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Ten-year survival of hepatocellular carcinoma patients undergoing radiofrequency ablation as a first-line treatment

World Journal of Gastroenterology 2016年第10期22卷 2993-3005页

作者： wei yang Kun Yan S Nahum Goldberg Muneeb Ahmed Jung-Chieh Lee wei wu Zhong-Yi Zhang Song Wang min-hua chen Key Laboratory of Carcinogenesis and Translational Research (ministry of Education) Department of UltrasoundPeking University Cancer Hospital and Institute Division of Image-guided Therapy Department of RadiologyHadassah Hebrew University Medical Center Laboratory for minimally Invasive Tumor Therapies Department of RadiologyBeth Israel Deaconess Medical Center/Harvard Medical School

AIM: To investigate the long-term survival and prognostic factors in hepatocellular carcinoma (HCC) patients undergoing radiofrequency ablation (RFA) as a first-line ***: From 2000 to 2013, 316 consecutive patients with 404 HCC (1.0-5.0 cm; mean: 3.2 ± 1.1 cm) underwent ultrasonography-guided percutaneous RFA as a first-line treatment. There were 250 males and 66 females with an average age of 60.1 ± 10.8 years (24-87 years). Patients were followed for 1 year to > 10 years after RFA (234, 181, 136, and 71 for 3, 5, 7, and 10 years, respectively). Overall local response rates and long-term survival rates were assessed. Survival results were generated using Kaplan-Meier estimates, and multivariate analysis was performed using the Cox regression ***: In total, 548 RFA sessions were performed and major complications occurred in 10 sessions (1.8%). Local tumor progression and/or new tumor development were observed in 43.3% (132/305) of the patients during the follow-up period. Overall 5- and 10-year survival rates were 49.7% and 28.4%, respectively. Based on multivariate analysis, three factors were identified as independent prognostic factors for overall survival: Child-Pugh classification (HR = 4.054, P < 0.001), portal vein hypertension (HR = 2.743, P = 0.002), and tumor number (HR = 2.693, P = 0.003). The local progression-free 5- and 10-year survival rates were 42.7% and 19.5%. In addition to the Child-Pugh classification and the number of tumors, the number of RFA sessions (HR = 1.550, P = 0.002) was associated with local progression-free ***: RFA can achieve acceptable outcomes for HCC patients as a first-line treatment, especially for patients with Child-Pugh class A, patients with a single tumor and patients without portal vein hypertension.

关键词： Radiofrequency ablation Hepatocellular carcinoma Percutaneous Ultrasonography-guided Long term survival

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Influence of gallic acid on porcine neutrophils phosphodiesterase 4,IL-6,TNF-α and rat arthritis model

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Journal of Integrative Agriculture 2015年第4期14卷 758-764页

作者： JIANG dai-xun ZHANG Mei-hua ZHANG Qian chen Yi-shan MA Wen-jing wu wei-peng MU Xiang chen wu Beijing Key Laboratory of Traditional Chinese Veterinary Medicine Beijing University of Agriculture

Our previous studies showed that the anti-inflammatory effects of Paeonia lactiflora roots extract may be mediated, at least in part, through its gallic acid content, and this effect may be regulated in part by an inhibition on c AMP-phosphodiesterase（PDE）. To explore the anti-inflammatory effect and mechanism, the influence of gallic acid on neutrophils PDE4 activity and expression, TNF-α and IL-6 content and rat arthritis model were further studied. PDE4 activity and gene express were calculated respectively by substrate c AMP change examined with HPLC and real-time RT-PCR. The concentration of IL-6 and TNF-α in supernatant were assayed by ELISA method. Model of rat arthritis was caused by complete Freund＇s adjuvant. Results showed that gallic acid had a dose-dependent restraint on PDE4 activity of neutrophils in vitro, promoted significantly PDE4 A expression（P〈0.01）, and had no influence on the expressions of PDE4 B and 4D. However, PDE4 C expression was not detected. Gallic acid could promote IL-6 release（P〈0.05）, and inhibit TNF-α release of neutrophils（P〈0.05）. The experiment in vivo showed that gallic acid had obvious restraint on local inflammation of animal model（P〈0.05）. Therefore, the anti-inflammatory effect of gallic acid may be mediated in part through an inhibition on PDE4 activity and further an increase of IL-6 and a decrease of TNF-α of neutrophils, and this effect seemed to have no relationship with PDE4 expression.

