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Miyaoka-type inequalities for terminal threefolds with nef anti-canonical divisors

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Science China Mathematics 2025年第1期68卷 1-18页

作者： Masataka Iwai chen jiang Haidong Liu Department of Mathematics Graduate School of ScienceOsaka University Shanghai Center for Mathematical Sciences & School of Mathematical Sciences Fudan University Department of mathematics Sun Yat-sen University

In this paper,we study Miyaoka-type inequalities on Chern classes of terminal projective 3-folds with nef anti-canonical *** X be a terminal projective 3-fold such that-KXis *** show that if c1（X） · c2（X）≠0,then c1（X） · c2（X） ≥ 1/252;if further X is not rationally connected,then c1（X） · c2（X） ≥ 4/5 and this inequality is *** order to prove this,we give a partial classification of such varieties along with many *** also study the nonvanishing of c1（X）dim X-2· c2（X） for terminal weak Fano varieties and prove a Miyaoka-Kawamata-type inequality.

关键词： terminal threefolds Miyaoka-type inequality boundedness

Aerodynamic optimization design for high pressure turbines based on the adjoint approach

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Chinese Journal of Aeronautics 2015年第3期28卷 757-769页

作者： chen Lei chen jiang Heavy Engineering Research Association School of Energy and Power Engineering Beihang University

Abstract A first study on the continuous adjoint formulation for aerodynamic optimization design of high pressure turbines based on S2 surface governed by the Euler equations with source terms is presented. The objective function is defined as an integral function along the boundaries, and the adjoint equations and the boundary conditions are derived by introducing the adjoint variable vec- tors. The gradient expression of the objective function then includes only the terms related to phys- ical shape variations. The numerical solution of the adjoint equation is conducted by a finite- difference method with the Jameson spatial scheme employing the first and the third order dissipa- tive fluxes. A gradient-based aerodynamic optimization system is established by integrating the blade stagger angles, the stacking lines and the passage perturbation parameterization with the quasi-Newton method of Broyden Fletcher Goldfarb-Shanno （BFGS）. The application of the continuous adjoint method is validated through a single stage high pressure turbine optimization case. The adiabatic efficiency increases from 0.8875 to 0.8931, whilst the mass flow rate and the pressure ratio remain almost unchanged. The optimization design is shown to reduce the passage vortex loss as well as the mixing loss due to the cooling air injection.

关键词： Adjoint method Aerodynamic design High pressure turbineOptimization design Objective function

Recent Advancements in Nanomedicine for‘Cold’Tumor Immunotherapy

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Nano-Micro Letters 2021年第6期13卷 143-189页

作者： Qinjun chen Tao Sun chen jiang Key Laboratory of Smart Drug Delivery(Ministry of Education) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceDepartment of Pharmaceuticsand School of PharmacyResearch Center on Aging and MedicineFudan UniversityShanghai 201203People’s Republic of China

Although current anticancer immunotherapies using immune checkpoint inhibitors(ICIs)have been reported with a high clinical success rate,numerous patients still bear‘cold’tumors with insufficient T cell infiltration and low immunogenicity,responding poorly to ICI *** the advancements in precision medicine,in-depth mechanism studies on the tumor immune microenvironment(TIME)among cold tumors are required to improve the treatment for these *** has emerged as a promising drug delivery system in anticancer immunotherapy,activates immune function,modulates the TIME,and has been applied in combination with other anticancer therapeutic *** review initially summarizes the mechanisms underlying immunosuppressive TIME in cold tumors and addresses the recent advancements in nanotechnology for cold TIME reversal-based therapies,as well as a brief talk about the feasibility of clinical translation.

关键词： Tumor immune microenvironment Cold tumor Nanotechnology Immunosuppressive Combination therapy

3D analytical solution for a rotating transversely isotropic annular plate of functionally graded materials

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第7期8卷 1038-1043页

作者： chen jiang-ying chen Wei-qiu Faculty of Engineering Ningbo University Ningbo 315211 China Department of Civil Engineering Zhejiang University Hangzhou 310027 China

The analytical solution for an annular plate rotating at a constant angular velocity is derived by means of direct displacement method from the elasticity equations for axisymmetric problems of functionally graded transversely isotropic media. The displacement components are assumed as a linear combination of certain explicit functions of the radial coordinate, with seven undetermined coefficients being functions of the axial coordinate z. Seven equations governing these z-dependent functions are derived and solved by a progressive integrating scheme. The present solution can be degenerated into the solution of a rotating isotropic functionally graded annular plate. The solution also can be degenerated into that for transversely isotropic or isotropic homogeneous materials. Finally, a special case is considered and the effect of the material gradient index on the elastic field is illustrated numerically.

关键词： Functionally graded materials Transversely isotropic Rotating annular plate Analytical solution

Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2306-2325页

作者： Liang Han chen jiang jiangsu Key Laboratory of Neuropsychiatric Diseases Research College of Pharmaceutical SciencesSoochow UniversitySuzhou 215123China Key Laboratory of Smart Drug Delivery Ministry of EducationState Key Laboratory of Medical NeurobiologyDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 200032China

Bloode-brain barrier(BBB)strictly controls matter exchange between blood and brain,and severely limits brain penetration of systemically administered drugs,resulting in ineffective drug therapy of brain ***,during the onset and progression of brain diseases,BBB alterations evolve *** this review,we focus on nanoscale brain-targeting drug delivery strategies designed based on BBB evolutions and related applications in various brain diseases including Alzheimer’s disease,Parkinson’s disease,epilepsy,stroke,traumatic brain injury and brain *** advances on optimization of small molecules for BBB crossing and non-systemic administration routes(e.g.,intranasal treatment)for BBB bypassing are not included in this review.

