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山西中医学院学报 2011年第1期12卷 43-45页

作者：陈筱云陈家礼山西中医学院第二中医院山西太原030024

通过对药引源流及历代医家对药引的探讨,总结陈家礼教授对药引功效的认识及临床应用,认为药引既可以引药入经,直达病所,提高疗效,又可以照顾兼病兼症、固护正气、降低毒性、矫除药物异味等。

关键词：陈家礼药引临床应用

Exploring negative ion behaviors and their influence on properties of DC magnetron sputtered ITO films under varied power and pressure conditions

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Chinese Physics B 2024年第10期33卷 442-449页

作者： Maoyang Li Chaochao Mo Peiyu Ji Xiaoman Zhang jiali chen Lanjian Zhuge Xuemei Wu Haiyun Tan Tianyuan Huang School of Physical Science and Technology Soochow UniversitySuzhou 215000China Suzhou Maxwell Technologies Co. Ltd.Suzhou 215000China Jiangsu Key Laboratory of Frontier Material Physics and Devices Suzhou 215000China School of Optoelectronic Science and Engineering Soochow UniversitySuzhou 215000China Analysis and Testing Center Soochow UniversitySuzhou 215000China School of Optical and Electronic Information Suzhou City University&Suzhou Key Laboratory of BiophotonicsSuzhou 215104China

We deposited indium-tin-oxide(ITO)films on silicon and quartz substrates by magnetron sputtering technology in pure *** electrostatic quadrupole plasma diagnostic technology,we investigate the effects of discharge power and discharge pressure on the ion flux and energy distribution function of incidence on the substrate surface,with special attention to the production of high-energy negative oxygen ions,and elucidate the mechanism behind its *** the same time,the structure and properties of ITO films are systematically characterized to understand the potential effects of high energy oxygen ions on the growth of ITO *** with the kinetic property analysis of sputtering damage mechanism of transparent conductive oxide(TCO)thin films,this study provides valuable physical understanding of optimization of TCO thin film deposition process.

关键词： magnetron sputtering ion energy ITO thin film high energy oxygen anion

Medium-energy electron spectrometers on Macao Science Satellite-1

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Science China(Technological Sciences) 2024年第11期67卷 3324-3343页

作者： YE YuGuang LIU Ying ZOU Hong ZONG QiuGang chen jiali YU XiangQian SHI WeiHong OU JiaMing LIU JianBin YU LiJia ZHOU Jun HUANG He YUAN ShiGeng SU Wen SUO Le State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyCNSA Macao Center for Space Exploration and ScienceMacao 999078China School of Earth and Space Sciences Peking UniversityBeijing 100871China Shandong Aerospace Electro-technology Yantai 264043China School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China DFH Satellite Co.Ltd. Beijing 100081China Institute of Remote Sensing Satellite China Academy of Space TechnologyBeijing 100094China

The Macao Science Satellite-1 is a two-satellite constellation specifically designed to study the geomagnetic field and particle radiation environment in low Earth orbit,particularly in the South Atlantic Anomaly region,with a low inclination *** of the two MSS-1 satellites carries a medium-energy electron spectrometer(MES).The MES sensor heads are based on pinhole imaging technology,which can simultaneously measure 50-600 keV electrons incident from nine directions with a field of view(FOV)of 180°×30°.The two MESs can realize the pitch angle coverage of medium energy electrons at most positions in the *** MSS-1 A/B MESs can realize direct observation of precipitating electrons and electrons near their loss *** can help to study the electron generation mechanism in the inner radiation belt and quantify the precipitation of magnetospheric energetic *** with the geomagnetic index,solar wind parameters,interplanetary magnetic field conditions,etc.,it can also help to build a dynamic evolution model of energetic electrons in the near-Earth space,to realize the early warning and prediction of space weather based on the observation data,which can provide safety for spacecraft and astronauts in the nearEarth space.

关键词： Macao Science Satellite-1 medium-energy electron spectrometer inner radiation electrons Southern Atlantic Anomaly pitch angle distribution

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli Si Naijia Xue Yi Liu Ran Zheng Ying chen jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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低纹波空间可调高压电源设计

北京大学学报（自然科学版） 2024年第2期60卷 195-202页

作者：陈佳黎邹鸿叶雨光北京大学空间物理与应用技术研究所北京100871

为了满足空间探测载荷(如质谱仪和能量粒子探测器等)对高压电源输出纹波的要求,设计一款小功率、低纹波、最大输出电压为10 kV的可调高压直流电源。设计中使用罗耶架构的逆变器和倍压整流电路,利用反馈回路,使纹波电压峰峰值小于2 V;使... 详细信息

为了满足空间探测载荷(如质谱仪和能量粒子探测器等)对高压电源输出纹波的要求,设计一款小功率、低纹波、最大输出电压为10 kV的可调高压直流电源。设计中使用罗耶架构的逆变器和倍压整流电路,利用反馈回路,使纹波电压峰峰值小于2 V;使用51系列单片机控制电源输出电压,监测电源的工作状态。除在原理设计方面降低输出电压纹波外,还提出其他降低输出电压纹波的措施。测试结果表明,所设计的高压电源具有输出电压稳定可调、纹波低的特点,可以满足空间探测载荷对高压电源的基本性能要求。

