检索结果-南通市图书馆

Cidan Capsule in Combination with Adjuvant Transarterial Chemoembolization Reduces Recurrence Rate after Curative Resection of Hepatocellular Carcinoma:A Multicenter,Randomized Controlled Trial

引用

Chinese Journal of Integrative Medicine 2023年第1期29卷 3-9页

作者： ZHENG Dong-hai YANG Jia-mei WU Jian-xiong chenG Shu-qun ZHANG Shao-geng WU Dong LI Aijun FU Xiao-hui LI Xun QI Fu-chen DUAN Wei-hong chen jun-hui YANG Zhi-ying LIANG Lu ZENG Jin-xiong ZHENG Wei-da WU Meng-chao Department of Oncology Beijing Weida Traditional Chinese Medicine Cancer HospitalBeijing100023China Department of Hepatic Surgery the Third Affiliated Hospital of Naval Medical UniversityShanghai200433China Department of Abdominal Surgery Cancer Hospital of Chinese Academy of Medical SciencesBeijing100021China Department of Hepatic Surgery the Fifth Medical Center of PLA General HospitalBeijing100161China Department of Hepatic Surgery the First Hospital of Lanzhou UniversityLanzhou730013China Department of Hepatic Surgery Huai’an First People’s HospitalNanjing Medical UniversityHuai’anJiangsu Province223399China Department of Hepatic Surgery PLA Rocket Army General HospitalBeijing100088China Department of Interventional Therapy Shenzhen Hospital of Peking UniversityShenzhenGuangdong Province518036China Department of Hepatic Surgery China-Japan Friendship HospitalBeijing100029China Department of Hepatic Surgery Baotou Central HospitalBaotouInner Mongolia Autonomous Region014042China Department of Traditional Chinese Medicine No.900 Hospital of the Joint Logistics Support Force of PLAFuzhou350025China

Objective:To evaluate the efficacy and safety of Cidan Capsule combined with adjuvant transarterial chemoembolization(TACE) in patients with a high risk of early recurrence after curative resection of hepatocellular carcinoma(HCC).Methods:A multicenter,randomized controlled trial was conducted in patients with high-risk recurrence factors after curative resection of HCC from 9 medical centers between July 2014 and July 2018.Totally249 patients were randomly assigned to TACE with or without Cidan Capsule administration groups by stratified block in a 1:1 ratio.Postoperative adjuvant TACE was given 4-5 weeks after hepatic resection in both groups.Additionally,125 patients in the TACE plus Cidan group were administrated Cidan Capsule(0.27 g/capsule,5 capsules every time,4 times a day) for 6 months with a 24-month follow-up.Primary endpoints included diseasefree survival(DFS) and tumor recurrence rate(TRR).Secondary endpoint was overall survival(OS).Any drugrelated adverse events(AEs) were observed and recorded.Results:As the data cutoff on July 9th,2018,the median DFS was not reached in the TACE plus Cidan group and 234.0 days in the TACE group(hazard ratio,0.420,95%confidence interval,0.290-0.608;P<0.01).The 1-and 2-year TRR in the TACE plus Cidan and TACE groups were 31.5%,37.1%,and 60.8%,63.4%,respectively(P<0.01).Median OS was not reached in both groups.The1-and 2-year OS rates in TACE plus Cidan and TACE groups were 98.4%,98.4%,and 89.5%,87.9%,respectively(P<0.05).The most common grade 3-4 AEs included fatigue,abdominal pain,lumbar pain,and nausea.One serious AE was reported in 1 patient in the TACE plus Cidan group,the death was due to retroperitoneal mass hemorrhage and hemorrhagic shock,and was not related to study drug.Conclusions:Cidan Capsule in combination with TACE can reduce the incidence of early recurrence in HCC patients at high-risk of recurrence after radical hepatectomy and may be an appropriate option in postoperative anti-recurrence treatment.(Registration No.NCT02253511)

关键词： hepatocellular carcinoma hepatectomy recurrence survival transarterial chemoembolization Cidan Capsule

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Safety evaluation of human umbilical cord-mesenchymal stem cells in type 2 diabetes mellitus treatment:A phase 2 clinical trial

