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Effect of Rongchang capsule (茸菖胶囊) on seizure behavior,cognitive impairment,and hippocampal DNA damage and inflammatory factors in epileptic rats

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Journal of Traditional Chinese Medicine 2021年第3期41卷 438-446页

作者： PIAO Xiang WANG Wei chen hanjiang YAN Rong LI Mengquan Department of pediatrics Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China Institute of Paediatrics of Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200071China Department of pediatrics Graduate School of Tianjin University of Traditional Chinese MedicineTianjin 300193China

OBJECTIVE: To observe the behavioral changes and changes in DNA fragments and related inflammatory factors in the hippocampus of epileptic rats pretreated with Rongchang capsule(茸菖胶囊).METHODS: Eighty Sprague-Dawley rats were randomly divided into the normal group(NG), model group(MG), sodium valproate group(VG), and Rongchang capsule group(RG)(n = 20 in each group). Pentylentetrazol was administered to the MG, VG, and RG to induce epilepsy. The VG and RG were pretreated with 1/2 the therapeutic dose of sodium valproate and Rongchang capsule, respectively. Changes in convulsion behavior and water maze learning were observed. Single cell gel electrophoresis was used to detect changes in the DNA in the hippocampus. The tail length(TL) and Olive tail moment(OTM) of cells were analyzed by GASP software. The expression of interleukin-1β(IL-1β),high mobility group box 1(HMGB1), transforming growth factor-β(TGF-β), and CCL4 in the hippocampus was determined by Western blotting.RESULTS: Rongchang capsule had a weaker effect on convulsive latency than sodium valproate, but significantly reduced seizure susceptibility. The spatial learning ability of the RG was better than that of the VG(P ≤ 0.01). The TL and OTM were significantly higher in the MG than the NG(P < 0.01). The RG had a better TL and OTM than the VG(P < 0.01).Combined with the microscopy results, DNA damage was most pronounced in the MG. Drug intervention decreased the DNA damage in the VG and RG. The expressions of IL-1β, CCL4, and HMGB1 in the hippocampus were significantly greater in the MG than the NG(P < 0.01), and were significantly reduced in the RG and VG compared with the MG(P < 0.01);however, there was no intergroup difference in the expression of TGF-β. The average values for the expression of inflammatory factors in the hippocampus were higher in the RG than in the VG;thus, Rongchang capsule may have a weaker effect on reducing the expression of inflammatory factors in the hippocampus than sodium valproate.CONCLUSION: Pretreatment with Rongchang ca

关键词： epilepsy inflammation cognitive dysfunction hippocampus interleukin-1beta HMGB proteins transforming growth factor beta Rongchang capsule

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水泥固化锌污染黄土力学特性试验研究

西北大学学报（自然科学版） 2024年第1期54卷 33-41页

作者：陈汉江崔素丽张登飞李世雄李治嘉辜超颖西北大学地质学系/大陆动力学国家重点实验室陕西西安710069

聚焦于重金属污染黄土而劣化的实际工程问题,探究水泥固化重金属污染黄土的强度、应力-应变特性,以水泥固化锌离子污染黄土为研究对象,考虑水泥掺量和养护龄期的影响,进行无侧限抗压强度的系列试验,分析其应力-应变曲线、无侧限抗压强... 详细信息

聚焦于重金属污染黄土而劣化的实际工程问题,探究水泥固化重金属污染黄土的强度、应力-应变特性,以水泥固化锌离子污染黄土为研究对象,考虑水泥掺量和养护龄期的影响,进行无侧限抗压强度的系列试验,分析其应力-应变曲线、无侧限抗压强度、破坏应变、变形模量的变化规律,进而构建水泥固化锌离子污染黄土在无侧限条件下的应力-应变本构模型。研究表明,经水泥固化后的锌离子污染黄土应力-应变曲线为强软化型,试样呈脆性破坏,可分为弹性、弹塑性、应力下降、残余稳定4个阶段;随着养护龄期、水泥掺量的增加,无侧限抗压强度增大,破坏应变基本呈现减小趋势;变形模量与无侧限抗压强度呈现非线性关系;构建的考虑养护龄期、水泥掺量影响的应力-应变本构模型,可准确描述水泥固化锌离子污染黄土单轴压力下的变形全过程。

关键词：固化锌污染黄土重金属变形模量无侧限抗压强度应力-应变曲线

Harnessing Theaflavin-3，3'-Digallate for Virulence Attenuation: A Targeted Approach Against Foodborne Staphylococcus aureus Pathogenicity

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Food Science and Human Wellness 2024年

作者： Yujia chen hanjiang Du Lei Wang Yueying Wang Zhangyu Du Dongbin Guo Li Wang Bingmei Wang Wei Li Department of Gastrocolorectal Surgery General Surgery Center The First Hospital of Jilin University Faculty of Medicine International University of Health and Welfare Department of Gastric and Colorectal Surgery Jilin Cancer Hospital College of Integrated Traditional Chinese and Western Medicine Changchun University of Chinese Medicine Clinical Medical College Changchun University of Chinese Medicine