关键词：高压电源倍压整流低纹波可变输出单片机

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应用本科毕业设计管理模式研究

国家教育行政学院学报 2009年第4期136卷 38-42页

作者：陈嘉莉徐州工程学院管理学院江苏徐州221008

基于对我国应用本科教育的深入调查研究和多年的实践,笔者认为,对应用型本科毕业设计(论文)管理的研究,应提升到如何创造和实现其核心价值的高度上来,才能抓住实质,引向深入,才能创新管理模式,真正起到提高管理水平的作用。本文针对我... 详细信息

基于对我国应用本科教育的深入调查研究和多年的实践,笔者认为,对应用型本科毕业设计(论文)管理的研究,应提升到如何创造和实现其核心价值的高度上来,才能抓住实质,引向深入,才能创新管理模式,真正起到提高管理水平的作用。本文针对我国应用型本科教育核心价值的创造和实现,以及本科毕业设计(论文)管理存在的问题,重点论述了应用本科毕业设计(论文)管理模式构建。

关键词：应用本科核心价值毕业设计(论文) 管理模式

政府指标的生产:类型与过程--以A省民政规划指标编制为例

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华中师范大学学报（人文社会科学版） 2022年第5期61卷 49-64页

作者：陈那波陈嘉丽中国人民大学社会学理论与方法研究中心、社会与人口学院北京100872 广东省经纬社会发展研究服务中心广东广州510627

指标治理作为中国国家治理的一个重要机制已经日益引起社会科学研究的重视,已有的研究主要关注的是围绕着指标治理末端而展开的治理行动,而缺乏对指标生产机制的重视和相应的经验研究。本研究以A省民政在编制五年规划中的指标生产过程为... 详细信息

指标治理作为中国国家治理的一个重要机制已经日益引起社会科学研究的重视,已有的研究主要关注的是围绕着指标治理末端而展开的治理行动,而缺乏对指标生产机制的重视和相应的经验研究。本研究以A省民政在编制五年规划中的指标生产过程为例,展现了绩效获取与风险规避两大要素是如何形塑包括对标层、酝酿层、影响层与参与层在内的决策主体在指标生产过程中的态度和行为,从而导致了不同类型的指标(绩优型、创新型、回应型和形式型)在生产过程中的出场与退场,并最终形成了基于“安全绩效获取逻辑”的指标生产结果。研究为政府指标生产提供了一个细致的案例,并企求在此基础上对指标治理研究形成新的启发。

关键词：指标治理指标生产基层治理

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河南省促进新型城镇化的财政保障机制研究

地域研究与开发 2013年第6期32卷 50-53页

作者：陈佳丽河南省工程咨询中心郑州450008

以河南省2012年基本公共服务财政支出为基数,从对影响财政支出的义务教育、社会保障与就业、计生与卫生服务、基本住房保障等主要因素入手,深入分析了河南省基本公共服务财政保障存在的主要问题及其深层次原因,详细测算了2013—2015年... 详细信息

以河南省2012年基本公共服务财政支出为基数,从对影响财政支出的义务教育、社会保障与就业、计生与卫生服务、基本住房保障等主要因素入手,深入分析了河南省基本公共服务财政保障存在的主要问题及其深层次原因,详细测算了2013—2015年河南城镇基本公共服务财政支出需求,重点分析研究了河南省新型城镇化的财政保障机制,提出了城镇常住人口全覆盖的财政保障的目标、任务、对策及主要措施。

关键词：新型城镇化基本公共服务财政保障机制河南省

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang jiali Wu Yu Wang Hanlin Huang Jun Ke Feng chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Peptidomics as a tool to analyze endogenous peptides in milk and milk-related peptides

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Food Bioscience 2022年第6期50卷 1397-1415页

作者： Jianting Ning Mohan Li Weiyan chen Huiwen Zhao jiali chen Mei Yang Xueyan Cao Xiqing Yue College of Food Science Shenyang Agricultural UniversityShenyang110866China

As a subset of the proteome, peptidomics is the best tool to analyze peptides in different food matrices. Milk peptides are produced by protease hydrolysis in the mammary gland, which plays an important role in the growth and development of infants. However, methods of probing endogenous peptides are limited because the concentration of peptides is low, the peptides are easily lost during extraction/enrichment, and database searches are complicated. Based on the peptidomics analysis process, this paper reviews the research progress and applications of endogenous peptides with a focus on extraction, fractionation, identification, and bioinformatics analysis. Additionally, in-depth analysis of endogenous peptides in milk and milk-related products using joint strategies (a combined analysis of proteome/peptidomics/metabolomic approaches) was also introduced. New methodologies are provided to study peptides through bioinformatics and tracking the release of bioactive peptides from various milk sources by in vitro digestion models, which can better track the utilization of endogenous peptides in vivo. Challenges and future perspectives are also discussed, with a goal of exploring more bioactive peptides in milk and dairy products as well as simulating human milk in formula milk powder in the future.

关键词： Peptidomics Milk Endogenous Bioactive peptides In silico screening