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教育数字化时代高校教育新形态的建设与发展对策

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延边大学学报（社会科学版） 2024年第1期57卷 135-141页

作者：陈路舟福州大学至诚学院福州350000

教育数字化与教育新形态有助于实现教育公平、推进高校教育高质量发展、推动教学改革创新。在数字化时代,教育数字化是我国数字中国战略的一部分。现阶段我国高校教育发展虽然进行了数字化转变,但是仍然存在缺乏有效的数字化教育内容和... 详细信息

教育数字化与教育新形态有助于实现教育公平、推进高校教育高质量发展、推动教学改革创新。在数字化时代,教育数字化是我国数字中国战略的一部分。现阶段我国高校教育发展虽然进行了数字化转变,但是仍然存在缺乏有效的数字化教育内容和平台、教师数字素养不足、数字基础设施不足的问题。基于教育数字化背景下的高校教育现状,可以建立健全数字化平台,吸纳优质教学资源;构建数字素养发展新机制,提升教师数字素养;完善数字基础设施建设,发挥数字技术优势,以期推动高校教育新形态的形成,助力教育数字化建设及我国教育强国建设。

关键词：教育数字化高校教育教育新形态智慧教育

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大鼠过度训练时间与血乳酸值变化的关系探讨

四川体育科学 1997年第1期16卷 23-24页

作者：陈协芳程旭光泸州医学院成都体育学院

本文通过大鼠高强度大运动量训练模拟过度训练并进行血乳酸值测定和运动时间动态观察，结果表明：整个训练期间运动后血乳酸值均较对照组显著升高（Ｐ＜０．０１），后期升高幅度较早期、中期显著下降（Ｐ＜０．０５）；每天的运动时间... 详细信息

本文通过大鼠高强度大运动量训练模拟过度训练并进行血乳酸值测定和运动时间动态观察，结果表明：整个训练期间运动后血乳酸值均较对照组显著升高（Ｐ＜０．０１），后期升高幅度较早期、中期显著下降（Ｐ＜０．０５）；每天的运动时间早期到中期逐渐增加，后期显著下降（Ｐ＜０．０５）。因而初步提出了血乳酸值下降的变化可能是过度训练的早期反应，运动能力提高的同时可能潜在过度训练的发生。

关键词：过度训练运动能力血乳酸

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中医多专家智能生成系统的研制

泸州医学院学报 1987年第4期 273-278页

作者：陈培李静梁凤凌孙同郊周德端泸州医学院电子计算机室泸州医学院电子计算机室泸州医学院中西医结合研究室

本系统运用人工智能和数据库技术与模糊集理论,对中医辨证论治的思维过程进行科学归纳和高精度模拟,注意解决知识表述的不确定性问题,从临床、教学、科研的灵活实用角度,增强系统功能。现已生成诊治腹痛、胃痛、泄泻、便秘、乙型肝炎等... 详细信息

本系统运用人工智能和数据库技术与模糊集理论,对中医辨证论治的思维过程进行科学归纳和高精度模拟,注意解决知识表述的不确定性问题,从临床、教学、科研的灵活实用角度,增强系统功能。现已生成诊治腹痛、胃痛、泄泻、便秘、乙型肝炎等病证的中医专家系统,经415个病例的验证,处方与医理设计的正确率100%,与临床的实际符合率96％以上。

关键词：中医专家人工智能数据库技术诊疗系统

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线性广义系统的D型迭代学习控制

华中科技大学学报（自然科学版） 2007年第5期35卷 34-37页

作者：李必文郑绿洲陈伯山华中科技大学数学系湖北武汉430074 湖北师范学院数学系湖北黄石435002

根据误差收敛准则,提出了线性广义系统的迭代学习控制算法,利用矩阵理论及不等式技巧给出了线性定常广义系统在D型学习律作用下的迭代控制收敛性结果,这一结果是全新的,其对时变系统也成立;另外,针对线性定常广义离散时间系统,给出了一... 详细信息

根据误差收敛准则,提出了线性广义系统的迭代学习控制算法,利用矩阵理论及不等式技巧给出了线性定常广义系统在D型学习律作用下的迭代控制收敛性结果,这一结果是全新的,其对时变系统也成立;另外,针对线性定常广义离散时间系统,给出了一种通过最优化目标函数确定控制器参数的设计方法.

