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Influence of oxygen content on the microstructure and mechanical properties of cold rolled Ti-32.5Nb-6.8Zr-2.7Sn-x O alloys after aging treatment

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Journal of Materials Science & Technology 2018年第11期34卷 2100-2106页

作者： Chunbo Lan Feng chen huijuan chen Yulong Wu Xiangwei Wu Jiangsu Key Laboratory of Advanced Metallic Materials Southeast University

The influence of oxygen（O） content on the microstructure and mechanical properties of cold rolled Ti-32.5 Nb-6.8 Zr-2.7 Sn-xO（TNZS-xO; x = 0,0.***.0.6; mass%） alloys after aging at temperature range from 350 to 600℃ for 24 h was investigated. Results showed that the cold rolled TNZS-xO alloys possess single βphase. During the aging process, O could not only effectively suppress the precipitation of ω phase but also retard the formation and decomposition of a phase. In addition, the corresponding temperatures of the maximal volume fraction of α phase precipitation and the（α＋β）/β transus temperatures of the TNZS-xO alloys were all increased with the increasing of O content. For mechanical properties, it was found that the strength and Young＇s modulus of the TNZS-xO alloys increased owing to the ω phase and/or a phase precipitation and decreased owing to the a phase decomposition. However, the elongation showed the opposite change tendency with the above mentioned strength. The mechanical properties of TNZS-xO alloys can be controlled over a wide range by subjecting to aging treatment and/or changing their 0 content. When aged at or below 450 ℃,the TNZS-xO alloys exhibit great potential to become a series of new candidates for biomedical applications since they possess high strength（870-1460 MPa）, low Young＇s modulus（45.1-75.6 GPa）, high strength-to-modulus ratio（0.018-0.02） and appropriate elongation（7.2%-14.9%）, which are superior to those of Ti-6 Al-4 V alloy and suitable for the use as bio-implant materials.

关键词： Ti-32,5Nb-6.8Zr-2.7Sn-xO alloys Aging treatment Microstructure Mechanical properties

Microstructure,texture evolution and mechanical properties of cold rolled Ti-32.5Nb-6.8Zr-2.7Sn biomedical beta titanium alloy

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Journal of Materials Science & Technology 2018年第5期34卷 788-792页

作者： Chunbo Lan Yu Wu Lili Guo huijuan chen Feng chen jiangsu key laboratory of advanced metallic materials southeast university Nanjing 211189 China

Ti-32.5 Nb-6.8 Zr-2.7 Sn（TNZS,wt%） alloy was produced by using vacuum arc melting method,followed by solution treatment and cold rolling with the area reductions of 50% and 90%.The effects of cold rolling on the microstructure,texture evolution and mechanical properties of the experimental alloy were investigated by optical microscopy,X-ray diffraction,transmission electron microscopy and universal material testing *** results showed that the grains of the alloy were elongated along rolling direction and stress-induced α＇＇ martensite was not detected in the deformed *** plastic deformation mechanisms of the alloy were related to {112} 111 type deformation twinning and dislocation ***,the transition from γ-fiber texture to α-fiber texture took place during cold rolling and a dominant {001} 110α-fiber texture was obtained after 90% cold *** the increase of cold deformation degree,the strength increased owing to the increase of microstrain,dislocation density and grain refinement,and the elastic modulus decreased owing to the increase of dislocation density as well as an enhanced intensity of {001} 110α-fiber texture and a weakened intensity of {111} 112γ-fiber *** 90% cold rolled alloy exhibited a great potential to become a new candidate for biomedical applications,since it possesses low elastic modulus（47.1 GPa）,moderate strength（883 MPa） and high elastic admissible strain（1.87%）,which are superior than those of Ti-6 Al-4 V alloy.

