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Clinical significance and prognostic value of tumor necrosis factor-α and dickkopf related protein-1 in ankylosing spondylitis

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World Journal of Clinical Cases 2020年第7期8卷 1213-1222页

作者： Jun-Hui Xiong jian Liu jian chen Department of Rheumatology Lishui People’s HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Ankylosing spondylitis(AS)frequently occurs in people aged 30-45 years,and its prevalence is generally believed to be between 0.1%and 1.4%*** present,the“gold standard”for diagnosis of AS requires the provision of pelvic X-rays,which makes it more difficult to perform in population-based epidemiological ***,the identification of serological indicators related to the diagnosis,treatment,and prognosis of AS patients is of great *** To analyze the therapeutic,diagnostic significance and prognostic value of dickkopf-related protein-1(DKK-1)and tumor necrosis factor-α(TNF-α)in *** A total of 113 patients with active AS were selected as the research group,and 100 healthy subjects who underwent physical examination were selected as the control *** levels of DKK-1 and TNF-α in peripheral blood in the two groups were *** diagnostic and predictive values of DKK-1 and TNF-α for AS were analyzed with ROC curves,and the factors influencing AS recurrence were analyzed with COX *** Before treatment,the research group showed lower DKK-1 levels but higher TNF-αlevels than the control group(both aP<0.05).In the research group,DKK-1 was up-regulated and TNF-αwas down-regulated after 12 wk of treatment(aP<0.05).The area under the curve,sensitivity and specificity of DKK-1 combined with TNF-αfor diagnosing AS were 0.934,82.30%and 97.00%,*** treatment,the area under the curve,cutoff value,sensitivity and specificity of DKK-1 for predicting the curative effect were 0.825,68.42 pg/mL,73.68%and 80.00%,respectively,and those of TNF-αwere 0.863,32.79 ng/L,92.11%and 77.33%,***-1 and TNF-αlevels after treatment were closely related to the curative effect(aP<0.05).C-reactive protein,the Bath Ankylosing Spondylitis Disease Activity Index,DKK-1,and TNF-αwere risk factors for AS recurrence(aP<0.05).CONCLUSION DKK-1 and TNF-αare effective in the diagnosis and treatment of AS and are risk f

关键词： Dickkopf-related protein-1 Tumor necrosis factor-α Ankylosing spondylitis Diagnosis Prognosis Peripheral blood

2D and 3D stability analysis of slurry trench in frictional/cohesive soil

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第2期14卷 94-100页

作者： Chang-yu HAN Jin-jian chen jian-hua WANG Xiao-he XIA Department of Civil Engineering Shanghai Jiaotong University

A 2D and 3D kinematically admissible rotational failure mechanism is presented for homogeneous slurry trenches in frictional/cohesive *** approaches are derived to obtain the upper bounds on slurry trench stability in the strict framework of limit *** is shown that the factor of safety from a 3D analysis will be greater than that from a 2D *** with the limit equilibrium method,the limit analysis method yields an unconservative estimate on the safety factors.A set of examples are presented in a wide range of parameters for 2D and 3D homogeneous slurry *** factor of safety increases with increasing slurry and soil bulk density ratio,cohesion,friction angle,and with decreasing slurry level depth and trench depth ratio,trench width and depth *** is convenient to assess the safety for the homogeneous slurry trenches in practical applications.

关键词： Limit analysis Stability Slurry trench Diaphragm wall

Optimization of Two-Dimensional Gel Electrophoresis for Kenaf Leaf Proteins

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Agricultural Sciences in China 2011年第12期10卷 1842-1850页

作者： chen Tao QI jian-min XU jian-tang chen Pin-pin TAO Ai-fen chen Fu-cheng chen Wei Key Laboratory for Genetics Breeding and Multiple Utilization of Crops Ministry of Education/Fujian Agriculture and Forestry University Fuzhou 350002. P.R.China

To establish a suitable and effective protocol of protein extraction for two-dimensional gel electrophoresis （2-DE） analysis in kenaf leaf tissues, three extraction methods （trichloroacetic acid/acetone, urea/thiourea, and phenol extraction methods） were applied to the extraction of kenaf leaf protein. The results were compared in regard to protein extraction efficiency, sodiumdodecyl sulfate-polyacrylamide gel electrophoresis （SDS-PAGE）, and 2-DE gels. Furthermore, the 2-DE system was optimized for four aspects： the pH range of IPG （immobilized pH gradient） stripes, sampling methods, sample volumes, and concentration of polyacrylamide gels. The data presented showed that the phenol extraction method is the best method to perform 2-DE analysis of kenaf leaf protein. The protein extracted from phenol extraction method reached the purity of （26.40±0.859）%, showed （25.67±1.53） protein bands in one dimension SDS-PAGE gels, and （1 374±54.44） protein spots on 2-DE gels. The research also indicates that kenaf leaf protein spots were distributed mainly within the pH range of 4-8. More clear background with a better distribution effect and many protein spots could be obtained on 2-DE gels under the conditions of active rehydration loading, 24 cm IPG strips （linear pH gradient of 4-7）, 1.4 mg samples, and 12% SDS-PAGE gels.