引用

World Journal of Clinical Cases 2023年第21期11卷 5083-5096页

作者： Xiao-Fen Lian Dong-hui Lu Hong-Li Liu Yan-Jing Liu Yang Yang Yuan Lin Feng Xie Cai-Hao Huang Hong-Mei Wu Ai-Mei Long chen-jun hui Yu Shi Yun chen Yun-Feng Gao Fan Zhang Department of Endocrinology Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Department of Endocrinology Huizhou Central People’s HospitalHuizhou 516000Guangdong ProvinceChina Department of Endocrinology Longgang District Central Hospital of ShenzhenShenzhen 518000Guangdong ProvinceChina

BACKGROUND Progressive pancreaticβcell dysfunction is a fundamental aspect of the pathology underlying type 2 diabetes mellitus(T2DM).Recently,mesenchymal stem cell(MSC)transplantation has emerged as a new therapeutic method due to its ability to promote the regeneration of pancreaticβcells.However,current studies have focused on its efficacy,and there are few clinical studies on its safety.AIM To evaluate the safety of human umbilical cord(hUC)-MSC infusion in T2DM treatment.METHODS An open-label and randomized phase 2 clinical trial was designed to evaluate the safety of hUC-MSC transplantation in T2DM in a Class A hospital.Ten patients in the placebo group received acellular saline intravenously once per week for 3 wk.Twenty-four patients in the hUC-MSC group received hUC-MSCs(1×106 cells/kg)intravenously once per week for 3 wk.Diabetic clinical symptoms and signs,laboratory findings,and imaging findings were evaluated weekly for the 1st mo and then at weeks 12 and 24 post-treatment.RESULTS No serious adverse events were observed during the 24-wk follow-up.Four patients(16.7%)in the hUC-MSC group experienced transient fever,which occurred within 24 h after the second or third infusion;this did not occur in any patients in the placebo group.One patient from the hUC-MSC group experienced hypoglycemic attacks within 1 mo after transplantation.Significantly lower lymphocyte levels(weeks 2 and 3)and thrombin coagulation time(week 2)were observed in the hUC-MSC group compared to those in the placebo group(all P<0.05).Significantly higher platelet levels(week 3),immunoglobulin levels(weeks 1,2,3,and 4),fibrinogen levels(weeks 2 and 3),D-dimer levels(weeks 1,2,3,4,12,and 24),and neutrophil-to-lymphocyte ratios(weeks 2 and 3)were observed in the hUC-MSC group compared to those in the placebo group(all P<0.05).There were no significant differences between the two groups for tumor markers(alpha-fetoprotein,carcinoembryonic antigen,and carbohydrate antigen 199)or blood fat.No liver damage or other side effects were observ

关键词： Type 2 diabetes mellitus Cell transplantation Human umbilical cord-mesenchymal stem cells Safety Lymphocytes Immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimizing the frequency ratio method for landslide susceptibility assessment: A case study of the Caiyuan Basin in the southeast mountainous area of China

引用

Journal of Mountain Science 2020年第2期17卷 340-357页

作者： ZHANG Yi-xing LAN Heng-xing LI Lang-ping WU Yu-ming chen jun-hui TIAN Nai-man State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China School of Geological Engineering and Geomatics Chang'an UniversityXi'an 710064China

Bivariate statistical analysis of data-driven approaches is widely used for landslide susceptibility assessment, and the frequency ratio(FR) method is one of the most popular. However, the results of such assessments are dominated by the number of classes and bounds of landslide-related causative factors, and the optimal assessment is unknown. This paper optimizes the frequency ratio method as an example of bivariate statistical analysis for landslide susceptibility mapping based on a case study of the Caiyuan Basin, a region with frequent landslides, which is located in the southeast coastal mountainous area of China. A landslide inventory map containing a total of 1425 landslides(polygons) was produced, in which 70% of the landslides were selected for training purposes, and the remaining were used for validationpurposes. All datasets were resampled to the same 5 m × 5 m/pixel resolution. The receiver operating characteristic(ROC) curves of the susceptibility maps were obtained based on different combinations of dominating parameters, and the maximum value of the areas under the ROC curves(AUCs) as well as the corresponding optimal parameter was identified with an automatic searching algorithm. The results showed that the landslide susceptibility maps obtained using optimal parameters displayed a significant increase in the prediction AUC compared with those values obtained using stochastic parameters. The results also showed that one parameter named bin width has a dominant influence on the optimum. In practice, this paper is expected to benefit the assessment of landslide susceptibility by providing an easy-to-use tool. The proposed automatic approach provides a way to optimize the frequency ratio method or other bivariate statistical methods, which can furtherfacilitate comparisons and choices between different methods for landslide susceptibility assessment.