关键词： gallic acid phosphodiesterase 4 inflammation IL-6 TNF-α neutrophils

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解毒活血汤调控YAP/ACSL4通路抑制铁死亡治疗急性肾损伤的作用与机制研究

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中国中药杂志 2024年第1期49卷 151-161页

作者：程冉田瑞敏黄丽华王晓婉郭珊吴爱君黎创陈静李淑菊陈明毛炜徐鹏广州中医药大学第二附属医院&广东省中医院省部共建中医湿证国家重点实验室广东广州510120 广州中医药大学第二临床医学院广东广州510405 广东省中医药科学院广东广州510006 澳门科技大学中医药学院中国澳门999078 黑龙江省中医药科学院黑龙江哈尔滨150036

解毒活血汤出自王清任《医林改错》,是国医大师张琪教授根据急性肾损伤(acute kidney injury,AKI)热毒瘀滞病机从古方中筛选出应用临床数十年的有效方剂,该文拟从调控铁死亡(ferroptosis)角度阐释解毒活血汤对AKI的治疗作用及其潜在机... 详细信息

解毒活血汤出自王清任《医林改错》,是国医大师张琪教授根据急性肾损伤(acute kidney injury,AKI)热毒瘀滞病机从古方中筛选出应用临床数十年的有效方剂,该文拟从调控铁死亡(ferroptosis)角度阐释解毒活血汤对AKI的治疗作用及其潜在机制。将32只雄性C57BL/6小鼠随机分为4组:正常组、模型组及解毒活血汤低、高剂量组,每组8只。由于临床AKI的治疗普遍以支持或替代疗法为主,尚无特效药,故该实验未设置阳性药物组。解毒活血汤低剂量组对应0.5倍的临床等效剂量,高剂量组则对应临床等效剂量,予以每日晨间灌胃,连续干预7 d;正常组及模型组小鼠分别灌以相应体积的纯水。给药第5天时,除正常组外其余各组小鼠均按20 mg·kg^(-1)的剂量腹腔注射顺铂溶液进行造模,正常组给予生理盐水注射。造模72 h后取材,留取小鼠血清及肾脏组织,检测血清肌酐(serum creatinine,Scr)、尿素氮(blood urea nitrogen,BUN)水平以评价小鼠肾脏功能变化;酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)法检测血清肾损伤分子1(kidney injury molecule 1,KIM-1)的表达水平;苏木素-伊红(hematoxylin-eosin,HE)染色法观察小鼠肾组织病理学改变;过碘酸雪夫(periodic acid-Schiff,PAS)染色法观察肾脏糖原沉积变化;普鲁士蓝染色观察肾组织铁沉积水平;生化比色法检测肾组织中还原型谷胱甘肽(glutathione,GSH)含量、超氧化物歧化酶(superoxide dismutase,SOD)以及过氧化氢酶(catalase,CAT)活力。采用Wes-tern blot法检测小鼠肾组织中酰基辅酶A合成酶长链家族成员4(acyl-CoA synthetase long chain family member 4,ACSL4)、溶血磷脂酰胆碱酰基转移酶3(lysophosphatidylcholine acyltransferase 3,LPCAT3)及Hippo通路关键分子Yes相关蛋白(Yes-associated protein,YAP)蛋白表达;免疫组化法检测YAP在肾组织中的定位与相对表达;再采用实时荧光定量PCR法检测ACSL4及谷胱甘肽过氧化物酶4(glutathione peroxidase 4,GPX4)mRNA表达。结果显示,与正常组相比,顺铂诱导的AKI小鼠血清中Scr、BUN、KIM-1水平显著升高;肾组织病理显示,模型组小鼠肾小管上皮细胞发生显著萎缩坏死脱落,肾小管刷状缘消失,管内大量蛋白管型填充,小管空泡样变性,肾间质增宽且可见水肿,肾脏结构严重损伤,肾小管损伤评分显著升高;肾组织部分区域有明显的铁沉积;肾组织GSH含量、SOD及CAT活力显著降低;同时,肾组织中铁死亡标志分子ASCL4、LPCAT3显著升高,GPX4显著降低,YAP显著上调。与模型组相比,高剂量解毒活血汤可有效保护肾脏功能,降低Scr、BUN、KIM-1水平,减轻肾脏病理损伤及糖原沉积和铁沉积;提升肾组织中GSH含量、SOD及CAT活力。进一步的机制研究表明,解毒活血汤组ACSL4、LPCAT3及YAP蛋白表达较模型组显著降低,而GPX4水平显著升高。综上,解毒活血汤可以通过调控YAP/ACSL4信号通路抑制铁死亡,对顺铂诱导的AKI发挥保护作用。

