检索结果-南通市图书馆

Electroacupuncture activates AMPKα1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer’s disease by regulating hippocampal mitochondrial dynamics

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第5期22卷 588-599页

作者： wei-wei Jia hua-wei lin Min-guang Yang Ya-ling Dai Yan-yi Ding Wen-shan xu Si-nuo wang Ya-jun Cao Sheng-xiang Liang zhi-fu wang Cong chen wei-lin liu College of Rehabilitation Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina The Institute of Rehabilitation Industry Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina

Objective Studies have shown that electroacupuncture(EA)can alleviate cognitive impairments from Alzheimer’s disease(AD)by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK),but the specific mechanism involved remains to be ***,this study explores the potential mechanism by which EA improves cognitive function from the perspective of mitochondrial *** The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKα1-subunit conditional knockout(AMPKα1-cKO)were used for *** evaluate the effects of EA treatment on cognitive function,the T-maze and Morris water maze were *** addition,chemical exchange saturation transfer,thioflavin staining,transmission electron microscopy,mitochondrial membrane potential,and Western blotting were used to examine the potential mechanisms underlying the effects of EA on APP/PS1 *** Both APP/PS1 mice and AMPKα1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory *** of the AMPK/peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α)pathway increased pathological amyloid-β(Aβ)deposition and aggravated the dysfunction in mitochondrial *** addition,EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1αpathway,specifically by reducing pathological Aβdeposition,normalizing energy metabolism,protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins,and downregulating the expression of fission ***,the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by AMPKα1 *** The regulation of hippocampal mitochondrial dynamics and reduction in Aβdeposition via the AMPK/PGC-1αpathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.

关键词： Adenosine monophosphate-activated protein kinase Alzheimer’s disease Cognitive impairment Electroacupuncture Hippocampus Mitochondrial dynamics

Ideal Cardiovascular Health is Inversely Associated with Subclinical Atherosclerosis: A Prospective Analysis

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2019年第4期32卷 260-271页

作者： wang Long niu Jing Ya ZHAO zhi Yun LI Mian xu Min LU Jie Li wang Tian Ge chen Yu Hong wang Shuang Yuan DAI Meng LI lin liu shan shan wang wei Qing xu Yu BI Yu Fang National Clinical Research Center for Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseasesand Department of Endocrine and Metabolic DiseasesRui-Jin HospitalShanghai Jiao Tong University School of Medicine

Objective Ideal cardiovascular health(CVH) could predict a lower risk of developing cardiovascular diseases. This study was conducted to investigate the association between ideal CVH and subclinical atherosclerosis in a population cohort of Chinese adults aged ≥ 40 years. Methods This study was designed as a cross-sectional analysis of 8,395 participants who had complete data at baseline and a prospective analysis of 4,879 participants who had complete data at 4.3 years of follow-up. Ideal CVH metrics were defined according to the American Heart Association. Subclinical atherosclerosis was evaluated by plaques in carotid arteries, carotid intima-media thickness(CIMT), brachial-ankle pulse wave velocity(baPWV), and urinary albumin-to-creatinine ratio(UACR). Results Both the prevalence and incidence of atherosclerosis measures were found to be decreased with increasing numbers of ideal CVH metrics at baseline(all P values for trend line(both P values for trend line significant association with baPWV(P for trend = 0.0505). Taking participants with 0-1 ideal metric as reference, we found that participants with 5-6 ideal metrics had significantly lower risks of developing carotid plaques(odds ratio, OR = 0.46; 95% confidence interval, CI 0.27-0.79), increased CIMT(OR = 0.60; 95% CI 0.42-0.84), and increased baPWV(OR = 0.57; 95% CI 0.34-0.97) after full adjustments. A significant interactive effect of age and CVH was detected on CIMT and baPWV progression(both P values for interaction linical atherosclerosis in middle-aged and elderly Chinese adults, whereas its dose-response effect was attenuated in individuals aged ≥ 60 years and partially weakened in male participants.

