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Mechanistic insights into the key marine dimethylsulfoniopropionate synthesis enzyme DsyB/DSYB

mLife 2022年第2期1卷 114-130页

作者： Chun-Yang Li Jason C.Crack Simone Newton-Payne Andrew R.J.Murphy Xiu-Lan chen Benjamin J.Pinchbeck Shun Zhou Beth T.Williams Ming Peng Xiao-Hua Zhang Yin chen Nick E.Le Brun jonathan D.Todd Yu-Zhong Zhang Frontiers Science Center for Deep Ocean Multispheres and Earth System College of Marine Life SciencesOcean University of ChinaQingdaoChina State Key Laboratory of Microbial Technology Marine Biotechnology Research CenterShandong UniversityQingdaoChina Laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and TechnologyQingdaoShandongChina School of Chemistry Centre for Molecular and Structural BiochemistryUniversity of East AngliaNorwich Research ParkNorwichUK School of Biological Sciences University of East AngliaNorwichUK School of Life Sciences University of WarwickCoventryUK

Marine algae and bacteria produce approximately eight billion tonnes of the organosulfur molecule dimethylsulfoniopropionate(DMSP)in Earth's surface oceans *** is an antistress compound and,once released into the environment,a major nutrient,signaling molecule,and source of climate-active *** methionine transamination pathway for DMSP synthesis is used by most known DMSP-producing algae and *** S-directed S-adenosylmethionine(SAM)-dependent 4-methylthio-2-hydroxybutyrate(MTHB)S-methyltransferase,encoded by the dsyB/DSYB gene,is the key enzyme of this pathway,generating S-adenosylhomocysteine(SAH)and 4-dimethylsulfonio-2-hydroxybutyrate(DMSHB).DsyB/DSYB,present in most haptophyte and dinoflagellate algae with the highest known intracellular DMSP concentrations,is shown to be far more abundant and transcribed in marine environments than any other known S-methyltransferase gene in DMSP synthesis ***,we demonstrate in vitro activity of the bacterial DsyB enzyme from Nisaea denitrificans and provide its crystal structure in complex with SAM and SAH-MTHB,which together provide the first important mechanistic insights into a DMSP synthesis *** and mutational analyses imply that DsyB adopts a proximity and desolvation mechanism for the methyl transfer *** analysis suggests that this mechanism may be common to all bacterial DsyB enzymes and also,importantly,eukaryotic DSYB enzymes from e.g.,algae that are the major DMSP producers in Earth's surface oceans.

关键词： catalytic mechanism DMSP synthesis marine sulfur cycle S-methyltransferase

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个性化氧化锆基台对种植体周围软硬组织影响的前瞻性临床研究

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中华口腔医学杂志 2020年第11期55卷 885-890页

作者：徐俊华 Jiang jonathan 沈晨露陈肖依朱丽琴王慧明浙江大学医学院附属第一医院口腔种植中心杭州310002 Department of Medicine St Vincent Hospital University of MelbourneVICAustralia 浙江大学医学院附属口腔医院种植科·口腔医学院浙江省口腔生物医学研究重点实验室杭州310006

目的观察用氧化锆临时冠磨改回切为个性化修复基台1年内种植体周围软硬组织的变化。方法采用以修复为导向的种植即刻修复方案,计算机辅助设计与辅助制作技术制作氧化锆临时修复体和种植导板,导板引导下植入种植体并即刻安装氧化锆临时... 详细信息

目的观察用氧化锆临时冠磨改回切为个性化修复基台1年内种植体周围软硬组织的变化。方法采用以修复为导向的种植即刻修复方案,计算机辅助设计与辅助制作技术制作氧化锆临时修复体和种植导板,导板引导下植入种植体并即刻安装氧化锆临时修复体。3个月后种植体骨结合完成,口内磨改回切氧化锆临时修复体形成个性化氧化锆种植修复基台,全冠修复方法取模制作永久修复体。纳入2017年1月至2018年2月就诊于浙江大学医学院附属第一医院口腔种植中心的30例上前牙单牙缺失患者,男性18例,女性12例,年龄(36.2±6.1)岁(26~50岁)。患者在戴入最终修复体后即刻、6个月及1年时复查,记录种植体存留率,检查探诊深度和探诊出血指数,根尖X线片测量种植体周围骨水平变化,采用牙龈乳头指数(apilla index score,PIS)评价牙龈乳头充盈度。结果戴入最终修复体后1年30枚种植体的存留率为100%,植体周围探诊深度均小于5 mm。戴入最终修复体后6个月及1年的骨吸收量分别为0 (0,0) mm和0 (-0.2,0) mm,差异无统计学意义(P>0.05)。戴入最终修复体即刻、6个月及1年时PIS分别为3.0 (2.0,4.0)、3.0 (2.8,4.0)和3.0 (3.0,4.0)。结论戴入最终修复体后1年,30枚种植的植体周围骨组织和牙龈组织均较稳定。