Addressing the uncontrolled spread and increase in antibiotic resistance in methicillin-resistant Staphylococcus aureus （MRSA） will require new control strategies， particularly to improve the safety of food. Our results revealed the efficacy of Theaflavin-3，3'-digallate （TFBG）， which is a novel polyphenol derived from tea， in targeting the key regulatory protein MgrA in S. aureus. Through fluorescence anisotropy， we showed that the IC50of TFBG was 26.76 μg/mL. TFBG uniquely counters S. aureus by regulating its virulence factors and adhesion processes rather than by killing the bacteria directly. This compound alters the expression of key virulence factors and modulates the transcription levels of genes related to adhesion in S. aureus， ultimately reducing the bacteria’s ability to adhere to fibrinogen and its hemolytic activity. Our assays confirmed that TFBG directly interacts with the MgrA protein in MRSA， and we identified critical binding sites. Our in vivo studies highlighted the potent efficacy of TFBG. TFBG administration is an innovative approach to improve food safety by diminishing MRSA virulence and reducing its pathogenicity.

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电石渣增强改性聚氯乙烯塑料

高分子材料科学与工程 2015年第12期31卷 98-103页

作者：陈韩江田生慧何慧华南理工大学材料科学与工程学院广东广州510640

通过扫描电镜、X射线衍射和粒径分析等对电石法生产聚氯乙烯(PVC)过程中产生的废渣——电石渣进行理化性质表征,结果表明电石渣主要成分是氢氧化钙,且含有少量的镁铁化合物,其中粒径为8μm,是一种粒径分布较宽的工业废渣。采用偶联剂对... 详细信息

通过扫描电镜、X射线衍射和粒径分析等对电石法生产聚氯乙烯(PVC)过程中产生的废渣——电石渣进行理化性质表征,结果表明电石渣主要成分是氢氧化钙,且含有少量的镁铁化合物,其中粒径为8μm,是一种粒径分布较宽的工业废渣。采用偶联剂对电石渣进行改性并将其作为填料应用到硬质PVC塑料中,研究了偶联剂种类及用量、改性电石渣用量对PVC塑料性能的影响。研究表明,电石渣填充PVC塑料的各项性能与重质碳酸钙填充效果相近,偶联剂KH570改性电石渣效果最好,当KH570用量为填料的2%时,20 phr改性电石渣填充PVC塑料力学性能最优;热重分析显示随着改性电石渣的加入,PVC塑料的热稳定性能得到大幅提升。

关键词：电石渣聚氯乙烯理化性质偶联剂

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胎痫“禀赋异质,精不化气”病机探析

中医杂志 2022年第11期63卷 1009-1012页

作者：马融陈汉江张喜莲戎萍路岩莉天津中医药大学第一附属医院/国家中医针灸临床医学研究中心天津市300381

婴幼儿早发性癫痫性脑病符合古籍中“胎痫”的论述,异质性是其显著特征,结合异质性与禀赋、精气的内在联系,提出其核心病机是禀赋异质、精不化气,主要体现在肾精“量不足”和“质改变”两个方面。认为养胎不慎、胎元受损是重要的致病因... 详细信息

婴幼儿早发性癫痫性脑病符合古籍中“胎痫”的论述,异质性是其显著特征,结合异质性与禀赋、精气的内在联系,提出其核心病机是禀赋异质、精不化气,主要体现在肾精“量不足”和“质改变”两个方面。认为养胎不慎、胎元受损是重要的致病因素,五脏脏气不平、气化失序、痰气逆乱是发病之始。治疗以补肾培元为主,强调动态辨证施治,佐以健脾、柔肝、涤痰、熄风等法。

关键词：早发性癫痫性脑病胎痫禀赋异质精不化气病机

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基于五脏相通理论从肾论治抽动障碍

中医学报 2023年第12期38卷 2505-2511页

作者：陈朝远李晓凤陈汉江张喜莲天津中医药大学第一附属医院/国家中医针灸临床医学研究中心天津300381 天津中医药大学第二附属医院天津300250

五脏相通理论立论于五行学说,本于天人相应的整体观念。天地气化流行生成五行,人禀天地之气生,五行在人乃成五脏。五行之间存在生克制化,五脏间气化法度基本概括了人体的病证机理。肾为一身阴阳之根,心肾水火既济,肝肾阴阳互根互制,肺... 详细信息

五脏相通理论立论于五行学说,本于天人相应的整体观念。天地气化流行生成五行,人禀天地之气生,五行在人乃成五脏。五行之间存在生克制化,五脏间气化法度基本概括了人体的病证机理。肾为一身阴阳之根,心肾水火既济,肝肾阴阳互根互制,肺肾金水相生,脾肾为先后天之本,是五脏阴阳寒热调节的核心。抽动障碍具有症状多样,病证复杂的疾病特点,其病机根于外者,多由外感引起;其病机根于内者,多与先天相关。临证时,应以肾为核心,通过把握疾病症状、证候,定位病邪所在脏腑,分清主次,依据“审察病机,先其所因”“必先五脏,伏其所主”“权衡五脏,动态辨治”三步法辨治。

