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Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 136-152页

作者： Xiaoju Guo Xiaoxiao chen Jiayi Ding Feng Zhang Shunyang chen Xin Hu Shiji Fang Lin Shen chenying Lu Zhongwei Zhao Jianfei Tu Gaofeng Shu minjiang chen Jiansong Ji Lishui Central Hospital Shaoxing UniversityShaoxing 312000China Zhejiang Key Laboratory of Imaging and Interventional Medicine Imaging Diagnosis and Interventional Minimally Invasive InstituteThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Clinical College of The Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000China Key Laboratory of Precision Medicine of Lishui Lishui 323000China

Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by the acidic and hypoxic tumor environment. Herein, we have successfully formulated PLGA-based nanoparticles concurrently loaded with doxorubicin (DOX), hemoglobin (Hb) and CaCO3 by a CaCO3-assisted emulsion method, aiming at the effective treatment of TNBC. We found that the obtained nanomedicine (DHCaNPs) exhibited effective drug encapsulation and pH-responsive drug release behavior. Moreover, DHCaNPs demonstrated robust capabilities in neutralizing protons and oxygen transport. Consequently, DHCaNPs could not only serve as oxygen nanoshuttles to attenuate tumor hypoxia but also neutralize the acidic tumor microenvironment (TME) by depleting lactic acid, thereby effectively overcoming the resistance to chemotherapy. Furthermore, DHCaNPs demonstrated a notable ability to enhance antitumor immune responses by increasing the frequency of tumor-infiltrating effector lymphocytes and reducing the frequency of various immune-suppressive cells, therefore exhibiting a superior efficacy in suppressing tumor growth and metastasis when combined with anti-PD-L1 (αPD-L1) immunotherapy. In summary, this study highlights that DHCaNPs could effectively attenuate the acidic and hypoxic TME, offering a promising strategy to figure out an enhanced chemo-immunotherapy to benefit TNBC patients.

关键词： CaCO3-based nanoparticles Hypoxia attenuation Acidity neutralization Reversal of chemotherapy resistance Enhanced chemo-immunotherapy

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影像组学在肝细胞癌研究中的应用进展

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肝胆胰外科杂志 2024年第1期36卷 59-64页

作者：徐晓飞陈敏江纪建松丽水市中心医院浙江省影像诊断与介入微创重点实验室/放射科浙江丽水323000

肝细胞癌(HCC)是全球范围内最常见的原发性肝癌类型,也是导致肝癌相关死亡的主要原因之一。传统的HCC诊断和鉴别方法存在一定的局限性,而影像组学作为一种新兴的技术手段,为HCC的识别检测、准确诊断、个体化治疗决策和预后预测提供了新... 详细信息

肝细胞癌(HCC)是全球范围内最常见的原发性肝癌类型,也是导致肝癌相关死亡的主要原因之一。传统的HCC诊断和鉴别方法存在一定的局限性,而影像组学作为一种新兴的技术手段,为HCC的识别检测、准确诊断、个体化治疗决策和预后预测提供了新的可能性。本文旨在对影像组学在HCC研究领域的最新应用进展进行综述。

关键词：影像组学肝细胞癌进展诊断预后

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Recent progresses on the new condensed forms of single-walled carbon nanotubes and energy-harvesting devices

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Chinese Science Bulletin 2012年第2期57卷 181-186页

作者： chen minjiang YU Fang HU LiJun SUN LianFeng National Center for Nanoscience and Technology Beijing 100190China Graduate School of Chinese Academy of Sciences Beijing 100049China