关键词： Cold rolling Ti-32.5Nb-6.8Zr-2.7Sn alloy Microstructure Texture evolution Mechanical properties Biomedical alloy

Comparative study of two lattice Boltzmann multiphase models for simulating wetting phenomena: implementing static contact angles based on the geometric formulation

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Applied Mathematics and Mechanics(English Edition) 2018年第4期39卷 513-528页

作者： Feng YE Qinfeng DI Wenchang WANG Feng chen huijuan chen Shuai HUA Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University

Wetting phenomena are widespread in nature and industrial applications. In general, systems concerning wetting phenomena are typical multicomponent/multiphase complex fluid systems. Simulating the behavior of such systems is important to both scientific research and practical applications. It is challenging due to the complexity of the phenomena and difficulties in choosing an appropriate numerical method. To provide some detailed guidelines for selecting a suitable multiphase lattice Boltzmann model, two kinds of lattice Boltzmann multiphase models, the modified S-C model and the H-C-Z model, are used in this paper to investigate the static contact angle on solid surfaces with different wettability combined with the geometric formulation(Ding, H. and Spelt, P.D. M. Wetting condition in diffuse interface simulations of contact line motion. Physical Review E, 75(4), 046708(2007)). The specific characteristics and computational performance of these two lattice Boltzmann method(LBM) multiphase models are analyzed including relationship between surface tension and the control parameters, the achievable range of the static contact angle, the maximum magnitude of the spurious currents(MMSC), and most importantly, the convergence rate of the two models on simulating the static contact angle. The results show that a wide range of static contact angles from wetting to non-wetting can be realized for both models. MMSC mainly depends on the surface tension. With the numerical parameters used in this work, the maximum magnitudes of the spurious currents of the two models are on the same order of magnitude. MMSC of the S-C model is universally larger than that of the H-C-Z model. The convergence rate of the S-C model is much faster than that of the H-C-Z model. The major foci in this work are the frequently-omitted important details in simulating wetting phenomena. Thus, the major findings in this work can provide suggestions for simulating wetting phenomena with LBM multiphase

关键词： lattice Boltzmann method(LBM) wetting phenomenon static contact angle

Visible and near-infrared light activated azo dyes

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Chinese Chemical Letters 2021年第8期32卷 2359-2368页

作者： huijuan chen Weijie chen Yan Lin Yuan Xie Sheng Hua Liu Jun Yin Key Laboratory of Pesticide and Chemical Biology Ministry of EducationHubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei UniversityWuhan 430062China Guangdong Provincial Key Laboratory of Radioactive and Rare Resource Utilization Shaoguan 512026China Department of Pharmacy Jiangxi University of Traditional Chinese MedicineNanchang 330013China

The photoisomerization properties of azo derivatives have been widely used in the fields of materials and *** serious restriction to the development of functional azo-based materials is the necessity to trigger switching by UV light,which damage the corresponding surfaces and penetrate only partially through the ***,developing the visible and near-infrared light activated azo switches can solve this *** review provides a summary of molecular design strategies for driving the isomerization of azo derivatives with visible light and near-infrared light:(1) smart design directly excited by visible light,(2) the addition of upconversion nanoparticles,(3) the employment of twophoton absorption,(4) indirect excitation in combination with metal sensitizer.

关键词： Photochromism Azo dyes Visible light activation Near-infrared light activation

Status and Progress on an HTS Strand with Quasi-isotropic Critical Current

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CSEE Journal of Power and Energy Systems 2021年第1期7卷 150-155页

作者： Jian Du Jianlong Sun Yang Nie Siming Mo Yuan Cai huijuan chen Wen Yuan Yinshun Wang the State Grid Jiangsu Electric Power Co. Ltd.Economic Research InstituteNanjing 210008China the Key Laboratory of HV and EMC Beijing North China Electric Power UniversityNorth China Electric Power UniversityBeijing 102206China the Jiangsu Etern Company Limited Suzhou 215211China the Eastern Superconducting Science&Technology(Suzhou)Co.Ltd Suzhou 215200China

The coated conductors(CCs),also known as the second-generation high-temperature superconducting(2G HTS)tape,has attractive potential applications in transmissions at low magnetic field/liquid nitrogen temperatures and high-field applications at low temperatures due to their excellent critical current density and mechanical *** critical current density has strong anisotropy,particularly at 77 *** the single tape has limited capacity of carrying current,the cable or strand making of multi-tapes,stacked in parallel,is *** recent years,several cables,such as the Roebel cable,CORC cable,TSTC cable,TS cable,and the HTSCroCo cable,were *** paper presents a status and progress on a type of HTS strand made from REBCO *** quasi-isotropic critical current is experimentally confirmed for liquid nitrogen temperature,mechanical characteristics,AC losses,thermal stability,and quench characterizations are also ***,the feasible process for the production of practical length of such strand is described by processing 10 m long sample,which is promising for applications of high fields or power transmission.

