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Journal of Geriatric Cardiology 2014年第1期11卷 39-43页

作者： Jin-Da WANG hua-wei ZHANG Qian XIN Jun-Jie yang Zhi-Jun SUN Hong-Bin LIU Lianchen Luo-Shan DU Yun-dai chen Department of Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China

Background In order to acquire a high quality image with a low radiation dose, prospective electrocardiogram （ECG）-triggered computed tomography coronary angiography （CTCA） requires a stable heart rate （HR）〈 65 beats/min. Esmolol has the advantage of reduc-ing HR. The objective of this article is to assess the value of intravenous esmolol treatment before prospective ECG-tr/ggered high-pitch spiral acquisition for CTCA. Methods From March 2013 to June 2013, 313 patients underwent prospective ECG-triggered CTCA. Two hundred and thirty two of them received esmolol before angiography. We retrospectively analyzed clinical characteristics, esmolol dose, radiation exposure dose, and the change in HR and blood pressure in these 232 patients. Results A total of 232 patients with a HR 〉 65 beats/rain before CTCA examination received intravenous esmolol treatment （mean dose of 57.26±15.39 rag）, The mean initial HR （HR1）, slowest HR （HR2）, and the HR 30 min after HR2 （HR3） were 75.06± 5.59, 60.75 ±4.00, and 75.54 ± 5.96 beats/min, respectively （HR1 vs. HR2, P 〈 0.0001; HRI vs. HR3, P = 0.377）. The mean time from esmolol administration to HR2 was 24.25 ± 4.97 s and the mean effective radiation dose was 2.28 ± 0.02 mSv. Conclusions HR could be rapidly controlled at an optimum level with intravenous esmolol before prospective ECG-triggered high-pitch spiral acquisition for CTCA. Consequently, the patients received a very low radiation dose.

关键词： Esmolol Electrocardiogram Coronary angiography Heart rate

短时程脊髓电刺激对药物治疗无效的急性带状疱疹神经病理性疼痛和运动麻痹的疗效观察

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生物医学工程与临床 2024年第3期28卷 376-380页

作者：慕玮瑶史春雨吴纯高献忠王然华敏徐晨婕徐州医科大学麻醉学院江苏徐州221004 南京医科大学附属南京医院麻醉疼痛与围术期医学科江苏南京210002

目的探讨短时程脊髓电刺激(st-SCS)治疗药物无效的急性带状疱疹神经病理性疼痛和肢体运动麻痹的临床疗效。方法选择2019年8月1日至2023年6月30日于南京医科大学附属南京医院疼痛科门诊收治的药物治疗无效的中重度急性带状疱疹神经痛(疱... 详细信息

目的探讨短时程脊髓电刺激(st-SCS)治疗药物无效的急性带状疱疹神经病理性疼痛和肢体运动麻痹的临床疗效。方法选择2019年8月1日至2023年6月30日于南京医科大学附属南京医院疼痛科门诊收治的药物治疗无效的中重度急性带状疱疹神经痛(疱疹起始后1个月内)的34例患者,其中男性15例,女性19例;年龄51~73岁,平均年龄62.6岁;带状疱疹肢体麻痹累及单侧上肢21例,累及单侧下肢13例。接受st-SCS治疗,对治疗效果进行了回溯性分析,分别记录治疗前后各时间节点的疼痛程度的数字评定量表(NRS)评分、匹兹堡睡眠质量指数(PSQI)和疱疹累及的上肢腋神经、正中神经、尺神经及下肢股神经、腓肠神经在运动和感觉方面的神经传导速度(MNCV、SNCV),以及肌力评定量表(MRC)评级记录肌力变化详情。同时记录电刺激治疗周期内出现的不良反应。结果治疗前NRS为(8.2±0.8)分,治疗后14 d、1个月、3个月、6个月NRS评分显著下降[(4.3±1.1)分、(2.9±1.1)分、(2.3±0.9)分、(1.9±0.9)分],差异有显著统计学意义(t=16.52、22.45、27.62、29.60,P<0.001)。治疗前PSQI为14.6±1.6,治疗后3个月、6个月PSQI逐渐下降(5.6±1.1、3.9±0.8),差异有显著统计学意义(t=25.12、32.30,P<0.001)。说明睡眠质量也得到了显著的改善。治疗后3、6个月患者尺神经、正中神经及累及下肢股神经MNCV较治疗前有显著提高(P<0.001),且尺神经、腋神经和股神经SNCV较治疗前差异有统计学意义(P<0.05)。治疗后1、3、6个月,MRC评分逐步提高[(36.4±2.9)分、(38.6±3.7)分、(39.7±3.9)分],较治疗前差异有显著统计学意义(P<0.001)。结论st-SCS可以缓解急性带状疱疹神经痛并且促进受损神经的修复,改善肌力和提高睡眠质量,且不良反应少、安全性高。

