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Journal of Integrative Medicine 2024年第5期22卷 614-620页

作者： Yong-guang Fang Shi-lin Huang Nan-nan chen Department of Hematology PLA 967th HospitalDalian 116021Liaoning ProvinceChina

Introduction There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL).Here,we report a case series of realgar-indigo naturalis formula(RIF)for the successful treatment of patients with relapsed and ATO-resistant *** presentation Two patients in the first relapse and one in the second relapse failed to achieve hematologic complete remission(HCR)when reinduced by ATO;the other five patients progressed to relapse during ATO-based regimens for post-remission *** eight patients received RIF in three doses per day totaling 130 mg/kg(≤30 pills)as induction therapy and achieved HCR at a median time of 46.5 *** received 5 years of post-remission therapy,which consisted of combined chemotherapy followed by *** this period,the patients did not experience renal dysfunction or QT interval *** the last follow-up,three patients survived without relapse,two patients survived with a second or third relapse and third or fourth remission,and the other three patients relapsed for a third or fourth time and *** 5-year overall survival and event-free survival rates were 75.0%(95%confidence interval[CI]:31.5–93.1)and 37.5%(95%CI:5.6–71.7),*** RIF for induction therapy and RIF combined with chemotherapy for post-remission therapy may represent an effective and safe protocol for the treatment of patients with relapsed and ATO-resistant APL.

关键词： Acute promyelocytic leukemia Realgar-indigo naturalis formula Arsenic Trioxide Resistant Case report

Self-supported NiFe-LDH nanosheets on NiMo-based nanorods as high-performance bifunctional electrocatalysts for overall water splitting at industrial-level current densities

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Nano Research 2024年第5期17卷 3769-3776页

作者： Yan Zhang Biao Feng MingLei Yan Zhen Shen Yiqun chen Jingyi Tian Fengfei Xu Guanghai chen Xizhang Wang lijun Yang Qiang Wu Zheng Hu Key Laboratory of Mesoscopic Chemistry of Ministry of Education(MOE)and Jiangsu Provincial Lab for Nanotechnology School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China College of Water Conservancy and Hydropower Engineering Sichuan Agricultural UniversityYa’an 625014China

Efficient,durable and economic electrocatalysts are crucial for commercializing water electrolysis ***,we report an advanced bifunctional electrocatalyst for alkaline water splitting by growing NiFe-layered double hydroxide(NiFe-LDH)nanosheet arrays on the conductive NiMo-based nanorods deposited on Ni foam to form a three-dimensional(3D)architecture,which exhibits exceptional performances for both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).In overall water splitting,only the low operation voltages of 1.45/1.61 V are required to reach the current density of 10/500 mA·cm^(-2),and the continuous water splitting at an industrial-level current density of 500 mA·cm^(-2) shows a negligible degradation(1.8%)of the cell voltage over 1000 *** outstanding performance is ascribed to the synergism of the HER-active NiMo-based nanorods and the OER-active NiFe-LDH nanosheet arrays of the hybridized 3D ***,the dense NiFe-LDH nanosheet arrays enhance the local pH on cathode by retarding OH-diffusion and enlarge the electrochemically active surface area on anode,while the conductive NiMo-based nanorods on Ni foam much decrease the charge-transfer resistances of both *** study provides an efficient strategy to explore advanced bifunctional electrocatalysts for overall water splitting by rationally hybridizing HER-and OER-active components.

关键词： alkaline water splitting bifunctional electrocatalysts layered double hydroxides high durability industrial current densities

Adaptive strategies of high and low nucleic acid prokaryotes in response to declining resource availability and selective grazing by protozoa

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Science China Earth Sciences 2024年第6期67卷 1872-1884页

