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Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification

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International Journal of Oral Science 2024年第3期16卷 448-459页

作者： Kang Li Caihua zhang Ruoxing zhou Maosheng {2.g Rongsong Ling Gan Xiong Jieyi Ma Yan zhu Shuang {2. Jie {2. Demeng {2. liang Peng State Key Laboratory of Oncology in South china Department of Oral and Maxillofacial SurgeryInstitute of Precision MedicineCenter for Translational MedicineThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina institute for Advanced Study Shenzhen UniversityShenzhenChina Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-Sen UniversityGuangzhouChina Senior Department of Oncology The Fifth Medical Center of PLA General HospitalBeijingChina

Head and neck squamous cell carcinoma(HNSCC)is characterized by high recurrence or distant metastases rate and the prognosis is *** is mounting evidence that tumor-infiltrating B cells(TIL-Bs)have a crucial,synergistic role in tumor ***,little is known about the role TIL-Bs play in immune microenvironment and the way TIL-Bs affect the outcome of immune checkpoint *** single-cell RNA sequencing(scRNA-seq)data from the Gene Expression Omnibus(GEO)database,the study identified distinct gene expression patterns in *** samples were categorized into TIL-Bs inhibition and TIL-Bs activation groups using unsupervised *** classification was further validated with TCGA HNSCC data,correlating with patient prognosis,immune cell infiltration,and response to *** found that the B cells activation group exhibited a better prognosis,higher immune cell infiltration,and distinct immune checkpoint levels,including elevated PD-L1.A prognostic model was also developed and validated,highlighting four genes as potential biomarkers for predicting survival outcomes in HNSCC ***,this study provides a foundational approach for B cells-based tumor classification in HNSCC,offering insights into targeted treatment and immunotherapy strategies.

关键词： prognosis elevated offering

Inhibition of EGFR attenuates EGF-induced activation of retinal pigment epithelium cell via EGFR/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1018-1027页

作者： Yu-Sheng zhu Si-Rui zhou Hui-Hui {2. Tong Wang Xiao-Dong chen Faculty of Life sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effect of epidermal growth factor receptor(EGFR)inhibition by erlotinib and EGFR siRNA on epidermal growth factor(EGF)-induced activation of retinal pigment epithelium(RPE)***:Human RPE cell line(ARPE-19 cells)was activated by 100 ng/mL *** and EGFR siRNA were used to intervene EGF *** viability,proliferation,and migration were detected by methyl thiazolyl tetrazolium(MTT)assay,bromodeoxyuridine(BrdU)staining assay and wound healing assay,***/protein kinase B(AKT)pathway proteins and N-cadherin,α-smooth muscle actin(α-SMA),and vimentin were tested by Western blot *** was also determined by immunofluorescence ***:EGF treatment for 2.h induced a significant increase of ARPE-19 cells’viability,proliferation and migration,phosphorylation of EGFR/AKT proteins,and decreased total EGFR *** suppressed ARPE-19 cells’viability,proliferation and migration through down regulating total EGFR and AKT protein *** also inhibited EGF-induced an increase of proliferative and migrative ability in ARPE-19 cells and clearly suppressed EGF-induced EGFR/AKT proteins phosphorylation and decreased expression of N-cadherin,α-SMA,and vimentin ***,EGFR inhibition by EGFR siRNA significantly affected EGF-induced an increase of cell proliferation,viability,and migration,phosphorylation of EGFR/AKT proteins,and up-regulation of N-cadherin,α-SMA,and vimentin ***:Erlotinib and EGFR-knockdown suppress EGF-induced cell viability,proliferation,and migration via EGFR/AKT pathway in RPE *** inhibition may be a possible therapeutic approach for proliferative vitreoretinopathy(PVR).