关键词：广义系统迭代学习控制 D型学习律

Effect of acidity of drugs on the prediction of human oral absorption by biopartitioning micellar chromatography

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Journal of Pharmaceutical Analysis 2010年第4期22卷 233-240页

作者： Xiao-Juan Ren1,Shu-Rong Wang2,Li-Ping Wu1,Yu-Jie Liu1,Cong chen1,Li-Ming Ye11.West China School of Pharmacy,Sichuan University,chengdu 610041 2.The Affiliated Hospital of luzhou Medical College,luzhou 646000,China West China School of Pharmacy Sichuan University Chengdu 610041 China luzhou Medical College Luzhou 646000 China

Biopartitioning micellar chromatography(BMC)is a potentially high throughput and low cost alternative for in vitro prediction of drug absorption,which can mimic the drug partitioning process in biological *** this paper,a data set of 56 compounds representing acidic,basic,neutral and amphoteric drugs from various structure classes with human oral absorption(HOA)data available were employed to show the effect of acidity of drugs in oral absorption *** was reciprocally correlated to the negative value of the capacity factor(kBMC)determined by BMC at pH 7.4 and *** relationships between kBMC and the corresponding HOA values of all compounds were rather poor,but the correlations were improved when the acidity of drugs was taken into ***,the proposed models allowed obtaining of good predictive values for both highly and poorly absorbed *** is demonstrated that the constructed models derived from compounds with the same kind of charge property are of more practically meaningful and rigorous.

关键词： biopartitioning micellar chromatography oral absorption acidity

Effects of multidrug resistance, antisense RNA on the chemosensitivity of hepatocellular carcinoma cells

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 552-559页

作者： Bo Li, Tian Ye, Lei Zhao, De-Hua Li, Xing-Hua Gou, Lan-Ying Zhao, Lei Han, Lin chen, Lu-Nan Yan and Jian-Ping Gong Department of Hepatobiliary Surgery, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China Department of Traditional Chinese Surgery, Second Affiliated Hospital, luzhou Medical College, luzhou 646000, China Genetic Engineering Laboratory, chengdu Di’ao Group Co., Ltd., chengdu 610041, China Department of General Surgery, West China Hospital, Sichuan University, chengdu 610041, China Department of Hepatobiliary Surgery Second Affiliated Hospital Chongqing University of Medical Sciences Chongqing 400010 China.

BACKGROUND: Multidrug resistance is a major obstacle in cancer chemotherapy. We examined whether the antisense RNA of multidrug resistance gene 1 (mdr1) could reverse multidrug resistance in the human hepatocellular carcinoma (HCC) cell line SMMC7721/ADM. METHODS: The recombinant adenoviruses pAdEasy- GFP-ASmdr1 product was produced by the adenoviral vector AdEasy system, which can express antisense RNA against the mdr1 gene. Following that, the recombinant adenovirus was transfected into the P-glycoprotein- producing multidrug resistance cell line, SMMC7721/ADM human HCC cells resistant to adriamycin (ADM) and daunorubicin (DNR). In order to investigate the reversal of multidrug resistance phenotype, we measured the expression of mdr1 mRNA by RT-PCR and the production of P-glycoprotein by flow cytometry. The sensitivities for ADM and DNR SMMC7721/ADM cells were examined by [3-(4, 5-dimethylthi-azol-2-yl)-2,5 diphenyl-terazolium bromide] (MTT) analysis. RESULTS: The low-level expression of mdr1 mRNA and P-glycoprotein production were observed in parental sensitive cells SMMC/7721 in addition to the overexpressionof mdr1 mRNA and P-glycoprotein in SMMC7721/ADM cells. The transfection of antisense-RNA into SMMC7721/ ADM cells resulted in decreases of mdr1 mRNA and P-glycoprotein, but increase of drug sensitivities. The sensitivities of transfected SMMC7721/ADM cells to ADM and DNR in IC50 reduced by 31.25% and 62.96% respectively. CONCLUSIONS: Mdr1 antisense RNA can increase the sensitivities of SMMC7721/ADM cells to anticancer drug by decreasing the expression of the mdr1 gene and inhibiting P-glycoprotein expression. This strategy may be applicable to cancer patients with P-glycoportein mediated multidrug resistance.