关键词：牙种植即刻修复氧化锆计算机辅助设计个性化基台

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Epidermal radio frequency electronics for wireless power transfer

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Microsystems & Nanoengineering 2016年第1期2卷 52-60页

作者： Xian Huang Yuhao Liu Gil Woo Kong Jung Hun Seo Yinji Ma Kyung-In Jang jonathan A.Fan Shimin Mao Qiwen chen Daizhen Li Hank Liu Chuxuan Wang Dwipayan Patnaik Limei Tian Giovanni A.Salvatore Xue Feng Zhenqiang Ma Yonggang Huang John A.Rogers Department of Biomedical Engineering School of Precision Instrument and Opto-electronics EngineeringTianjin UniversityTianjin 300072China Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Electrical and Computer Engineering University of Wisconsin-MadisonMadisonWI 53706USA Department of Civil and Environmental Engineering Northwestern UniversityEvanstonIL 60208USA Department of Engineering Mechanics Center for Mechanics and MaterialsTsinghua UniversityBeijing 100084China Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and TechnologyDaegu 42988Republic of Korea Department of Electrical Engineering Stanford UniversityStanfordCA 94305USA

Epidermal electronic systems feature physical properties that approximate those of the skin,to enable intimate,long-lived skin interfaces for physiological measurements,human–machine interfaces and other applications that cannot be addressed by wearable hardware that is commercially available today.A primary challenge is power supply;the physical bulk,large mass and high mechanical modulus associated with conventional battery technologies can hinder efforts to achieve epidermal characteristics,and near-field power transfer schemes offer only a limited operating *** we introduce an epidermal,farfield radio frequency(RF)power harvester built using a modularized collection of ultrathin antennas,rectifiers and voltage *** components,separately fabricated and tested,can be integrated together via methods involving soft contact *** studies of the individual components and the overall performance in various dielectric environments highlight the key operational features of these systems and strategies for their *** results suggest robust capabilities for battery-free RF power,with relevance to many emerging epidermal technologies.

关键词： antenna design epidermal electronics modularization silicon nanomembrane soft-contact lamination specific absorption rate wireless power

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我的画并不是图像，而是一种私人的图形文字

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散文诗世界 2020年第1期 121-123页

作者： chen Malul jonathan Crow 汪晓雪(译) 不详

读大学的第一年,卡夫卡发现了自己的绘画天赋。可卡夫卡父母的梦破碎了,这个喜欢白日做梦的年轻人,不会接管他父亲的百货商场。深思熟虑过后,卡夫卡的父母提出了唯一的解决方法:不管喜不喜欢,他都要上大学学一个专业。

关键词：百货商场卡夫卡图形文字第一年年轻人深思熟虑

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Aromatic alcohols oxidation and hydrogen evolution over π-electron conjugated porous carbon nitride rods

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Nano Research 2022年第12期15卷 10148-10157页

作者： Jiawei Xia Neeta Karjule Gabriel Mark Michael Volokh Haiqun chen Menny Shalom Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation CenterChangzhou UniversityChangzhou213164China Department of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology Ben-Gurion University of the NegevBeer-Sheva8410501Israel

Photocatalysis using polymeric carbon nitride(CN)materials is a constantly evolving field,where the variation of synthetic procedures allows the constant improvement of activity by tackling the intrinsic limitations of these materials(optical absorbance,specific surface area,charge migration,etc.).Amongst the possible photocatalytic reactions,the most popular application of CNs is the hydrogen evolution reaction(HER)from *** this work,we design precisely-controlled carbon-doped porous CN rods with extended π-electron conjugation from supramolecular assemblies of melem and co-monomers,which partially substitute nitrogen for carbon atoms at the pyrimidine ring of the *** hydrogen bonds and good thermal stability of the melem-based supramolecular framework allow synthesizing a more ordered structure for improved charge migration;the control from the molecular level over the position of carbon-substituted nitrogen positions tailors the band alignment and photogenerated charge *** optimal photocatalyst shows an excellent HER rate(up to 10.16 mmol·h-1·g-1 under 100 W white light-emitting diode(LED)irradiation,with an apparent quantum efficiency of 20.0%at 405 nm,which is 23.2 times higher compared to a reference bulk CN).To fully harness the benefits of the developed metal-free CNs,selective oxidation reaction of aromatic alcohols is demonstrated with high conversion and selectivity.

