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Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 616-622页

作者： Zhou-wen chen li-ying chen Hong-lei DAI Jian-hua chen li-zheng FANG Department of General Practice Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Objective： To investigate the relationship between alanine aminotransferase （ALT） levels and metabolic syndrome （MS） in nonalcoholic fatty liver disease （NAFLD）. Methods： A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study. The diagnosis of fatty liver was based on ultrasound imaging. MS was defined according to the criteria of the Adult Treatment Panel III. ALT, triglyceride （TG）, high density lipoprotein cholesterol （HDL-c）, fasting plasma glucose （FPG）, height, weight, waist circumference （WC）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） were measured in each subject to analyze the relationship between MS and ALT activity Results：（1） The prevalence of NAFLD in men （30.94%） was significantly higher than that in women （15.65%）; （2） The incidence of MS in NAFLD （33.83%） was significantly greater than that in non-NAFLD （10.62%）; （3） Of the 6470 subjects with NAFLD, in the age-adjusted partial correlation analysis, there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex （P〈0.01）, except that ALT levels multiple stepwise regression analysis, SBP lost its significance, and had no correlation with HDL-c in women. Moreover, in the WC, body mass index （BMI）, age, DBP, TG and FPG were independently associated with ALT levels in both sexes （P〈0.05）. HDL-c remained significant and was independently related to ALT levels in men; （4） ALT levels were significantly higher in subjects with MS compared to those without MS （P〈0.001）. Mean ALT levels increased with the number of MS components in each sex （P〈0.05 for trend）. Conclusion： We found a strong relationship between ALT levels and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations.

关键词： Nonalcoholic fatty liver disease (NAFLD) Alanine aminotransferase (ALT) Metabolic syndrome (MS)

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核桃叶片生理性焦枯与矿质元素关系研究

林业科学研究 2024年第1期37卷 140-149页

作者：王霞磊梁鑫淼刘佳乐贾鹏陈利英齐国辉河北农业大学林学院河北保定071000 河北省核桃技术创新中心河北临城054300 河北绿岭果业有限公司河北临城054300 河北省(邢台)核桃产业技术研究院河北临城054300

[目的]以叶片营养诊断为主的方法对核桃叶片的矿质元素等指标进行测定和分析,找出核桃叶片焦枯发生的原因,为核桃生产栽培管理提供理论依据。[方法]按叶片焦枯程度对核桃树进行分级,测定不同焦枯程度、不同时期核桃叶片中N、P、K、Na、C... 详细信息

[目的]以叶片营养诊断为主的方法对核桃叶片的矿质元素等指标进行测定和分析,找出核桃叶片焦枯发生的原因,为核桃生产栽培管理提供理论依据。[方法]按叶片焦枯程度对核桃树进行分级,测定不同焦枯程度、不同时期核桃叶片中N、P、K、Na、Ca、Mg、Fe、Mn、Cu、Zn、B元素含量、叶绿素含量,并进行叶片矿质元素间、矿质元素与焦枯程度之间的相关性分析和多元Logistic回归分析。[结果]不同焦枯程度的叶片光合色素的含量随着焦枯程度及时间的推移大体呈下降的趋势,焦枯现象会从叶缘向叶片中部发展。病情程度与N含量呈显著正相关,相关系数为0.63,与P含量呈极显著正相关,相关系数为0.76,与Mn、B含量呈极显著负相关,相关系数分别为-0.73、-0.91。B含量与病情程度的Logistic回归系数值为-0.872,且呈现出0.05水平的显著性(p<0.05),对焦枯程度有显著的负向影响关系。且喷施不同浓度的B肥后焦枯症状得到了有效缓解。[结论]测定分析了‘绿岭’核桃焦枯叶片11种矿质元素含量的关系,发现缺B是引起‘绿岭’核桃叶片焦枯的最主要原因。

关键词：核桃叶片矿质元素生理性焦枯

Effects of PAHs on Biotransformation Enzymatic Activities in Fish

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Chemical Research in Chinese Universities 2011年第3期27卷 413-416页

作者： LU Guang-hua chen Wei li ying ZHU Zhi Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes Ministry of Education College of Environment Hohai University Nanjing 210098 P. R. China