关键词： AC loss critical current mechanical characteristics quasi-isotropic strand stability

Comparison of short period InAs/GaSb superlattices on GaSb and GaAs substrates

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Science China(Technological Sciences) 2009年第1期52卷 23-27页

作者： GUO Jie chen huijuan SUN WeiGuo HAO RuiTing XU YingQiang NIU ZhiChuan Material School NorthWest Polytechnical UniversityXi’an 610000China Luoyang Optical Electronics Center Luoyang 471009China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China

Type II superlattices (SLs) short period InAs(4ML)/GaSb(8ML) were grown by molecular-beam epitaxy on lattice-mismatched GaAs substrates and on GaSb substrates. A smooth GaSb epilayer was formed on GaAs substrates by inserting mulit-buffer layers including an interfacial misfit mode AlSb quantum dot layer and AlSb/GaSb superlattices smooth layer. SLs grown on GaAs substrates (GaAs-based SLs) showed well-resolved satellite peaks in XRD. GaSb-based SLs with better structural quality and smoother surface showed strong photoluminescence at 2.55 μm with a full width at half maximum (FWHM) of 20 meV, narrower than 31 meV of GaAs-based SLs. Inferior optical absorption of GaAs-based SL was observed in the range of 2―3 μm. Photoresponse of GaSb-based SLs showed the cut-off wavelength at 2.6 μm.

关键词： InAs/GaSb superlattice substrates infrared detector

The osteogenic niche-targeted arsenic nanoparticles prevent colonization of disseminated breast tumor cells in the bone

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Acta Pharmaceutica Sinica B 2022年第1期12卷 364-377页

作者： Cong Liu Anzhi Hu huijuan chen Jing Liang Mancang Gu Yang Xiong Chao-Feng Mu School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Center for Synthetic Biochemistry Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou Institute of Biomaterials and EngineeringWenzhou 325011China

Up to 70% of patients with late-stage breast cancer have bone metastasis. Current treatment regimens for breast cancer bone metastasis are palliative with no therapeutic cure. Disseminated tumor cells(DTCs) colonize inside the osteogenic niches in the early stage of bone metastasis. Drug delivery into osteogenic niches to inhibit DTC colonization can prevent bone metastasis from entering its late stage and therefore cure bone metastasis. Here, we constructed a 50% DSS6 peptide conjugated nanoparticle to target the osteogenic niche. The osteogenic niche was always located at the endosteum with immature hydroxyapatite. Arsenic-manganese nanocrystals(around 14 nm) were loaded in osteogenic niche-targeted PEG-PLGA nanoparticles with an acidic environment-triggered arsenic release. Arsenic formulations greatly reduced 4 T1 cell adhesion to mesenchymal stem cells(MSCs)/preosteoblasts(pre-OBs) and osteogenic differentiation of osteoblastic cells. Arsenic formulations also prevented tumor cell colonization and dormancy via altering the direct interaction between 4 T1 cells and MSCs/*** chemotactic migration of 4 T1 cells toward osteogenic cells was blocked by arsenic in mimic 3 D osteogenic niche. Systemic administration of osteogenic niche-targeted arsenic nanoparticles significantly extended the survival of mice with 4 T1 syngeneic bone metastasis. Our findings provide an effective approach for osteogenic niche-specific drug delivery and suggest that bone metastasis can be effectively inhibited by blockage of tumor cell colonization in the bone microenvironment.

