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Chinese Journal of Electronics 2020年第2期29卷 233-241页

作者： PANG Shanchen YAO Jiamin LIU Ting ZHAO Hua chen hongqi College of Computer and Communication Engineering China University of Petroleum Weihai Science and Technology Bureau College of Computer Science and Engineering Shandong University of Science and Technology College of Intelligence and Computing Tianjin University

Text similarity measurements are the basis for measuring the degree of matching between two or more texts. Traditional large-scale similarity detection methods based on a digital fingerprint have the advantage of high detection speed, which are only suitable for accurate detection. We propose a method of Chinese text similarity measurement based on feature phrase *** language processing(NLP) technology is used to pre-process text and extract the keywords by the Term frequency-Inverse document frequency(TF-IDF) model and further screen out the feature words. We get the exact meaning of a word and semantic similarities between words and a How Net semantic dictionary. We substitute concepts to get the feature phrases and generate a semantic fingerprint and calculate similarity. The experimental results indicate that the method proposed is superior in similarity detection in terms of its accuracy rate,recall rate, and F-value to the traditional and digital fingerprinting method.

关键词： Term frequency-Inverse document frequency(TF-IDF) model Semantic fingerprint Similarity Characteristic phrases

CXCR6-based immunotherapy in autoimmune,cancer and inflammatory infliction

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3255-3262页

作者： Tingting Li Jie Pan hongqi chen Yongliang Fang Yang Sun Department of Gastroenterology the Second Medical CenterNational Clinical Research Center for Geriatric DiseasesState Key Laboratory of Kidney DiseasesChinese PLA General HospitalBeijing 100853China State Key Laboratory of Pharmaceutical Biotechnology Department of Biotechnology and Pharmaceutical SciencesSchool of Life SciencesNanjing UniversityNanjing 210023China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Department of Urology Boston Children’s HospitalDepartments of Microbiology and SurgeryHarvard Medical SchoolBostonMA 02115USA Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China

T cells, including both CD4^(+) and CD8^(+)T cells, play a pivotal role in mediating various inflammation and immune disorders. A long-standing challenge in T cell-based immunotherapy is to precisely inactivate or delete the pathogenic T cells in inflammation and autoimmune diseases, or to selectively expand the immunocompetent T cell in tumor or other immune compromised situations, without inducing global immunosuppression or zealous immune activation respectively. To achieve this, a specific marker is needed to differentiate the pathogenic or immunocompetent T cell among the rests. Indeed,recent progress of immunology strongly suggests that CXC chemokine receptor 6(CXCR6, CD186) is such a kind of marker. Here, we review the emerging role of CXCR6 as a novel target for immunotherapy and discuss the underlying mechanism. We propose that CXCR6-based immunotherapy will play a significant role in autoimmune, nonalcoholic steatohepatitis(NASH), tumor, coronavirus disease 2019(COVID-19) and even ageing-related inflammatory infliction.

关键词： CXCR6 CXCL16 Inflammation Autoimmune diseases Tumor Immunotherapy Nonalcoholic steatohepatitis COVID-19

Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

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Nano-Micro Letters 2024年第9期16卷 478-499页

作者： Yao Xiao Zaijin Tao Yufeng Ju Xiaolu Huang Xinshu Zhang Xiaonan Liu Pavel A.Volotovski Chao Huang hongqi chen Yaozhong Zhang Shen Liu Department of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Trauma Department Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus Shanghai Haohai Biological Technology Limited Liability Company 1386 Hongqiao RdShanghai 200336People’s Republic of China Department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traumatic peritendinous adhesion presents a significant challenge in clinical *** study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured *** results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are ***,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely *** biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA *** studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis *** was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

关键词： Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion

Mechanism of the December 2015 Catastrophic Landslide at the Shenzhen Landfill and Controlling Geotechnical Risks of Urbanization

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Engineering 2016年第2期2卷 230-249页

作者： Yueping Yin Bin Li Wenpei Wang Liangtong Zhan Qiang Xue Yang Gao Nan Zhang hongqi chen Tiankui Liu Aiguo Li China Institute of Geo-Environment Monitoring China Geological Survey Beijing 100081 China Institute of Geo-Mechanics Chinese Academy of Geological Sciences China Geological Survey Beijing 100081 China MOE Key Laboratory of Soft Soils and Geoenvironmen~-al Engineering Zhejiang University Hangzhou 310058 China Institute o fRock and Soil Mechanics Chinese Academy of Sciences Wuhan 430071 China Urban Planning Land & Resources Commission of Shenzhen Municipality Shenzhen Guangdong 518034 China Shenzhen Geotechnical Investigation & Surveying Institute Co. Ltd. Shenzhen Cuangdong 518026 China

