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Neoadjuvant camrelizumab(an anti-PD-1 antibody)plus chemotherapy or apatinib(a VEGFR-2 inhibitor)for initially unresectable stage II–III non-small-cell lung cancer:a multicentre,two-arm,phase 2 exploratory study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3015-3023页

作者： Haoran Xia Han zhang Zheng Ruan Huibiao zhang liangdong Sun Hezhong {3. Yongxin zhou Lele zhang Dongliang Bian Xinsheng zhu Jing zhang Fenghuan Sun Huansha Yu Nan Song Xiaogang Liu Yuming zhu Haiping zhang Wenxin He Jian {3. Jie Yang Guohan {3. Shiliang Xie Dongfang Tang Xiaomiao zhang liang Duan Deping Zhao Qinchuan Li Peng zhang Gening Jiang Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Thoracic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghaiChina Department of Thoracic Surgery Changhai HospitalNaval Medical UniversityShanghaiChina Department of Thoracic-Cardiovascular Surgery Tongji HospitalTongji University School of MedicineShanghaiChina Central Laboratory Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Experimental Animal Center Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Oncology Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai East HospitalTongji University School of MedicineShanghaiChina

This multicentre,two-arm,phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell lung cancer(NSCLC).Eligible patients regardless of PD-L1 expression received neoadjuvant camrelizumab 200 mg and platinum-doublet chemotherapy every 3.weeks(arm A)or those with PD-L1-positive tumors received neoadjuvant camrelizumab and apatinib 250 mg once daily(arm B),for 2–4 cycles,followed by *** primary endpoint was major pathological response(MPR)*** patients in arm A and 21 in arm B were *** rates were 50.0%(15/3.)in arm A and 42.9%(9/21)in arm B,with all patients achieving R0 *** these patients,the MPR and pathological complete response rates were both 20.0%(95%CI 4.3.48.1)in arm A and were 55.6%(95%CI 21.2–86.3.and 11.1%(95%CI 0.3.48.2)in arm B,*** corresponding objective response rates were 3..3.(95%CI 11.8–61.6)and 55.6%(95%CI 21.2–86.3..With a median follow-up of 22.4 months(95%CI 19.0–26.0),the median event-free survival was not reached(NR;95%CI 13.6-NR)in arm A and 16.8 months(95%CI 8.6-NR)in arm *** 3.or above treatment-related adverse events occurred in eight(26.7%)patients in arm A and three(14.3.)in arm *** analysis showed baseline TYROBP expression was predictive of treatment response in arm *** camrelizumab plus chemotherapy or apatinib exhibits preliminary efficacy and manageable toxicity in patients with initially unresectable stage II–III NSCLC.

关键词： Surgery chemotherapy treatment

Observation of signature inversion in the πh_(9/2)(×)νi_(13.2) oblate band

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Science China(physics,Mechanics & Astronomy) 2005年第4期48卷 442-449页

作者： XIE chengying1,2, zhou xiaohong1,2, zhang yuhu1, GUO Yingxiang1, LEI Xiangguo1, ZHENG Yong1, LIU Min{3., SONG Litao1, WANG Hualei1, YU Haiping1, GUO Wentao 1, LUO Peng1, WU Zhijun1, zhu lihua3.& WU Xiaoguang3.⒈ institute of modern physics, chinese academy of sciences, lanzhou 73.000, China ⒉ Graduate School of the chinese academy of sciences, Beijing 100049, China ⒊ institute of Atomic Energy Research, Beijing 102413. China institute of modern physics Chinese Academy of Sciences Lanzhou China Graduate School of the chinese academy of sciences Beijing China institute of Atomic Energy Research Beijing China

High-spin states in 190Tl have been studied via the 160Gd(3.Cl, 5nγ) reaction. The level scheme, consisting of the π h9 /2 νi13.2 oblate band and a cascade with character of single particle excitations, has been established. Spin values have been firmly assigned to the oblate band in 190Tl, resulting in low-spin signature inversion in the π h9 /2 νi13.2 oblate band for the first time. Based on the similarity of the level structure in doubly odd Tl nuclei, spin values for the oblate bands in 192―200Tl should be re-assigned, and a consistent low-spin signature inversion has occurred in these oblate deformed nuclei. The low-spin signature inversion phenomena can be interpreted qualitatively by using the 2-quasiparticle plus rotor model including p-n residual interactions.