关键词：解毒活血汤急性肾损伤(AKI) 铁死亡 Yes相关蛋白(YAP) 酰基辅酶A合成酶长链家族成员4(ACSL4)

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Intrahepatic biliary injuries associated with radiofrequency ablation of hepatic malignancies

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Chinese Medical Journal 2011年第13期124卷 1957-1963页

作者： FU ying yang wei wu Jin-yu YAN Kun wu wei XING Bao-cai chen min-hua Department of Ultrasound Key Laboratory of Carcinogenesis and Translational Research (Ministryof Education) Peking University Cancer Hospital & InstituteBeijing 100142 China Department of Oncology Surgery Key Laboratory of Carcinogenesis and Translational Research (Ministryof Education) Peking University Cancer Hospital & InstituteBeijing 100142 China

Background Biliary injury after radiofrequency ablation can cause serious consequences including death. However, there are limited data regarding bile duct changes with or without complications associated with radiofrequency ablation of hepatic malignancies. This study aimed to assess the incidence, prognosis and risk factors of intrahepatic biliary injury associated with radiofrequency ablation. Methods Between June 2001 and January 2009, 638 patients with hepatic malignancies （405 with hepatocellular carcinoma, and 233 with liver metastasis） who had 955 treatment sessions were enrolled in this study. Imaging and laboratory data, the course of treatment, and patient outcomes were reviewed retrospectively. The risk factors of biliary injury and the impact on overall survival of patients were analyzed. The chi-square test, Fisher＇s exact test, Kaplan-Meier curves and stepwise Logistic regression model were used for statistical analysis where appropriate. Results Biliary injury was observed in 17 patients after 17 ablation sessions based on imaging findings. The overall incidence of biliary injury was 1.8% （17/955） with an average onset time of 12 weeks （2-36 weeks）. Mild, moderate and severe complications of biliary injury were identified in 9, 6 and 2 cases, respectively. The median survival time after detection of biliary injury was 40 months. There seemed no notable difference in overall survival between patients with and those without biliary injuries. By multivariate analysis, vessel infiltration （P=-0.034） and treatment session 〉4 times （P=0.025） were independent risk factors for biliary injury of hepatocellular carcinoma; while tumor located centrally was the only independent risk factor in the metastasis group （P=0.043）. Conclusions The incidence of biliary injury was not frequent （1.8%）. Through appropriate treatment, intrahepatic bile duct injuries seemed not affect the patients＇ long-term survival. Additionally, risk factors may be helpful for selecting ra

关键词： hepatic malignancy radiofrequency ablation biliary tract injury complications

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PET微塑料水解再造缺陷铁基金属有机框架及其应用研究

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中国环境科学 2024年第9期44卷 5222-5233页