关键词： erlotinib epidermal growth factor receptor protein kinase B epithelial-mesenchymal transition retinal pigment epithelium cell

Observation of signature inversion in the πh_(9/2.(×)νi_(13/2. oblate band

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Science china(physics,Mechanics & Astronomy) 2005年第4期48卷 442-449页

作者： XIE chengying1,2. zhou xiaohong1,{2., GUO Yingxiang1, LEI Xiangguo1, ZHENG Yong1, LIU Minliang1, SONG Litao1, WANG Hualei1, YU Haiping1, GUO Wentao 1, LUO Peng1, WU Zhijun1, zhu lihua3 & WU Xiaoguang3 ⒈ institute of modern physics, chinese academy of sciences, lanzhou 730000, china ⒉ Graduate School of the chinese academy of sciences, Beijing 100049, china ⒊ institute of Atomic Energy Research, Beijing 102.13, china institute of modern {2. Chinese Academy of Sciences Lanzhou China Graduate School of the chinese academy of sciences Beijing China institute of Atomic Energy Research Beijing China

High-spin states in 190Tl have been studied via the 160Gd(35Cl, 5nγ) reaction. The level scheme, consisting of the π h9 /2. νi13/2.oblate band and a cascade with character of single particle excitations, has been established. Spin values have been firmly assigned to the oblate band in 190Tl, resulting in low-spin signature inversion in the π h9 /2. νi13/2.oblate band for the first time. Based on the similarity of the level structure in doubly odd Tl nuclei, spin values for the oblate bands in 192.2.0Tl should be re-assigned, and a consistent low-spin signature inversion has occurred in these oblate deformed nuclei. The low-spin signature inversion phenomena can be interpreted qualitatively by using the 2.quasiparticle plus rotor model including p-n residual interactions.

关键词： deformed odd-odd 190Tl, oblate rotational bands, signature inversion, 2.qp+rotor model.

Development of Ti–V–Cr–Mn–Mo–Ce high-entropy alloys for high-density hydrogen storage in water bath environments

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Rare Metals 2024年第10期43卷 5229-5241页

作者： Hua-zhou Hu Hou-Qun Xiao Xin-Cong He Wen-Hao zhou Xiao-Xuan {2. Rui-zhu Tang Jie Li Chuan-Ming Ma Qing-Jun chen Key Laboratory of Rare Earths Chinese Academy of SciencesJiangxi Institute of Rare EarthsGanjiang Innovation AcademyChinese Academy of Sciences

The V-based body-centered cubic （BCC）-type hydrogen storage alloys have attracted significant attention due to their high theoretical hydrogen storage capacity of3.80 wt%.However,their practical application faces challenges related to low dehydriding capacity and poor activation *** overcome these challenges,a BCC-type Ti–V–Cr–Mn–Mo–Ce high-entropy alloy（HEA） with an effectively dehydriding capacity of 2.5 wt% above 0.1 MPa was *** introduction of Mo and conducting heat treatment,the precipitation of Ti-rich phase in HEA was successfully suppressed,resulting in improved compositional uniformity and dehydriding ***,the effective dehydriding capacity increased significantly from 0.60 wt% to 2.50 wt% a65℃,surpassing that of other types of hydrogen storage alloys under the same ***,the addition of 1 wt%Ce enabled initial hydrogen absorption at 2.℃ without the need for activation at 400℃.Furthermore,Ce doping reduced the dehydriding activation energy of the Ti–V–Cr–Mn–Mo–Ce HEA from 52.71 to 42.82.kJ·mol-1Additionally,the enthalpy value of dehydrogenation decreased from 46.89 to 17.96 k J·mol-1,attributed to a decrease in the hysteresis factor from 0.68 to *** findings provide valuable insights for optimizing the hydrogen storage property of HEA.

关键词： BCC structure Ce doping Heat treatment High-entropy alloys Hydrogen storage alloys

SARS-CoV-2.envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan Yi-Lin zhang zhuo-Er Qiu Lei {2. Xiao-Chun Hou Junqing Yue Yu-Yun zhou Jie Sheng Lei Zhao Yun-Xin zhu Jing Sun Jincun Zhao Wen-liang zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2.E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2.4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2.E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2.infection.