关键词：短时程脊髓电刺激急性期带状疱疹运动麻痹疼痛神经传导速度

Systematic Review of Acupuncture for Functional Constipation

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Journal of Acupuncture and Tuina Science 2014年第2期12卷 89-95页

作者： Zhang wei Sun Jian-hua Pei Li-xia wu Xiao-liang chen Lu Jiao dai-yan Hong Jue The Second Clinical Medical School of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Traditional Chinese Medicine

Objective： To systematically analyze the therapeutic efficacy and safety of acupuncture in treating functional constipation （FC）. Methods： By searching the Cochrane Library, PubMed, Web of Science, Embase, CBM, CNKI, WanFang databases, the randomized controlled trials （RCTs） comparing acupuncture with Western medication in treating FC were retrieved, from the inception of the databases to September 2013. When the literatures were arranged according to the inclusion and exclusion criteria, and the methodological qualities were evaluated, RevMan 5.2 was adopted for meta-analysis. Results： Ten RCTs were included, covering 1 041 cases of FC. The meta-analysis showed that there was no significant difference in comparing spontaneous bowel movements per week between shallow acupuncture at Tianshu （ST 25） and Western medication [MD=0.47, 95% CI （-1.28, 0.34）]; there was a significant difference in comparing the spontaneous bowel movements per week between deep acupuncture at Tianshu （ST 25） and Western medication [MD =0.53, 95% CI （0.13, 0.92）], but the difference was insignificant according to the sensitivity analysis [MD=0.38, 95% Cl （-0.03, 0.80）], indicating the low reliability of the conclusion. Regarding the Cleveland clinic score （CCS）, the difference between shallow acupuncture at Tianshu （ST 25） and Western medication was insignificant [MD = 0.39, 95% Cl （-1.13, 1.91）]; the difference between deep acupuncture at Tianshu （ST 25） and Western medication was significant [MD=2.64, 95% Cl （1.32, 3.97）]. In the evaluation of security, the incidence rate of adverse events in acupuncture treatment （0.31%） was significantly lower than that in Western medication treatment （3.4%）. Conclusion： Although the present systematic review showed that deep acupuncture at Tianshu （ST 25） should have better therapeutic efficacy than Western medication, the reliability and quality of the evidences were poor, and thus the above results require proving by more RCTs of higher quality.

关键词： Acupuncture Therapy Constipation Randomized Controlled Trial System Review

Synthesis,crystal structures and luminescence properties of europium and terbium picolinamide complexes

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Chinese Chemical Letters 2014年第6期25卷 887-891页

作者： Jun-Hui Xue Xiao-Hui hua Li-min yang wei-Hong Li Yi-Zhuang Xu Guo-Zhong Zhao Gao-Hui Zhang Ke-Xin Liu Jia-Er chen Jin-Guang wu Beijing National Laboratory for Molecular Sciences State Key Laboratory for Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry andMolecular EngineeringPeking University Department of Chemistry Renmin University of China State Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsSchool of PhysicsPeking University Department of Physics Capital Normal University

The novel coordination structures of europium and terbium chloride-picolinamide complexes （EuCl3-（C6H6N2O）2.5H2O, Eu-pa and TbCl3.（C6H6N2O）2.5H2O, Tb-pa） are reported. The crystal structures in the solid state are characterized by X-ray single crystal diffraction, FTIR, Raman, FIR, THz and luminescence spectroscopy. In the crystal structures, the pyridyl nitrogen and carbonyl oxygen atoms in picolinamide are coordinated to the metal ions to form a five-membered ring structure. The experimental results indicate the similar coordination structures of Eu and Tb-pa complexes and the changes of hydrogen bonds and conformation provide models for the coordination structures of the ligands induced by complexation. The results of lanthanide ions with ligands having amide groups.