关键词： Cardiovascular health Subclinical atherosclerosis Cohort

Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2022年第1期35卷 4-12页

作者： wang Jia Lu CAO Qiu Yu XIN Zhuo jun liu shan shan xu Min wang Tian Ge LU Jie Li chen Yu Hong wang Shuang Yuan ZHAO zhi Yun xu Yu NING Guang wang wei Qing BI Yu Fang LI Mian Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective The association between neutrophil-to-lymphocyte ratio(NLR)with subclinical macrovascular and microvascular diseases has been less *** sought to examine the association between NLR and new-onset subclinical macrovascular and microvascular abnormalities in the Chinese *** From a community cohort,we included 6,430 adults aged≥40 years without subclinical macrovascular and microvascular diseases at *** measured subclinical macrovascular and microvascular abnormalities separately using the ankle-brachial index(ABI),brachial-ankle pulse wave velocity(baPWV),and *** During a mean follow-up of 4.3 years,110 participants developed incident abnormal ABI,746 participants developed incident elevated baPWV,and 503 participants developed incident *** regression analysis indicated that NLR was significantly associated with an increased risk of newonset abnormal ABI,elevated baPWV,and *** to overweight/obese participants,we found a much stronger association between NLR and subclinical vascular abnormalities in participants with normal ***,we found an interaction between the NLR and body mass index(BMI)on the risk of new-onset abnormal ABI(P for interaction:0.01).Conclusion NLR was associated with subclinical macrovascular and microvascular diseases in the Chinese ***,in participants with normal weight,the association between NLR and subclinical vascular abnormalities was much stronger.

关键词： Neutrophil-to-lymphocyte ratio Subclinical macrovascular and microvascular diseases Body mass index Prospective cohort study

Detecting and Monitoring Tidal Dissipation of Hot Jupiters in the Era of SiTian

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2022年第5期22卷 36-46页

作者： Fan Yang wei wang Xing wei Hui Zhang Ji-lin Zhou Su-Su shan Jie Zheng wei-Kai Zong Ming Yang Yu Bai Song wang Jia-chen Zheng Yu-Ru xu Yu-Feng Li You-jun Lu Ji-Feng liu Department of Astronomy Beijing Normal UniversityBeijing 100875China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China

Transit Timing Variation(TTV)of hot Jupiters provides direct observational evidence of planet tidal *** tidal dissipation through TTV needs high precision transit timings and long timing *** this work,we predict and discuss the potential scientific contribution of the SiTian Survey in detecting and analyzing exoplanet *** develop a tidal dissipation detection pipeline for the SiTian Survey that aims at time-domain astronomy with 721 m optical *** pipeline includes the modules of light curve deblending,transit timing acquisition and TTV *** is capable of detecting more than 25,000 exoplanets among which we expect~50 sources to show evidence of tidal *** present detection and analysis of tidal dissipating targets,based on simulated SiTian light curves of XO-3b and WASP-161 *** transit light curve modeling gives consistent results within 1σto input values of simulated light ***,the parameter uncertainties predicted by Markov Chain Monte Carlo are consistent with the distribution obtained from simulating and modeling the light curve 1000 *** timing precision of SiTian observations is~0.5 minutes with one transit *** show that differences between TTV origins,e.g.,tidal dissipation,apsidal precession and multiple planets,would be significant,considering the timing precision and *** detection rate of tidal dissipating hot Jupiters would answer a crucial question of whether the planet migrates at an early formation stage or random stages due to perturbations,e.g.,planet scattering or secular *** identified targets would be constructive given that the sample would extend tenfold.