关键词： Bone metastasis Osteogenic niche Breast cancer Arsenic trioxide Bone marrow Bone colonization Arsenic-manganese nanocrystal Immature hydroxyapatite

Comparison of lateral episiotomy,traditional midwifery without episiotomy,and hands-off techniques delivery on pelvic floor function

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Gynecology and Obstetrics Clinical Medicine 2021年第1期1卷 40-43页

作者： Jingjing Gong Lili Xing Xiaodan Li Xiaona Wang huijuan chen Department of Obstetrics and Gynecology Peking University People’s HospitalPR China

Background Prolonged vaginal delivery times and episiotomy are associated with damage to the muscles of the pelvic floor,and with complications that include postpartum sexual dysfunction and urinary stress *** study was to compare the pelvic floor function among postpartum women who underwent three midwifery practices during labor:lateral episiotomy,traditional midwifery without episiotomy,and hands-off techniques *** We included 320 primipara who were full-term pregnancy and underwent vaginal delivery in Department of Obstetrics,Peking University People’s Hospital,China.117 women had episiotomy during labor and were classified into the lateral episiotomy group;103 had traditional midwifery without episiotomy and were classified into the traditional midwifery practice group;and 100 experienced hands-off techniques during labor and were classified into the hands-off techniques delivery *** duration of the second stage of labor,and postpartum pelvic floor muscle strength were compared between the three study *** There were no significant differences between the three groups for the duration of the second stage of labor and postpartum pelvic floor muscle strength(P>0.05).However,the incidence of postpartum urinary stress incontinence and sexual dysfunction in the hands-off techniques delivery group was significantly lower than in the lateral episiotomy groups and the traditional midwifery practice group(P<0.01).Conclusions Hands-off techniques delivery could reduce damage to the pelvic floor and improve the quality of life for women after delivery.

关键词： floor function damage

Early application of nerve growth factor affects serum inflammatory cytokine levels in neonatal hypoxic ischemic encephalopathy

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Neural Regeneration Research 2007年第7期2卷 437-439页

作者： Jingguo chen huijuan Huang Kaijun Zheng Ronghua Xia Jian chen Xiufang Yang Chunhua Ye Qiang Lin Department of Neonatology Sun Yat-sen Hospital of Sun Yat-sen University Zhongshan 528403 Guangdong Province China

BACKGROUND： It has been demonstrated that there are changes of various cytokines, chemokines and adhesion factors in neonatal hypoxic ischemic encephalopathy （HIE）. What are the changes of interleukin-6 and interleukin-18 in serum of HIE neonates.OBJECTIVE： To observe the dynamic changes of interleukin-6 and interleukin-18 in peripheral serum at different time after HIE in neonates, and analyze the possible therapeutic efficacy of early application of NGF.DESIGN： A non-randomized controlled observation synchronically.SETTING： Department of Neonatology, Sun Yat-sen Hospital affiliated to Sun Yat-sen University.PARTICIPANTS： Sixty neonates with HIE were selected from the Department of Neonatology, Sun Yat-sen Hospital affiliated to Sun Yat-sen University from January 2004 to October 2006, including 32 boys and 28 girls, who were all accorded with the diagnostic standards for moderate to severe HIE. The neonates were divided into two groups NGF-treated group （n =30）, HIE group （n =30）. The HIE neonates in the NGF-treated group were given routine treatment and intramuscular injection of NGF within 24 hours after birth. Those in the HIE group were given routine treatments. Meanwhile, 30 apneic normal neonates （17 boys and 13 girls） at the same period were selected as the control group. The gestational age was 37 - 42 weeks in all the three groups, the body mass at birth was 2 500 - 4 000 g. Informed contents were obtained from the relatives of all the enrolled neonates.METHODS： The HIE neonates in the NGF-treated group were given routine treatment and intramuscular injection of NGF （2 000 U） within 24 hours after birth, once a day, 10 days as a course. Those in the HIE group were given routine treatments. Blood samples （3 mL） were drawn from femoral vein in all the neonates 1, 3 and 7 days after birth. The levels of interleukin-6 and interleukin-18 in serum were detected with enzyme-linked immunoabsorbent assay （ELISA）.MAIN OUTCOME MEASURES： Serum levels of i

关键词： cerebral hypoxia ischemia brain nerve growth factor interleukin-6 interleukin-18