&College of Rare Earths Jiangxi University of Science and TechnologyGanzhou 341000China Fujian Key Laboratory for Rare Earth Functional Materials Longyan 366300China School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China

Post-sinter annealing process plays an important role in the microstructures and magnetic properties of the Nd-Fe-B sintered *** this paper,systematically investigated are the magnetic properties and microstructures of the as-sintered and post-sinter annealed Nd-Fe-B magnets with Pr-Fe-Ga boundary *** choice consecutive annealing methods are adopted at high and low temperatures,namely the 1 st annealing at 880℃ for 2 h and then the 2^(nd) annealing at 440℃ for 3 *** is exceptional to find out that both the remanence and coercivity are improved after 2^(nd) annealing process for this type of *** coercivity is hugely increased from 10.09 kOe for the as-sintered sample to 17.19 kOe for the 2^(nd) annealed magnet,with a significant increment of 70.37%in *** extraordinary magnetic properties of B_(r)=14.44 kGs,H_(cj)=17.19 kOe and(BH)_(max)=51.08 MGOe are obtained for the designated Nd-Fe-B sintered magnets without heavy rare earth(HRE)elements manufactured by dual alloy *** Curie temperature is monotonically decreased from 634 K to 602 K while the c-axis alignment degree is optimized after *** observation and analysis indicate that the elemental distribution patterns are altered after the 2^(nd) *** diffusion of the aggregate(Pr,Nd,Cu,Ga)-rich phase from triple junctions into the grain boundary regions is ascribed to the formation of thin and continuous grain boundary layer,which is critical to improve the microstructures and magnetic properties.

关键词： Nd-Fe-B sintered magnets HRE-free Dual alloy method Post-sinter annealing Magnetic properties

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适用于硅胶基材的可拉伸导电油墨的研究进展

材料导报 2025年第4期39卷 230-236页

作者：谭彩凤王永生张清芳任铮恩溪弄刘儒平刘婕妤陈艳李葆李路海陈寅杰辛智青北京印刷学院北京市印刷电子工程技术研究中心北京102600 贵州省仁怀市申仁包装印务有限责任公司贵州仁怀564507

印刷电子正逐渐从柔性电子向可拉伸电子方向发展,开发平面的可拉伸导体对可拉伸电子具有重要的意义。快速制备柔软的但有一定强度的可拉伸导体的方法是将导电材料与弹性聚合物复合形成导电油墨并印刷在弹性基材上。基于硅胶的弹性基材... 详细信息

印刷电子正逐渐从柔性电子向可拉伸电子方向发展,开发平面的可拉伸导体对可拉伸电子具有重要的意义。快速制备柔软的但有一定强度的可拉伸导体的方法是将导电材料与弹性聚合物复合形成导电油墨并印刷在弹性基材上。基于硅胶的弹性基材具有良好的生物相容性、热稳定性和化学稳定性,弹性接近皮肤,被用于表皮电子器件、智能软体机器人、可穿戴电子器件等。鉴于硅胶表面非极性的特性,为实现印刷的墨层与硅胶表面之间高的粘附牢度,对印刷油墨提出较高要求。本文重点介绍了两类用于硅胶基材的可拉伸导电油墨且将其进行对比,并分析了印刷后图案的后处理方式对拉伸性的影响。指出采用非极性连结料并选择相容性好的导电组分制备导电油墨是硅胶基材上印刷可拉伸电极的关键;复合不同导电组分、在墨层中引入多孔结构、氙灯烧结有利于提升硅胶基可拉伸电子器件的性能。

关键词：可拉伸导体印刷技术硅胶基材导电油墨

Effects and regulation mechanisms of post-sinter annealing treatment on magnetic properties and microstructures of Nd-Fe-B sintered magnets with varying boron contents

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Journal of Materials Science & Technology 2024年第14期181卷 63-70页