作者： chen HU liuqian YU Xiaowei chen Jihua liU Yao ZHANG John BATT Xilin XIAO Qiang SHI Rui ZHANG Tingwei LUO Nianzhi JIAO Dapeng XU College of the Environment and Ecology Xiamen UniversityXiamen 361102China State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesFujian Key Laboratory of Marine Carbon SequestrationXiamen UniversityXiamen 361102China Joint Lab for Ocean Research and Education(LORE)of Dalhousie University Canadaand Shandong University and Xiamen UniversityXiamen 361102China Earth Ocean and Atmospheric Sciences ThrustThe Hong Kong University of Science and Technology(Guangzhou)Guangzhou 510000China Institute of Marine Science and Technology Shandong UniversityQingdao 266237China Department of Oceanography Dalhousie UniversityHalifaxNova Scotia B3H 4R2Canada Institute for Advanced Study Shenzhen UniversityShenzhen 518060China Carbon Neutral Innovation Research Center Xiamen UniversityXiamen 361102China

Prokaryotes play a fundamental role in global ocean biogeochemical ***,how the abundance and metabolic activity of ecologically distinct subgroups(i.e.,high nucleic acid(HNA)and low nucleic acid(LNA)cells),and their regulating factors,change in response to changing marine environmental conditions remains poorly ***,we delved into the time-evolving dynamic responses of the HNA and LNA prokaryotic subgroups to declining resource availability and selective grazing by protozoa by conducting a 73-day incubation experiment in a large-volume(117,000 L)macrocosm that facilitates community-level *** found that the metabolic activity of the HNA subgroup was higher than that of the LNA subgroup when the macrocosm was resource replete but that the HNA subgroup declined more rapidly than the LNA subgroup as the resources became increasingly scarce,leading to a steadily increasing contribution of LNA cells to prokaryotic ***,as resources in the macrocosm became limited,protozoan grazing preference shifted from the HNA to the LNA subgroup and the contributions of the LNA subgroup to the carbon flow within the macrocosm *** findings highlight the resilience of LNA cells in resource-limited environments,illuminate the critical role of selective grazing by protozoa in balancing distinct prokaryotic subgroups under changing resource conditions,and demonstrate the complex and adaptive interactions between protozoa and prokaryotes across diverse environmental contexts.

关键词： Microbial loop Macrocosm experiment Prokaryote Top-down and bottom-up controls Carbon flow

Evaluation and salivary biochemistry associations of sour-salty taste interaction

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Journal of Future Foods 2024年第4期4卷 376-382页

作者： Hongnan Jiang Ye chen Jianshe chen Louise Dye Xinmiao Wang Laboratory of Food Oral Processing School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Zhejiang-UK Joint Laboratory of Food Sensory Science Zhejiang Gongshang UniversityHangzhou 310018China School of Food Science and Nutrition University of LeedsLeeds LS29JTUK

Taste interaction is a well-known phenomenon in sensory stodies,but how to quantify the magnitode of the effect of one tastant on other taste attribute(s)is still largely unsolved,let alone further explorations from a salivary biochemistry *** acquiring the individual taste threshold and evaluating the just noticeable difference(JND).this stody firstly established a quantitative method to assess the magnitude of taste interaction in a binary taste mixture by evaluating the concentration difference upon psychologically-comparable *** change of salty taste intensity(CSI)was therefore defined as the subtraction of JND using sour-salty taste stimulant from JND using pure salty taste stimulant,with a dimension of concentration in mmol/*** was then used to demonstrate how citric acid affected salty taste perception in a salty-sour binary taste mixture in 16 young and healthy *** of citric acid used in the binary taste mixtore were 0.***.0.09.0.***.0.24 and 0.40 mmolL,*** results showed that salty taste perception was enhanced(average CSI of 0.93 mmolL)when the citric acid concentration was low(at 0.05 and 0.09 mmolL).but with an increasing concentration of citric acid ranging from 0.14 to 0.40 mmol/L,this effect gradually turned from enhancement to suppression of salty taste perception(correspondingly a continoously decreasing CSI all the way down to an average of-2.94 mumol/L).It was also found that cystatin SN concentration in participants'unstimulated saliva samples was significantly negatively correlated with salty taste threshold(with and without the presence of citric acid),and it was one of the most significant factors affecting CSI,s shown in multiple regression *** anhydrase VI concentration in participants'unstimulated saliva sanples was also found to be significantly negatively correlated with salty taste recognition(with and without presence of citric acid).but it did not pose signific

关键词： Taste interaction evaluation Sensory analysis Salty taste perception Salivay biochemical components