We demonstrate an effective method to prepare a new condensed form of single-walled carbon nanotubes(crystal of SWNTs) using a series of diamond wire drawing dies.X-ray diffraction indicates that the SWNTs form a two-dimensional triangular lattice with a lattice constant of 19.62 ?.An intertube spacing of 3.39 ? of between adjacent SWNTs results in a sharp(002) reflection in the X-ray diffraction ***,we developed an approach based on the Coulomb explosion to separate SWNTs from their *** separated SWNTs have a typical length of several microns and form a nanotree at one end of the original *** separation is convenient and involves no *** studying devices comprising SWNTs,we find that a four-probe technique can be employed to study the filling of and flow within the inner channel of an individual ***/voltage can drive water molecules to have directional flow along an SWNT,and the flowing of water inside an SWNT can induce a voltage gradient force(an induced electromotive force) along the *** energy conversion is realized by the mutual coupling of water dipoles and charge carriers present in *** results suggest that SWNTs can be exploited as molecular channels for water and may find potential application in nanoscale energy ***,a surface-energy generator comprising SWNTs was demonstrated to harvest the surface energy of *** performance(the induction rate for Voc,the value of Voc and the output power) can be significantly enhanced by the Marangoni effect.

关键词：单壁碳纳米管收集装置 Marangoni效应 X射线衍射分析感应电动势能源定向流动能量转换

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肺肉瘤样癌临床特征及预后分析

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中华结核和呼吸杂志 2024年第4期47卷 319-324页

作者：冯小艺陈闽江徐燕钟巍刘潇衍高晓星赵静王孟昭中国医学科学院北京协和医学院北京协和医院呼吸与危重症医学科北京100730

目的总结肺肉瘤样癌(PSC)患者的临床特征、治疗及转归,以提高临床对PSC的认识。方法回顾性分析2015年1月1日至2023年11月30日,在北京协和医院住院诊治、经病理确诊为PSC患者43例的临床资料,其中男32例,女11例,年龄26~87(62.79±9.59)岁... 详细信息

目的总结肺肉瘤样癌(PSC)患者的临床特征、治疗及转归,以提高临床对PSC的认识。方法回顾性分析2015年1月1日至2023年11月30日,在北京协和医院住院诊治、经病理确诊为PSC患者43例的临床资料,其中男32例,女11例,年龄26~87(62.79±9.59)岁。根据是否行根治性切除手术分为可手术切除组和不可手术组,比较2组患者肿瘤的特点及治疗方式。通过Kaplan-Meier法绘制生存曲线比较2组患者的预后。结果纳入的43例PSC患者中31例吸烟。肿瘤以周围型更常见,影像多以实性软组织团块影为主要表现,14例肿块最大径>5 cm。在23例完善NGS基因检测的患者中,KRAS突变率为43.5%,TP53突变率30.4%,MET突变率为8.7%,均为MET-14外显子跳跃突变。13例进行了PD-L1表达检测,其中10例高表达。43例平均OS为24.6个月(13.0~52.7个月)。其中,22例行根治性肺叶切除加纵隔淋巴结清扫术,13例随访期间出现术后复发,7例死亡;平均DFS为12.3个月,未达到平均OS,1年OS率为77.3%。21例处于不可手术切除的局部晚期或晚期,15例死亡;平均PFS为2.5个月,平均OS为6.2个月,1年OS率为42.9%。17例接受了免疫治疗,1例接受了MET抑制剂谷美替尼靶向治疗。结论PSC在老年、吸烟、男性中发生率更高,是一种恶性程度高、预后较差的NSCLC,基于其分子生物学的特征,可进行PD-L1和肿瘤分子检测来指导治疗。

关键词：癌,肉瘤样预后临床特点免疫治疗靶向治疗

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Studies on the properties of surface and edges of N-layer graphenes

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Science China(Physics,Mechanics & Astronomy) 2011年第10期54卷 1729-1738页

作者： chen minjiang ZHOU HaiQing QIU CaiYu YANG HuaiChao YU Fang SUN LianFeng National Center for Nanoscience and Technology Beijing 100190 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Tsinghua University Beijing 100084 China peking University Beijing 100871 China

Graphene, a new two-dimensional carbon material, is a rising star of physics, chemistry and materials science. In this work, we report the recent experimental researches on the Raman spectra and the temperature-dependent features of graphenes and car- bon nanoscrolls, which are evolved from graphene and have an open tubular structure. The layer-dependent Raman enhancing characteristics of n-layer graphenes for crystal violet, and the thickness-dependent morphologies of gold on n-layer graphenes are also systematically investigated. Meanwhile, the aggregations of ferromagnetic and paramagnetic atoms at edges of gra- phenes and graphite are observed and the mechanisms are discussed.

