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电针“四白”和“颧髎”激活小鼠躯体感觉运动皮层的兴奋性神经元

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针刺研究 2024年第5期49卷 480-486页

作者：张芷晴申晨薇陈明权杜梓霏陈秋怡姬昌张文捷许能贵刘健华广州中医药大学广州510006 广州中医药大学第二临床医学院广州510120 广州中医药大学针灸康复临床医学院华南针灸研究中心广州510006 广州中医药大学基础医学院广州510006 暨南大学第一附属医院广州510630

目的:探讨电针“四白”和“颧髎”对小鼠躯体感觉皮层和初级运动皮层神经元的激活状态及其分型的影响。方法:雄性C57BL/6J小鼠随机分为空白组和电针组,每组6只。电针组电针“四白”和“颧髎”,干预30 min。采用免疫荧光染色法观察躯体... 详细信息

目的:探讨电针“四白”和“颧髎”对小鼠躯体感觉皮层和初级运动皮层神经元的激活状态及其分型的影响。方法:雄性C57BL/6J小鼠随机分为空白组和电针组,每组6只。电针组电针“四白”和“颧髎”,干预30 min。采用免疫荧光染色法观察躯体感觉皮层和初级运动皮层即刻早期基因c-Fos的阳性细胞密度,以及c-Fos阳性细胞和钙/钙调蛋白依赖性蛋白激酶Ⅱ(CaMKⅡ)/γ-氨基丁酸(GABA)共表达细胞的百分比,分析电针后躯体感觉皮层和初级运动皮层c-Fos神经元的类型。另取10只小鼠,采用光纤钙成像技术分别观察电针前后躯体感觉皮层和初级运动皮层兴奋性神经元钙活动的变化。结果:在躯体感觉皮层和初级运动皮层中,电针组的c-Fos阳性细胞密度显著高于空白组(P<0.05)。在躯体感觉皮层和初级运动皮层中,电针组c-Fos和CaMKⅡ共表达细胞百分比显著高于空白组(P<0.01)。光纤记录钙成像结果显示,与电针前相比,电针期间躯体感觉皮层和初级运动皮层兴奋性神经元的自发钙活动显著上升(P<0.01);电针后,其自发钙活动较电针期间显著降低(P<0.05)。结论:在生理状态下,针刺“四白”和“颧髎”能够有效激活躯体感觉皮层和初级运动皮层的兴奋性神经元。

关键词：电针躯体感觉皮层初级运动皮层四白颧髎

Periodically poled linbO3 crystals from 1D and 2D to 3D

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Science China(Technological Sciences) 2020年第7期63卷 1110-1126页

作者： wang TianXin chen Pengcheng xu Chuan zhang Yong wei DunZhao HU XiaoPeng ZHAO gang XIAO min ZHU ShiNing National Laboratory of Solid State Microstructures College of Engineering and Applied Sciencesand School of Physicsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

A periodically-poled linbO3(PPLN) crystal features space-dependent second-order nonlinear coefficients, which is one of the most important materials to effectively control nonlinear optical interactions through quasi-phase matching(QPM). By using electric-field poling method, 1D and 2D PPLN crystals have been successfully fabricated for laser frequency conversion, quantum light sources, nonlinear beam shaping and nonlinear optical imaging. Recently, femtosecond laser engineering technique is utilized to prepare 3D domain structures inside linbO3 crystal, which provides a promising platform to control nonlinear interacting waves in 3D configuration. After 40 years of developments, PPLN crystals still have exciting prospects in fundamental researches and practical applications for integrated photonic chip, quantum information processing,and so on.

关键词： periodically-poled linbO3 quasi-phase matching nonlinear optics

A score model for predicting post-liver transplantation survival in HBV cirrhosis-related hepatocellular carcinoma recipients: a single center 5-year experience

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Hepatobiliary & Pancreatic Diseases International 2015年第1期14卷 43-49页

作者： Li-Ying wang Shu-Sen Zheng Xiao xu wei-lin wang jian Wu min zhang Yan Shen Sheng Yan Hai-Yang Xie Xin-Hua chen Tian-An jiang Fen chen Division of Hepatobiliary and Pancreatic Surgery Department of Surgery First Affiliated Hospital Zhejiang University School of Medicine Key Laboratory of Combined Multi-Organ Transplantation Ministry of Health

BACKGROUND： The prognostic prediction of liver transplantation（LT） guides the donor organ allocation. However, there is currently no satisfactory model to predict the recipients’ outcome, especially for the patients with HBV cirrhosis-related hepatocellular carcinoma（HCC）. The present study was to develop a quantitative assessment model for predicting the post-LT survival in HBV-related HCC ***： Two hundred and thirty-eight LT recipients at the Liver Transplant Center, First Affiliated Hospital, Zhejiang University School of Medicine between 2008 and 2013 were included in this study. Their post-LT prognosis was recorded and multiple risk factors were analyzed using univariate and multivariate analyses in Cox ***： The score model was as follows： 0.114×（Child-Pugh score）-0.002×（positive HBV DNA detection time）＋0.647×（number of tumor nodules）＋0.055×（max diameter of tumor nodules）＋0.231×ln AFP＋0.437×（tumor differentiation grade）.The receiver operating characteristic curve analysis showed that the area under the curve of the scoring model for predicting the post-LT survival was 0.887. The cut-off value was 1.27, which was associated with a sensitivity of 72.5% and a specificity of 90.7%, ***： The quantitative score model for predicting post-LT survival proved to be sensitive and specific.

关键词： HBV cirrhosis hepatocellular carcinoma liver transplantation Hangzhou criteria post-LT survival

Identifying the Risk of SARS-CoV-2 Infection and Environmental Monitoring in Airborne Infectious Isolation Rooms(AIIRs)

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Virologica Sinica 2020年第6期35卷 785-792页

作者： Zhi-gang Song Yan-Mei chen Fan Wu lin xu Bang-Fang wang Lei Shi Xiao chen Fa-Hui Dai Jia-Lei She jian-min chen Edward CHolmes Tong-yu Zhu Yong-Zhen zhang Shanghai Public Health Clinical Center State Key Laboratory of Genetic EngineeringSchool of Life SciencesFudan UniversityShanghai 201508China College of Marine Sciences South China Agricultural UniversityGuangzhou 510642China Department of Environmental Science and Engineering Fudan UniversityShanghai 200438China Marie Bashir Institute for Infectious Diseases and Biosecurity School of Life and Environmental Sciences and School of Medical SciencesThe University of SydneySydneyNSW 2006Australia

Healthcare workers(HCWs)are at high risk of occupational exposure to the new pandemic human coronavirus,SARSCoV-2,and are a source of nosocomial transmission in airborne infectious isolation rooms(AIIRs).Here,we performed comprehensive environmental contamination surveillance to evaluate the risk of viral transmission in AIIRs with 115 rooms in three buildings at the Shanghai Public Health Clinical Center,Shanghai,during the treatment of 334 patients infected with *** results showed that the risk of airborne transmission of SARS-CoV-2 in AIIRs was low(1.62%,25/1544)due to the directional airflow and strong environmental hygiene ***,we detected viral RNA on the surface of foot-operated openers and bathroom sinks in AIIRs(viral load:55.00–3154.50 copies/mL).This might be a source of contamination to connecting corridors and object surfaces through the footwear and gloves used by *** risk of infection was eliminated by the use of disposable footwear covers and the application of more effective environmental and personal hygiene *** the help of effective infection control procedures,none of 290 HCWs was infected when working in the AIIRs at this *** study has provided information pertinent for infection control in AIIRs during the treatment of COVID-19 patients.

关键词： SARS-CoV-2 COVID-19 Nosocomial transmission AIIRs Environmental sampling

Genotypes of Heading Date of Middle Indica Rice in the Mid-lower Region of the Yangtze River

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Journal of Integrative Plant Biology 2007年第12期49卷 1772-1781页

作者： Jun-Feng xu ling jiang Xiang-Jin wei Wen-wei zhang Shi-Jia Liu Liang-ming chen lin-Guang Luo jian-min Wan State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Nanjing 210095 China Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China

