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Visual dual chemodynamic/photothermal therapeutic nanoplatform based on superoxide dismutase plus Prussian blue

Nano Research 2019年第5期12卷 1071-1082页

作者： Shan Lei jinxing chen Kun Zeng Mozhen Wang Xuewu Ge CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

Enzyme-based anticancer therapy is more attractive for the less side effect than conventional ***,the poor stability and low membrane permeability of enzymes during the intracellular delivery are constraints for its practical *** this work,we synthesized novel near-infrared (NIR)-responsive core-shell-structured Prussian blue@fibrous SiO2 (PBFS) nanoparticles as the carrier of superoxide dismutase (SOD) and a glutathione (GSH)-activated Fenton reagent (DiFe).The PBFS nanoparticles are further modified with aGSH-responsive cationic polymer (poly(2-(acryloyloxy)-N,N-dimethyl-N-(4-(((2-((2-(((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)oxy)ethyl)disulfaneyl)ethoxy)carbonyl)amino)benzyl)ethan-1-aminium,PSS) containing disulfide bonds and *** SOD and DiFe are loaded on the PBFS-PSS nanoparticles,dual chemodynamic/photothermal therapeutic nanoparticulate systems (PBFS-PSS/DiFe/SOD) are *** vitro experiments show that PBFS-PSS/DiFe/SOD nanoparticles have good biocompatibility and can be tracked under fluorescence microscope during the intracellular delivery process in MCF-7 tumor cells due to the GSH-activated release of *** also exhibit high efficiency in NIR photothermal conversion and GSH-activated Fenton reaction in tumor cells,thus achieving high-efficient killing effect of tumor cells based on the combination of photothermal and chemodynamic therapeutic performance (PTT and CDT).This work offers a novel pathway to construct a visual multifunctional nanomedicine platform for future cancer therapy.

关键词： copper-zinc superoxide dismutase Fenton reagent Prussian blue near-infrared (NIR) photothermal therapy fluorescence

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Ultrastable and ultrasensitive pH-switchable carbon dots with high quantum yield for water quality identification,glucose detection,and two starch-based solid-state fluorescence materials

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Nano Research 2020年第11期13卷 3012-3018页

作者： Daiyong Chao jinxing chen Qing Dong Weiwei Wu Desheng Qi Shaojun Dong College of Chemistry Jilin UniversityChangchun130012China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China

It is attractive and encouraging to develop new fluorescent carbon dots(CDs)with excellent optical properties and promising applications ***,highly-efficient green emissive CDs(m-CDs)with a high quantum yield(QY)of 71.7%in water are prepared through a facile solvothermal ***,the m-CDs exhibit excellent fluorescence stability in the pH range of 1–***,the fluorescence intensity of the m-CDs is almost completely quenched as the pH is increased from 9 to *** mechanism of the unique pH-responsive behavior is discussed in detail and a plausible mechanism is *** to the unique pH-responsive behavior,the m-CDs are used as a on-off fluorescent probe for water quality *** combining the reversible pH-ultrasensitive optical properties of the m-CDs in the pH range of 9–10 with the glucose oxidase-mimicking(GOx-mimicking)ability of Au nanoparticles(AuNPs),glucose can be quantitatively ***,two environment-friendly starch-based solid-state fluorescence materials(powder and film)are developed through green preparation routes.

关键词： carbon dot high quantum yield pH-ultrasensitive optical properties water quality identification glucose detection solid-state fluorescence materials

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Engineering surface strain for site-selective island growth of Au on anisotropic Au nanostructures

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Nano Research 2023年第4期16卷 5873-5879页

作者： Fan Yang Ji Feng jinxing chen Zuyang Ye Jihua chen Dale KHensley Yadong Yin Department of Chemistry University of CaliforniaRiversideCalifornia 92521USA Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTennessee 37831-6494USA Institute of Functional Nano&Soft Materials Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China

