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Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice

Chinese Journal of Natural Medicines 2024年第3期22卷 235-248页

作者： LAI Junzhong LIANG Jiadi chen kunsen GUAN Biyun chen Zhirong chen Linqin FAN Jiqiang ZHANG Yong LI Qiumei SU Jingqian chen Qi LIN Jizhen The Cancer Center Fujian Medical University Union HospitalFuzhou 350001China Fujian Key Laboratory of Innate Immune Biology Biomedical Research Center of South ChinaFujian Normal UniversityFuzhou 350117China The Department of Otolaryngology Head&Neck SurgeryUniversity of Minnesota Medical SchoolMinneapolisMN 55455USA

Carrimycin(CA),sanctioned by China’s National Medical Products Administration(NMPA)in 2019 for treating acute bronchitis and sinusitis,has recently been observed to exhibit multifaceted biological activities,encompassing anti-inflammatory,antiviral,and anti-tumor *** these applications,its efficacy in sepsis treatment remains *** study introduces a novel function of CA,demonstrating its capacity to mitigate sepsis induced by lipopolysaccharide(LPS)and cecal ligation and puncture(CLP)in mice *** research employed in vitro assays,real-time quantitative polymerase chain reaction(RT-qPCR),and RNA-seq analysis to establish that CA significantly reduces the levels of pro-inflammatory cytokines,namely tumor necrosis factor-alpha(TNF-α),interleukin 1 beta(IL-1β),and interleukin 6(IL-6),in response to LPS ***,Western blotting and immunofluorescence assays revealed that CA impedes Nuclear Factor Kappa B(NF-κB)activation in LPS-stimulated RAW264.7 *** these findings,in vivo experiments demonstrated that CA effectively alleviates LPS-and CLP-triggered organ inflammation in C57BL/6 *** insights were gained through 16S sequencing,highlighting CA’s pivotal role in enhancing gut microbiota diversity and modulating metabolic pathways,particularly by augmenting the production of short-chain fatty acids in mice subjected to ***,a comparative analysis revealed that CA’s anti-inflammatory efficacy surpasses that of equivalent doses of aspirin(ASP)and ***,these findings suggest that CA exhibits significant therapeutic potential in sepsis *** discovery provides a foundational theoretical basis for the clinical application of CA in sepsis management.

关键词： Carrimycin Inflammation Lipopolysaccharide Cecal ligation and puncture Sepsis Gut microbiota

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Aloin ameliorates cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating gut microbiota

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Food Science and Human Wellness 2024年

作者： Jingqian Su Jianbin Xiao Siyuan chen Heng Zhao Xiaoni Zhang Zhihua Feng kunsen chen Biyun Guan Wenzhi chen Youqiang chen Duo chen Qi chen Fujian Key Laboratory of Innate Immune Biology， Biomedical Research Center of South China， College of Life Science， Fujian Normal University The Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Products of the State Oceanic Administration， Fujian Key Laboratory of Special Marine Bioresource Sustainable Utilization， Southern Institute of Oceanography， College of Life Science， Fujian Normal University

Most Aloe species are used as new food or functional food ingredient. Even though widely known for its health benefits， the anti-inflammatory effects and underlying mechanisms of Aloin (Alo)， an anthraquinone compound isolated from plant species of the genus Aloe， remain unidentified. Here， we investigated the protective effects of Alo against cecal ligation and puncture (CLP)-induced sepsis and microflora in mice. Alo significantly improved CLP-induced sepsis and the survival rate of septic mice， downregulated the expression of proinflammatory factors， and decreased the infiltration of inflammatory cells in tissues. Alo upregulated the proportion of peritoneal macrophages， reduced the number of peritoneal bacteria， decreased the content of short-chain fatty acids and bile acids in the abdominal cavity， and suppressed TLR-2/4/NF-κB/NLRP3/Caspase-1/3/8 signaling. Furthermore， Alo altered the composition of the microbiome and promoted the growth of Lactobacillus， which showed a stronger anti-inflammatory effect. Whole-genome analysis identified the genes Saa3， Il10， Fpr1， and Eif4a1 associated with the protective effects of Alo in mice with CLP-induced sepsis. Overall， our results provide novel insights into the therapeutic potential and mechanism of action of Alo in the treatment of sepsis.

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房地产开发项目管理的重点与难点分析

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江西建材 2019年第12期 238-239页

作者：陈昆森漳州中梁房地产开发有限公司

房地产开发项目管理工作受到了社会各界的广泛重视,革新工作理念和方法,引用先进的手段和经验,提升房地产开发项目的整体质量。本文结合案例,以房地产开发项目管理的重点与难点为主线,进行简要的分析和描述。

关键词：房地产项目管理难点分析

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Zr基块体非晶合金的成分设计及其性能研究

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材料导报 2021年第24期35卷 24113-24116页

作者：朱坤森陶平均张超汉陈育淦张维建杨元政广东工业大学材料与能源学院广州510006

根据二元共晶混合法设计Zr-Cu-Ni-Al非晶合金成分,利用铜模吸铸法制备Zr-Cu-Ni-Al合金棒材。采用XRD、DSC、SEM及准静态压缩实验研究了所设计合金的非晶形成能力和力学性能。结果表明:所设计的Zr-Cu-Ni-Al合金均为非晶态结构,其过冷液相... 详细信息

根据二元共晶混合法设计Zr-Cu-Ni-Al非晶合金成分,利用铜模吸铸法制备Zr-Cu-Ni-Al合金棒材。采用XRD、DSC、SEM及准静态压缩实验研究了所设计合金的非晶形成能力和力学性能。结果表明:所设计的Zr-Cu-Ni-Al合金均为非晶态结构,其过冷液相区(Δ_(T x))均超过65 K,有较好的非晶形成能力,其中Zr_(55.7)Cu_(22.4)Ni_(7.2)Al_(14.7)合金的Δ_(T x)最宽,达到82 K;合金的塑性变形能力由低到高依次为:Zr_(57)Cu_(18.67)Ni_(8)Al_(16.33)、Zr_(56.36)Cu_(20.53)-Ni_(7.6)Al_(15.51)、Zr_(54.4)Cu_(26.13)Ni_(6.4)Al_(13.07)和Zr_(55.7)Cu_(22.4)Ni_(7.2)Al_(14.7),其中Zr_(55.7)Cu_(22.4)Ni_(7.2)Al_(14.7)的塑性达到5.5%,抗压强度达到1885 MPa,其他三种合金的塑性均不足2%。剪切带的增殖和交互作用与非晶合金的塑性和强度密切相关。合金试样断口中均有熔滴存在,这表明在合金变形过程中,断裂处的合金组织发生了粘性流动,并伴有脉纹产生。合金在塑性变形中均发生了锯齿流变,锯齿流变与自由体积的变化密切相关。

关键词：非晶合金成分设计塑性变形剪切带锯齿流变

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