关键词： supramolecular assembly π-electron conjugation carbon nitride photocatalytic hydrogen evolution reaction selective aromatic alcohol oxidation

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Dual inhibition of ACK1 and KIT in Gastrointestinal Stromal Tumor

Dual inhibition of ACK1 and KIT in Gastrointestinal Stromal ...

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中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年

作者： Jiaming chen Jiongyan Ding Adrián Mari?o-Enríquez jonathan A.Fletcher Wen-Bin Ou Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and Medicine Zhejiang SciTech University Department of Pathology Brigham and Women’s Hospital and Harvard Medical School

Gastrointestinal stromal tumor(GIST) is the most common malignant tumor of gastrointestinal *** and activated Oncogene KIT and PDGFRA mutation and abnormal activation are the main factors for the occurrence and progression of *** have KIT(85%) or PDGFRA(10%) gene mutations. At present, KIT has become an important tumor biomarker for the diagnosis of GIST. Imatinib(IM), a specific KIT/PDGFRA inhibitor, become a firstline drug for the treatment of GIST. Clinical studies have demonstrated that IM has a remarkable benefit for GIST patients. However, most of the patients eventually acquired resistance to IM after treatment with drugs for two years. The second-line drug sunitinib has a good effect on IM resistant GISTs, but it has badly clinical side effects. Therefore, it is urgent to solve the problem of GIST IM ***1 is a member of the non-receptor tyrosine kinase family, studies have reported that ACK1 has abnormal expression and activation in many kinds of tumors, such as prostate cancer, hepatocellular carcinoma, breast cancer, stomach cancer, pancreatic cancer and so on. Therefore, in the present project, we focused on studying the expression, activation and biological function of ACK1 and the additive effects of dual targeting ACK1 and KIT on GIST signaling pathway, proliferation and metastasis. The results showed that ACK1 overexpressed in GIST cell lines and tumor samples. In addition, it was observed that ACK1 strongly phosphorylated in IM sensitive GIST cell lines(GIST-T1) and IM resistant GIST cell line(GIST 430) by Coimmunoprecipitation(Co-IP). However, there is no interaction between ACK1 and KIT proteins. Inhibition of KIT(IM and Sunitinib) did not reduce ACK1 phosphorylation, and inhibition of ACK1(AIM-100) little affected KIT activation. Treatment with AIM-100 inhibited ACK1 activation in a dose-dependent manner, which further verified that there is no interaction between ACK1 and KIT. MTT assay showed that ACK1 inactivation on

关键词： GIST ACK1 KIT AIM-100 IM resistance

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健身锻炼心理预测因素与运动损伤的相关性研究

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体育科学 2011年第11期31卷 27-34页

作者：陈金鳌陆彩凤王欣左弯弯 jonathan R.Baldridge 苏州大学体育学院江苏苏州215021 吴江市体育局体育科学研究所江苏吴江215200 盐城工学院体育与艺术教学部江苏盐城224001 莫瑞州立大学美国肯塔基莫瑞42071

目的：从运动心理学角度探讨大众健身人群风险认知、风险承担、运动能力判断、运动损伤经历等心理预测因素与运动损伤的相关性,同时测定以上因素对实际健身锻炼中运动损伤的预测效度,并探究其间的性别差异,旨在为进一步有效减少和预防... 详细信息

目的：从运动心理学角度探讨大众健身人群风险认知、风险承担、运动能力判断、运动损伤经历等心理预测因素与运动损伤的相关性,同时测定以上因素对实际健身锻炼中运动损伤的预测效度,并探究其间的性别差异,旨在为进一步有效减少和预防运动损伤提供理论依据。方法：从健身俱乐部新入会的学员中,随机选取300名（男性150人,女性150人）年龄在26~35岁之间的健康成年志愿者组成实验组,进行为期12周,每周3~4次的健身锻炼。要求受试者在俱乐部每次锻炼前及时记录并提供风险认知、风险承担、运动能力判断及运动损伤经历等信息。利用运动损伤风险量表（RISSc）、风险承担行为量表（RTB）和李克特五级评分法（Likert-Type Scale）等对以上因素进行测试与评价。之后,对实验数据进行相关性分析、多元Logistic回归分析和多元方差分析等统计学处理。结果：1）＂风险认知＂并不与＂风险承担＂或＂运动损伤＂呈负相关;2）低水平的＂风险认知＂和＂运动能力判断＂使锻炼者受伤风险显著增加,其比值比（ORs）区间为：3.79~7.95;3）＂运动能力高估＂与＂运动损伤＂呈正相关;4）＂运动能力判断＂与＂风险承担＂呈正相关;5）＂风险承担＂与＂运动能力高估＂、＂运动损伤＂或＂运动损伤经历＂之间不存在相关性;6）＂运动损伤经历＂与运动损伤之间也不存在相关性;7）女性的＂风险认知＂水平比男性高,＂风险承担＂水平比男性低;但在＂运动能力判断＂和＂运动能力高估＂上,并无性别差异,且随后男性和女性在健身锻炼中发生的运动损伤量较为接近。结论：1）健身锻炼心理预测因素中,＂风险认知＂不与运动损伤呈负相关;＂运动能力高估＂与运动损伤呈正相关;＂风险承担＂与运动损伤之间无相关性。2）低水平的＂风险认知＂和＂运动能力判断＂是健身锻炼者发生运动损伤的重要心理危险因素;3）女性风险认知力比男性高,运动能力判断（高估）与男性相似,风险承担行为比男性少,且易受过去运动损伤经历的影响。