Controlled growth of islands on plasmonic metal nanoparticles represents a novel strategy in creating unique morphologies that are difficult to achieve by conventional colloidal synthesis processes,where the nanoparticle morphologies are typically determined by the preferential development of certain crystal *** work exploits an effective surface-engineering strategy for site-selective island growth of Au on anisotropic Au *** ligand modification is first employed to direct the site-selective deposition of a thin transition layer of a secondary metal,e.g.,Pd,which has a considerable lattice mismatch with *** selective deposition of Pd on the original seeds produces a high contrast in the surface strain that guides the subsequent site-selective growth of Au *** strategy proves effective in not only inducing the island growth of Au on Au nanostructures but also manipulating the location of grown *** taking advantage of the iodide-assisted oxidative ripening process and the surface strain profile on Au nanostructures,we further demonstrate the precise control of the islands’number,coverage,and wetting degree,allowing fine-tuning of nanoparticles’optical properties.

关键词： plasmonic Au nanorods island growth seed-mediated growth site-selective

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Diatomic Fe-Fe catalyst enhances the ability to degrade organic contaminants by nonradical peroxymonosulfate activation system

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Nano Research 2023年第4期16卷 4678-4684页

作者： Minghua Li jinxing chen Weiwei Wu Shuangli Wu Lili Xu Shaojun Dong College of Chemistry Jilin UniversityChangchun 130012China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China

Atomically dispersed catalysts have been widely studied due to their high catalytic activity and atom ***-atom catalysts have achieved breakthrough progress in the degradation of emerging organic contaminants(EOCs)by activating peroxymonosulfate(PMS).However,the construction of atomically dispersed catalysts with diatomic/multiatomic metal active sites by activating PMS to degrade pollutants is still seldom reported,despite the unique merits of atom-pair in synergistic electronic modulation and breaking stubborn restriction of scaling relations on catalytic *** have synthesized Fe1-N-C,Fe_(2)-N-C,and Fe_(3)-N-C catalysts with monoatomic iron,diatomic iron,and triatomic iron active center,*** results show that the catalytic degradation activity of Fe_(2)-N-C is twice that of Fe1-N-C and Fe_(3)-N-C due to its unique Fe_(2)N6 coordination structure,which fulfilled the complete degradation of rhodamine B(RhB),bisphenol A(BPA),and 2,4-dichlorophenol(2,4-DP)within 2 *** paramagnetic resonance(EPR)and radical quenching experiments confirmed that the reaction was a nonradical reaction on the catalyst *** singlet oxygen and Fe(IV)are the key active species.

关键词： diatomic catalyst peroxymonosulfate nonradical contaminant

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Catalase-imprinted Fe3O4/Fe@fibrous SiO2/polydopamine nanoparticles： An integrated nanoplatform of magnetic targeting, magnetic resonance imaging, and dual-mode cancer therapy

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Nano Research 2017年第7期10卷 2351-2363页

作者： jinxing chen Shan Lei Kun Zeng Mozhen Wang Anila Asif Xuewu Ge CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230016 China Interdisciplinary Research Centre in Biomedical Materials (IRCSM) COMSATS Institute of Information Technology Lahore 54000 Pakistan

Recent advances in the research on the molecular mechanism of cell death and methods for preparation of nanomaterials make the integration of various therapeutic approaches, targeting, and imaging modes into a single nanoscale complex a new trend for the development of future nanotherapeutics. Hence, a novel ellipsoidal composite nanoplatform composed of a magnetic Fe3O4/Fe nanorod core （-120 nm） enwrapped by a catalase （CAT）-imprinted fibrous SiO2/ polydopamine （F-SiO2/PDA） shell with thickness 70 nm was prepared in this work. In vitro experiments showed that the Fe3O4/Fe@F-SiO2/PDA nanoparticles can selectively inhibit the bioactivity of CAT in tumor cells by the molecular imprinting technique. As a result, the H2O2 level in tumor cells was elevated dramatically. At the same time, the Fe304FFe core released Fe ions to catalyze the conversion of H2O2 to ＊OH in tumor cells. Eventually, the concentration of ＊OH in tumor cells rapidly rose to a lethal level thus triggering apoptosis. Combined with the remarkable near-infrared light （NIR） photothermal effect of the CAT- imprinted PDA layer, the Fe3O4/Fe@F-SiO2/PDA nanoparticles can effectively kill MCF-7, HeLa, and 293T tumor cells but are not toxic to nontumor cells. Furthermore, these nanoparticles show good capacity for magnetic targeting and suitability for magnetic resonance imaging （MRI）. Therefore, the integrated multifunctional nanoplatform opens up new possibilities for high-efficiency visual targeted nonchemo therapy for cancer.