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太阳能驱动界面蒸发海水淡化技术研究进展

太阳能学报 2024年第8期45卷 423-431页

作者：孙梦茜陈志莉陈黎唐珊李光学桂林理工大学环境科学与工程学院桂林541004

为深入了解太阳能界面蒸发海水淡化技术的发展与应用,从光吸收和热管理两个角度介绍目前太阳能界面蒸发的研究进展,并讨论界面蒸发海水淡化技术的发展方向和应用前景。总结不同类别、不同结构的光热转换材料对光热利用效率的影响,归纳... 详细信息

为深入了解太阳能界面蒸发海水淡化技术的发展与应用,从光吸收和热管理两个角度介绍目前太阳能界面蒸发的研究进展,并讨论界面蒸发海水淡化技术的发展方向和应用前景。总结不同类别、不同结构的光热转换材料对光热利用效率的影响,归纳不同形式的热量损失对界面蒸发速率的影响,探讨太阳能界面蒸发海水淡化技术目前存在的挑战和未来发展,以期对后续海水淡化技术的实际应用提供参考。

关键词：太阳能海水淡化界面蒸发光热转换材料热管理

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CSCO guidelines for colorectal cancer version 2024:Updates and discussions

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Chinese Journal of Cancer Research 2024年第3期36卷 233-239页

作者： liubo chen Hanguang Hu Ying Yuan Shanshan Weng Department of Medical Oncology(Key Laboratory of Cancer Prevention and Intervention China National Ministry of EducationKey Laboratory of Molecular Biology in Medical SciencesZhejiang ProvinceChina)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Zhejiang Provincial Clinical Research Center for CANCER Hangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China

According to the latest global cancer statistics,colorectal cancer(CRC)is the most common malignancy of the digestive system and the second most lethal among all cancer types(1).In China,CRC is the second most prevalent cancer,following only after lung cancer(2).The first version of the Chinese Society of Clinical Oncology(CSCO)guideline was launched in 2017 and has been updated annually based on the latest findings of clinical research,drug accessibility and expert consensus(3-8).Here,we present the main updates of the 2024 version compared to the 2023 version.

关键词： CSCO colorectal cancer

Immune status and combined immunotherapy progression in Kirsten rat sarcoma viral oncogene homolog(KRAS)-mutant tumors

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Chinese Journal of Cancer Research 2024年第4期36卷 421-441页

作者： Dongsheng He Rilan Bai Naifei chen Jiuwei Cui Cancer Center the First Hospital of Jilin UniversityChangchun 130021China

Kirsten rat sarcoma viral oncogene homolog(KRAS)is the most frequently mutated oncogene,occurring in various tumor *** extensive efforts over the past 40 years to develop inhibitors targeting KRAS mutations,resistance to these inhibitors has eventually emerged.A more precise understanding of KRAS mutations and the mechanism of resistance development is essential for creating novel inhibitors that target specifically KRAS mutations and can delay or overcome *** has developed rapidly in recent years,and in-depth dissection of the tumor immune microenvironment has led researchers to shift their focus to patients with KRAS mutations,finding that immune factors play an essential role in KRAS-mutant(KRAS-Mut)tumor therapy and targeted drug *** and transitions from targeted therapy to immunotherapy have provided new hope for treating refractory ***,we reviewed KRAS mutation-targeted treatment strategies and resistance issues,focusing on our in-depth exploration of the specific immune status of patients with KRAS mutations and the impact of body immunity following KRAS *** aimed to guide innovative approaches combining RAS inhibition with immunotherapy,review advances in preclinical and clinical stages,and discuss challenges and future directions.

