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RNA Editing Sites Exist in Protein-coding Genes in the Chloroplast Genome of Cycas taitungensis

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Journal of Integrative Plant Biology 2011年第12期53卷 961-970页

作者： Haiyan chen likun Deng Yuan Jiang Ping Lu Jianing Yu College of Life Sciences Shaanxi Normal University Xi＇an 710062 China

RNA editing is a post-transcriptional process that results in modifications of ribonucleotides at specific locations. In land plants editing can occur in both mitochondria and chloroplasts and most commonly involves C-to-U changes, especially in seed plants. Using prediction and experimental determination, we investigated RNA editing in 40 protein-coding genes from the chloroplast genome of Cycas taitungensis. A total of 85 editing sites were identified in 25 transcripts. Comparison analysis of the published editotypes of these 25 transcripts in eight species showed that RNA editing events gradually disappear during plant evolution. The editing in the first and third codon position disappeared quicker than that in the second codon position, ndh genes have the highest editing frequency while serine and proline codons were more frequently edited than the codons of other amino acids. These results imply that retained RNA editing sites have imbalanced distribution in genes and most of them may function by changing protein structure or interaction. Mitochondrion protein-coding genes have three times the editing sites compared with chloroplast genes of Cycas, most likely due to slower evolution speed.

关键词： chloroplasts Cycas taitungensis ndh genes post-transcriptional modification RNA editing transcripts

Core competitiveness of the western enterprise in China: risks and countermeasures

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Ecological Economy 2007年第2期3卷 209-216页

作者： chen Yijun Peng likun Department of Management Sichuan University of Science and EngineeringZigong 643000P.R.China

Core competitiveness is the source of competitive advantages as well as the guarantee of value growth of the enterprise. This paper discusses the cause of the risks of the core competitiveness of enterprises and the west enterprise, introduces analytical methods of the risks of the core competitiveness and measures guard against the risks of the core competitiveness.

关键词： Core competitiveness Risk Risk-proof

Problems of private industrial economic development and its countermeasures for Zigong City,Sichuan Province,China

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Ecological Economy 2007年第4期3卷 456-463页

作者： Peng likun chen Yijun Department of Management Science Sichuan University of Science ＆ ENGINEERING Zigong 643000P.R.China

The differences of regional economic development between underdeveloped areas and developed areas are mainly embodied by different levels of private economic development. Since 20-year reform and opening-up to the outside world, the private industry of Zigong has developed gradually, become more and more economically competitive, and played a more and more important role in the economic structure of Zigong. This paper analyzes the problems of private economy and its countermeasures based on the research on its status quo.

关键词： West China Small and medium-sized cities,Zigong City Private economry Countermeasures for development

Progress and perspective of Li_(1+x)Al_(x)Ti_(2-x)(PO_(4))_(3) ceramic electrolyte in lithium batteries

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InfoMat 2021年第11期3卷 1195-1217页

作者： Ke Yang likun chen Jiabin Ma Yan-Bing He Feiyu Kang Shenzhen All-Solid-State Lithium Battery Electrolyte Engineering Research Center Tsinghua Shenzhen International Graduate SchoolInstitute of Materials Research(IMR)ShenzhenChina School of Materials Science and Engineering Tsinghua UniversityBeijingChina

The replacement of liquid organic electrolytes with solid-state electrolytes(SSEs)is a feasible way to solve the safety issues and improve the energy density of lithium *** SSEs materials that can well match with high-voltage cathodes and lithium metal anode is quite significant to develop high-energy-density lithium ***_(1+x)Al_(x)Ti_(2-x)(PO_(4))_(3)(LATP)SSE with NASICON structure exhibits high ionic conductivity,low cost and superior air stability,which enable it as one of the most hopeful candidates for all-solidstate batteries(ASSBs).However,the high interfacial impedance between LATP and electrodes,and the severe interfacial side reactions with the lithium metal greatly limit its applications in *** review introduces the crystal structure and ion transport mechanisms of LATP and summarizes the key factors affecting the ionic *** side reaction mechanisms of LATP with Li metal and the promising strategies for optimizing interfacial compatibility are *** also summarize the applications of LATP including as surface coatings of cathode particles,ion transport network additives and inorganic fillers of composite polymer *** last,this review proposes the challenges and the future development directions of LATP in SSBs.