关键词： deformed odd-odd 190Tl, oblate rotational bands, signature inversion, 2-qp+rotor model.

Study of proton resonances in ^(18)Ne via resonant elastic scattering of ^(17)F+p and its astrophysical implication

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Science China(physics,Mechanics & Astronomy) 2011年第S1期54卷 32-36页

作者： HE JianJun1, HU Jun1,2, XU ShiWei1, chen ZhiQiang1, zhang XueYing1, WANG JianSong1, YU XiangQing1, zhang LiYong1,2, LI Long1,2, YANG YanYun1,2, MA Peng1,2, zhang XueHeng1, HU ZhengGuo1, GUO ZhongYan1, XU Xing1,2, YUAN XiaoHua1, LU Wan1,2, YU YuHong1, ZANG YongDong1,2, TANG ShuWen1,2, YE RuiPing1,2, chen JinDa1,2, JIN ShiLun1,2, DU chengMing1,2, WANG ShiTao1,2, MA JunBing1,2, LIU LongXiang1,2, BAI Zhen1,2, LEI XiangGuo1, SUN ZhiYu1, zhang yuhu1, zhou xiaohong1, XU HuShan1, SU Jun3. LI ErTao3. WANG HongWei4, TIAN WenDong4 & LI XiangQing5 1 institute of modern physics (IMP), chinese academy of sciences, lanzhou 73.000, China 2 Graduate University of chinese academy of sciences, Beijing 100049, China 3.China institute of Atomic Energy (CIAE), Beijing 102413. China 4 Shanghai institute of Applied physics (SINAP), chinese academy of sciences, Shanghai 201800, China 5 School of physics and State Key Laboratory of Nuclear physics and Technology, Peking University, Beijing 100871, China institute of modern physics (IMP) Chinese Academy of Sciences Lanzhou China Graduate University of chinese academy of sciences Beijing China China institute of Atomic Energy (CIAE) Beijing China Shanghai institute of Applied physics (SINAP) Chinese Academy of Sciences Shanghai China School of physics and State Key Laboratory of Nuclear physics and Technology Peking University Beijing China

The proton resonant properties in 18Ne, which determine the reaction rate of the key stellar 14O(α,p)17F reaction, have been studied by using a technique of proton resonant elastic scattering of 17F+p. A 4.22 MeV/nucleon 17F radioactive ion (RI) beam was produced via a projectile-fragmentation reaction, and separated by a Radioactive Ion Beam Line in lanzhou (RIBLL). By bombarding a thick (CH2)n target, the energy spectra of the recoiled protons were measured by two ΔE-E silicon telescopes at the center-of-mass scattering angles of θc.m.≈175°±5°, θc.m.≈152°±8°, respectively. Several proton resonances in 18Ne were ob served clearly. A further R-matrix analysis of the experimental data is under way to determine the resonant parameters. The present work reports the preliminary results briefly.

关键词： resonant reaction reaction rate explosive burning accreting binary systems

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan Yi-Lin zhang zhuo-Er Qiu Lei chen Xiao-Chun Hou Junqing Yue Yu-Yun {3. Jie Sheng Lei Zhao Yun-Xin zhu Jing Sun Jincun Zhao Wen-{3. {3. Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope

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Journal of Geriatric Cardiology 2024年第6期21卷 651-657页

作者： Bin TU Zi-Hao LAI Ai-Yue chen Zhi-Yuan WENG Si-Min CAI zhu-Xin zhang Li-Kun {3. Li-Hui ZHENG Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesNational Key LaboratoryChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiac Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Cardiovascular Department The First Affiliated HospitalFujian Medical UniversityFujian Institute of HypertensionFujianChina Department of Cardiovascular The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiangChina

BACKGROUND Cardioneuroablation(CNA)has shown encouraging results in patients with vasovagal syncope(VVS).However,data on different subtypes was *** This observational study retrospectively enrolled 141 patients[mean age:40±18 years,51 males(3..2%)]with the diagnosis of *** characteristics among different types of VVS and the outcomes after CNA were *** After a mean follow-up of 4.3.1.5 years,41 patients(29.1%)experienced syncope/pre-syncope events after ***/pre-syncope recurrence significantly differed in each subtype(P=0.04).The cardioinhibitory type of VVS had the lowest recurrence rate after the procedure(n=6,16.7%),followed by mixed(n=26,3..6%)and vasodepressive(n=9,45.0%).Additionally,a significant difference was observed in the analyses of the Kaplan-Meier survival curve(P=0.02).Syncope/pre-syncope burden was significantly reduced after CNA in the vasodepressive type(P4±1.0 ms vs.9.0±1.6 ms,P=0.01).Patients with DC4 ms had an 8.1(HR=8.1,95%CI:2.2-3..0,P=0.02)times risk of syncope/pre-syncope recurrence after CNA compared to patients with DC≥8.4 ms,and this association still existed after adjusting for age and sex(HR=8.1,95%CI:2.2-3..1,P=0.02).CONCLUSIONS Different subtypes exhibit different event-free *** vasodepressive type exhibited the lowest event-free rate,but those patients with DC≥8.4 ms might benefit from CNA.

关键词： syncope subtypes diagnosis

CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson's disease

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Neural Regeneration Research 2024年第1期19卷 196-204页

作者： Xiang chen Yuwan Lin Zhiling zhang Yuting Tang Panghai Ye Wei Dai Wenlong zhang Hanqun Liu Guoyou Peng Shuxuan Huang Jiewen Qiu Wenyuan Guo Xiaoqin {3. {3.ohua Wu Yaoyun Kuang Pingyi Xu Miaomiao {3. Department of Neurology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Neurology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina School of Basic Medical sciences Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's ***-ATPase participates in the synthesis of cellular adenosine triphosphate(ATP)and plays a central role in mitochondrial energy ***,the specific roles of wild-type(WT)CHCHD2 and T611-mutant CHCHD2 in regulating F1FO-ATPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 T61I affects mitochondrial function through regulating F1FO-ATPase activity,remain unclea ***,in this study,we expressed WT CHCHD2 and T61l-mutant CHCHD2 in an MPP^(+)-induced SH-SY5Y cell model of *** found that CHCHD2 protected mitochondria from developing MPP^(+)-induced *** normal conditions,ove rexpression of WT CHCHD2 promoted F1FO-ATPase assembly,while T61I-mutant CHCHD2 appeared to have lost the ability to regulate F1FO-ATPase *** addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and *** weeks after transfection with AAV-CHCHD2 T61I,we intraperitoneally injected 1-methyl-4-phenyl-1,2,3.6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this *** findings suggest that WT CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1F0-ATPase structure and function.

关键词： ATP synthase(F1F0-ATPase) coiled-coil helix coiled-coil helix domain containing 2 dopaminergic neuron mitochondrial dysfunction neurodegeneration oligomycin sensitivity-conferring protein Parkinson's disease T61I mutation tyrosine hydroxylase

TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance

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Zoological Research 2024年第4期45卷 937-950页

作者： Yi-Fu zhu Rong-Hua Yu Shuai zhou Pei-Pei Tang Rui zhang Yu-Xin Wu Ran Xu Jia-Ming Wei Ying-Ying Wang Jia-Li zhang Meng-Ke Li Xiao-Jing Shi Yu-Wei zhang Guang-Zhi Liu Rick FThorne Xu Dong zhang Mian Wu Song chen School of Life sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Translational Research institute of Henan Provincial People’s Hospital and People'’s Hospital of Zhengzhou University Tianjian Laboratory of Advanced Biomedical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan 450053China institute of Medicinal Biotechnology Jiangsu College of NursingHuai’anJiangsu 223300China Laboratory Animal Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China Henan Key Laboratory of Stem cell Differentiation and Modification Henan Provincial People’s HospitalHenan UniversityZhengzhouHenan 450053China School of Biomedical sciences and Pharmacy The University of NewcastleNSW 2308Australia