关键词： kenaf protein extraction proteome two-dimensional gel electrophoresis

NUMERICAL SIMULATION OF THE ENERGY DISSIPATION CHARACTERISTICS IN STILLING BASIN OF MULTI-HORIZONTAL SUBMERGED JETS

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Journal of Hydrodynamics 2010年第5期22卷 732-741页

作者： chen jian-gang ZHANG jian-min XU Wei-lin WANG Yu-rong State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Chengdu 610065 China

3-D numerical simulation was carried out for the water flow in a stilling basin with multi-horizontal submerged jets by using two different turbulence models, namely, the VOF RNG k-ε and Mixture RNG k-ε turbulence models. The calculated water depth, velocity profile and pressure distribution are in good agreement with the data obtained in experiments. It indicates that the numerical simulation can effectively be used to study the water flow movement and the energy dissipation mechanism. The numerical simulation results show that the turbulent kinetic energy distribution obtained by using the Mixture turbulence model covers a region about 18% larger than that calculated by using the VOF turbulence model, and is in better agreement with the actual situation. Furthermore, the Mixture turbulence model is better than the VOF turbulence model in calculating the air entrainment.

关键词： multi-horizontal submerged jets numerical simulation VOF method Mixture method hydraulic characteristics stilling basin

PCB CT Image Element Segmentation Model Optimizing the Semantic Perception of Connectivity Relationship

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Computers, Materials & Continua 2024年第11期81卷 2629-2642页

作者： chen chen Kai Qiao Jie Yang jian chen Bin Yan School of Information Systems Engineering PLA Strategy Support Force Information Engineering UniversityZhengzhou450001China

Computed Tomography(CT)is a commonly used technology in Printed Circuit Boards(PCB)non-destructive testing,and element segmentation of CT images is a key subsequent *** the development of deep learning,researchers began to exploit the“pre-training and fine-tuning”training process for multi-element segmentation,reducing the time spent on manual ***,the existing element segmentation model only focuses on the overall accuracy at the pixel level,ignoring whether the element connectivity relationship can be correctly *** this end,this paper proposes a PCB CT image element segmentation model optimizing the semantic perception of connectivity relationship(OSPC-seg).The overall training process adopts a“pre-training and fine-tuning”training process.A loss function that optimizes the semantic perception of circuit connectivity relationship(OSPC Loss)is designed from the aspect of alleviating the class imbalance problem and improving the correct connectivity ***,the correct connectivity rate index(CCR)is proposed to evaluate the model’s connectivity relationship recognition *** show that mIoU and CCR of OSPC-seg on our datasets are 90.1%and 97.0%,improved by 1.5%and 1.6%respectively compared with the baseline *** visualization results,it can be seen that the segmentation performance of connection positions is significantly improved,which also demonstrates the effectiveness of OSPC-seg.

关键词： Semantic segmentation PCB non-destructive testing mask image modeling connectivity relationship

Study on Floral and Pollen Characters of Tetraploid Rice

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Agricultural Sciences in China 2009年第10期8卷 1149-1158页

作者： LIU jian-xin chen jian-guo chen Dong-ling SONG Zhao-jian DAI Bing-cheng CAI De-tian College of Life Sciences Hubei University Wuhan 430062 P.R.China Cotton and Fibre Research Institute of Xiaoshan Zhejiang Academy of Agricultural Sciences Hangzhou 311202 P.R. China