关键词： Automatic optimization Frequency ratio GIS Landslide susceptibility assessment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于MATLAB的圆弧齿轮泵水力设计与性能分析

引用

液压与气动 2024年第4期48卷 45-52页

作者：陈君辉司国雷陈川史广泰孙国栋四川航天烽火伺服控制技术有限公司四川成都611130 西华大学能源与动力工程学院四川成都610039

传统的齿轮泵具有困油、性能低等劣势,因此为了设计出性能更好的齿轮泵,采用外啮合、双圆弧、斜流道的理念设计了圆弧齿轮泵,基于MATLAB软件拟合得出过渡线,计算出齿数、齿宽和螺旋角等重要参数,并通过UG软件设计了几组圆弧齿轮泵,最后... 详细信息

传统的齿轮泵具有困油、性能低等劣势,因此为了设计出性能更好的齿轮泵,采用外啮合、双圆弧、斜流道的理念设计了圆弧齿轮泵,基于MATLAB软件拟合得出过渡线,计算出齿数、齿宽和螺旋角等重要参数,并通过UG软件设计了几组圆弧齿轮泵,最后通过数值模拟分析了结构参数对圆弧齿轮泵性能的影响。结果表明,随着齿数、螺旋角等参数的改变,圆弧齿轮泵的增压能力和流动稳定性也随之发生改变,尤其在齿数较多时,其进出口压差逐渐增大,流道内高速区域较多,啮合区域以及进油腔、排油腔内的二次回流较少,流动更加稳定;随着转速的增加齿轮泵所受应力明显增加,高应力区域主要集中在轮轴交界处以及啮合处,主动轮与轮轴的交界面是等效应力最大的地方。

关键词：圆弧齿轮泵水力设计性能分析等效应力

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

在线固相萃取净化-液相色谱-串联质谱法直接测定植物粗提物中的23种全氟化合物

引用

分析化学 2024年第2期52卷 286-300页

作者：申楠韩同竹盛璨璨何秀平陈军辉刘晨光李先国中国海洋大学海洋化学理论与工程技术教育部重点实验室自然资源部第一海洋研究所自然资源部海洋生态环境科学与技术重点实验室青岛市现代分析与近海生态环境安全保障重点实验室

采用全自动在线固相萃取净化技术去除植物粗提物中的基质干扰组分，建立了一种超高效液相色谱-串联质谱(UHPLC-MS/MS)同步测定植物叶片组织中23种全氟化合物(Per-and polyfluoroalkyl substances,PFASs)(13种全氟羧酸类、4种全氟磺酸类... 详细信息

采用全自动在线固相萃取净化技术去除植物粗提物中的基质干扰组分，建立了一种超高效液相色谱-串联质谱(UHPLC-MS/MS)同步测定植物叶片组织中23种全氟化合物(Per-and polyfluoroalkyl substances,PFASs)(13种全氟羧酸类、4种全氟磺酸类和6种新型替代品)的新方法。植物样品经1%甲酸-甲醇溶液提取两次再旋蒸至干，用70%甲醇溶液复溶后直接进样分析。通过WAX在线固相萃取柱对PFASs进行自动化净化后，切换六通阀，将PFASs冲洗至适用于碱性流动相体系的C18分析柱上，采用含0.4%氨水的甲醇/水二元流动相体系进行梯度洗脱，在16 min内即可实现各目标化合物的色谱分离。采用串联质谱在多重反应监测(MRM)模式下进行PFASs的在线检测，并用内标法进行定量分析。方法学考察结果表明，植物叶片样品中23种目标PFASs的平均加标回收率为64.2%～125.5%，相对标准偏差(RSD)为0.7%～12.8%，各目标PFASs在相应的质量浓度范围内线性关系良好，相关系数(R2)大于0.990，检出限(LOD,S/N=3)在0.02～0.50μg/kg之间。采用本方法对海洋绿潮藻浒苔和4种树叶实际样品中的PFASs进行检测，共检出6种PFASs，其中PFBA为主要污染物。与文献报道的离线固相萃取法相比，本方法简化了样品前处理过程，为植物组织中典型PFASs及其新型替代品的日常监测提供了一种简便、快捷和准确的方法。