关键词：抽动障碍五脏相通从肾论治

高迁移蛋白B1参与儿童癫痫发生机制及中医药干预进展

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中国中西医结合儿科学 2022年第2期14卷 115-119页

作者：陈汉江张喜莲戎萍马融天津中医药大学第一附属医院儿科/国家中医针灸临床医学研究中心天津300193

癫痫的防治策略已经由控制癫痫发作向控制癫痫发生前移。癫痫发生是癫痫的萌芽和前期阶段,是癫痫形成的“时间窗口期”,也是药物干预的最佳阶段。神经元损伤与免疫炎症是癫痫发生的基本特征,免疫炎症参与儿童癫痫发生的全过程。研究发... 详细信息

癫痫的防治策略已经由控制癫痫发作向控制癫痫发生前移。癫痫发生是癫痫的萌芽和前期阶段,是癫痫形成的“时间窗口期”,也是药物干预的最佳阶段。神经元损伤与免疫炎症是癫痫发生的基本特征,免疫炎症参与儿童癫痫发生的全过程。研究发现抑制早期炎症因子(白细胞介素-1、肿瘤坏死因子α等)并不能阻止癫痫发生,近年来晚期炎症因子高迁移蛋白B1(HMGB1)在癫痫发生中的特殊地位越来越被重视。在功能上,HMGB1存在细胞内基因调控和细胞外促炎的两种不同功能。抑制HMGB1的转胞易位是调控其功能的关键。HMGB1通过两个经典的转导通路激活下游免疫反应:HMGB1-RAGE轴和HMGB1-TLRs轴。中药主要通过HMGB1/TRL4/NF-κB通路调节免疫炎症反应干预癫痫发生的进程。本文从HMGB1的源流、结构、功能、释放形式、信号通路、抑制剂及中医药干预的概况进行综述,为中医药干预HMGB1及癫痫发生提供文献依据。

关键词：癫痫发生 HMGB1 免疫炎症中医药

Domain-Invariant Similarity Activation Map Contrastive Learning for Retrieval-Based Long-Term Visual Localization

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IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 313-328页

作者： hanjiang Hu Hesheng Wang Zhe Liu Weidong chen Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China IEEE Department of Automation Institute of Medical RoboticsKey Laboratory of System Control and Information Processing of Ministry of EducationKey Laboratory of Marine Intelligent Equipment and System of Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China Department of Computer Science and Technology University of CambridgeCambridge CB30FDUnited Kingdom

Visual localization is a crucial component in the application of mobile robot and autonomous driving.Image retrieval is an efficient and effective technique in image-based localization methods.Due to the drastic variability of environmental conditions,e.g.,illumination changes,retrievalbased visual localization is severely affected and becomes a challenging problem.In this work,a general architecture is first formulated probabilistically to extract domain-invariant features through multi-domain image translation.Then,a novel gradientweighted similarity activation mapping loss(Grad-SAM)is incorporated for finer localization with high accuracy.We also propose a new adaptive triplet loss to boost the contrastive learning of the embedding in a self-supervised manner.The final coarse-to-fine image retrieval pipeline is implemented as the sequential combination of models with and without Grad-SAM loss.Extensive experiments have been conducted to validate the effectiveness of the proposed approach on the CMU-Seasons dataset.The strong generalization ability of our approach is verified with the RobotCar dataset using models pre-trained on urban parts of the CMU-Seasons dataset.Our performance is on par with or even outperforms the state-of-the-art image-based localization baselines in medium or high precision,especially under challenging environments with illumination variance,vegetation,and night-time images.Moreover,real-site experiments have been conducted to validate the efficiency and effectiveness of the coarse-to-fine strategy for localization.

关键词： Deep representation learning place recognition visual localization

马融教授治疗小儿癫痫常用安神类药物经验介绍

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天津中医药 2022年第9期39卷 1104-1106页

作者：魏娟李天星陈汉江张喜莲天津中医药大学第一附属医院天津300381 国家中医针灸临床医学研究中心天津300381

癫痫是儿科神经系统常见病,中医药治疗有一定特色。马融教授认为其核心病机为本虚标实、痰伏脑络、气机逆乱、窍闭风动;主要致病因素为风、火、惊、痰、瘀、虚等。在临床实践中,应抓住病机关键,确立治疗主线,结合不同时期致病因素特点,... 详细信息

癫痫是儿科神经系统常见病,中医药治疗有一定特色。马融教授认为其核心病机为本虚标实、痰伏脑络、气机逆乱、窍闭风动;主要致病因素为风、火、惊、痰、瘀、虚等。在临床实践中,应抓住病机关键,确立治疗主线,结合不同时期致病因素特点,选择适宜的安神类药物配伍运用。文章介绍了马融教授治疗小儿癫痫应用安神类药物的经验。

关键词：小儿癫痫安神类药物名医经验马融