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Description of Concrete Durability Damage Process

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Wuhan University Journal of Natural Sciences 2006年第3期11卷 653-656页

作者： chen Yueshun wei jun ZHAO Xiaolong School of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan 430074Hubei China

Based on the damage mechanics, the concrete damage grade of relative stable environment in measurable spatial is constructed in this paper, and the concrete damage evolving model and corresponding failure rule is constructed based on the damage grade fore-defined. Therefore, the concrete health status and the residual life-span can be assessed according to the mea,sured damage grade. It is propitious to drive the development of concrete durability assessment and life-span forecast. Its feasibility of concrete damage process description and health assessment is validated with the exampie in this paper, in which the damage state is described with the ultrasound velocity attenuation, and the freeze-thaw process is regarded as the concrete durability degradation influeneing factor to reflect the concrete durability degradation process.

关键词： concrete durability damage life-span assessment health monitoring ultrasonic velocity

Hydroxylation of 3-nitrotyrosine by hydroxyl radical

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Chinese Chemical Letters 2007年第5期18卷 542-544页

作者： jun chen Dong wei Qun Shi Yu Fen Zhao Yan Mei Li Key Laboratory of Bioorganic Phosphorous Chemistry ＆ Chemical Biology （Ministry of Education） Department of Chemistry Tsinghua University Beijing 100084 China

Hydroxylation of 3-nitrotyrosine （3-NT） and 3-NT containing peptide Gly-nitroTyr-Gly in aqueous solution by hydroxyl radical were investigated with gamma irradiation. The structures of the hydroxylated products were confirmed by electrospray ionization mass spectrometry and ^1H NMR spectrometry. The reactivity of 3-nitrotyrosine has been investigated using density functional theory （DFT） calculation.

关键词： 3-Nitrotyrosine Hydroxyl radical DFT Selective hydroxylation

Intron-Targeted Intron-Exon Splice Conjunction (IT-ISJ) Marker and Its Application in Construction of Upland Cotton Linkage Map

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Agricultural Sciences in China 2008年第10期7卷 1172-1180页

作者： ZHENG Jing ZHANG Zheng-sheng chen Li WAN Qun HU Mei-chun WANG wei ZHANG Ke LIU Da-jun chen Xiao wei Xin-qi Key Laboratory of Biotechnology ＆ Crop Quality Improvement Ministry of Agriculture/Southwest University Chongqing 400716 P.R.China

To develop a new DNA maker, which could be used in genetic diversity analysis and genetic map construction in plants, IT-ISJ （intron targeted intron-exon splice junction） primer combinations, which were designed according to the intronexon splice junction conserved sequences, were used to construct cotton genetic linkage map in the present study. 49 out of 704 IT-ISJ primer combinations showed polymorphism between upland cotton high quality cultivar Yumian 1 and multiple dominant gene line T586, and the polymorphic primer combinations accounted for 7.0% of total primer combinations. 49 IT-ISJ primer combinations were used to genotype 270 F2：7 recombinant inbred lines developed from （Yumian 1 × T586） F2, and 58 IT-ISJ loci were obtained. 58 IT-ISJ, together with 150 SSR and 8 morphological loci, were used to conduct linkage analysis, and a linkage map including 22 linkage groups and 113 loci （49 IT-ISJ, 62 SSR, and 2 morphological loci） was constructed. The linkage map covered 714.5 cM with an average interval of 6.3 cM between two markers, accounting for 16.1% of cotton genome. The present study demonstrated that the polymorphism of IT-ISJ marker is high, and it could be effectively applied in plant genetic map construction.

关键词： IT-ISJ (intron targeted intron-exon splice junction) linkage map upland cotton (Gossypium hirsutum L.)

Genetic characterization of a Chinese family with familial idiopathic pulmonary fibrosis

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Chinese Medical Journal 2012年第11期125卷 1945-1951页

作者： ZHANG Xin JIANG jun chen wei-jun SU Long-xiang XIE Li-xin Department of Respiratory Medicine Hainan Branch of Chinese People's Liberation Army General HospitalSanyaHainan 572000China Department of Respiratory Medicine Chinese People's Liberation Army General HospitalBeijing 100853China Beijing Institute of Gcnomics Chinese Academy of SciencesBeijing 100101China