关键词： N-layer graphene Raman spectroscopy edge ferromagnetism

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^(125)I放射性粒子条联合胆道支架与单纯胆道支架植入治疗恶性胆道梗阻的术后院内感染发生率及临床疗效的对照研究

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中华介入放射学电子杂志 2024年第2期12卷 144-149页

作者：陈丽陈敏江任建敏谢艳茹涂建飞纪建松温州医科大学附属第五医院(丽水市中心医院)肿瘤中心浙江丽水323000 浙江省影像诊断与介入微创研究重点实验室温州医科大学附属第五医院(丽水市中心医院)检验科

目的回顾性研究联合组[^(125)I(iodine)粒子条+胆道支架]及常规组(单纯胆道支架组)治疗恶性胆道梗阻(malignant biliary obstruction,MBO)的术后院内感染发生率及临床疗效。方法收集2019年4月至2022年6月期间因MBO就诊于温州医科大学附... 详细信息

目的回顾性研究联合组[^(125)I(iodine)粒子条+胆道支架]及常规组(单纯胆道支架组)治疗恶性胆道梗阻(malignant biliary obstruction,MBO)的术后院内感染发生率及临床疗效。方法收集2019年4月至2022年6月期间因MBO就诊于温州医科大学附属第五医院(丽水市中心医院)且经皮肝穿刺胆道引流术(percutaneous transhepatic cholangial drainage,PTCD)序贯行胆道支架植入的128例(联合组70例、常规组58例)MBO患者的临床资料,所有病例PTCD术中获取胆汁,术后监测相关指标及不良事件情况,分析2组的术后院内感染发生率、术后总胆红素下降速率、支架通畅时间、不良事件发生率等。结果2组术后院内感染发生率比较,差异无统计学意义(8.5%∶8.6%;P>0.05);WBC(blood cell count)计数>10×10^(9)/L者较WBC计数≤10×10^(9)/L者,PTCD术中胆汁阳性率相对更高(48%∶26.2%;P10×109/L者胆汁阳性率更高,该类患者建议及早使用抗生素;胆道常见病原体前3位分别为肺炎克雷伯菌、大肠杆菌、铜绿假单胞菌。

关键词：院内感染胆道感染胆道梗阻胆道支架

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输尿管周围静脉环致尿路梗阻1例

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中华全科医师杂志 2024年第9期23卷 980-982页

作者：高瑞杰纪建松陈家骏陈敏江余日胜浙江大学医学院附属第二医院放射科杭州310009 浙江大学丽水医院放射科丽水323000

输尿管周围静脉环是一种罕见的下腔静脉变异。报道1例输尿管周围静脉环致尿路梗阻的患者的诊治过程, 旨在提高临床医生对该病的认识。

关键词：腔静脉,下螺旋锥束计算机体层摄影术输尿管梗阻

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Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

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Frontiers of Medicine 2021年第6期15卷 933-937页

作者： Chun Bian Xinyue Zhao Yaping Liu minjiang chen Shuying Zheng Xinlun Tian Kai-Feng Xu Department of Internal Medicine State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China Department of Pulmonary and Critical Care Medicine State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100730China Department of Electron Microscope Laboratory Peking University People’s HospitalBeijing100034China

Neurofibromatosis(NF)is a genetic disease in which the lungs are rarely ***,in NF cases with lung involvement,chest computed tomography may show bilateral basal reticulations,apical bullae,and cysts without ***,we report a patient diagnosed with NF on the basis of the results of genetic testing who presented with early-onset wet cough and *** the differential diagnosis of bronchiectasis combined with his early-onset wet cough,sinusitis,and sperm quality decline,we considered the possibility of primary ciliary dyskinesia(PCD).Further electron microscopy analysis of cilia and identification of homozygous mutations in the RSPH4A gene confirmed the diagnosis of ***,for patients with NF,when an image change exists in the lungs that does not correspond to NF,the possibility of other diagnoses,including PCD,must be considered.

关键词： primary ciliary dyskinesia neurofibromatosis bronchiectasis transmission electron microscopy genetic sequencing

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Fucoidan-based dual-targeting mesoporous polydopamine for enhanced MRI-guided chemo-photothermal therapy of HCC via P-selectin-mediated drug delivery

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Asian Journal of Pharmaceutical Sciences 2022年第6期17卷 908-923页

作者： Gaofeng Shu Lin Shen Jiayi Ding Junchao Yu Xiaoxiao chen Xiaoju Guo Enqi Qiao Yaning chen chenying Lu Zhongwei Zhao Yongzhong Du minjiang chen Jiansong Ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention ResearchThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Department of radiology Lishui Hospital of Zhejiang UniversitySchool of MedicineLishui 323000China Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Shaoxing University School of Medcine Shaoxing 312000China

The development of novel theranostic agents with outstanding diagnostic and therapeutic performances is still strongly desired in the treatment of hepatocellular carcinoma(HCC).Here,a fucoidan-modified mesoporous polydopamine nanoparticle dual-loaded with gadolinium iron and doxorubicin(FMPDA/Gd^(3+)/DOX)was prepared as an effective theranostic agent for magnetic resonance imaging(MRI)-guided chemo-photothermal therapy of *** was found that FMPDA/Gd^(3+)/DOX had a high photothermal conversion efficiency of 33.4%and excellent T1-MRI performance with a longitudinal relaxivity(r1)value of 14.966 m M^(-1)·s^(-1).Moreover,the results suggested that FMPDA/Gd^(3+)/DOX could effectively accumulate into the tumor foci by dual-targeting the tumor-infiltrated platelets and HCC cells,which resulted from the specific interaction between fucoidan and overexpressed p-selectin *** excellent tumor-homing ability and MRI-guided chemo-photothermal therapy therefore endowed FMPDA/Gd^(3+)/DOX with a strongest ability to inhibit tumor growth than the respective single treatment ***,our study demonstrated that FMPDA/Gd^(3+)/DOX could be applied as a potential nanoplatform for safe and effective cancer theranostics.

关键词： Mesoporous polydopamine Fucoidan P-selectin target Platelets bridge Cancer theranostics

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Thickness-dependent morphologies of Ag on n-layer MoS2 and its surface-enhanced Raman scattering

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Nano Research 2016年第6期9卷 1682-1688页

作者： Ya Deng minjiang chen Jian Zhang Zihao Wang Wenbin Huang Yun Zhao Jean PierreNshimiyimana Xiao Hu Xiannian Chi Gu Hou ,Xueyao Zhang Yanjun Guo Lianfeng Sun CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology 8eijing 100190 China School of Physics Shandong University Jinan 250100 China Chinese Academy of Sciences Beijing 100049 China

The size and density of Ag nanoparticles on n-layer MoS2 exhibit thickness- dependent behavior. The size and density of these particles increased and decreased, respectively, with increasing layer number （n） of n-layer MoS2. Furthermore, the surface-enhanced Raman scattering （SERS） of Ag on this substrate was observed. The enhancement factor of this scattering varied with the thickness of MoS2. The mechanisms governing the aforementioned thickness dependences are proposed and discussed.

关键词： MoS2 nanoparticle thickness-dependent surface-enhanced Ramanscattering (SERS)

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