关键词： crystal structure interfaces ionic conductivity Li_(1+x)Al_(x)Ti_(2-x)(PO_(4))_(3) lithium batteries

Decontamination of Chemical Warfare Agents by Novel Oximated Acrylate Copolymer

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Chemical Research in Chinese Universities 2019年第6期35卷 1095-1104页

作者： WEN Xianfang YE Lin chen likun KONG Lingce YUAN Ling XI Hailing ZHONG Jinyi State Key Laboratory of NBC Protection for Civilian Beijing 102205P.R.China School of Material Science and Engineering Beijing Institute of TechnologyBeijing 100081P.R.China Research Institute of Chemical Defense Beijing 102205P.R.China

A novel acrylate copolymer,polymethylacrylate-β-(bromoacetyl ethyl)ester-co-N,N-dimethylacrylamide[P(MABE-co-DMAA)]was synthesized by the copolymerization of N,N-dimethylacrylamide and methylacrylate-β-(bromoacetyl ethyl)***,the copolymer was oximated by 4-pyridinium aldoxime(4-PAM),and was abbreviated as PAM-P(MABE-co-DMAA).A maximum oxime conversion of 53.7%was *** as-prepared oximated copolymer PAM-P(MABE-co-DMAA)effectively decontaminated chemical warfare agents(CWAs)including methylphosphonofluoridate(sarin or GB),S-2-(diisopropylamino)ethyl O-ethyl methylphosphonothioate(VX),and 2,2′-dichloroethyl sulfide(sulfur mustard,or HD).The detoxification rates were 90.6%for GB,85.7%for VX,and 90.5%for *** analysis,high performance liquid chromatography-mass spectrometry(HPLC/MS)and gas chromatography-mass spectrometry(GC/MS)were used to identify the decontamination products,and the decontamination mechanism was concluded to be a combination of nucleophilic substitution and a second order Beckmann ***,the active decontamination materials,such as decontamination cloths and covers could be made from the oximated copolymer by virtue of its processability,as well as its strong ability to degrade CWA.

关键词： Oximated copolymer Chemical warfare agent Decontamination material Broad-spectrum decontaminating Detoxification rate

Engineering Ferroelectric Interlayer between Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)and Lithium Metal for Stable Solid-State Batteries Operating at Room Temperature

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Energy & Environmental Materials 2023年第6期6卷 305-311页

作者： Tian Gu likun chen Yanfei Huang Jiabin Ma Peiran Shi Jie Biao Ming Liu Wei Lu Yanbing He Shenzhen All-Solid-State Lithium Battery Electrolyte Engineering Research Center Institute of Materials Research(IMR)Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518055China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

The poor contact and side reactions between Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)(LATP)and lithium(Li)anode cause uneven Li plating and high interfacial impendence,which greatly hinder the practical application of LATP in high-energy density solid-state Li metal *** this work,a multifunctional ferroelectric BaTiO_(3)(BTO)/poly(vinylidene fluoride-co-trifluoroethylene-co-chlorotrifluoroethylene)(P[VDF-TrFE-CTFE])composite interlayer(B-TERB)is constructed between LATP and Li metal anode,which not only suppresses the Li dendrite growth,but also improves the interfacial stability and maintains the intimate interfacial contact to significantly decrease the interfacial resistance by two orders of *** B-TERB interlayer generates a uniform electric field to induce a uniform and lateral Li deposition,and therefore avoids the side reactions between Li metal and LATP achieving excellent interface *** a result,the Li/LATP@B-TERB/Li symmetrical batteries can stably cycle for 1800 h at 0.2 mA cm^(-2)and 1000 h at 0.5 mA cm^(-2).The solid-state LiFePO_(4)/LATP@B-TERB/Li full batteries also exhibit excellent cycle performance for 250 cycles at 0.5 C and room *** work proposes a novel strategy to design multifunctional ferroelectric interlayer between ceramic electrolytes and Li metal to enable stable room-temperature cycling performance.

关键词： BaTiO_(3) dendrites ferroelectric Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3) lithium metal

Structure,magnetic properties and giant magneto-striction studies in [Tb/Fe/Dy]_n nano-multilayer film

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Chinese Science Bulletin 2009年第4期54卷 608-611页

作者： LI XiaoDong ZHAO ZhenJie HUANG SuMei PAN likun chen YiWei YANG XieLong SUN Zhuo Department of Physics Engineering Research Center for Nanophotonics & Advanced Instrument Ministry of Education East ChinaNormal University Shanghai 200062 China

[Tb/Fe/Dy]n nano-multilayer films, with precise composition of Tb0.27Dy0.73Fe2, were prepared by the multi-targets magnetron sputtering technique at room temperature (sample A) and 300℃ substrate temperature (sample B). Both of the nano-multilayer films show columnar structures perpendicular to the film plane according to the scanning electron microscopy results. The magnetic hysteresis loops and the giant magnetostriction (GMS) property of the two samples indicate the perpendicular anisotropy in them. In spite of the perpendicular anisotropy, both of the samples present GMS effect. In a very low applied field of 0.18 T, the GMS value in sample B is 89.3 ppm, which is about four times of that in sample A, 23.5 ppm. The good low-field GMS effect in sample B might attribute to the Laves phase of R-Fe2 segregated from the amorphous matrix under the thermal annealing of the substrate. The relation between the magnetization process and GMS property of the perpendicular anisotropy nano-multilayer films is further investigated.