关键词： planets and satellites gaseous planets-planets and satellites physical evolution-planets and satellites dynamical evolutionand stability-planetsandsatellites detection

Towards the full realization of the RIBLL2 beam line at the HIRFL-CSR complex

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2018年第2期63卷 78-80页

作者： Bao-hua Sun Jian-wei Zhao xue-Heng Zhang Li-Na Sheng zhi-Yu Sun Isao Tanihata Satoru Terashima yong Zheng Li-hua Zhu Li-Min Duan liu-Chun He Rong-Jiang Hu Guang-Shuai Li Wen-Jian lin wei-Ping lin Chuan-Ye liu Zhong liu chen-Gui Lu Xin-Wen Ma Li-jun Mao Yi Tian Feng wang Meng wang Shi-Tao wang Jia-Wen Xia Xiao-Dong xu Hu-shan xu zhi-Guo xu Jian-cheng Yang Da-Yu Yin You-Jin Yuan Wen-Long Zhan Yu-Hu Zhang Xiao-Hong Zhou School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China International Research Center for Nuclei and Particles in the Cosmos Beijing 100191 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

More than 99%of the mass in the visible universe—the material that makes up ourselves,our planet,stars—is in the atomic *** the matter has existed for billions of years,only over the past few decades have we had the tools and the knowledge necessary to get a basic understanding of the structure and dynamic of *** physicists around the world have made tremendous strides by initiating a broad range of key

关键词： HIRFL-CSR 横梁建筑群排队原子核物理学家试验性世界

Specific pupylation as IDEntity reporter(SPIDER)for the identification of protein-biomolecule interactions

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2023年第8期66卷 1869-1887页

作者： He-wei Jiang Hong chen Yun-Xiao Zheng xue-Ning wang Qingfeng Meng Jin Xie Jiong Zhang ChangSheng Zhang Zhao-wei xu Zi-Qing chen Lei wang wei-Sha Kong Kuan Zhou Ming-Liang Ma Hai-Nan Zhang Shu-Juan Guo jun-Biao xue Jing-Li Hou Zhe-Yi liu Wen-xue niu Fang-jun wang Tao wang wei Li Rui-Na wang yong-jun Dang Daniel MCzajkowsky JianFeng Pei Jia-Jia Dong Sheng-Ce Tao shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province School of PharmacyAnhui Medical UniversityHefei 230032China Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of the Chinese Academy of SciencesChinese Academy of SciencesShanghai 200240China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Key Laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationFuzhou 350122China Department of Molecular Biology Princeton UniversityNew Jersey 08540USA Instrumental Analysis Center Shanghai Jiao Tong UniversityShanghai 200240China CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Systems Biology Shenzhen Bay LaboratoryPeking University Shenzhen Graduate SchoolShenzhen 518055China Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Key Laboratory of Metabolism and Molecular Medicine the Ministry of EducationDepartment of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200240China Center for Novel Target and Therapeutic Intervention Chongqing Medical UniversityChongqing 400016China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Protein-biomolecule interactions play pivotal roles in almost all biological *** a biomolecule of interest,the identification of the interacting protein(s)is *** this need,although many assays are available,highly robust and reliable methods are always *** combining a substrate-based proximity labeling activity from the pupylation pathway of Mycobacterium tuberculosis and the streptavidin(SA)-biotin system,we developed the Specific Pupylation as IDEntity Reporter(SPIDER)method for identifying protein-biomolecule *** SPIDER,we validated the interactions between the known binding proteins of protein,DNA,RNA,and small *** successfully applied SPIDER to construct the global protein interactome for m^(6)A and m RNA,identified a variety of uncharacterized m^(6)A binding proteins,and validated SRSF7 as a potential m^(6)A *** globally identified the binding proteins for lenalidomide and Cob ***,we identified SARS-CoV-2-specific receptors on the cell ***,SPIDER is powerful and highly accessible for the study of proteinbiomolecule interactions.