关键词：健身锻炼心理预测风险认知风险承担运动能力判断运动能力高估运动损伤经历运动损伤性别差异

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10 Gbps wavelength division multiplexing using UV-A, UV-B, and UV-C micro-LEDs

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Photonics Research 2022年第2期10卷 516-523页

作者： Daniel M.Maclure jonathan J.D.McKendry Mohamed Sufyan Islim Enyuan Xie cheng chen Xiaobin Sun Xudong Liang Xiaohui Huang Hanaa Abumarshoud Johannes Herrnsdorf Erdan Gu Harald Haas Martin D.Dawson Institute of Photonics Department of PhysicsSUPAUniversity of StrathclydeGlasgow G11RDUK LiFi Research and Development Centre Department of Electronic&Electrical EngineeringUniversity of StrathclydeTechnology&Innovation CentreGlasgow G11RDUK Fraunhofer Center of Applied Photonics Technology&Innovation CentreGlasgow G11RDUK Zhixin Semiconductor(Hangzhou)Co. Ltd.Hangzhou 311200China

Deep ultraviolet(DUV) optical wireless communications have seen increased interest in recent years due to the unique properties of light in this spectral region. However, the reported DUV data rates remain significantly lower than comparable demonstrations at visible wavelengths due to lower modulation bandwidths and/or output power of the sources. Here, we present a wavelength division multiplexing demonstration using three UV microlight-emitting diodes emitting at nominal peak wavelengths of 285, 317, and 375 nm, respectively, each with an emitting area of approximately 1369 μm^(2)(equivalent to circular device pixels of diameter;0 μm). Using orthogonal frequency division multiplexing, data rates of 4.17, 3.02, and 3.13 Gbps were achieved from the 285, 317, and 375 nm devices, respectively, for a combined data rate of 10.32 Gbps transmitted over a distance of 0.5 m.

关键词： Gbps multiplexing diodes

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SUPRASPINAL CONTROL OF SPINAL CORD REFLEX PLASTICITY

SUPRASPINAL CONTROL OF SPINAL CORD REFLEX PLASTICITY

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中国生理学会第21届全国代表大会暨学术会议

作者： Xiang Yang chen, jonathan S. Carp, jonathan R. Wolpaw (Wadsworth Center, New York State Dept of Health and State University of New York Albany, NY 12201, USA

＜正＞ Descending activity from the brain shapes spinal cord function throughout life（Ann Rev Neu-rosci 24:807-843,2001）,yet the pathways and the processes through which this activity inducesand maintains spinal cord plasticity are poorly *** are using a simple conditioning modelto explore these pathways and processes.

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A Record of the Invasive Golden Apple Snail Pomacea canaliculata (Lamarck 1819) at Black Dragon Spring,Dianchi Basin

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Zoological Research 2007年第3期28卷 325-328页

作者：杜丽娜 jonathan Davies 陈小勇崔桂华杨君兴中国科学院昆明动物研究所系统动物学研究室

The golden apple snail Pomacea canaliculata （Lamarck 1819） was first recorded at Black Dragon Spring, Dianchi Basin, Baiyi Township, Songming County, Kunming City, Yunnan Province, China, in October 2004. The water from the spring flows into the Songhuaba Reservoir, the major drinking water resource for Kunming City, and part of the Dianchi Lake basin. This is the first record of this invasive snail in the Dianchi Lake Basin. Pomacea canaliculata originates from Central and South America, and in Asia the snail has spread through deliberate and accidental introductions to the Philippines, Vietnam, Thailand, Laos, Cambodia, Malaysia, Indonesia, Papua New Guinea, Korea, Japan and South China. It has become a major pest in rice-growing areas, resulting in huge damage to crops. Strict prevention and control measures have to be implemented to prevent the spread of the snail in Yunnan, together with public awareness campaigns to inform the public of the dangers of this invasive snail.

关键词： Golden apple snail Pomacea canaliculata Dianchi basin Kunming Yunnan China

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