Middle indica cultivars are planted in the middle to lower regions of the Yangtze River. Hybrid combinations with these cultivars have a high yield potential but the presence of late-transgressive-segregants limits the further exploitation of heterosis. To understand the genetic basis of the heading date in these middle maturing cultivars, we carried out a genetic analysis of 10 typical middle-season cultivars using a number of heading date isogenic lines under both long and short day conditions. The results showed that Teqing, 752, CDR22, Bo B, 9311 and 11-32B carry two photoperiod sensitive genes E1 or Se.1 and E3, and Teqing, 752 and CDR22 carry a dominant early-heading gene Ef-1 while Bo B, 9311 and 11-32B carry a recessive late-heading gene ef-1. Based on the findings of the present and previous works on Guichao 2, minghui 63, Nanjing 11 and Pei＇ai64S, it was concluded that all of these middle indica cultivars carried the recessive allele hd2, which could inhibit the expression of El or Se.1, and they formed rational combinations of genotype for heading date during a long period of evolution. The effects of the different combinations of genotype for heading date on rice cultivation and extension were discussed, and genetic basis of broad adaptability of hybrid middle indica cultivars was analyzed.

关键词： heading date inhibitor middle-season rice (Oryza sativa) photoperiod-sensitive gene tester lines.

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焙炒工艺对葵花籽仁油风味及微观结构的影响

粮食与油脂 2024年第2期37卷 74-80页

作者：郭劲廷张立伟罗质陈建国许毅郑竟成武汉轻工大学食品科学与工程学院湖北武汉430023 大宗粮油精深加工教育部重点实验室湖北武汉430023 阿拉山口金牧生物科技有限公司新疆阿拉山口833418

以葵花籽仁为原料制备葵花籽仁油。在单因素试验的基础上通过正交试验优化葵花籽仁油的焙炒工艺,并对其挥发性物质和微观结构进行分析。结果表明:最佳焙炒工艺为焙炒温度150℃、焙炒时间30 min、入榨水分含量3.5%,在此条件下制备的葵花... 详细信息

以葵花籽仁为原料制备葵花籽仁油。在单因素试验的基础上通过正交试验优化葵花籽仁油的焙炒工艺,并对其挥发性物质和微观结构进行分析。结果表明:最佳焙炒工艺为焙炒温度150℃、焙炒时间30 min、入榨水分含量3.5%,在此条件下制备的葵花籽仁油含有56种挥发性物质,其中吡嗪、醛类物质含量较高。微观结构分析表明,焙炒过程中细胞结构完整性被破坏,结晶度降低,蛋白质类和糖类物质含量增加。

关键词：葵花籽仁油风味微观结构挥发性物质

Iron-doping Accelerating NADH Oxidation over Carbon Nitride

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Chemical Research in Chinese Universities 2020年第6期36卷 1076-1082页

作者： zhang yuanyuan HUANG Xiaohua LI Jiashu lin gang LIU Wengang chen Zupeng LIU jian College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042P.R.China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037P.R.China

As a state-of-the-art conjugated polymer photocatalyst,graphitic carbon nitride(abbreviated as g-C3Na)has shown sreat potential in photocatalvtic cofactor(reduced form of nicotinamide adenine ***)***,Fe-doped g-CaNa was engineered for photocatalvtic NADH *** n-r interaction between the NADH molecule and the conjugated heptazine buildine block facilitates the adsorption of NADH onto the framework as revealed by density functional theory(DFT)calculations,Furthermore,iron doping promoted the oxidation kinetics of NADH under blue LED *** conversion ratio of NADH to its oxidized form could be up to 85.7%in 20 min,comparing with 59.4%for metal-free *** assay employing formate dehydrogenase(FDH)further verified the selectivity of the products,with 67.5%+2.6%of enzymatically active 1,4-NADH being regenerated following the oxidation *** experiments suggest the dominant role of photo-induced electrons in theoxidation of *** work could shed light on developing a novel cofactor regeneration route through the syner-gistic effect between the metal doping and noncovalent interaction based on the coniugated polymer.

关键词： Cofactor regeneration NADH oxidation Photocatalysis Carbon nitride π-πinteraction

Longitudinal transcriptome analyses show robust T cellimmunity during recovery from COVID-19

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Signal Transduction and Targeted Therapy 2021年第1期6卷 105-116页

作者： Hong-Yi Zheng min xu Cui-Xian Yang Ren-rong Tian Mi zhang jian-jian Li Xi-cheng wang Zhao-Li Ding Gui-Mei Li Xiao-Lu Li yu-Qi He Xing-Qi Dong Yong-gang Yao Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China yunnan Infectious Disease Hospital Kunming 650301China Kunming Biological Diversity Regional Center of Large Apparatus and Equipments Public Technical Service CenterChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is crucial for improving ***,we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell(PBMC)samples from 18 patients with coronavirus disease 2019(COVID-19)during their treatment,convalescence,and *** analyzing the regulatory networks of differentially expressed messenger RNAs(mRNAs),microRNAs(miRNAs)and long non-coding RNAs(lncRNAs)between the different clinical stages,we found that humoral immunity and type I interferon response were significantly downregulated,while robust T-cell activation and differentiation at the whole transcriptome level constituted the main events that occurred during recovery from *** formation of this T cell immune response might be driven by the activation of activating protein-1(AP-1)related signaling pathway and was weakly affected by other clinical *** findings uncovered the dynamic pattern of immune responses and indicated the key role of T cell immunity in the creation of immune protection against this disease.

关键词： immunity transcriptome interferon

The gender difference of utilization of cardiac implantable electronic device in China： data from Arrhythmia Interventional Therapy Data Registry

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Journal of Geriatric Cardiology 2018年第4期15卷 310-314页

作者： Ruo-Han chen Ke-Ping chen wei HUA Jing xu lin chen Yang-gang SU Xi SU jian-gang ZOU Ji YAN Jing-Feng wang Bao-Peng TANG Mei-Xiang XIANG Shu zhang Center of Arrhythmia Fuwai Hospital Chinese Academy of Medical Sciences Peking union Medical College Beijing China Department of Cardiology Tian Jing Chest Hospital Tianjing China Department of Cardiology FuJian Provincial Hospital Fuzhou China Department of Cardiology ZhongShan Hospital FuDang University Shanghai China Department of Cardiology WuHan Asia Cardiology Hospital Wuhan China Department of Cardiology the Ftrst Affiliated Hospital of Nangjing Medical University NanJing China Department of Cardiology AnHui Provincial Hospital Hefei China Department of Cardiology Sun- Yat-Sen Memorial Hospital Guangzhou China Department of Cardiology the First Affiliated Hospital of Xinjiang Medical University Urumichi China Department of Cardiology the Second Affiliated Hospital of Zhejiang University of School of Medical Hangzhou China

Background Cardiac implantable electronic devices （CIEDs） greatly improve survival and life quality of patients. However, there are gender differences regarding both the utilization and benefit of these devices. In this prospective CIED registry, we aim to appraise the gender differences in CIED utilization in China. Methods Twenty centers from 14 provinces in China were included in our registry study. All patients who underwent a CIED implantation in these twenty centers between Jan 2015 and Dec 2016 were included. Results A total of 8570 patients were enrolled in the baseline cohort, including 7203 pacemaker, 664 implantable cardiac defibrillators （ICD） implants and 703 cardiac resynchronization therapy device （CRT/D）. Totally, 4117 （48.0%） CIED patients were female, and more than 59% pacemaker patients were female, but women account only one third of ICD or CRT/D implantation in this registry. There were significant differences between genders at pacemaker and ICD indications. Female was more likely received a pacemaker due to sick sinus syndrome （SSS）（63.9% vs. 51.0%, P 〈 0.001）. Female patients receiving an ICD were more likely due to cardiac ion channel disease （29.2% vs. 4.2%, P 〈 0.001）. The percentage of utilization of dual-chamber pacemaker in female patients was significantly higher than male （85.3% vs. 81.1%, P 〈 0.001）. But male patients were more likely received a cardiac resynchronization therapy devices with defibrillator than female （56.5% vs. 41.9%, P = 0.001）. In pacemaker patient, male was more likely to have structure heart disease （31.3% vs. 28.0%, P = 0.002）. In ICD patient, male patients were more likely to have ischemic heart disease （48.2% vs. 29.2%, P 〈 0.001）. The mean age of women at the time of CRT/D implantation was older than men （P = 0.014）. Nonischemic cardiomyopathy （70.9%） was the most common etiology in the patients who underwent the treat？ment of CRT/D, no matter male or female. Conclusions In real-world setting, female do have

关键词： Cardiac implantable electronic devices Gender Registry