关键词： proximity labeling protein-biomolecule interaction proteomics pupylation

SAPT:a synchrotron-based proton therapy facility in shanghai

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou Zhang De-Ming Li Li-Ren Shen Hai-Rong Zhang zhi-ling chen Han-Wen Du Ming Gu Rui Li De-Kang liu Yue-Hu Pu jun-Feng Yu Jian-Feng chen Chu chen Chun-Long Guo Hao Guo Ge-Yang Jiang zhi-Qiang Jiang lin Jin Wen-Jing Li Xiu-Fang Li Ye lin Ming liu yong-Hao liu Ya-Juan liu Ming Lv Qing-Ru Mi Lian-hua Ouyang wei-Guo Shi Hang Shu Qi-Sheng Tang Kun wang zhi-shan wang jun Wu Xiao-Bing Wu Jia-Qiang xu Wen-Zhen xu Chong-Xian Yin cheng Yu Ren-Xian Yuan Qi-Bing Yuan Hai-Qun Zhang Miao Zhang Wen-zhi Zhang Li-Ying Zhao wei-Min Zhou Shou-Xian Fang Xi-Dong Sun Zhen-Tang Zhao shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu Shu-wei Duan Hong-tao Yang Yue-yi deng wei Li Ya-ni He Zhao-hui Ni yong-li Zhan shan lin zhi-yong Guo jun Zhu Jing-ai Fang xu-sheng liu Li-hua wang Rong wang Nian-song wang Xiao-hong cheng Li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru Jiang Hong-yu chen Wen-hu liu Hong-li lin Meng Liang Lu Ma Ming chen Li-qun Song Jian chen Qing Zhu Chang-ying Xing Yun Li Ji-ning Gao Rong-shan Li Ying Li Hao Zhang Ying Lu Qiao-ling Zhou jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(Pline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

Chromosome-scale assembly of the Dendrobium chrysotoxum genome enhances the understanding of orchid evolution

在线全文

学校读者我要写书评

暂无评论

Horticulture Research 2021年第1期8卷 2684-2697页

作者： yongxia Zhang Guo-Qiang Zhang Diyang Zhang xue-Die liu Xin-Yu xu wei-Hong Sun Xia Yu Xiaoen Zhu zhi-Wen wang Xiang Zhao Wen-Ying Zhong Hongfeng chen wei-Lun Yin Tengbo huang shan-Ce niu Zhong-Jian liu Guangdong Provincial Key Laboratory for Plant Epigenetics College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518071China Laboratory for Orchid Conservation and Utilization Orchid Conservation and Research CenterThe National Orchid Conservation CenterShenzhen 518114China School of Food Science and Technology Foshan UniversityFoshan 528225China Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization at College of Landscape Architecture Fujian Agriculture and Forestry UniversityFuzhou 350002China College of Forestry Fujian Agriculture and Forestry UniversityFuzhou 350002China PubBio-Tech Wuhan 430070China Key Laboratory of Plant Resources Conservation Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China College of Biological Sciences and Technology Beijing Forestry UniversityBeijing 100083China College of Horticulture Hebei Agricultural UniversityBaoding 071000China

As one of the largest families of angiosperms,the Orchidaceae family is *** represents the second largest genus of the ***,an assembled high-quality genome of species in this genus is ***,we report a chromosome-scale reference genome of Dendrobium chrysotoxum,an important ornamental and medicinal orchid *** assembled genome size of *** was 1.37 Gb,with a contig N50 value of 1.54 *** the sequences,95.75%were anchored to 19 *** were 30,044 genes predicted in the *** *** whole-genome polyploidization events occurred in *** terms of the second event,whole-genome duplication(WGD)was also found to have occurred in other Orchidaceae members,which diverged mainly via gene loss immediately after the WGD event occurred;the first duplication was found to have occurred in most monocots(tau event).We identified sugar transporter(SWEET)gene family expansion,which might be related to the abundant medicinal compounds and fleshy stems of ***-box genes were identified in ***,as well as members of TPS and Hsp90 gene families,which are associated with resistance,which may contribute to the adaptive evolution of *** also investigated the interplay among carotenoid,ABA,and ethylene biosynthesis in *** to elucidate the regulatory mechanisms of the short flowering period of orchids with yellow *** reference *** genome will provide important insights for further research on medicinal active ingredients and breeding and enhances the understanding of orchid evolution.

关键词： evolution flowers breeding