关键词： antisense nucleic acid multiple drug resistance P-glycoprotein

Monomeric C-reactive protein induces plasminogen activator inhibitor-1 expression by vascular smooth muscle cells

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Effects of amiodarone on small conductance Calcium-activated potassium current in human atrial myocytes

中国生理学会心血管生理学术研讨会

作者： Ni chen,Rong Li,Meiping Ren,Jianbo Wu Drug Discovery Research Center,luzhou Medical College,luzhou,Sichuan

＜正＞Objective:We examined the impact of C-reactive protein（CRP） on vascular smooth muscle cells（VSMC） expression of plasminogen activator inhibitor-1（PAI-1）.Methods and Results: PAI-1 secretion,and activity levels were significantly higher in VSMC isolated from CRP-transgenic（Tg） mice than from wild-type（WT） *** significantly increased PAI-1 activity in Human Umbilical Artery Smooth Muscle Cells（HUASMC）.Furthermore,we identified the role of monomelic CRP（mCRP） in the induction of PAI-1 in ***-1 secretion and activity were markedly enhanced by ***:mCRP increases PAI-1 expression and activity by VSMC in *** data offer important insights into the role of CRP in the pathogenesis of arterial thrombosis.

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Effects of amiodarone on small conductance Calcium-activated...

THE MAKING AND APPLICATION OF THE SAFE AND AUTOMATIC AIR EXHAUSTING TRANSFUSION SYSTEM

中国生理学会心血管生理学术研讨会

作者： Miaoling Li,Pengyun Li,Tao Li,Jun chen,Wenjun Huang,Yan Yang,Xiaorong Zeng~* Key laboratory of medical Electrophysiology,Ministry of Education Department of Electrophysiology,luzhou Medical College luzhou 646000 China

Introduction:In 2003,Yanfang Xu et al first reported the presence of small conductance Calcium-activated potassium current(SK2) in cardiac myocytes that plays a crucial role in cardiac ***,the SK2 channel is expressed more abundant in the atria compared with the ***2 channels are independent of voltage and sensitive to intracellular *** studies showed that Amiodarone possesses the pharmacological effects of classⅠ,Ⅱ,Ⅲ,andⅣantiarrhythmic agents mediating an atrial-selective drug effect. Consequently,We hypothesized that amiodarone might also be a potent target for SK channels. Aims:The aim of this study was to examined whether antiarrhythmic agent amiodarone affected SK channels in human ***:The preparations of right atrial appendage were obtained from 8 patients with sinus *** myocytes were isolated by enzymatic dissociation with two-step *** was used to observe SK channel protein *** ionic currents were recorded using whole-cell Conventional patch clamp techniques to detect the changes of SK channel current ***:Using the whole-cell Conventional patch-clamp recording techniques,an inward rectifier K mix current could be obtained from human atrial myocyte,I mix currents density(-6.13±1.35 pA/pF,n=12) in single myocyte could be partially inhibited by apamin(100nmol/L).The apamin-sensitive current was obtained by subtraction of the currents before and after treatment with ***2 current density was (-2.87±0.46pA/pF,n=12) at the test potential -130mV(holding in -40mV).and then added amiodarone(l,10,100μmol/L),the remaining I mix currents density was unchanged(n=5);after recording I mix currents,added amiodarone(l,10,100μmol/L),amiodarone showed a concentration-dependent inhibition effect on SK2 channel *** I mix currents density (n=5) was(-5.89±1.18) pA/pF,(-4.76±0.83) pA/pF,(-4.72±0.85) pA/pF respectively,and then added apamin(100nmol/L),SK2 current

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西南医科大学学报 1992年第4期 278-280页

作者： Liu Mingyoqg chen Qianshu Wang Shaoqiong Hu Zhengjie Yang Jiahui luzhou Medical College Hospital Yu Zhuancheng Dapartment of Physics

To offset the disadvantage of inability to exhaust air automatically of the currently—used transfusion system. the authors have developed a safe and automatic air exhausting transfusion system in accordance with the density difference between air and water and the physical principle of suction, hence the effective prevention of the disastrous consequence of air embolism caused by the air that enters the veins. The new transfusion system substantially enhances the safety factors of the infused patients. Having been used on 3000 clinical patients, the new transfusion system proves to be stable in its functions, safe,trustworthy, economical and applicable. Besides, this new transfusion system is easy to handle and is worthy of being widely used.

关键词： Automatic air exhaust Transfusion system