关键词： Blood-brain barrier Brain diseases Brain-targeting Drug delivery systems Nanoparticles

Delivery strategies for macromolecular drugs in cancer therapy

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Acta Pharmaceutica Sinica B 2020年第6期10卷 979-986页

作者： Qin Guo chen jiang Key Laboratory of Smart Drug Delivery Ministry of EducationState Key Laboratory of Medical NeurobiologyDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China

With the development of biotherapy,biomacromolecular drugs have gained tremendous attention recently,especially in drug development field due to the sophisticated functions in *** the past few years,a motley variety of drug delivery strategies have been developed for biomacromolecular drugs to overcome the difficulties in the druggability,e.g.,the instability and easily restricted by physiologic *** application of novel delivery systems to deliver biomacromolecular drugs can usually prolong the half-life,increase the bioavailability,or improve patient compliance,which greatly improves the efficacy and potentiality for clinical use of biomacromolecular *** this review,recent studies regarding the drug delivery strategies for macromolecular drugs in cancer therapy are summarized,mainly drawing on the development over the last five years.

关键词： Macromolecular drugs Delivery strategies Cancer therapy Membrane-camouflage systems Exosomes

AN ACCELERATED WAVEFORM RELAXATION APPROACH BASED ON MODEL ORDER REDUCTION FOR LARGE COUPLING SYSTEMS

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Journal of Computational Mathematics 2013年第2期31卷 190-208页

作者： Haibao chen Yaolin jiang College of Mathematics and Systems Science Xinjiang University Urumqi 830046 China School of Mathematics and Statistics Xi'an Jiaotong University Xi'an 710049 China

In this paper, we present an accelerated simulation approach on waveform relaxation using Krylov subspace for a large time-dependent system composed of some subsystems. This approach first allows these subsystems to be decoupled by waveform relaxation. Then the Arnoldi procedure based on Krylov subspace is provided to accelerate the simulation of the decoupled subsystems independently. For the new approach, the convergent conditions on waveform relaxation are derived. The robust behavior is also successfully illustrated via numerical examples.

关键词： Large coupling systems Waveform relaxation Model order reduction Krylovsubspace Convergence analysis Accelerating technique.

Charge-reversal nanoparticles: novel targeted drug delivery carriers

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Acta Pharmaceutica Sinica B 2016年第4期6卷 261-267页

作者： Xinli chen Lisha Liu chen jiang Key Laboratory of Smart Drug Delivery Ministry of Education Department of PharmaceuticsSchool of Pharmacy Fudan University State Key Laboratory of Medical Neurobiology Fudan University

Spurred by significant progress in materials chemistry and drug delivery, charge-reversal nanocarriers are being developed to deliver anticancer formulations in spatial-, temporal- and dosagecontrolled approaches. Charge-reversal nanoparticles can release their drug payload in response to specific stimuli that alter the charge on their surface. They can elude clearance from the circulation and be activated by protonation, enzymatic cleavage, or a molecular conformational change. In this review, we discuss the physiological basis for, and recent advances in the design of charge-reversal nanoparticles that are able to control drug biodistribution in response to specific stimuli, endogenous factors(changes in p H,redox gradients, or enzyme concentration) or exogenous factors(light or thermos-stimulation).

关键词： Cancer therapy Charge-reversal nanoparticles Drug delivery carriers Stimuli responsive Nanotechnology

A NON-OSCILLATORY KINETIC SCHEME FOR MULTI-COMPONENT FLOWS WITH THE EQUATION OF STATE FOR A STIFFENED GAS

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Journal of Computational Mathematics 2011年第6期29卷 661-683页

作者： Yibing chen Song jiang Institute of Applied Physics and Computational Mathematics P.O. Box 8009 Beijing 100088 China

We extend the traditional kinetic scheme for ideal gases to the Euler equations with the equation of state for a multi-component stiffened gas. Based on a careful analysis of the oscillation mechanism of the traditional kinetic scheme across contact discontinuities, we propose a new non-oscillatory kinetic （NOK） scheme for multi-component stiffened gases. The basic idea in the construction is to use a flux splitting technique to construct numerical fluxes which do not depend on the concrete form of the equilibrium state. The new scheme can not only can avoid spurious oscillations of the pressure and velocity near a material interface which are observed in the traditional kinetic schemes such as the kinetic flux vector splitting （KFVS） and BGK schemes, but also can deal with the stiffened gas equation of state. Moreover, we also carry out a careful analysis on the consistency condition, truncation error and positivity of the NOK scheme. A number of 1D and 2D numerical tests are presented which demonstrate the accuracy and robustness of the new scheme in the simulation of problems with smooth, weak and strong shock wave regions.

关键词： Kinetic scheme Non-oscillation Multi-component Stiffened gases.