关键词： Cancer KRAS mutation targeted therapy immunotherapy immune microenvironment

Beamspace maximum likelihood algorithm based on sum and difference beams for elevation estimation

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Journal of Systems Engineering and Electronics 2024年第3期35卷 589-598页

作者： chen Sheng ZHAO Yongbo HU Yili PANG Xiaojiao National Laboratory of Radar Signal Processing Xidian UniversityXi’an 710071China

Beamspace super-resolution methods for elevation estimation in multipath environment has attracted significant attention, especially the beamspace maximum likelihood(BML)algorithm. However, the difference beam is rarely used in superresolution methods, especially in low elevation estimation. The target airspace information in the difference beam is different from the target airspace information in the sum beam. And the use of difference beams does not significantly increase the complexity of the system and algorithms. Thus, this paper applies the difference beam to the beamformer to improve the elevation estimation performance of BML algorithm. And the direction and number of beams can be adjusted according to the actual needs. The theoretical target elevation angle root means square error(RMSE) and the computational complexity of the proposed algorithms are analyzed. Finally, computer simulations and real data processing results demonstrate the effectiveness of the proposed algorithms.

关键词： elevation estimation beamspace multipath environment maximum likelihood

海拉尔盆地油气勘探开发新领域、新类型及资源潜力

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石油学报 2024年第1期45卷 99-114页

作者：王小军蒙启安李跃吴海波李军辉邓海申文静陈方举侯思宇张守庆大庆油田有限责任公司黑龙江大庆163453 大庆油田有限责任公司勘探开发研究院黑龙江大庆163712

海拉尔盆地是位于中国北部边陲的中生代—新生代陆相断陷盆地,经过60余年的持续勘探,主力含油层系已进入开发中后期阶段,埋藏浅、规模大、易发现的构造油藏几乎已钻探殆尽,近年来的规模增储难度日益增大。通过系统回顾海拉尔盆地的油气... 详细信息

海拉尔盆地是位于中国北部边陲的中生代—新生代陆相断陷盆地,经过60余年的持续勘探,主力含油层系已进入开发中后期阶段,埋藏浅、规模大、易发现的构造油藏几乎已钻探殆尽,近年来的规模增储难度日益增大。通过系统回顾海拉尔盆地的油气勘探历程,结合当前勘探开发实践,指出向勘探程度较低的洼槽区和深部层系进军是打开海拉尔盆地油气勘探新局面的必经之路。海拉尔盆地在南屯组凝缩层段页岩油、铜钵庙组砂砾岩岩性油藏、侏罗系塔木兰沟组油藏和基岩潜山内幕油藏4个新领域具有较大的勘探潜力,石油总资源量预测达5.96×10^(8)t;新领域油藏与已发现的油藏具有空间互补性,构成了一个更加完整的从中—浅层到深层、从斜坡带到洼槽区、从常规到非常规的多层系多类型且油藏呈有序分布、差异富集的复杂断陷盆地含油气系统,可进一步挖掘其勘探潜力。

关键词：海拉尔盆地油气勘探洼槽区深部层系新领域新类型

Production and test of sPHENIX W/SciFiber electromagnetic calorimeter blocks in China

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Nuclear Science and Techniques 2024年第8期35卷 167-176页

作者： Xiao‑Zhou Yu Xi‑Yang Wang Wei‑Hu Ma Shi‑Hong Fu Peng‑Fei Sun Jin‑Xing Song Wan‑Bing He Yang Shen Long Ma Jin‑Hui chen Huan‑Zhong Huang Si‑Guang Wang Jing Zhou Xiao‑Mei li Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Fudan UniversityShanghai 200433China Science and Technology on Nuclear Data Laboratory China Institute of Atomic EnergyBeijing 102413China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

The sPHENIX experiment is a new generation of large acceptance detectors at the relativistic heavy ion collider at Brookhaven National Laboratory,with scientific goals focusing on probing the strongly interacting Quark–Gluon plasma with hard probes of jets,open heavy flavor particles,andγ*** EMCal detector,which covers the pseudo-rapidity region of|η|≤1.1,is an essential subsystem of *** this study,we focused on producing and testing EMCal blocks covering a pseudo-rapidity of|η|∈[0.8,1.1].These,in conjunction with the central pseudo-rapidity EMCal blocks,significantly enhance the sPHENIX physics capability of the jet andγparticle *** this paper,the detector module production and testing of sPHENIX W-powder/scintillating fiber(W/ScFi)electromagnetic calorimeter blocks are *** selection of the tungsten powder,mold fabrication,QA procedures,and cosmic ray test results are discussed.

关键词： sPHENIX Tungsten/scintillating fiber electromagnetic calorimeter Cosmic ray test