关键词：纳米多层模磁弹性效果正交各向异性 [铽/铁/镝]n纳米材料

Wearable membranes from zirconium-oxo clusters cross-linked polymer networks for ultrafast chemical warfare agents decontamination

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Chinese Chemical Letters 2022年第6期33卷 3241-3244页

作者： Litao Ma Jiamin Xie Xiaoshan Yan Zhiwei Fan Heguo Li Lin Lu likun chen Yi Xin Panchao Yin South China Advanced Institute for Soft Matter Science and Technology&State Key Laboratory of Luminescent Materials and Devices University of Technology Guangzhou 510641China State Key Laboratory of NBC Protection for Civilian Research Institution of Chemical DefenseBeijing 100191China

The urgent need for immediate personal protection against chemical warfare agents(CWAs)spurs the requirement on robust and highly efficient catalytic systems that can be conveniently integrated to wearable ***,as a new concept for CWA decontamination catalyst design,sub-nanoscale,catalytically active zirconium-oxo molecular clusters are covalently integrated in flexible polymer network as crosslinkers for the full exposure of catalytic sites as well as robust framework *** obtained membrane catalysts exhibit high swelling ratio with aqueous content as 84 wt%and therefore,demonstrate quasi-homogeneous catalytic activity toward the rapid hydrolysis of both CWA,soman(GD)(t_(1/2)=5.0 min)and CWA simulant,methyl paraoxon(DMNP)(t_(1/2)=8.9 min).Meanwhile,due to the covalent nature of cross-linkages and the high flexibility of polymer strands,the membranes possess promising mechanical strength and toughness that can stand the impact of high gas pressures and show high permeation for both CO_(2)and O_(2),enabling their extended applications in the field of collective/personal protective materials with body comfort.

关键词： Molecular clusters Chemical warfare agents Catalysis Polymer nanocomposites Wearable devices

QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study

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Signal Transduction and Targeted Therapy 2024年第2期9卷 797-806页

作者： Yan Huang Yunpeng Yang Yuanyuan Zhao Hongyun Zhao Ningning Zhou Yaxiong Zhang likun chen Ting Zhou Gang chen Ting Wu Lu Lu Shilin Xue Xiaoyan Kang Li Zhang Wenfeng Fang Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineNo.651 Dongfeng East RoadGuangzhouGuangdong 510060China Department of Medicine Qilu Pharmaceutical Co.Ltd.JinanChina

First-line chemoimmunotherapy(with or without bevacizumab)has improved outcomes in advanced non-small cell lung cancer(NSCLC).Here,this open-label,multi-cohort phase II study(NCT05329025)was done to investigate the safety and efficacy of QL1706(a single bifunctional MabPair product against PD-1 and CTLA-4)and chemotherapy with or without bevacizumab in this *** were enrolled into five different cohorts based on genotype(cohorts 1-4,epidermal growth factor receptor[EGFR]wild-type;cohort 5,EGFR-mutant and progressed on EGFR-tyrosine kinase inhibitors[TKIs]).Between June 11,2021 and December 29,2021,91 patients were *** frequent treatment-related adverse events(TRAEs)included decreased appetite(60[65.9%]),anemia(60[65.9%]),infusion-related reactions(48[52.7%]),and pruritus(44[48.4%]).Grade≥3 TRAEs occurred in 30(33.0%)***-seven(45%)patients with wild-type EGFR achieved partial response(PR)(objective response rate[ORR]=45%)and had a median progression-free survival(mPFS)of 6.8 months(95%CI:5.2-9.7).For 31 patients harboring mutated EGFR,17(54.8%)achieved PR(ORR=54.8%),with an mPFS of 8.5 months(95%CI:5.72-not evaluable).Overall,QL1706 plus chemotherapy,regardless of having bevacizumab,was generally tolerable and had promising antitumor activity for EGFR wild-type advanced NSCLC in first-line ***,QL1706 plus chemotherapy and bevacizumab showed favorable antitumor activity for patients who had EGFR mutated NSCLC but failed in TKI therapy,demonstrating a potential for treating this population.

关键词： bevacizumab chemotherapy phase