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A microarray analysis of early activated pathways in concanavalin A-induced hepatitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 366-377页

作者： Qing-yi CAO Feng chen jie li Shan-shan WU Jing WANG Zhi chen State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital School ofl Medicine Zhejiang University Hangzhou 310003 China

Objective:To explore the mechanisms of fulminant hepatitis(FH) in the early stages,and to determine the critical pathways in its initiation and ***:Twelve BALB/c mice were divided into four groups:one group left as negative control and sacrificed immediately after injection of phosphate-buffered saline(PBS),and another three groups with concanavalin A(Con A) administration sacrificed at 1,3,and 6 h after *** GeneChip Mouse 430 2.0 Array was employed to evaluate the expression profile of each of the 12 *** analysis was done on the microarray data to extract the genes that were differentially *** analysis was carried out to determine relevant pathways within which regulated genes were significantly ***:A total of 393,8354 and 11 344 differentially expressed genes were found,respectively,at three time *** 0-1 h and 1-3 h,most of the pathways enriched with regulated genes were related to immune response and inflammation,among which Toll-like receptor(TLR) signaling and mitogen-activated protein kinase(MAPK) signaling appeared during both phases,while cytokine-cytokine receptor interaction,apoptosis,T cell receptor signaling,and natural killer(NK) cell-mediated cytotoxicity pathways emerged during the second *** found to be significant during 3-6 h were mostly related to metabolic ***:The TLR signaling pathway dominates the early responses of Con A-induced FH in *** stimulates the production of type I cytokines,therefore recruiting and activating T/NK *** T/NK cells exert their cytotoxicity on hepatocytes through inducing death receptorintermediated apoptosis,resulting in liver injury.

关键词： Concanavalin A Fulminant hepatitis Microarray Expression profile Pathway analysis

Effects of aspirin and enoxaparin in a rat model of liver fibrosis

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World Journal of Gastroenterology 2017年第35期23卷 6412-6419页

作者： chen-jie li Zhi-Hui Yang Xiao-liu Shi De-liang liu Department of Gastroenterology Second Xiangya Hospital of Central South University Department of Medicine Hospital of National University of Defense Technology

AIM To examine the effects of aspirin and enoxaparin on liver function, coagulation index and histopathology in a rat model of liver *** Forty-five male Sprague-Dawley rats were randomly divided into the control group(n = 5) and model group(n = 40). Thioacetamide(TAA) was used to induce liver fibrosis in the model group. TAA-induced fibrotic rats received TAA continuously(n = 9), TAA + low-dose aspirin(n = 9), TAA + high-dose aspirin(n = 9) or TAA + enoxaparin(n = 9) for 4 wk. All rats were euthanized after 4 wk, and both hematoxylin-eosin and Masson staining were performed to observe pathological changes in liver tissue. RESULTS liver fibrosis was assessed according to the METAVIR score. Compared with untreated cirrhotic controls, a significant improvement in fibrosis grade was observed in the low-dose aspirin, high-dose aspirin and enoxaparin treated groups, especially in the high-dose aspirin treated group. Alanine aminotransferase and total bilirubin were higher, albumin was lower and both prothrombin time and international normalized ratio were prolonged in the four treatment groups compared to controls. No significant differences among the four groups were *** Aspirin and enoxaparin can alleviate liver fibrosis in this rat model.

关键词： Aspirin Enoxaparin Thioacetamide liver fibrosis Rat

Full-thickness myotomy is associated with higher rate of postoperative gastroesophageal reflux disease

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World Journal of Gastroenterology 2016年第42期22卷 9419-9426页

作者： Xue-Hong Wang Yu-Yong Tan Hong-Yi Zhu chen-jie li De-liang liu Department of Gastroenterology the Second Xiangya Hospital of Central South University