Background Idiopathic pulmonary fibrosis （IPF） is a chronic inflammatory interstitial lung disease with an unknown cause. Recent studies have shown that genetic factors play an important role in the pathogenesis of IPF. Methods To explore the genetic background of patients with IPF, a candidate gene approach was employed to screen for mutations in seven genes among members with familial IPF in mainland of China. Results Within six of the candidate genes, a total of 31 point mutations were identified. Among the missense mutations, the SFTPA1 exon 6 CAG〉AAG （GIn238Lys） and SFTPB exon 2 CAC〉CCC （His2Pro） mutations caused changes in the physical and chemical properties of amino acids. Each sequence alteration was identified in sporadic IPF patients, control specimens （pneumonia patients and healthy persons）. Genotype frequencies and allele frequencies of codon 238 in exon 6 of SFTPA1 were noted significantly higher in patients with IPF than those in other two control subjects. The computational protein structure prediction by protein homology modeling confirmed differences in three-dimensional structure between mutant SFTPA1 and original SFTPAI. Conclusions Although the functions of the mutant candidate genes vary, these genes may ultimately result in damage to alveolar epithelial cells, initiating the progress of pulmonary fibrosis. In particular, while pathophysiological mechanisms need to be illustrated, the GIn238Lys missense variant of exon 6 in the SFTPA1 may have potential susceptibility in the development of IPF, which was shown in patients with sporadic IPF with a statistically higher frequency.

关键词： idiopathic pulmonary fibrosis familial interstitial lung disease genetics Chinese

Molecular Characterization of Coxsackievirus B1 Strains Isolated from Patients with Hand Foot and Mouth Disease in Yunnan,Southwest China

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Biomedical and Environmental Sciences 2024年第5期37卷 543-548页

作者： XU Dan Han ZHANG Ming chen jun wei Feng Chang Zeng LIU Yu Han CHU Zhao Yang LIU Wen Jing LI Li MA Shao Hui Institute of Medical Biology Chinese Academy of Medical Sciencesand Peking Union Medical CollegeKunming 650118YunnanChina Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease Kunming 650118YunnanChina School of Life Sciences Yunnan UniversityKunming 650504YunnanChina School of Medicine Yunnan UniversityKunming 650504YunnanChina Department of Clinical Laboratory Kunming Maternal and Child Health hospital Kunming 650031YunnanChina

Coxsackievirus(CV)B belongs to the species Enterovirus B,genus Enterovirus of the family *** B(EV-B)includes 63 serotypes:CVB1-6;CVA9;echoviruses E1-7,9,11-21,24-27,and 29-33;EV-B69,EV-B 73-75,EV-B77-88,EV-B 93,EV-B 9... 详细信息

关键词： Coxsackievirus Patients belongs

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu jun Shen Xin Zhang Lingcong Chao Liang chen Ding Zhang Tao wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

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部分相干光束照射的透镜轴棱锥获得均匀焦线

光学技术 2007年第3期33卷 361-363页

作者：陈俊玮蒲继雄福建电大三明分校福建三明市365000 华侨大学电子科学与技术系福建泉州362021

从部分相干光的交叉谱密度函数传输公式出发,推导了高斯谢尔模型(GSM)光束被球差透镜衍射后轴上光强分布的解析公式,并进行了数值模拟和物理分析。结果表明,具有一定束腰宽度和空间相干度的GSM光束经过负球差透镜聚焦后,可以获得轴上光... 详细信息

从部分相干光的交叉谱密度函数传输公式出发,推导了高斯谢尔模型(GSM)光束被球差透镜衍射后轴上光强分布的解析公式,并进行了数值模拟和物理分析。结果表明,具有一定束腰宽度和空间相干度的GSM光束经过负球差透镜聚焦后,可以获得轴上光强的均匀分布。通过改变GSM光束的束腰宽度和空间相干度来实现轴上光强均匀分布的方法很简单,转换效率高。

关键词：物理光学球差透镜部分相干光

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双圆盾构隧道施工引起的地面沉降预测

岩土力学 2011年第4期32卷 991-996页

作者：魏纲陈伟军魏新江浙江大学城市学院杭州310015 浙江大学岩土工程研究所杭州310058

将随机介质理论应用于双圆盾构隧道施工引起的地面沉降计算,假定开挖后土体移动模式为不均匀收敛,推导了土体损失引起的地面沉降计算公式。算例分析结果表明:预测结果与实测值比较吻合;双圆叠加模型计算结果明显偏大,原因是没有考虑双... 详细信息

将随机介质理论应用于双圆盾构隧道施工引起的地面沉降计算,假定开挖后土体移动模式为不均匀收敛,推导了土体损失引起的地面沉降计算公式。算例分析结果表明:预测结果与实测值比较吻合;双圆叠加模型计算结果明显偏大,原因是没有考虑双圆盾构重叠部分减少的土体开挖面积,仍按两个单圆的土体开挖面积来计算,导致土体损失量比实际大;将双圆叠加模型计算结果按实际土体开挖面积相应折减,发现其计算结果仍比实测值大,表明双圆盾构隧道不能简单地采用两个单圆叠加得到。对双圆叠加模型进行修正,提出修正系数取值,修正后的双圆叠加模型计算值与实测值较吻合。

关键词：双圆盾构隧道地面沉降随机介质理论

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu chen Xue-jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary