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Acta Mechanica Sinica 2010年第1期26卷 21-25页

作者： Jie Zhao chen chen Yan liang jian Wang School of Materials Science and Engineering Dalian University of Technology116024 Dalian China

Haliotis discus hannai Ino （abalone shell） and Hemifusus tuba conch shell have been studied for the purpose to comparatively investigate the mechanisms by which nature designs composites. It is shown that both shells are composed of aragonite and a small amount of proteins while the conch shell shows finer microstructure but lower strength than aba- lone shell. It is also shown that the fresh shells exhibits better property than those after heat-treatments. It is therefore sup- posed that the size of inorganic substance is not a dominant factor to improve strength, while both proteins in shells and the microstructure of inorganic matter also play important roles.

关键词： Abalone Conch Mechanical properties Aragonite

Antioxidant xanthones and anthraquinones isolated from a marine-derived fungus Aspergillus versicolor

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Chinese Journal of Natural Medicines 2018年第3期16卷 219-224页

作者： WU Ze-Hong LIU Dong XU Ying chen jian-liang LIN Wen-Han The Eighth Affiliated Hospital Sun Yat-sen University State Key Laboratory of Natural and Biomimetic Drugs Peking University Shenzhen Key Laboratory of Marine Bioresource & Eco-environmental Science Shenzhen Engineering Laboratory for Marine Algal Biotechnology College of Life Science Shenzhen University

Chemical examination of an EtOAc extract of cultured Aspergillus versicolor fungus from deep-sea sediments resulted in the isolation of four xanthones, eight anthraquinones and five alkaloids, including a new xanthone, oxisterigmatocystin D （1） and a new alkaloid, aspergillusine A （13）. High resolution electron impact mass spectrometry （HR-EI-MS）, FT-IR spectroscopy, and NMR techniques were used to elucidate the structures of these compounds, and the absolute configuration of compound 1 was established by its NMR features and coupling constant. Furthermore, the biosynthesis pathway of these xanthones and anthraquinones were deduced, and their antioxidant activity and cytotoxicity in human cancer cell lines （HTC-8, Bel-7420, BGC-823, A549, and A2780） were evaluated. The trolox equivalent antioxidant capacity （TEAC） assay indicated most of the xanthones and anthraquinones possessing moderate antioxidant activities. The Nrf2-dependent luciferase reporter gene assay revealed that compounds 6, 7, 9, and 12 potentially activated the expression of Nrf2-regulated gene. In addition, compounds 5 and 11 showed weak cytotoxicity on A549 with the ICs0 values of 25.97 and 25.60 gmol·L^-1, respectively.

关键词： Aspergillus versicolor Xanthones Anthraquinones Antioxidant activity Cytotoxicity

Creep constitutive model considering nonlinear creep degradation of fractured rock

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International Journal of Mining Science and Technology 2024年第1期34卷 105-116页

作者： Wang Chunping Liu jianfeng chen liang Liu jian Wang Lu Liao Yilin Beijing Research Institute of Uranium Geology Beijing 100029China CAEA Innovation Center for Geological Disposal of High-Level Radioactive Waste Beijing 100029China State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China School of Architecture and Civil Engineering Xihua UniversityChengdu 610039China

Stability analysis of underground constructions requires a model study of rock masses’ long-term performance. Creep tests under different stress conditions was conducted on intact granite and granite samples fractured at 30° and 45° angles. The experimental results indicate that the steady creep strain rates of intact and fractured rock present an exponential increase trend with the increase of stress level. A nonlinear creep model is developed based on the experimental results, in which the initial damage caused by fracture together with the damage caused by constant load have been taken into consideration. The fitting analysis results indicated that the model proposed is more accurate at identifying the full creep regions in fractured granite, especially the accelerated stage of creep deformation. The least-square fit error of the proposed creep model is significantly lower than that of Nishihara model by almost an order of magnitude. An analysis of the effects of elastic modulus, viscosity coefficient, and damage factors on fractured rock strain rate and creep strain is conducted. If no consideration is given to the effects of the damage, the proposed nonlinear creep model can degenerate into to the classical Nishihara model.

关键词： Fractured rock Damage Creep Beishan granite Geological disposal

Digital signal acquisition system for complex nuclear reaction experiments

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Nuclear Science and Techniques 2024年第1期35卷 124-133页

作者： Wei-liang Pu Yan-Lin Ye jian-Ling Lou Jia-Hao chen School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China Institute of Applied Physics and Computational Mathematics Beijing 100094China

A digital data-acquisition system based on XIA LLC products was used in a complex nuclear reaction experiment using radioactive ion beams.A flexible trigger system based on a field-programmable gate array(FPGA)parametrization was developed to adapt to different experimental sizes.A user-friendly interface was implemented,which allows converting script language expressions into FPGA internal control *** proposed digital system can be combined with a conventional analog data acquisition system to provide more *** performance of the combined system was veri-fied using experimental data.

关键词： Digital signal acquisition system Trigger Programmable logic Timestamp

Lipid metabolism, amino acid metabolism, and prostate cancer: a crucial metabolic journey

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Asian Journal of Andrology 2024年第2期26卷 123-134页

作者： Lin chen Yu-Xin Xu Yuan-Shuo Wang jian-liang Zhou School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal UniversityHangzhou 311121China School of Pharmacy Guangxi Medical UniversityNanning530021China

Prostate cancer(PCa)is one of the most common malignancies in males worldwide,and its development and progression involve the regulation of multiple metabolic *** in lipid metabolism affect the proliferation and metastatic capabilities of PCa *** cells increase lipid synthesis and regulate fatty acid oxidation to meet their growth and energy ***,changes occur in amino acid metabolism in *** cells exhibit an increased demand for specific amino acids,and they regulate amino acid transport and metabolic pathways to fulfill their proliferation and survival *** changes are closely associated with disease progression and treatment response in PCa ***,a comprehensive investigation of the metabolic characteristics of PCa is expected to offer novel insights and approaches for the early diagnosis and treatment of this disease.

关键词： amino acid metabolism lipid metabolism metabolic pathways prostate cancer treatment strategies

Effects of grafting cell penetrate peptide and RGD on endocytosis and biological effects of Mg-CaPNPs-CKIP-1 siRNA carrier system in vitro

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Journal of Central South University 2021年第5期28卷 1291-1304页

作者： YI Man-fei chen liang-jian HE Hui-li SHI Lei SHAO Chun-sheng ZHANG Bo Department of Stomatology the Third Xiangya HospitalCentral South UniversityChangsha 410013China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Calcium phosphate nanoparticles(CaPNPs)have good biocompatibility as gene carriers;however,CaPNPs typically exhibit a low transfection *** penetrate peptide(TAT)can increase the uptake of nanoparticles but is limited by its *** adhesion peptide adhesion peptide on carriers can enhance their *** Plekho1 gene encodes casein kinase-2 interacting protein-1(CKIP-1),which can negatively regulate osteogenic *** on the above,we produced a Mg-CaPNPs-RGD-TAT-CKIP-1 siRNA carrier system via hydrothermal synthesis,silanization and *** effects of this carrier system on cell endocytosis and biological effects were evaluated by cell culture in *** results demonstrate that CaPNPs with 7%Mg(60 nm particle size,short rod shape and good dispersion)were suitable for use as gene *** carrier system boosted the endocytosis of MG63 cells and was helpful for promoting the differentiation of osteoblasts,and the dual-ligand system possessed a synergistic *** findings of this study show the tremendous potential of the Mg-CaPNPs-RGD-TAT-CKIP-1 siRNA carrier system for efficient delivery into cells and osteogenesis inducement.

关键词： calcium phosphate nanoparticles adhesion peptide cell penetrate peptide endocytosis siRNA

The influence of yttrium and manganese additions on the degradation and biocompatibility of magnesium-zinc-based alloys:In vitro and in vivo studies

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Journal of Magnesium and Alloys 2024年第2期12卷 608-624页

作者： Lei Shi Yang Yan Chun-sheng Shao Kun Yu Bo Zhang liang-jian chen Third Xiangya Hospital Central South UniversityChangsha 410013China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China School of Materials Science and Engineering Central South UniversityChangsha 410083China Department of Mechanical Engineering City University of Hong KongHong KongChina

The repair and regeneration of bone defects are highly challenging orthopedic ***,Mg-based implants have gained popularity due to their unique biodegradation and elastic modulus similar to that of human *** aim of our study is to develop a magnesium alloy with a controllable degradation that can closely match bone tissue to help injuries heal in vivo and avoid cytotoxicity caused by a sudden increase in ion *** this study,we prepared and modified Mg-3Zn,Mg-3Zn-1Y,and Mg-2Zn-1Mn by hot extrusion,and used Mg-2.5Y-2.5Nd was as a *** then investigated the effect of additions of Y and Mn on alloys'*** results show that Mn and Y can improve not only compression strength but also corrosion *** alloy Mg-2Zn-1Mn demonstrated good cytocompatibility in vitro,and for this reason we selected it for implantation in *** degraded Mg-2Zn-1Mn implanted a bone defect area did not cause obvious rejection and inflammatory reaction,and the degradation products left no signs of damage to the heart,liver,kidney,or ***,we find that Mg-2Zn-1Mn can promote an osteoinductive response in vivo and the formation of bone regeneration.