AIM To compare long-term occurrence of gastroesophageal reflux disease(GERD) between two different types of peroral endoscopic myotomy(POEM) for *** We included all patients with achalasia who underwent POEM at our hospital from August 2011 to October 2012 and had complete GERD evaluation with ≥ 3 years of follow-up. They were divided into circular or full-thickness myotomy groups according to the depth of myotomy. Demographics, Eckardt score, manometry results, 24-h pH monitoring, and GERD symptoms were recorded and compared between the two *** We studied 56 patients(32 circular myotomy and 24 fullthickness myotomy) with complete GERD evaluation. There was no significant difference between the two groups in terms of treatment success(defined as Eckardt score ≤ 3), postoperative Eckardt score, mean basal lower esophageal sphincter pressure, and 4-s integrated relaxation pressure(4s IRP). Postoperative abnormal esophageal acid exposure was found in 25 patients(44.6%). A total of 13 patients(23.2%) had GERD symptoms and 12 had esophagitis(21.4%). Clinically relevant GERD(abnormal esophageal acid exposure associated with GERD symptoms and/or esophagitis) was diagnosed in 13 patients(23.2%).Multivariate analysis revealed that full-thickness myotomy and low level of postoperative 4s IRP were predictive factors for clinically relevant *** Efficacy and manometry are comparable between achalasia patients treated with circular or full-thickness myotomy. But patients with full-thickness myotomy and low postoperative 4sI RP have more GERD.

关键词： Achalasia Gastroesophageal reflux disease Peroral endoscopic myotomy Circular myotomy Fullthickness myotomy

Effects of Abiotic Environmental Factors on Soybean Cyst Nematode

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Agricultural Sciences in China 2009年第3期8卷 317-325页

作者： DUAN Yu-xi ZHENG Ya-nan chen li-jie ZHOU Xiao-min WANG Yuan-yuan SUN Jing-shuang North Plant Nematology Laboratory Deportment of Plant Protection Shenyang Agricultural University Shenyang 110161 P.R.China Department of Plant Science McGill University Montreal H3A 2T5 Canada

As a pest, in order to complete its life history and reproduces effectively, soybean cyst nematode （SCN）（Heterodera glycines Ichinche 1952） must adapt to various environments and conditions for long periods of evolution. The nematode is widely dispersed year after year. Controlling this pest requires understanding characters and adaptability of SCN. Effects of abiotic factors, such as temperature, soil humidity, agrotype, pH value, ions, plant exudates, agricultural chemical and cultivation systems on SCN, are reviewed in this paper. The results show that SCN is able to endure various environmental stresses, especially low temperature. Because of its special life history, cyst stage help SCN over winter, resistance of SCN to environmental stress is strong. A few studies have reported the mechanism of SCN environmental adaptability. We emphasized the importance of studying environmental adaptability of SCN, which would benefit the control of SCN by ecological means.

关键词： soybean cyst nematodes (SCN) abiotic environmental factors ecological

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全氧燃烧玻璃熔窑的数值模拟

建筑材料学报 2016年第5期19卷 915-920,949页

作者：陈杰李阳西安科技大学材料科学与工程学院陕西西安710054

采用Fluent软件,选取标准k-ε湍流模型、涡耗散反应模型与DO辐射模型,利用UDF函数将玻璃液面与玻璃熔窑火焰空间进行耦合,获得玻璃熔窑火焰空间和玻璃液的温度、速度及压力分布模型,从而更为细致全面地分析了玻璃熔窑工作时的传热传质过... 详细信息

采用Fluent软件,选取标准k-ε湍流模型、涡耗散反应模型与DO辐射模型,利用UDF函数将玻璃液面与玻璃熔窑火焰空间进行耦合,获得玻璃熔窑火焰空间和玻璃液的温度、速度及压力分布模型,从而更为细致全面地分析了玻璃熔窑工作时的传热传质过程.结果表明:所提出的模型能够比较客观地反映玻璃的熔制过程,对优化窑炉设计,提高窑炉使用寿命,降低成本和工作风险,改善工况具有一定的指导意义.

关键词：全氧燃烧玻璃熔窑数值模拟

Cyano migration-mediated radical-polar crossover cyclopropanation

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Science China Chemistry 2025年第01期 241-248页

作者： Ziqiang Wang Yasu chen jie li chen Zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

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Role of Regulatory T cell in Clinical Outcome of Traumatic Brain Injury

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Chinese Medical Journal 2015年第8期128卷 1072-1078页

作者： Min li Yun-Peng lin jie-li chen Hong li Rong-Cai Jiang Jian-Ning Zhang Department of Neurosurgery Tianjin Neurological Institute Tianjin Medical University General Hospital Tianjin 300052 China Department of Neurology Henry Ford Hospital Detroit MI 48202 USA Department of Neurosurgery Second Hospital of Tianjin Medical University Tianjin 300211 China