作者： qingfang Huang Qingzheng Jiang Kexiang Zhong Dakun chen Deqin Xu Dawei Shi Gang Fu Junlin Yan Sajjad Ur Rehman Qiang Ma Renhui Liu Zhenchen Zhong Jiangxi Key Laboratory for Rare Earth Magnetic Materials and Devices&College of Rare Earths Jiangxi University of Science and TechnologyGanzhou341000China Institute of Rare Earth Magnetic Material Xiamen Tungsten Co.LtdXiamen361010China Fujian Key Laboratory for Rare Earth Functional Materials Longyan366300China Ganjiang Innovation Academy Chinese Academy of ScienceGanzhou341000China National Rare Earth Function Materials Innovation Center Ganzhou341000China

In traditional Nd-Fe-B-based sintered magnets,the composition,role of each element and microstruc-tures have been extensively investigated globally since they were invented in ***,the effects of boron(B)content and post-sinter annealing(PSA)on the microstructure and magnetic properties have been least studied so far and the relative mechanisms are not yet *** this paper,we investigated the influence of B on the magnetic performance and microstructure of Nd-Fe-B sintered magnets origi-nally containing copper(Cu),gallium(Ga)and titanium(Ti).It is shown that the intrinsic coercivity has a substantial increment of 2.86 kOe and the remanence has a slight reduction of 0.16 kGs when B content is reduced from 0.980 wt.%to 0.900 wt.%.Moreover,there is a coercivity increment of 27.3%and 65.3%for samples with 0.980 wt.%and 0.900 wt.%B content after PSA,*** is shown that the im-pacts of B content and PSA are significant and their regulation mechanisms are worthwhile to be studied ***,it is revealed by microstructural analysis that high coercivity of the sample with 0.900 wt.%B after PSA results from the uniform distribution of Ga,Cu,Nd,and the formation of RE 6(Fe,M)14(RE=Pr,Nd,M=Cu,Ga)compound in triple junction *** dilution of Fe content in grain boundary phases(GB phases)also plays an important *** is found out that decrease of the re-manence is mainly due to reduction of the matrix phase and c-axis alignment *** this study,we explored a new path to develop Nd-Fe-B-based sintered magnets with high comprehensive properties by novel approaches through varying B content,PSA technique and co-adding trace elements.

关键词： Magnetic property RE_(6)(Fe,M)_(14) compound Nd-Fe-B sintered magnets Post-sinter annealing Regulation mechanism

Three-Dimensional M-Shaped Resection for Nasal Alar Hypertrophy in Asian Patients

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第1期3卷 1-4页

作者： Yiqing QIU qingfang ZHAO Zhixiong chen Yichen SHEN Mengmeng LUO Qiaoyun QIU Jinghong XU Department of Plastic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310000China

Background Nasal alarplasty is an important component of esthetic rhinoplasty in *** two main surgical techniques that correct alar hypertrophy by reducing the height or length often leave external scars and are associated with a high relapse *** We developed a new technique,called three-dimensional(3D)M-shaped resection,which corrects both the nasal alar height and length and simultaneously minimizes external *** performed this procedure from January 2013 to September 2016 in 49 consecutive female patients diagnosed with saddle nose and nasal alar *** mean age was 28.6(range,18–40)*** patients had previously undergone simple *** alar length and height,nostril length and width,and maximal nose width were analyzed preoperatively and postoperatively from *** After a mean of 9(range,3–24)months of follow-up,surgery was considered successful in 46 women(94%)with good cosmetic *** three patients,nasal alar hypertrophy recurred(6 months postoperatively).There were no early complications such as hematomas,infections,skin or mucosal necrosis,or wound *** mean reductions postoperatively were 1.7 mm and 0.9 mm for nasal alar length and height,respectively,1.6 mm for both nostril length and width,and 3.5 mm for nose *** The 3D M-shaped resection for nasal alar hypertrophy effectively reduced hypertrophy in 94%of patients for up to 24 months,producing minimal external scars and good cosmetic *** is a simple and convenient technique that is an effective and safe option for nasal alarplasty.

关键词： Nasal alar hypertrophy Three-dimensional M-shaped resection Invisible external scars