关键词：在线固相萃取植物叶片全氟化合物超高效液相色谱-串联质谱

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

不同有机肥替代比例对橘园土壤及果实品质影响研究

引用

中国土壤与肥料 2024年第5期 78-88页

作者：常健玮刘国群颜雯婷刘洋徐铖陈俊辉秦华浙江农林大学环境与资源学院浙江杭州311300 衢州市柯城区农业农村局浙江衢州324000 衢州市衢江区农业农村局浙江衢州324022

为降低柑橘化肥氮用量促进橘园可持续发展,开展有机肥替代化肥对柑橘果实品质、土壤养分、微生物活性以及细菌群落的影响研究。采用单因素随机区组设计,设置4个有机肥替代化肥处理:0(CK)、25%替代(T1)、50%替代(T2)、75%替代(T3)。在柑... 详细信息

为降低柑橘化肥氮用量促进橘园可持续发展,开展有机肥替代化肥对柑橘果实品质、土壤养分、微生物活性以及细菌群落的影响研究。采用单因素随机区组设计,设置4个有机肥替代化肥处理:0(CK)、25%替代(T1)、50%替代(T2)、75%替代(T3)。在柑橘成熟期,取样测定土壤养分、果实品质、土壤酶活性、土壤细菌群落以及全年柑橘CO_(2)通量。施用有机肥显著提升土壤速效养分进而提升柑橘果重、维生素C、可溶性固形物等果实品质。有机肥替代化肥提升了土壤微生物活性,提高了土壤CO_(2)排放通量。施用有机肥显著提升了土壤β-葡萄糖苷酶、酸性磷酸酶活性,显著降低了亮氨酸氨基肽酶活性。有机肥替代化肥显著提升了土壤细菌群落多样性,提高了土壤抗病菌如红游动菌属(Rhodoplanes)与芽胞杆菌属(Bacillus)的相对丰度。RDA分析结果表明:有机肥替代化肥对土壤细菌群落产生影响,其中土壤有效磷、有机质、pH、有效镁是本试验中影响橘园土壤细菌群落的关键因子。有机肥替代显著提高了土壤微生物活性,提升了土壤速效养分,增加了有益菌的相对丰度,对柑橘健康生长发挥了重要作用,其中有机肥替代基肥中50%的化肥在提升土壤速效养分与柑橘品质方面效果最佳,与施用化肥的对照相比,显著提升34.58%柑橘果重、14.02%横径、15.21%纵径、25.43%可溶性固形物含量、16.46%维生素C含量。研究结果可为合理开展柑橘园有机肥替代化肥,提高柑橘品质和促进橘园可持续发展提供参考。

关键词：有机肥替代柑橘土壤呼吸土壤细菌群落

来源：

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Role of polarization evolution in the hysteresis effect of Pb-based antiferroelecrtics

引用

Chinese Chemical Letters 2024年第4期35卷 516-519页

作者： Botao Gao He Qi hui Liu jun chen Beijing Advanced Innovation Center for Materials Genome Engineering Department of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 201899China Hainan University Haikou 570228China

The electric field-induced irreversible domain wall motion results in a ferroelectric(FE) hysteresis. In antiferroelectrics(AFEs), the irreversible phase transition is the main reason for the hysteresis effects, which plays an important role in energy storage performance. Compared to the well-demonstrated FE hysteresis,the structural mechanism of the hysteresis in AFE is not well understood. In this work, the underlying correlation between structure and the hysteresis effect is unveiled in Pb(Zr,Sn,Ti)O_(3) AFE system by using in-situ electrical biasing synchrotron X-ray diffraction. It is found that the AFE with a canting dipole configuration, which shows a continuous polarization rotation under the electric field, tends to have a small hysteresis effect. It presents a negligible phase transition, a small axis ratio, and electric field-induced lattice changing, small domain switching. All these features together lead to a slim hysteresis loop and a high energy storage efficiency. These results offer a deep insight into the structure-hysteresis relationship of AFEs and are helpful for the design of energy storage material.