作者：蒋文斌姜晨晨韦选香徐李聪王姗丽 Hasan MD Shahib 吴明华余德游浙江理工大学纺织科学与工程学院(国际丝绸学院) 浙江理工大学生态染整技术教育部工程研究中心浙江杭州310018 浙江理工大学桐乡研究院有限公司浙江桐乡314500

为了有效去除聚对苯二甲酸乙二酯(PET)微塑料,采用碱性水解方法将PET微塑料升级再造,制备缺陷铁基金属有机框架(Fe-MOFs)催化剂,用于催化臭氧深度处理模拟印染废水.结果表明,在Na OH浓度为2mol/L、水解温度120℃、水解时间120min的条件... 详细信息

为了有效去除聚对苯二甲酸乙二酯(PET)微塑料,采用碱性水解方法将PET微塑料升级再造,制备缺陷铁基金属有机框架(Fe-MOFs)催化剂,用于催化臭氧深度处理模拟印染废水.结果表明,在Na OH浓度为2mol/L、水解温度120℃、水解时间120min的条件下,PET微塑料去除率达100%,对苯二甲酸钠盐(Na_(2)TPA)产率达97.4%;以PET微塑料水解产物为前驱体,发展了2种简易方法制备缺陷型Fe-MOFs催化剂.通过扫描电子显微镜(SEM)、X射线粉末衍射仪(PXRD)、傅里叶红外光谱仪(FT-IR)及X射线光电子能谱仪(XPS)等对缺陷Fe-MOFs催化剂的形貌特征、晶体结构、分子结构以及元素种类进行表征,证明催化剂具有缺陷结构.研究评估了2种催化剂催化臭氧降解AO-7性能,其中D-Fe-MOF催化剂可在3min内完全降解AO-7,反应速率常数达0.926min^(-1),是W-Fe-MOF催化剂和单独臭氧的3.6倍和7.3倍.

关键词： PET微塑料碱性水解升级再造缺陷金属有机框架催化臭氧

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Traditional Chinese medicine treatment for COVID-19:An overview of systematic reviews and meta-analyses

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Journal of Integrative Medicine 2022年第5期20卷 416-426页

作者： Han-ting wu Cong-hua Ji Rong-chen dai Pei-jie Hei Juan Liang Xia-qiu wu Qiu-shuang Li Jun-chao yang wei Mao Qing Guo School of Public Health Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006Zhejiang ProvinceChina

Background:Coronavirus disease 2019(COVID-19)is a rapidly spreading disease that has caused an extensive burden to the ***,a large number of clinical trials have examined the efficacy of traditional Chinese medicine(TCM)for treating and preventing COVID-19,with coinciding proliferation of reviews summarizing these ***:This study aimed to evaluate the methodological quality and evidence quality of systematic reviews and meta-analyses on the efficacy of *** strategy:Seven electronic databases,including PubMed,Cochrane Library,Web of Science,China National Knowledge Infrastructure,Chongqing VIP,Wanfang Data and SinoMed,were searched for systematic reviews and meta-analyses in October *** terms such as“Chinese medicine,”“Lianhua Qingwen”and“COVID-19”were *** criteria:Systematic reviews and meta-analyses of randomized controlled trials that evaluated the efficacy of TCM treatment of COVID-19 were *** extraction and analysis:A Measurement Tool to Assess Systematic Reviews Version 2.0(AMSTAR 2)was used to evaluate the methodological *** quality of evidence was graded using the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)*** extraction and analysis were performed by two reviewers ***:There were 17 meta-analyses included in our *** intervention group was defined as TCM combined with Western medicine,while the control group was Western medicine *** methodological quality of all the included studies was moderate to poor.A total of 89 outcome indicators were evaluated,of which,8 were rated as moderate quality,39 as low quality,and 41 as very low *** one outcome measure was graded as being of high *** moderate quality of evidence indicated that,for the treatment of COVID-19,the clinical efficacy of TCM in combination with Western medicine was better,in terms of lung recovery,rate of conversion to severe/critical cases,sympt

关键词： Medicine Chinese traditional Integrative medicine COVID-19 Systematic review Meta-analysis