This paper presents findings from an investigation of the large-scale construction solid waste （CSW） landslide that occurred at a landfill at Shenzhen, Guangdong, China, on December 20, 2015, and which killed 77 people and destroyed 33 houses. The landslide involved 2.73 - 106 m3 of CSW and affected an area about 1100 m in length and 630 m in maximum width, making it the largest landfill landslide in the world. The investigation of this disaster used a combination of unmanned aerial vehicle surveillance and multistage remote-sensing images to reveal the increasing volume of waste in the landfill and the shifting shape of the landfill slope for nearly two years before the landslide took place, beginning with the creation of the CSW landfill in March, 2014, that resulted in the uncertain conditions of the landfill＇s boundaries and the unstable state of the hydrologic performance. As a result, applying conventional stability analysis methods used for natural landslides to this case would be difficult. In order to analyze this disaster, we took a multistage modeling technique to analyze the varied characteristics of the land- fill slope＇s structure at various stages of CSW dumping and used the non-steady flow theory to explain the groundwater seepage problem. The investigation showed that the landfill could be divided into two units based on the moisture in the land：（1） a front uint, consisted of the landfill slope, which had low water content; and （2） a rear unit, consisted of fresh waste, which had a high water content. This struc- ture caused two effects-surface-water infiltration and consolidation seepage that triggered the landslide in the landfill. Surface-water infiltration induced a gradual increase in pore water pressure head, or piezometric head, in the front slope because the infiltrating position rose as the volume of waste placement increased. Consolidation seepage led to higher excess pore water pressures as the loading of waste increased. We also investi

关键词： Construction solid waste (CSW)Landfill landslideFactor of safety (FOS)Geotechnical risk

Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics

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Acta Pharmaceutica Sinica B 2022年第1期12卷 149-166页

作者： Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo cheng Xianjia Qi Yuxian Shen Qiang Xu hongqi chen Dijun chen Yang Sun State Key Laboratory of Pharmaceutical Biotechnology Chemistry and Biomedicine Innovation Center(Chem BIC)School of Life SciencesNanjing UniversityNanjin 210023China Biopharmaceutical Research Institute School of Basic Medical SciencesAnhui Medical UniversityHefei 230032China Department of Colorectal Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyang 110042China The First Clinical College of Nanjing University of Chinese Medicine Nanjing 210023China Shanghai Xu Ran Biotechnology Co. Ltd.Shanghai 201109China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Colorectal cancer(CRC), a malignant tumor worldwide consists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. Collectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for colon cancer immunotherapy.

关键词： Tumor microenvironment PTPN11 SHP099 STING Type I interferon Colorectal cancer scRNA-seq Macrophage

Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

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Journal of Pharmaceutical Analysis 2023年第7期13卷 726-744页

作者： Xiaofan Sun Lisha Zhou Yi Wang Guoliang Deng Xinran Cao Bowen Ke Xiaoqi Wu Yanhong Gu Haibo cheng Qiang Xu Qianming Du hongqi chen Yang Sun Department of Rheumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing210008China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Colon and Rectal Surgery Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing210001China Laboratory of Anesthesia and Critical Care Medicine Department of AnesthesiologyTranslational Neuroscience CenterWest China Hospital and State Key Laboratory of BiotherapySichuan UniversityChengdu610044China Genergy Bio-technology(Shanghai)Co. LtdShanghai200241China The First Affiliated Hospital of Nanjing Medical University Jiangsu Province HospitalNanjing210029China Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor The First Clinical College of Nanjing University of Chinese MedicineNanjing210023China General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjing210006China School of Basic Medicine&Clinical Pharmacy China Pharmaceutical UniversityNanjing210009China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai200030China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhouJiangsu221004China

Colorectal tumors often create an immunosuppressive microenvironment that prevents them from responding to ***(CBD)is a non-psychoactive natural active ingredient from the cannabis plant that has various pharmacological effects,including neuroprotective,antiemetic,anti-inflammatory,and antineoplastic *** study aimed to elucidate the specific anticancer mechanism of CBD by single-cell RNA sequencing(scRNA-seq)and single-cell ATAC sequencing(scATAC-seq)***,we report that CBD inhibits colorectal cancer progression by modulating the suppressive tumor microenvironment(TME).Our single-cell transcriptome and ATAC sequencing results showed that CBD suppressed M2-like macrophages and promoted M1-like macrophages in tumors both in strength and ***,CBD significantly enhanced the interaction between M1-like macrophages and tumor cells and restored the intrinsic anti-tumor properties of macrophages,thereby preventing tumor ***,CBD altered the metabolic pattern of macrophages and related anti-tumor signaling *** found that CBD inhibited the alternative activation of macrophages and shifted the metabolic process from oxidative phosphorylation and fatty acid oxidation to glycolysis by inhibiting the phosphatidylinositol 3-kinase-protein kinase B signaling pathway and related downstream target ***,CBD-mediated macrophage plasticity enhanced the response to anti-programmed cell death protein-1(PD-1)immunotherapy in xenografted *** together,we provide new insights into the anti-tumor effects of CBD.