关键词： Antiferroelectric Hysteresis effect Structure refinement Perovskite In situ synchrotron radiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Remarkable Wear Resistance in a Complex Concentrated Alloy with Nanohierarchical Architecture and Composition Undulation

引用

Research 2024年第1期2023卷 403-416页

作者： Yushan Geng Wenyuan chen hui Tan jun cheng Shengyu Zhu jun Yang Weimin Liu State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049PR China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 264000PR China

Sustained wear damages on the sliding surfaces of alloys are generally the culprit responsible for the failure of various mechanical systems.Inspired by high-entropy effects,here we deliberately deploy nanohierarchical architecture with composition undulation in a Ni50(AlNbTiV)_(50) complex concentrated alloy,which yields ultralow wear rate within the order of 10^(−7) to 10^(−6) mm^(3)/Nm between room temperature and 800℃.Such remarkable wear resistance heretofore represents one of the highest wear resistance reported for the bulk alloys or composites,and originates from the multi-type adaptive friction interface protection governed by intrinsically nano-coupled grains and nanoprecipitates.This cooperative heterostructure releases gradient frictional stress in stages upon wear at room temperature through the coexistence of multiple deformation pathways while activating a dense nanocrystalline glaze layer upon wear at 800℃ to minimize adhesive and oxidative wear.Our work uncovers a practical avenue for tailoring wear properties with multicomponent heterostructures over a wide temperature range.

关键词： wear alloys friction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

非惩罚制度下医院护理不良事件的上报情况及影响因素分析

引用

医院管理论坛 2024年第1期41卷 15-18页

作者：陈雅妮周冰冰陈慧君孙佳何林瑜温州医科大学附属第一医院

目的分析非惩罚制度背景下护理不良事件上报情况及影响因素,为提高护理不良事件的上报率提供参考。方法于2022年1—2月随机抽取我院316名护理人员作为研究对象,利用问卷调查法对护理不良事件上报的影响因素进行分析。结果担心对个人... 详细信息

目的分析非惩罚制度背景下护理不良事件上报情况及影响因素,为提高护理不良事件的上报率提供参考。方法于2022年1—2月随机抽取我院316名护理人员作为研究对象,利用问卷调查法对护理不良事件上报的影响因素进行分析。结果担心对个人形象产生影响、担心受到处罚和不良事件上报流程过于复杂是影响护理人员护理不良事件上报的主要因素;不同分级护理人员的护理不良事件上报影响因素不同,不良事件的上报流程过于复杂是1级和5级护理人员的主要影响因素(p<0.05);担心对个人形象产生影响和担心受到处罚是2级、3级和4级护理人员的主要影响因素(p<0.05);其他因素对不同分级护理人员护理不良事件上报的影响评分差异无统计学意义(p﹥0.05)。结论非惩罚制度背景下护理不良事件上报的影响因素主要为担心对个人形象产生影响、担心受到处罚和不良事件上报流程过于复杂,应当在加强护理人员有关非惩罚制度教育的基础上,加强对现有护理不良事件上报流程的全面优化。

关键词：护理人员非惩罚制度护理不良事件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pancreatic giant malignancy simulating a gastrointestinal stromal tumor

引用

Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 431-433页

作者： Ben-Jie Liu chen-hui Jin Yan-Lun Guo Zhi-Gang Ke jun-jun Huang Lin-Ping Cao Department of Hepatobiliary Surgery Department of General SurgeryPujiang Branch of the First Affiliated HospitalZhejiang University School of MedicineJinhua 322200China Department of Pathology Pujiang Branch of the First Affiliated HospitalZhejiang University School of MedicineJinhua 322200China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Pancreatic acinar cell carcinoma(PACC)is a rare malignant tumor of pancreatic epithelial cells,which produces pancreatic exocrine enzymes.PACC originates from acinar cells and terminal branches of the pancreatic ducts in the exocrine tissue of the pancreas.PACC accounts for 1%−2%of pancreatic exocrine tumors[1].Herein,we present an elderly woman with PACC who recovered after effective laparoscopic surgery.The tumor was located on the left side of the abdomen;imaging suggested that it was a gastrointestinal stromal tumor of the gastric wall origin,infiltrating the tail of the pancreas and omentum,while postoperative pathology suggested PACC.

关键词： Pancreatic gastrointestinal pancreas

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：