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13.designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental *** highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained ***,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in *** deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse ***,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate ***,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this ***,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO ***,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

关键词： Non-canonical autophagy TAX1BP1 FIP200 p62 Aggregates Neural stem cell

Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia:a multicenter,randomized,open-label,phase 3.trial

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2669-2678页

作者： Biqi zhou Jia chen Tianhui Liu Yishan Ye Yanming zhang Yiyang Ding Hong Liu MingQing {3. Xiao Ma Xiaoli Li Longfei Zhao Zhihong Lin He Huang Yang Xu Depei Wu National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina institute of Blood and Marrow Transplantation Collaborative Innovation Center of HematologySoochow UniversitySuzhouChina Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Hematology The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’anHuai’anChina Soochow Hopes Hematology Hospital SuzhouChina Department of Hematology Hygeia Suzhou Yongding HospitalSuzhouChina

Coinfusion of unrelated cord blood(UCB)units in haploidentical hematopoietic cell transplantation(haplo-HCT)(haplo-cord HCT)for hematopoietic malignancies showed promising results in previous reports,but the efficiency of haplo-cord HCT in acute myeloid leukemia(AML)still lacks sufficient *** multicenter,randomized,phase 3.trial(*** NCT03.1953.)aimed to assess the efficacy and safety of haplo-cord HCT in AML patients.A total of 268 eligible patients aged 18-60 years,diagnosed with measurable residual disease in AML(excluding acute promyelocytic leukemia),with available haploidentical donors and suitable for allotransplantation,were randomly allocated(1:1)to receive haplo-cord HCT(n=13.)or haplo-HCT(n=13.).The 3.year overall survival(OS)was the primary endpoint in this *** median follow-up was 3..50 months(IQR 24.75-46.50).The 3.year OS of Haplo-cord HCT group was better than haplo-HCT group(80.5%,95%confidence interval[CI]:73.7-87.9 vs.67.8%95%CI 60.0-76.5,p=0.013..Favorable progression-free survival(70.3.,95%CI 62.6-78.8 vs.57.6%,95%CI 49.6-67.0,p=0.012)and cumulative incidence of relapse(12.1%,95%CI 12.0-12.2 vs.3..3.,95%CI 3..1-3..4,p=0.024)were observed in haplo-cord HCT *** 3.4 adverse events(AEs)within two years posttransplantation in the two groups were ***-cord HCT patients exhibited a faster cumulative incidence of neutrophil recovery(p=0.026)and increased T-cell reconstitution in the early period ***-cord HCT can improve OS in AML patients without excessive AEs,which may exert additional benefits for recipients of haplo-HCT.

关键词： hematopoietic acute phase

Configural processing of different topologically structured figures:an ERP Study

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Science China(Life sciences) 2009年第12期52卷 1198-1204页

作者： zhang JunJun1, zhu WeiNa2,3.4, DING XiaoJun1, zhou ChangLe1, HU XinTian2,3.& MA YuanYe2,3. 1 Lab of Mind, Art and Computation, Xiamen University, Xiamen 3.1005, China 2 Kunming {3. of Zoology,{3., Kunming 650223. China 3.State Key Laboratory of Brain and Cognitive Science, {3. of Biophysics,{3., Beijing 1001001, China 4 School of Information Science, Yunnan University, Kunming 650223. China Lab of Mind Art and Computation Xiamen University Xiamen China Kunming institute of Zoology Chinese Academy of Sciences Kunming China State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing China School of Information Science Yunnan University Kunming China

According to chen's theory, topological differences are perceived faster than feature differences in early visual perception. We hypothesized that topological perception is caused by the sensitivity in discriminating figures with and without "holes" . An ERP experiment was conducted utilizing a passive paradigm to investigate the differences in perceiving figures with "hole" and with "no-hole" . The results showed differences in N170 components between figures with "holes" and with "no-holes" . The inversion of the "hole" could influence the latency of N170, but the inversion of the "no-hole" could not, which indicated that global features are processed first in the "hole" perception whilst local features are given priority to the "no-hole" perception. This result was similar to studies concerning face and non-face objects, suggesting a configural processing of the "hole" .

关键词： visual evoked potential topological perception N170