关键词： molecular imprintednanoparticles reactive oxygen species NIR photothermal therapy magnetic targeting magnetic resonanceimaging (MRI)

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Self-templated formation of cobalt-embedded hollow N-doped carbon spheres for efficient oxygen reduction

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Nano Research 2021年第8期14卷 2819-2825页

作者： Ayaz Mahsud Jianian chen Xiaolei Yuan Fenglei Lyu Qixuan Zhong jinxing chen Yadong Yin Qiao Zhang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesJoint International Research Laboratory of Carbon-Based Functional Materials and DevicesSoochow University199 Ren’ai RoadSuzhou 215123China School of Chemistry and Chemical Engineering Nantong UniversityNantong9 Seyuan RoadNantong226019China Department of Chemistry Materials Science and Engineering programand UCR Center for CatalysisUniversity of CaliforniaRiversideCA 92521USA

The slow kinetics at the cathode of oxygen reduction reaction(ORR)seriously limits the efficiencies of fuel cells and metal-air ***,the state-of-the-art ORR electrocatalyst,suffers from high cost,low earth abundance,and poor *** a self-templated strategy based on metal-organic frameworks(MOFs)is proposed for the fabrication of hollow nitrogen-doped carbon spheres that are embedded with cobalt nanoparticles(Co/HNC).The Co/HNC manifests better ORR activities,methanol tolerance,and stability than commercial Pt/*** high ORR performance of Co/NHC can be attributed to the hollow structure which provides enlarged electrochemically active surface area,the formation of more Co-N species,and the introduction of *** work highlights the significance of rational engineering of MOFs for enhanced ORR activity and stability and offers new routes to the design and synthesis of high-performance electrocatalysts.

关键词： cobalt self-templated metal organic framework hollow sphere oxygen reduction reaction

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Prussian blue with intrinsic heme-like structure as peroxidase mimic

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Nano Research 2018年第9期11卷 4905-4913页

作者： jinxing chen Qingqing Wang Liang Huang Hui Zhang Kai Rong He Zhang Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Science and Technology of Chino Hefei 230026 Chino University of Chinese Academy of Sciences Beijing 100049 China

Despite the intrinsic peroxidase-like activity of Prussian blue nanopartides （PBNPs）, their enzyme-mimic mechanism has been scarcely investigated to date. Herein, we probed the catalytic site of PBNPs for the first time, by comparing their peroxidase-like activity with that of a series of Prussian blue analogs （PBAs） in which Fe atoms were replaced by Co, Ni, and Cu. The PBNPs exhibited the highest maximal reaction velocity （1.941 μM·s^-1）, which was at least 13 times higher than that of the PBAs, demonstrating that the peroxidase-like properties of PBNPs could be ascribed to the FeNx （x=4-6） instead of the FeC6 units. Notably, the PBNPs/H2O2 couple also showed much higher oxidizability than .OH radicals produced from the Fenton reaction, implying that a high active Fe（W）=O intermediate might be formed in the FeNx units. This study can thus pave the way for the wider application of PBNPs in biomimetic reactions.