关键词： airway inflammation elevated

Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope

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Journal of Geriatric Cardiology 2024年第6期21卷 651-657页

作者： Bin TU Zi-Hao LAI Ai-Yue chen Zhi-Yuan WENG Si-Min CAI zhu-Xin {2. Li-Kun zhou Li-Hui ZHENG Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesNational Key LaboratoryChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiac Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Cardiovascular Department The First Affiliated HospitalFujian Medical UniversityFujian Institute of HypertensionFujianChina Department of Cardiovascular The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiangChina

BACKGROUND Cardioneuroablation(CNA)has shown encouraging results in patients with vasovagal syncope(VVS).However,data on different subtypes was *** This observational study retrospectively enrolled 141 patients[mean age:40±18 years,51 males(36.2.)]with the diagnosis of *** characteristics among different types of VVS and the outcomes after CNA were *** After a mean follow-up of 4.3±1.5 years,41 patients(2..1%)experienced syncope/pre-syncope events after ***/pre-syncope recurrence significantly differed in each subtype(P=0.04).The cardioinhibitory type of VVS had the lowest recurrence rate after the procedure(n=6,16.7%),followed by mixed(n=2.,30.6%)and vasodepressive(n=9,45.0%).Additionally,a significant difference was observed in the analyses of the Kaplan-Meier survival curve(P=0.02..Syncope/pre-syncope burden was significantly reduced after CNA in the vasodepressive type(P1).Vasodepressive types with recurrent syncope/pre-syncope after CNA have a lower baseline deceleration capacity(DC)level than those without(7.4.1.0 ms vs.9.0±1.6 ms,P=0.01).Patients with DC1(HR=8.1,95%CI:2.2.30.0,P=0.02.times risk of syncope/pre-syncope recurrence after CNA compared to patients with DC≥8.4 ms,and this association still existed after adjusting for age and sex(HR=8.1,95%CI:2.2.30.1,P=0.02..CONCLUSIONS Different subtypes exhibit different event-free *** vasodepressive type exhibited the lowest event-free rate,but those patients with DC≥8.4 ms might benefit from CNA.

关键词： syncope subtypes diagnosis

An organic visible-photocatalytic-adsorbence mechanism to high-efficient removal of heavy metal antimony ions

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Materials Reports(Energy) 2024年第3期4卷 49-59页

作者： Linji Yang Ke Sun Tao Liu Ciyuan Huang Libin zhang Yang zhou Kai {2. Shangfei Yao Ziyang zhang {2.fu Zhao Hongxiang zhu Bingsuo Zou Shuangfei Wang Dongfeng Xue School of Chemistry and Chemical Engineering Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresSchool of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China Department of Biochemistry and Cell Biology YouJiang Medical University for NationalitiesBaise CityGuangxi Zhuang Autonomous Region 533000China Shenzhen institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518110China

Purification of emerging heavy metal antimony contaminated water based on advanced ingenious *** activated modified coconut shell charcoal(CSC)was synthesized and evaluated as a substrate-supported loaded organic photovoltaic material,PM6:PYIT:PM6-b-PYIT,to prepare a surprisingly highly efficient,stable,environmentally friendly,and recyclable organic photocatalyst(CSC–N–P.P.P),which showed excellent effects on the simultaneous removal of Sb(Ⅲ)and Sb(Ⅴ).The removal efficiency of CSC-N-P.P.P on Sb(Ⅲ)and Sb(Ⅴ)reached an amazing 99.9%in quite a short duration of 15 *** the same time,under ppb level and indoor visible light(~1 W m^(2.),it can be treated to meet the drinking water standards set by the European Union and the *** Environmental Protection Agency in 5 min,and even after 2. cycles of recycling,the efficiency is still maintained at about 80%,in addition to the removal of As(Ⅲ),Cd(Ⅱ),Cr(Ⅵ),and Pb(Ⅱ)can also be *** catalyst not only solves the problems of low reuse rate,difficult structure adjustment and high energy consumption of traditional photocatalysts but also has strong applicability and practical *** pioneering approach provides a much-needed solution strategy for removing highly toxic heavy metal antimony pollution from the environment.