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Safety and efficacy of thalidomide in patients with transfusiondependentβ-thalassemia:a randomized clinical trial

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3723-3729页

作者： Jiang-ming chen wei-Jian Zhu Jie Liu Gui-Zhen Wang Xiao-Qin chen Yun Tan wei-wei Xu Li-wei Qu Jin-Yan Li huan-Ju yang Lan huang Ning Cai wei-Da Wang Ken huang Jian-Quan Xu Guo-Hui Li Sheng He Tian-ying Luo Yi huang Song-hua Liu Wen-Qiang wu Qi-yang Lu Mei-Guang Zhou Shu-ying chen Rong-Lan Li Mei-Ling Hu ying huang Jin-hua wei Jun-min Li Sai-Juan chen Guang-Biao Zhou Department of Hematology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Department of Hematology Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 541000 GuangdongChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Reproductive Medicine The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000 HebeiChina State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhou 510060 GuangdongChina State Key Laboratory of Medical Genomics Shanghai Institute of HematologyNational Research Center for Translational MedicineRuijin Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences&University of Chinese Academy of SciencesBeijing 100101China Department of Pediatrics Affiliated Hospital of Youjiang Medical University for NationalitiesBaise City 533000 GuangxiChina Department of Hematology Yulin Guinan HospitalYulin 537005 GuangxiChina Department of neurology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Guangxi Key Laboratory of Basic Research on Birth Defects Prevention and Treatment Guangxi Zhuang Autonomous Region Women and Children Health Care HospitalNanning 530000 GuangxiChina Department of Hematology Guigang People’s HospitalGuigang 537100 GuangxiChina Department of Hematology Hospital of Traditional Chinese Medicine of Wuzhou CityWuzhou 543002 GuangxiChina Department of Hematology Wuzhou Red Cross HospitalWuzhou 543002 GuangxiChina Department of Hematology Hechi People’s HospitalHechi City 547000 GuangxiChina

Thalidomide inducesγ-globin expression in erythroid progenitor cells,but its efficacy on patients with transfusion-dependentβ-thalassemia(TDT)remains *** this phase 2,multi-center,randomized,double-blind clinical trial,we aimed to determine the safety and efficacy of thalidomide in TDT patients.A hundred patients of 14 years or older were randomly assigned to receive placebo or thalidomide for 12 weeks,followed by an extension phase of at least 36 *** primary endpoint was the change of hemoglobin(Hb)level in the *** secondary endpoints included the red blood cell(RBC)units transfused and adverse *** the placebo-controlled period,Hb concentrations in patients treated with thalidomide achieved a median elevation of 14.0(range,2.5 to 37.5)g/L,whereas Hb in patients treated with placebo did not significantly *** the 12 weeks,the mean RBC transfusion volume for patients treated with thalidomide and placebo was 5.4±5.0 U and 10.3±6.4 U,respectively(P<0.001).Adverse events of drowsiness,dizziness,fatigue,pyrexia,sore throat,and rash were more common with thalidomide than *** the extension phase,treatment with thalidomide for 24 weeks resulted in a sustainable increase in Hb concentrations which reached 104.9±19.0 g/L,without blood *** increase in Hb concentration and reduction in RBC transfusions were associated with nonβ0/β0 and HBS1L-MYB(rs9399137 C/T,C/C;rs4895441 A/G,G/G)*** results demonstrated that thalidomide is effective in patients with TDT.

关键词： transfusion patients thalidomide

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Correction to： Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures

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Neuroscience Bulletin 2018年第2期34卷 403-404页

作者： Yun-Jian dai Zheng-Hao Xu Bo Feng Ceng-Lin Xu hua-wei Zhao Deng-Chang wu wei-wei Hu Zhong chen Department of Pharmacology Key Laboratory of Medical Neurobiology of the Ministry of Health of China Zhejiang Province Key Laboratory of Neurobiology Basic Medical College College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Department of Neurology Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

In the original publication of the article, the representativeEEG of female rat pups with FS in Figure 1 C and D wasincorrectly intercepted from that of male rat pups. Thiscorrection does not affect the conclusions of...

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猪伪狂犬病病毒gG、gE和TK基因多重PCR检测方法的建立及应用

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动物医学进展 2024年第9期45卷 7-12页

作者：吴晓敏陈润山李华明项维徐梦然杨荣荣雷连成张付贤长江大学动物科学学院湖北荆州434023 湖北省十堰市房县畜牧兽医服务中心湖北十堰442100 吉林大学动物医学学院吉林长春130062

建立准确鉴别猪群伪狂犬病病毒(Porcine pseudorabies virus,PRV)野毒株和基因缺失疫苗株高效多重PCR方法,对PRV gG、gE和TK基因保守区域设计合成特异性引物,优化反应体系和条件,建立多重PCR鉴别检测方法,对临床样品进行检测应用。结果... 详细信息

建立准确鉴别猪群伪狂犬病病毒(Porcine pseudorabies virus,PRV)野毒株和基因缺失疫苗株高效多重PCR方法,对PRV gG、gE和TK基因保守区域设计合成特异性引物,优化反应体系和条件,建立多重PCR鉴别检测方法,对临床样品进行检测应用。结果成功建立了鉴别PRV gG、gE和TK基因缺失疫苗株和野毒株感染的多重PCR检测方法,该方法对PRV gG、gE和TK基因可进行特异性扩增,对猪圆环病毒2型、猪繁殖与呼吸综合征病毒、猪流行性腹泻病毒和猪副猪嗜血杆菌等相关病原均无扩增,对携带gG、gE和TK混合阳性质粒的最低检测限为2.5×10^(-5) ng/μL,具有良好的重复性。用该方法检测53份猪组织样品,检出PRV野毒感染的样品7份,与国标方法和单一PCR法检测结果符合率为100%。建立的猪伪狂犬病病毒野毒株和基因缺失疫苗株多重PCR鉴别检测方法具有良好的特异性、灵敏性和重复性,在生产中可快速、高效鉴别猪群PRV野毒感染和基因缺失疫苗免疫,可为PRV的快速鉴别检测、流行病学调查和防控提供技术支持。

关键词：猪伪狂犬病病毒 gG基因 gE基因 TK基因多重PCR

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UPLC-Q-TOF-MS/MS法分析紫辛鼻鼽颗粒化学成分及入血成分

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中成药 2024年第4期46卷 1093-1102页

作者：康雨胡军华章晨峰肖伟戴翠红林夏王振中南京中医药大学江苏南京210000 江苏康缘药业股份有限公司中药制药过程控制与智能制造技术全国重点实验室江苏连云港222001

目的建立UPLC-Q-TOF-MS/MS法分析紫辛鼻鼽颗粒化学成分及入血成分。方法分析采用Agilent ZORBAX SB-C_(18)色谱柱(1.8μm, 2.1 mm×100 mm);流动相0.2%甲酸-乙腈,梯度洗脱;体积流量0.2 mL/min;柱温30℃;电喷雾离子源;正负离子扫描。... 详细信息

目的建立UPLC-Q-TOF-MS/MS法分析紫辛鼻鼽颗粒化学成分及入血成分。方法分析采用Agilent ZORBAX SB-C_(18)色谱柱(1.8μm, 2.1 mm×100 mm);流动相0.2%甲酸-乙腈,梯度洗脱;体积流量0.2 mL/min;柱温30℃;电喷雾离子源;正负离子扫描。根据准分子离子、保留时间、二级碎片离子结合对照品信息及文献报道进行成分鉴定。结果共鉴定出88种成分,其中28种经对照品比对确认。从大鼠血清中发现了30种成分,其中20种为原型成分,10种为代谢产物。结论该方法稳定可靠,可为紫辛鼻鼽颗粒药效物质基础、质量控制研究奠定基础。

关键词：紫辛鼻鼽颗粒化学成分入血成分 UPLC-Q-TOF-MS/MS

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