关键词： Magnesium alloy Biodegradation Biocompatibility Bone regeneration Bone defect repair

Processing of a low-costγ-γ'NiPtAl coating with improved oxidation resistance

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Rare Metals 2024年第6期43卷 2832-2841页

作者： Yan jiang liang-liang Wei jian He Hong-Bo Guo School of Materials Science and Engineering Beihang UniversityBeijing 100191China Key Laboratory of High-Temperature Structural Materials and Protective Coatings Ministry of Industry and Information TechnologyBeihang UniversityBeijing 100191China

A novelγ-γ'(Ni solid solution—Ni_(3)Al)NiPtAl coating was produced on advanced single-crystal(SC)superalloy N5 by electroplating of a thin Pt coating with~3μm in thickness followed by heat treatment at 1000℃in *** comparison,a traditionalγ-γ'NiPtAl coating was also produced by electroplating of a thick Pt coating with~6μm in thickness followed by heat treatment at 1100℃in *** novel coating has a mass gain of~0.5 mg·cm^(-2)after 100 h 1-h cyclic oxidation at 1150℃,showing better oxidation resistance than the traditional *** oxide scale mostly consisting ofα-Al_(2)O_(3)grew on the novel coating because the element Cr from the SC alloy substrate contributes to the formation ofα-Al_(2)O_(3).Pt content in the novel coating has significant effect on the oxidation *** optimized Pt content in the coating is about 16 at%,which is helpful to reduce the diffusion of harmful elements from the substrate into the coating but also to reduce the cost of the coating.

关键词： γ-γ'NiPtAl coating Platinum Oxidation Al_(2)O_(3) Superalloy

Non-interactive SM2 threshold signature scheme with identifiable abort

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Frontiers of Computer Science 2024年第1期18卷 171-185页

作者： Huiqiang liang jianhua chen School of Mathematics and Statistics Wuhan UniversityWuhan 430072China

A threshold signature is a special digital signature in which the N-signer share the private key x and can construct a valid signature for any subset of the included t-signer,but less than t-signer cannot obtain any *** the breakthrough achievements of threshold ECDSA signature and threshold Schnorr signature,the existing threshold SM2 signature is still limited to two parties or based on the honest majority setting,there is no more effective solution for the multiparty *** make the SM2 signature have more flexible application scenarios,promote the application of the SM2 signature scheme in the blockchain system and secure cryptocurrency *** paper designs a non-interactive threshold SM2signature schemebasedon partially homomorphic encryption and zero-knowledge *** the last round requires the message input,so make our scheme non-interactive,and the pre-signing process takes 2 rounds of communication to complete after the key *** allow arbitrary threshold t

关键词： SM2 signature secure multi-party computation threshold signature UC-secure dishonest majority

Advanced strategies for 3D-printed neural scaffolds:materials,structure,and nerve remodeling

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Bio-Design and Manufacturing 2024年第5期7卷 747-770页

作者： jian He liang Qiao Jiuhong Li Junlin Lu Zhouping Fu Jiafang chen Xiangchun Zhang Xulin Hu College of Basic Medicine and Forensic Medicine Henan University of Science and TechnologyLuoyang 471023China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyang 471003China Tea Research Institute Chinese Academy of Agricultural SciencesHangzhou 310008China Clinical Medical College Affiliated Hospital of Chengdu UniversityChengdu UniversityChengdu 610081China Department of Cardiovascular Surgery Department of BiotherapyCancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China

Nerve regeneration holds significant potential in the treatment of various skeletal and neurological disorders to restore lost sensory and motor *** potential of nerve regeneration in ameliorating neurological diseases and injuries is critical to human ***-dimensional(3D)printing offers versatility and precision in the fabrication of neural *** neural structures such as neural tubes and scaffolds can be fabricated via *** reviewcomprehensively analyzes the current state of 3D-printed neural scaffolds and explores strategies to enhance their *** highlights therapeutic strategies and structural design involving neural materials and stem ***,nerve regeneration materials and their fabrication techniques are *** applications of conductive materials in neural scaffolds are reviewed,and their potential to facilitate neural signal transmission and regeneration is ***,the progress in 3D-printed neural scaffolds applied to the peripheral and central nerves is comprehensively evaluated,and their potential to restore neural function and promote the recovery of different nervous systems is *** addition,various applications of 3D-printed neural scaffolds in peripheral and neurological diseases,as well as the design strategies of multifunctional biomimetic scaffolds,are discussed.

关键词： Nerve regeneration 3D printing based neural scaffolds Biomaterials Nervous system Design strategies