Background： Traumatic brain injury （TBI） is a life-threatening disease worldwide. Regulatory T cells （Treg ceils） were involved in the immunological system in central nervous system. It is defined as a subpopulation of CD4＋ cells that express CD25 and transcription lactor forkhead box P3. The level of circulating Treg cells increases in a variety of pathologic conditions. The purpose of this study was to uncover the role of circulating Treg cells in TBI. Methods： A clinical study was conducted in two neurosurgical intensive care units of Tianjin Medical University General Hospital and Second Hospital of Tianjin Medical University （Tianjin, China）. Forty patients and 30 healthy controls were recruited t＇rom August 2013 to November 2013. Circulating Treg cells was detected on the follow-up period of 1,4, 7, 14, and 21 days alter TBI. Blood sample （ 1 ml） was withdrawn in the morning and processed within 2 h. Results： There was no significant difference in the level of circulating Treg cells between TBI patients and normal controls during follow-up. TBI patients exhibited higher circulating Treg level than normal controls on the 1st day after TBI. Treg level was decreased on the 4th day, climbed tip on the 7th day and peaked on 14th day after TBI. Treg cells declined to the normal level on 21th day alter TBI. The level of circulating Treg cells was significantly higher in survival TBI patients when compared to nonsurvival TBI patients. TBI patients with improved conditions exhibited significantly higher circulating Treg level when compared to those with deteriorated conditions. The circulating Treg level was correlated with neurologic recovery after TBI. A better neural recovery and lower hospital mortality were found in TBI patients with circulating Treg cells more than 4.91% in total CD4＋ inononuclear cells as compared to those with circulating Treg cells less than 4.91% in total CD4 mononuclear cells in the first 14 days. Conclusions： The level of circulating Tr

关键词： Clinical Outcome Dynamic Change Prognostic Marker Regulatory T cell Traumatic Brain Injury

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CBTC列车安全定位中通信中断时间的研究

铁道学报 2012年第6期34卷 40-45页

作者：刘宏杰陈黎洁北京交通大学轨道交通控制与安全国家重点实验室北京100044 北京交通大学电子信息工程学院北京100044

通信中断的存在会对目前城市轨道交通的CBTC列车安全定位产生影响,进而影响列车安全间隔距离。CBTC车地通信系统大多采用无线局域网技术。越区切换中断是导致通信中断的主要原因,根据IEEE 802.11协议的越区切换流程,本文推导出越区切换... 详细信息

通信中断的存在会对目前城市轨道交通的CBTC列车安全定位产生影响,进而影响列车安全间隔距离。CBTC车地通信系统大多采用无线局域网技术。越区切换中断是导致通信中断的主要原因,根据IEEE 802.11协议的越区切换流程,本文推导出越区切换中断时间与列车速度的关系表达式,在此基础上根据安全定位的实现方法和移动闭塞系统中列车安全间隔距离的计算方法,推导出通信中断时间与影响安全定位的因素之一——估计的运行距离及列车运行安全间隔之间的关系表达式。建立两列列车追踪运行模型,仿真不同通信中断时间下两列车的追踪间隔距离。采用此关系表达式进行理论计算的结果与仿真结果验证了通信中断时间与估计的运行距离及列车运行安全间隔的关系表达式是合理的。

关键词：安全包络估计的运行距离安全间隔距离通信中断越区切换 802.11

基于随机Petri网的GSM-R双层网络建模与性能分析

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铁道学报 2012年第3期34卷 75-82页

作者：陈黎洁唐涛北京交通大学电子信息工程学院北京100044 北京交通大学轨道交通控制与安全国家重点实验室北京100044

利用随机Petri网,综合信道降质、链路中断、越区切换、灾害等因素,建立GSM-R的同站址网络与交织站址网络的故障模型,针对同站址与交织站址两种不同的网络结构,给出利用马尔可夫链求解可靠性与可用性的方法。通过马尔可夫链的有关概率分... 详细信息

利用随机Petri网,综合信道降质、链路中断、越区切换、灾害等因素,建立GSM-R的同站址网络与交织站址网络的故障模型,针对同站址与交织站址两种不同的网络结构,给出利用马尔可夫链求解可靠性与可用性的方法。通过马尔可夫链的有关概率分别计算:不同网络结构的可靠性;不同列车运行速度对应不同网络结构的可用性。分析计算结果表明:同站址网络的可靠性与可用性远高于交织站址网络,主要原因是同站址网络中一层基站业务中断时不会导致系统失效,交织站址网络中一层基站业务中断时,并联的另一层相邻两个基站均可以提供业务才不会导致系统失效。另外,同站址网络中越区切换速率较小,有效减小了列车越区切换对可靠性与可用性的影响。

关键词： GSM-R 可靠性可用性随机Petri网同站址网络交织站址网络