Polyploidization is the evolution trend of many crops, and the yield increased obviously after polyploidization. The polyploidization of rice often brings ＂gigas＂ of both vegetative organs and seeds. Howevere, in rice breeding, it is required for restoring lines to have not only big anthers but also abundant pollens. People often doubt that the enlargement of the floral organ may just be enlargement of cell size in polyploid rice. So, it is of significance to study characteristics of floral organs and pollens of several tetraploid rice varieties or lines. Floral organ and pollen characteristics of Sg99012 and HN2026 were studied comparatively by stages and different ploidy levels, with the materials 9311, HD9802S, and PA64S as the control. The results showed that chromosome doubling had much more influence on floral characteristics of every lines than seeding by stages, and the tetraploids of every lines displayed ＂gigas＂. In correlation analysis, spikelet length, spikelet width, and anther length had significant correlation; spikelet width and anther width had significant correlation, too. Both seeding by stages and chromosome doubling made the correlations of characters between every floral organ changed to some extent. Seeding by stages had little effect on pollen diameter and fertility of HN2026-4X and Sg99012-4X. But chromosome doubling increased pollen size of every lines remarkably, and also increased the pollen quantity of PMeS （polyploid meiosis stability） restoring line HN2026-4X and gene map restoring line 9311-4X remarkably, whereas only had little effect on that of sterile lines. Moreover, chromosome doubling changed pollen fertility and made the number of fertility pollen of 9311 reduced significantly, but the pollen fertility of HN2026 （PMeS restoring line） and PA64S （sterile line） almost had no change after chromosome doubling. The results showed that tetraploid restoring lines had advantage of abundant and big size pollens, and tetraploid sterile li

关键词： polyploid rice floral organ pollen significance testing correlation analysis

Spatial hotspot detection using polygon propagation

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International Journal of Digital Earth 2019年第7期12卷 825-842页

作者： Satya Katragadda jian chen Shaaban Abbady Center for Visual and Decision Informatics(CVDI) University of Louisiana at LafayetteLafayetteLAUSA Informatics Research Institute(IRI) University of Louisiana at LafayetteLafayetteLAUSA Department of Geography University of North AlabamaFlorenceALUSA Center for Advanced Computer Studies(CACS) University of Louisiana at LafayetteLafayetteLafayetteLAUSA

Spatial scan statistics is one of the most important models in order to detect high activity or hotspots in real world applications such as epidemiology,public health,astronomy and criminology applications on geographic *** scan statistic uses regular shapes like circles to detect areas of high activity;the same model was extended to eclipses to improve the *** recent works identify irregular shaped hotspots for data with geographical boundaries,where information about population within the geographical boundaries is *** the introduction of better mapping technology,mapping individual cases to latitude and longitude became easier compared to aggregated data for which the previous models were *** propose an approach of spatial hotspot detection for point data set with no geographical boundary *** algorithm detects hotspots as a polygon made up of a set of triangles that are computed by a Polygon Propagation *** time complexity of the algorithm is non-linear to the number of observations,which does not scale well for larger *** improve the model,we also introduce a MapReduce version of our algorithm to identify hotspots for larger datasets.

关键词： Spatial clustering MapReduce hotspot detection polygon propagation

Wear and transfer characteristics of carbon fiber reinforced polymer composites under water lubrication

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中国有色金属学会会刊:英文版 2004年第z1期14卷 332-340页

作者： JIA Jun-hong chen jian-min ZHOU Hui-di chen Lei State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China

The tribological characteristics of carbon fiber reinforced polymer composites under distilled-water-lubricated-sliding and dry-sliding against stainless steel were comparatively investigated. Scanning electron microscopy (SEM) was utilized to examine composite microstructures and modes of failure. The typical chemical states of elements of the transfer film on the stainless steel were examined with X-ray photoelectron spectroscopy (XPS). Wear testing and SEM analysis show that all the composites hold the lowered friction coefficient and show much better wear resistance under water lubricated sliding against stainless steel than those under dry sliding. The wear of composites is characterized by plastic deformation, scuffing, micro cracking, and spalling under both dry-sliding and water lubricated conditions. Plastic deformation, scuffing, micro cracking, and spalling, however, are significantly abated under water-lubricated condition. XPS analysis conforms that none of the materials produces transfer films on the stainless steel counterface with the type familiar from dry sliding, and the transfer of composites onto the counterpart ring surface is significantly hindered while the oxidation of the stainless steel is speeded under water lubrication. The composites hinder transfer onto the steel surface and the boundary lubricating action of water accounts for the much smaller wear rate under water lubrication compared with that under dry sliding. The easier transfer of the composite onto the counterpart steel surface accounts for the larger wear rate of the polymer composite under dry sliding.

关键词： friction and wear transfer film water lubrication carbon fiber polymer composite

Dietary reprogram of macrophages for cell competition: a promising strategy for malignant cancer control

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5153-5155页

作者： jian chen Zhaoliang Su Guangchuan Wang Department of Nephrology Affiliated Hospital of Jiangsu UniversityZhenjiang212013China International Genome Center Jiangsu UniversityZhenjiang212013China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai20031China

In a recent study published in Nature,Zhang et *** the nutrient competition between cancer cells as well as their competition with macrophages during cancer development.1 Their data demonstrated that tumor-associated macrophage(TAM)can be dietarily or genetically reprogrammed to win in the competition with MYC-overexpressing cancer cells,providing new insights into our understanding of tumor development and immunotherapy.

关键词： cancer malignant