关键词： Organic photocatalyst Photocatalysis Purification Indoor visible light

Permafrost carbon cycle and its dynamics on the Tibetan Plateau

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Science china(Life sciences) 2024年第9期67卷 1833-1848页

作者： Leiyi chen Guibiao Yang Yuxuan Bai Jinfeng Chang Shuqi Qin Futing Liu Mei He Yutong Song Fan zhang Josep Penuelas Biao {2. Guoying zhou Yuanhe Yang State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China china National Botanical Garden Beijing 100093China College of Environmental and Resource sciences Zhejiang UniversityHangzhou 310058China Key Laboratory of Forest Ecology and Environment of National Forestry and Grassland Administration Ecology and Nature Conservation InstituteChinese Academy of ForestryBeijing 100091China University of chinese academy of sciences Beijing 100049China Consejo Superior de Investigaciones Científicas(CSIC) Global Ecology Unit CREAF-CSIC-UAB(Universitat Autònoma de Barcelona)Barcelona 08193Spain Centre for Ecological Research and Forestry(CREAF) Barcelona 08193Spain institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking UniversityBeijing 100871China Northwest institute of Plateau Biology Chinese Academy of SciencesXining 810008China Key Laboratory of Tibetan Medicine Research Chinese Academy of SciencesXining 810008China

Our knowledge on permafrost carbon(C)cycle is crucial for understanding its feedback to climate warming and developing nature-based solutions for mitigating climate *** understand the characteristics of permafrost C cycle on the Tibetan Plateau,the largest alpine permafrost region around the world,we summarized recent advances including the stocks and fluxes of permafrost C and their responses to thawing,and depicted permafrost C dynamics within this *** find that this alpine permafrost region stores approximately 14.1 Pg(1 Pg=1015g)of soil organic C(SOC)in the top 3 *** substantial gaseous emissions and lateral C transport occur across this permafrost ***,the mobilization of frozen C is expedited by permafrost thaw,especially by the formation of thermokarst landscapes,which could release significant amounts of C into the atmosphere and surrounding water *** alpine permafrost region nevertheless remains an important C sink,and its capacity to sequester C will continue to increase by *** future perspectives,we would suggest developing long-term in situ observation networks of C stocks and fluxes with improved temporal and spatial coverage,and exploring the mechanisms underlying the response of ecosystem C cycle to permafrost *** addition,it is essential to improve the projection of permafrost C dynamics through in-depth model-data fusion on the Tibetan Plateau.

关键词： permafrost carbon climate change carbon release carbon sink permafrost thaw thermokarst formation

TAX1BP1 and FIP2.0 orchestrate non-canonical autophagy of p62.aggregates for mouse neural stem cell maintenance

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Zoological Research 2024年第4期45卷 937-950页

作者： Yi-Fu zhu Rong-Hua Yu Shuai zhou Pei-Pei Tang Rui {2. Yu-Xin Wu Ran Xu Jia-Ming Wei Ying-Ying Wang Jia-Li {2. Meng-Ke Li Xiao-Jing Shi Yu-Wei {2. Guang-Zhi Liu Rick FThorne Xu Dong {2. Mian Wu Song chen School of Life sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Translational Research institute of Henan Provincial People’s Hospital and People'’s Hospital of Zhengzhou University Tianjian Laboratory of Advanced Biomedical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan 450053China institute of Medicinal Biotechnology Jiangsu College of NursingHuai’anJiangsu 223300China Laboratory Animal Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China Henan Key Laboratory of Stem cell Differentiation and Modification Henan Provincial People’s HospitalHenan UniversityZhengzhouHenan 450053China School of Biomedical sciences and Pharmacy The University of NewcastleNSW 2308Australia

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip2.0 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP2.0 and ATG13(designated as FIP2.0-4A mutant or FIP2.0 KI)does not produce comparable detrimental *** highlights the likely critical involvement of the non-canonical functions of FIP2.0,the mechanisms of which have remained ***,utilizing genetic mouse models,we demonstrated that FIP2.0 mediates non-canonical autophagic degradation of p62.sequestome1,primarily via TAX1BP1 in *** deletion of Tax1bp1 in fip2.0hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip2.0hGFAP conditional knockout(cKO)mouse ***,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip2.0hGFAP cKI mice but also led to a marked reduction in p62.aggregate ***,a TAX1BP1 mutant incapable of binding to FIP2.0 or NBR1/p62.failed to achieve this ***,conditional deletion of Tax1bp1 in fip2.0hGFAP cKO mice exacerbated NSC deficiency and p62.aggregate accumulation compared to fip2.0hGFAP cKO ***,these findings illustrate the essential role of the FIP2.0-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62.aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

关键词： Non-canonical autophagy TAX1BP1 FIP2.0 p62 Aggregates Neural stem cell