关键词： Picolinamide FT-IR Complexation Crystal structure THz

Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency

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World Journal of Gastroenterology 2014年第2期20卷 498-508页

作者： ying-Yin Ni Yan chen Shun-Yuan Lu Bi-ying Sun Fang Wang Xiao-Lin wu Su-ying Dang Guo-hua Zhang Hong-Xin Zhang Yin Kuang Jian Fei ming-min Gu wei-Fang Rong Zhu-Gang Wang Department of Medical Genetics E-Institutes of Shanghai UniversitiesShanghai Jiao Tong University School of Medicine Research Centre for Experimental Medicine Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine Department of Physiology Shanghai Jiao Tong University School of Medicine Shanghai Research Centre for Model Organisms

AIM: To generate a Gpr128 gene knockout mouse model and to investigate its phenotypes and the biological function of the Gpr128 gene.

关键词： G-protein-coupled receptors Gpr128 Knockout mouse weight loss Intestinal contraction frequency

Diagnosis and treatment of herpangina:Chinese expert consensus

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World Journal of Pediatrics 2020年第2期16卷 129-134页

作者： Hui Yu Xing-Wang Li Quan-Bo Liu Hui-Ling Deng Gang Liu Rong-Meng Jiang Ji-Kui Deng ying-Zi Ye Jian-hua Hao ying-Hu chen Guang-min Nong Zhao-Bo Shen Chang-Shan Liu ying-Xue Zou Jin-Zhun wu Xing-Dong wu Bi-Quan chen Ru-Ping Luo Ai-wei Lin Yan chen Xiao-Dong Liu Department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina Infectious Disease Diagnosis and Treatment Center Beijing Ditan Hospital Capital Medical UniversityBeijingChina Department of Infectious Diseases Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Infectious Diseases The Children's Hospital of Xi'anXi'anChina Department of Infectious Diseases Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases Shenzhen Children's HospitalShenzhenChina Department of Internal Medicine Children's Hospital of Kaifeng CityKaifengChina Department of Infectious Diseases The Children's Hospital-Zhejiang University School of MedicineHangzhouChina Department of Pediatrics The First Affiliated Hospital of Guangxi Medical UniversityGuangxiChina Pneumology Department Henan Children's HospitalHenanChina Department of Pediatrics The Second Hospital of Tianjin Medical UniversityTianjinChina Department of Infectious Diseases Tianjin Children's HospitalTianjinChina Department of Pediatric Pneumology The First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Pediatrics Xiamen Maternal and Child Health Care HospitalXiamenChina Department of Infectious Diseases Anhui Provincial Children's HospitalHefeiChina Department of Infectious Diseases Hunan Children's HospitalHunanChina Department of Infectious Diseases Qilu Children's Hospital of Shandong UniversityShandongChina Department of Pediatrics Internal Medicine Affiliated Hospital of Zunyi Medical UniversityZunyiChina

Background Herpangina is a common infectious disease in childhood caused by an *** consensus is aiming to standardize and improve herpangina prevention and clinical *** The Subspecialty Group of Infectious Diseases,the Society of Pediatric,Chinese Medical Association and Nation Medical Quality Control Center for Infectious Diseases gathered 20 experts to develop the consensus,who are specialized in diagnosis and treatment of *** The main pathogenic serotypes of herpangina include Coxsackievirus-A,Enterovirus-A and *** diagnosis can be rendered on the basis of history of epidemiology,typical symptoms,characteristic pharyngeal damage and virological *** treatment is mainly symptomatic,and incorporates topical oral spray with antiviral *** course of herpangina generally lasts 4-6 days with a good *** The consensus could provide advices and references for the diagnosis,treatment and management of herpangina in children.