关键词： scRNA-seq scATAC-seq Cannabidiol Colorectal cancer Tumor microenvironment Macrophage

pH值对有机化合物富集与伏安溶出过程的影响

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理化检验（化学分册） 2000年第6期36卷 267-270页

作者：陈鸿琪山东临沂师范学院临沂276001

在碳糊电极上有机化合物的富集能够增加溶出伏安法的灵敏度和选择性。不同的有机化合物在碳糊电极上的富集机理不同 ,在电极上的伏安溶出条件也不同。使用碳糊电极时 ,对有机化合物的富集、溶出影响因素是多方面的 ,其中富集液和溶出液... 详细信息

在碳糊电极上有机化合物的富集能够增加溶出伏安法的灵敏度和选择性。不同的有机化合物在碳糊电极上的富集机理不同 ,在电极上的伏安溶出条件也不同。使用碳糊电极时 ,对有机化合物的富集、溶出影响因素是多方面的 ,其中富集液和溶出液的 p H值对它的影响十分重要。文中通过碳糊电极对一些简单有机化合物 ,如氯丙嗪 (冬眠灵 )、丁基羟基甲醚 ( BHA)、N,N-二甲基苯胺 ( DMA)、对苯二酚的富集与伏安溶出进程的研究 ,从理论和试验上说明这一影响规律 ,促进对使用碳糊电极测定有机物的研究 ,使方法更加成熟 ,早日用于实际测定。

关键词：碳糊电极溶出伏安法富集机理有机物测定 pH值

Common features in patients with intracerebral hemorrhage following superficial temporal artery-middle cerebral artery bypass in steno-occlusive cerebrovascular disease

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Neural Regeneration Research 2012年第20期7卷 1585-1590页

作者： Zhiqi Mao Meng Li Yan Ma Yanfei chen hongqi Zhang Feng Ling Department of Neurosurgery Xuanwu Hospital Capital Medical University Beijing 100053 China

Five patients treated for intracranial cerebral hemorrhage after superficial temporal artery-middle cerebral artery bypass in Xuwu Hospital, Capital Medical University, Beijing, China, from 2005-2011 were included in this study. Prior to superficial temporal artery-middle cerebral artery bypass, all patients showed diminished cerebrovascular reactivity and an ipsilateral ischemic lesion. Intracranial cerebral hemorrhage developed within 1-4 days following superficial temporal artery-middle cerebral artery bypass. Transcranial Doppler showed increased middle cerebral artery velocity of 50-100% in the operated hemisphere. These findings suggested that focal hyperperfusion, an ipsilateral ischemic lesion and diminished cerebrovascular reactivity are the important characteristics of intracerebral hemorrhage following superficial temporal artery-middle cerebral artery bypass in patients with steno-occlusive cerebrovascular disease.

关键词： cerebral hemorrhage STA-MCAo ,cclusion cerebrovascuiar disordersS uperfiCihy alperperfusionte mp ral artery-middlis echemic lesion cerebrovascular reactivityC erebral artery bypass stenosis

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论郭沫若革命文艺思想的现代生成和先锋性

广东社会科学 2008年第6期 149-154页

作者：陈红旗嘉应学院中文系

在《革命与文学》等一系列论文中,郭沫若用一些简单的马克思主义原理辨析了革命与文学的密切关系,该文表征了郭沫若革命文艺思想的现代生成和先锋性。是时,郭沫若建构了一种不同于以往的文艺观,推动后期创造社实现了"集体转向",并大力... 详细信息

在《革命与文学》等一系列论文中,郭沫若用一些简单的马克思主义原理辨析了革命与文学的密切关系,该文表征了郭沫若革命文艺思想的现代生成和先锋性。是时,郭沫若建构了一种不同于以往的文艺观,推动后期创造社实现了"集体转向",并大力倡导无产阶级革命文学。另外,在郭沫若的知识谱系中,"变数"是一个非常重要的社会科学关键词,它意指着他对文艺与革命等问题的辩证认知。

关键词：郭沫若《革命与文学》新兴文艺变数