Biotransformation and detoxification responses to the exposure to five polycyclic aromatic hydrocarbons were investigated in crucian（Carassius auratus）. Juvenile crucian were treated with a single intraperitoneal injection of each compound at dosages of 0.1, 1.0, 2.0, 5.0 and 8.0（or 10.0） mg/kg and sacrificed 15 d later to determine 7-ethoxyresorufin-O-deethylase（EROD） and glutathione S-transferases（GST） activities in gill S9 fractions. EROD activity is significantly increased by benzo（b）fluoranthene and indeno（1,2,3-cd）pyrene at all the doses. High dosages of PAHs induced GST activity and the inducing ability of them increased in the following order： fluorene fluorantheneindeno（1,2,3-cd）pyrenebenzo（g,h,i）perylenebenzo（b）fluoranthene. In all the cases, dose dependence appeared to exist. The gill EROD and GST in Carassius auratus are useful biomarkers to estimate sub-acute toxicity of both polycyclic aromatic hydrocarbons（PAHs） and PAHs-like compounds.

关键词： Polycyclic aromatic hydrocarbon Gill 7-Ethoxyresorufin-O-deethylase activity Glutathione S-transferases activity

Revealing Tissue Heterogeneity and Spatial Dark Genes from Spatially Resolved Transcriptomics by Multiview Graph Networks

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Research 2024年第2期6卷 629-645页

作者： ying li Yuejing Lu chen Kang Peiluan li Luonan chen School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang471023China Longmen Laboratory LuoyangHenan471003China Key Laboratory of Systems Biology Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai201100China Key Laboratory of Systems Health Science of Zhejang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310000China School of life Science and Technology ShanghaiTech UniversityShanghai201100.China

Spatially resolved transcriptomics(SRT)is capable of comprehensively characterizing gene expression patterns and providing an unbiased image of spatial *** fully understand the organizational complexity and tumor immune escape mechanism,we propose stMGATF,a multiview graph attention fusion model that integrates gene expression,histological images,spatial location,and gene *** better extract information,stMGATF exploits SimCLRv2 for visual feature exaction and employs edge feature enhanced graph attention networks for the learning potential embedding of each view.A global attention mechanism is used to adaptively integrate 3 views to obtain low-dimensional *** to diverse SRT datasets,stMGATF is robust and outperforms other methods in detecting spatial domains and denoising data even with different resolutions and *** particular,stMGATF contributes to the elucidation of tissue heterogeneity and extraction of 3-dimensional expression ***,considering the associations between genes in tumors,stMGATF can identify the spatial dark genes ignored by traditional methods,which can be used to predict tumor-driving transcription factors and reveal tumor immune escape mechanisms,providing theoretical evidence for the development of new immunotherapeutic strategies.

关键词： Spatial integrate driving

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专科医师规范化培训教学方式改革及效果评价

医院管理论坛 2024年第4期41卷 74-76页

作者：张宁陈立颖刘文娴首都医科大学附属北京安贞医院

目的分析心血管内科专培学员对案例教学联合团队教学方式的评价,评估教学方式改革的效果。方法将心血管内科专培学员随机分为教改组(案例教学联合团队教学)和对照组(传统讲授式教学),每组各17人。教改组采用案例教学联合团队教学,对照... 详细信息

目的分析心血管内科专培学员对案例教学联合团队教学方式的评价,评估教学方式改革的效果。方法将心血管内科专培学员随机分为教改组(案例教学联合团队教学)和对照组(传统讲授式教学),每组各17人。教改组采用案例教学联合团队教学,对照组采用传统讲授式教学。教改组学员接受问卷调查。两组学员均进行了理论知识和病例分析考试。结果专培学员认为案例教学联合团队教学更具优势、理论知识和病例分析考试得分也更高(p<0.05)。结论案例教学联合团队教学更具优势,可应用于心血管专培学员的教学。

关键词：专科医师规范化培训案例教学团队教学心血管专培学员

The joint Laplace transforms for killed diffusion occupation times

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 398-415页

作者： li ying-qiu chen Ye School of Mathematics and Statistics Changsha University of Science and TechnologyChangsha 410114China College of Mathematics and Computational Science Hunan University of Arts and ScienceChangde 415000China

The approach of li and Zhou(2014)is adopted to find the Laplace transform of occupation time over interval(0,a)and joint occupation times over semi-infinite intervals(-∞,a)and(b,∞)for a time-homogeneous diffusion process up to an independent exponential time e_(q)for 0licit expressions on the Laplace transform of occupation time and joint occupation time for Brownian motion with drift.