关键词： Prussian blue Prussian blue analogs peroxidase high-valent iron-oxo

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Cadmium sulfide as bifunctional mimics of NADH oxidase and cytochrome c reductase takes effect at physiological pH

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Nano Research 2022年第6期15卷 5256-5272页

作者： Hao Wang jinxing chen Qing Dong Xiuna Jia Dan Li Jin Wang Erkang Wang College of Chemistry Jilin UniversityChangchun 130012China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Chemistry and Physics State University of New York at Stony Brook Stony BrookNY 11794-3400USA

Recently,a study of mimic enzyme has received more ***,the investigation on the oxidoreductase activity of electron mediators in the biological respiratory chain is still ***,we found that cadmium sulfide(CdS)nanorods can catalyze the formation of superoxide *** to the role of the photo-generated holes and the nicotinamide adenine dinucleotide(NADH)oxidation promoted by superoxide anion(O_(2)^(•−)),the CdS exhibits NADH oxidase-like activity and can be coupled with dehydrogenase to realize the recycling of *** is worth mentioning that the bio-electron acceptor,cytochrome c(Cyt c),as a chromogenic substrate,can accept electrons transferred from O_(2)^(•−),which demonstrates the Cyt c reductase-like activity of CdS under physiological pH *** different substrates,O_(2)^(•−)induced from CdS show oxidizing capacity for NADH and reducing capacity for Cyt c,which provides a new perspective for the in-depth study of new nanozyme.

关键词： cytochrome c reductase nicotinamide adenine dinucleotide(NADH)oxidase superoxide anions enzyme mimic cadmium sulfide

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Influence of different illuminations with xenon or microwave sulfur lamp on jointing and tillering of wheat

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Chinese Science Bulletin 2002年第17期47卷 1433-1437,1498页

作者： chen Qilin LIU Yuequn YU Xinjian chen jinxing WENG Jun XU Chunhe Shanghai Institute of Plant Physiology Chinese Academy of SciencesShanghai 200032China Institute of Electronic Lamp Fudan UniversityShanghai 200433China

The emission of microwave sulfur lamp is mainly composed of visible light. The sulfur lamp, producing little infrared radiation, has high efficiency, long duration of illumination and less energy consumption. In order to probe the agricultural application of the lamp, experiments were carried out with wheat (cv. Yangmai 158) to emphatically study illuminating effects of xenon or sulfur lamp on tillering, jointing and net photosynthetic rate during tillering and jointing periods. Results indicated that there is almost no difference in net photosynthetic rate of wheat leaves growing under different lamps. Xenon lamp significantly advanced the time of jointing, decreased number of tillers, number of total leaves per plant and leaf size, as well as inhibited root growth. In contrast with xenon lamp, sulfur lamp evidently delays the time of heading and grain maturation, increased number of heads per plant, head length, total number of grains per plant, head weight and total grain weight per plant,

关键词： sulfur lamp xenon lamp joint tiller wheat.

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A revisiting of transition metal phosphide(Cu_(3)P and FeP)nanozymes for two sugar-related reactions

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Nano Research 2023年第1期16卷 189-194页

作者： Daiyong Chao Zhixuan Yu jinxing chen Qing Dong Weiwei Wu Youxing Fang Ling Liu Shaojun Dong College of Chemistry Jilin UniversityChangchun 130012China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Transition metal phosphides(TMPs)are essential catalysts for some general catalytic ***,their potentials for biological catalysis have seldom been ***,we investigated the enzyme-like properties of four TMPs(FeP,CoP,Ni_(2)P,and Cu_(3)P)towards two sugar-related *** the four TMPs,Cu_(3)P nanoparticles(NPs)efficiently catalyzed the hydrolysis of glycosidic bonds as glycoside hydrolase mimics,and FeP NPs possessed both glucose oxidase-like(GOx-like)and peroxidase-like activities,which combined into a cascade reaction for glucose’s simple and one-step colorimetric biosensor without ***_(3)P and FeP NPs with distinctive enzyme-like activities have shown unique biological catalysis potentials for further applications with an attractive and challenging goal of developing nanomaterials to mimic natural enzymes,which encourages more efforts to reveal TMP’s capabilities towards biocatalysis.

关键词： transition metal phosphide glycoside hydrolase mimic glucose oxidase-like activity peroxidase-like activity cascade reaction

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