关键词： Herpangina Diagnosis Treatment Consensus

牛病毒性腹泻病毒E2蛋白的真核表达及间接ELISA抗体检测方法的建立

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动物医学进展 2024年第4期45卷 51-56页

作者：刘丹黄小洁吴华伟孙淼陈延飞秦义娴侯力丹薛麒中国兽医药品监察所北京100081

为建立检测牛病毒性腹泻病毒(Bovine viral diarrhea virus,BVDV)抗体的间接ELISA方法,利用昆虫细胞真核表达系统成功表达E2蛋白,将纯化后的E2蛋白作为包被抗原,用方阵滴定方法对影响ELISA的各个因素进行优化,并进行特异性、敏感性和重... 详细信息

为建立检测牛病毒性腹泻病毒(Bovine viral diarrhea virus,BVDV)抗体的间接ELISA方法,利用昆虫细胞真核表达系统成功表达E2蛋白,将纯化后的E2蛋白作为包被抗原,用方阵滴定方法对影响ELISA的各个因素进行优化,并进行特异性、敏感性和重复性试验。结果表明,在昆虫细胞中表达了BVDV E2蛋白,Western blot证实目的蛋白可与BVDV阳性血清发生特异性反应。ELISA优化结果显示,E2蛋白最佳包被浓度为0.5μg/mL,最佳封闭液为1%明胶,最佳血清稀释度为1∶400,最佳血清作用方式为37℃作用30 min,酶标抗体的最佳作用方式为1∶2000稀释、37℃作用30 min,最佳底物作用时间为室温20 min,阳性临界值为OD 450≥0.423。与血清中和试验法进行比较,总符合率为97.8%,板内和板间重复性试验的变异系数均小于10%。该方法与牛常见病毒阳性血清均无交叉反应。说明建立的间接ELISA抗体检测方法特异性、敏感性和重复性良好,可用于大批量样本的临床检测和流行病学研究。

关键词：牛病毒性腹泻病毒 E2蛋白间接ELISA 抗体检测

Intraperitoneal hemorrhage during and after percutaneous radiofrequency ablation of hepatic tumors: reasons and management

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中华医学杂志(英文版) 2005年第20期 12-17页

作者： chen min-hua, dai ying, YAN Kun, yang wei, GAO Wen, wu wei, LIAO Sheng-ri and HAO Chun-yi Department of Ultrasound, School of Oncology, Peking University, Beijing 100036, China Department of Surgery, School of Oncology, Peking University, Beijing 100036, China

Background Introperitoneal hemorrhage is one of the mos t common complications of radiofrequency (RF) ablation of hepatic tumors. This study was designed to investigate the reason and management of intraperitoneal h emorrhage occurred during or after percutaneous RF ablation of hepatic tumors. Methods Three hundred and fifty-six patients with hepatic tumo rs have been treated at 592 procedures of ultrasound guided RF ablation. Intrap eritoneal hemorrhage occurred in 5 patients (0.8%). The reasons and management of intraperitoneal hemorrhage in these 5 cases were retrospectively analyzed. Results Two patients with liver metastasis and one hepatocellul ar carcinoma (HCC) patient suffered from hemorrhage during the RF treatment. Tw o patients with recurrent HCC after surgery developed hemorrhage 20 minutes or 4 hours after RF treatment. One case of hemorrhage was due to the inappropriate electrode positioning induced liver laceration while treating a 1 cm liver metas tasis near the liver capsule. One was due to the injury of a small vessel by th e RF needle in another liver metastasis patient. Three cases were due to tumor rupture with two cases induced by cough or position change after treating large protruding HCC lesions. Four (80%) of the 5 cases of hemorrhage were rapidly id e ntified by ultrasound. The causes and sites of bleeding during the RF treatment in three cases were confirmed through ultrasound, which were successfully treat ed using RF coagulation to achieve hemostasis of the bleeding site. Two patient s with post-ablation hemorrhage recovered in one hour and 24 hours, respectivel y after given blood transfusion and other conservative measures. No surgical in tervention was required. Two patients died of wide spread metastasis 23-36 mon ths afterwards and the other three patients have lived for 18-25 months to date . Conclusions It is important to perform close monitoring during and after RF ablation in order to identify intraperitoneal hemorrhage in tim