关键词： time-homogeneous diffusion process occupation time joint occupation time Laplace transform Brownian motion with drift

Group separation of coal components and new ideas of coal utilization as petroleum

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Mining Science and Technology 2009年第5期19卷 636-641页

作者： QIN Zhi-hong HOU Cui-li chen Juan ZHANG li-ying MA Jie-qiong School of Chemical Engineering and Technology China University of Mining ＆ Technology Xuzhou Jiangsu 221116 China

Four different groups of components were separated from coal under mild conditions of extraction and stripping process. Within these groups, and with pre-separation, individual utilization of all coal components can be realized, similar to petroleum components and enhance the inherent value and utilization value of coal, as well as increase environmental benefits. The characteristics of each component were analyzed with measurements by FTIR, GC/MS, TEM and the establishment of caking properties. The results show that coal can be separated into residues, ultra-pure coal, asphaltene components and light components by adding solvents for stripping into the CS2/NMP mixed extraction solution. Those four groups of components present great differences in the presence of carbon and hydrogen elements, in the structure of functional groups, in their macroscopic structure and micro-morphology and caking properties. Every component possesses its own inherent values and approaches. A new idea of coal processes and utilization, similar to the use of petroleum is proposed.

关键词： coal group components separation similarity to petroleum process and utilization

Effect of Micro-Area pH Value on Formation of Different Rust Phases of Weathering Steel in Initial Corrosion Period

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Journal of Iron and Steel Research International 2010年第9期17卷 69-72,78页

作者： chen Xiao-ping WANG Xiang-dong liU Qing-you MI Feng-yi chen ying li Yu-su Central Iron and Steel Research Institute Beijing 100081 China

The formation of protective rust layer of atmospheric corrosion resistance was discussed for weathering steel. The rust layers of experimental steels were made by using an accelerating industrial atmospheric corrosion test of dry-wet cyclic immersion. Furthermore XRD were used to measure and analyze the rust layers. The initial corrosion processes below thin water film were observed and the changes of micro-area pH value were measured. The results are as follows： The corrosion processes of P-RE weathering steel are obviously different from those of carbon steel. The surface of P-RE weathering steel rapidly forms a-FeOOH and the micro-area pH value is above 5.4 during the initial corrosion period. While the component of the rust layer for the carbon steel is mainly Fe3O4 and the microarea pH value is below 3.8.

关键词： weathering steel pH value micro area rust phase

NHC-derived carbon-centered luminescent radicals with shortwavelength emission via suppression of Kasha's rule

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Science China Chemistry 2024年第8期67卷 2679-2685页

作者： Can chen Xin li Xinhua Ouyang ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China College of Material Engineering Fujian Agriculture and Forestry University Fuzhou 350108China

Luminescent organic radicals have garnered increasing attention owing to their versatile applications in sensing, imaging, and organic light-emitting diodes(OLEDs), attributed to their unique emission properties originating from the doublet spin ***, the natural narrow bandgap of organic free radicals typically limits their emission to the long-wavelength *** luminescent organic radicals with short-wavelength emission remains a significant challenge. Herein, a series of carbon-centered radicals with short-wavelength emission(383–476 nm) by combining N-heterocyclic carbenes with various polycyclic aromatic hydrocarbons(PAHs)(2-naphthyl, 2a~Ⅰ and 2b~Ⅰ;2-phenanthryl, 2a~Ⅱand 2b~Ⅱ;2-anthryl, 2a~Ⅲand 2b~Ⅲ;3-phenanthryl, 2a~Ⅳand 2b~Ⅳ). Theoretical calculations reveal that the introduction of PAHs significantly increases the ΔE_(D2-D1) in 2a^(Ⅰ–Ⅲ)and 2b^(Ⅰ–Ⅲ)compared to that in phenyl-derived radical congeners. Consequently, the internal transition from D2 to D1 is impeded, leading to a high yield of D2 emission and a suppressed Kasha's rule, thereby overcoming the limitations imposed by their narrow bandgap. For 2a~Ⅳ and 2b~Ⅳ, despite a moderately large ΔED2-D1value, the ΔED3-D1value exceeds 1 e V, indicating that their emission likely originates from the D3 state. Furthermore, we utilized 2a~Ⅲand 2b~Ⅲ as emissive materials in OLEDs,resulting in blue emissions with external quantum efficiencies of 7.5% and 6.5%, respectively.

关键词： N-heterocyclic carbenes luminescent organic molecules carbon-centered radicals short-wavelength emission