关键词： liver neoplasm · radiofrequency ablation · compl ication · intraperitoneal hemorrhage · ultrasound

Patterns of Soil ^(15)N and Total N and Their Relationships with Environmental Factors on the Qinghai-Tibetan Plateau

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Pedosphere 2014年第2期24卷 232-242页

作者： ZHOU Lei SONG ming-hua WANG Shao-Qiang FAN Jiang-Wen LIU Ji-Yuan ZHONG hua-Ping YU Gui-Rui GAO Lu-Peng HU Zhong-min chen Bin wu wei-Xing SONG Ting Key Laboratory of Ecosystem Network Observation and Modelling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences University of Chinese Academy of Sciences

The patterns of soil nitrogen （N） isotope composition at large spatial and temporal scales and their relationships to environmental factors illustrate N cycle and sources of N, and are integrative indicators of the terrestrial N cycle and its response to global change. The objectives of this study were： i） to investigate the patterns of soil N content and natural abundance of 15N （δ15N） values in different ecosystem types and soil profiles on the Qinghai-Tibetan Plateau; ii） to examine the effects of climatic factors and soil characteristics on the patterns of soil N content and soil δ15N values; and iii） to test the relationship between soil δ15N values and soil C/N ratios across ecosystems and soil profiles. Soil profiles were sampled at 51 sites along two transects 1 875 km in length and 200 km apart and distributed in forest, meadow and steppe on the Qinghai-Tibetan Plateau. Each site was sampled every 10 cm from a soil depth of 0 to 40 cm and each sample was analyzed for soil N content and δ15N values. Our results indicated that soil N and 515N values （0-40 cm） in meadows were much higher than in desert steppe. Soil N decreased with soil depth for each ecosystem, while variations of soil ~15N values along soil profiles were not statistically significant among most ecosystems but for mountain meadow, lowland meadow, and temperate steppe where soil δ15N values tended to increase with soil depth. The parabolic relationship between soil δ15N values and mean annual precipitation indicated that soil δ15N values increased with increasing precipitation in desert steppe up to 500 mm, and then decreased with increasing precipitation across all other ecosystems. Moreover, the parabolic relationship between δ15N values and mean annual temperature existed in all individual ecosystem types. Soil N and δ15N values （0-0 cm） increased with an increase in soil silt and clay contents. Furthermore, a threshold of C/N ratio of about 11 divided the parabolic relationship between soi

关键词： desert steppe nitrogen isotope composition nutrient availability soil nitrogen

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撬拨复位内固定治疗老年股骨转子间骨折

临床骨科杂志 2024年第4期27卷 548-550页

作者：王昱晨杨胜鑫郑小罕吴建华刘志伟刘钢贵州医科大学附属医院创伤骨科贵州贵阳550001 兴义市人民医院创伤骨科贵州兴义562400

目的探讨撬拨复位内固定治疗老年股骨转子间骨折的疗效。方法采用撬拨复位内固定治疗72例老年股骨转子间骨折患者。记录手术时间、骨折复位情况、术后并发症发生情况、骨折愈合时间、髋关节活动度,采用Harris评分评价髋关节功能恢复情... 详细信息

目的探讨撬拨复位内固定治疗老年股骨转子间骨折的疗效。方法采用撬拨复位内固定治疗72例老年股骨转子间骨折患者。记录手术时间、骨折复位情况、术后并发症发生情况、骨折愈合时间、髋关节活动度,采用Harris评分评价髋关节功能恢复情况。结果患者均获得随访,时间12~24个月。术后X线片显示骨折均达解剖复位。手术时间25~50 min,其中通过辅助切口撬拨复位时间2~5 min。术后无心力衰竭、下肢静脉血栓及谵妄等并发症发生。骨折均愈合,时间7~10个月。末次随访时,髋关节屈曲110°~135°,超伸5°~15°;髋关节Harris评分70~95分,其中优64例,良6例,可2例,优良率97.2%。结论撬拨复位内固定治疗老年股骨转子间骨折,可使骨折快速解剖复位,有效缩短手术时间,更利于患者髋关节功能恢复。

关键词：股骨转子间骨折撬拨复位髓内钉老年人