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Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min liu Hao SU Meng-{1. LI Lan YU Ai-ling chen Ken HUANG Yun-ke ZHAO Qiu-long HUANG Wen-ya HUANG Xi institute of Traditional {1. Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(3. g/kg)were detected using ultra-performance liquid chromatography-mass *** 1. rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(3. g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 1. h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,3.0μL PGSDS per 1.m L of culture medium)or FTA(23.,1.3.,and 1.1. mg/m L)for 1. min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1.ET-1.,superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3.kinase(p-PI3.),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.1.%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,P1.and endothelial function-protective(lower VEGF,ET-1.P1.*** increases in aortic relaxation,endothelial NO levels and phosphorylated PI3./Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3./AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

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Dangling Ligand Enables an Iron Hexa-Coordinated Molecular Catalyst for Water Oxidation by Photocatalysis

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CCS Chemistry 2024年第3期6卷 623-630页

作者： Bing Yang Qi liu Xiang-Zhu Wei Tao Lei {1.-{1. Yang Xu-Zhe Wang Jing-Xin Jian Xin Jiang {3.-Ho Tung Li-Zhu Wu Key Laboratory of Photochemical Conversion and Optoelectronic Materials New Cornerstone Science LaboratoryTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190 School of Future Technology University of Chinese Academy of SciencesBeijing 100049

Photocatalytic water oxidation reaction by transition metal complexes remains a challenge because of their poor stability under irradiation,especially for earth-abundant metal *** this regard,ironbased water oxidation catalysts are prone to hydrolysis and/or dissociate the ligands to form nanoparticles under a real catalytic ***,we describe a unique hexa-coordinated catalyst 1.Fe^(II)(Py_(3.tacn)Cl_(2)]and its reference{1.[Fe^(II)(PhPy_(2)tacn)Cl_(2)]with a dangling pyridyl ligand and a phenyl group,*** anticipated that the dynamically open and close coordination behaviors of the pyridyl ligand enabled balance of the reactivity and stability of catalyst *** our delight,the“open form”of catalyst 1.provided a free coordination site,and the“close form”guaranteed its molecular integrity,resulting in a water oxidation reaction with high efficiency and *** turnover number and turnover frequency values of{1.3.2 and 60 s^(−1.are the highest known to date among iron-based homogeneous water oxidation systems under visible light irradiation.

关键词： water oxidation photocatalysis homogeneous catalysis iron complexes dangling ligand intermediates characterization

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Influence of Ru addition on microstructure and stress-rupture property of Ni-based single crystal superalloys

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Progress in Natural Science:Materials International 2010年第1期20卷 61-69页

作者： Jing-yang chen~1.Qiang FENG~(1.2),La-mei CAO~{1.Zu-qing SUN~1.1.State Key Laboratory for Advanced Metals and Materials,University of Science and Technology Beijing, Beijing 1.008{1.china 2.National Center for Materials Service Safety,University of Science and Technology Beijing,Beijing 1.008{1.china {1.National Key Laboratory of Science and Technology on Advanced High Temperature Structural Materials, Beijing institute of Aeronautical Materials,Beijing 1.0095,china Univ Sci & Technol Beijing State Key Lab Adv Met & Mat Beijing 100083 Peoples R China Univ Sci & Technol Beijing Natl Ctr Mat Serv Safety Beijing 100083 Peoples R China Beijing Inst Aeronaut Mat Natl Key Lab Sci & Technol Adv High Temp Struct M Beijing 100095 Peoples R China

The effects of Ru on the microstructure and stress-rupture property were investigated in two experimental Ni-based single crystal superalloys with and without Ru addition(5.1.,mass fraction).The results indicate that the morphology ofγ' precipitates in the dendrite core and interdendritic region are intermediate and nearly spherical,respectively,in the Ru-free alloy after being aged at 1.00℃for 8 *** Re partitioning ratio increases due to Ru addition and Ru partitioned preferentially to theγphase in both dendrite core and interdendritic region of the Ru-containing alloy,which results in more negative lattice misfit and more cuboidalγ' ***,theγ' volume fraction increases while the precipitate size and y channel width decreases due to Ru addition in both dendrite core and interdendritic *** addition improves the stress-rupture life at 1.00℃/1.0 MPa significantly due to higherγ' volume fraction,more negative lattice misfit and a well rafting structure as well as lessγchannel width.

关键词： Ni-based superalloys ruthenium elemental partitioning ratio lattice misfit γ’ morphology stress-rupture property

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The Fate of Mitochondria in Ibex-hirus Reconstructed Early Embryos

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Acta Biochimica et Biophysica Sinica 2004年第5期36卷 371-374页

作者： Yan JIANG, Shu-Zhen liu, Yan-Ling ZHANG, Man-Xi JIANG, {1.-Yuan SUN, and Da-Yuan chen* State Key Laboratory of Reproductive {3., institute of Zoology, the chinese academy of sciences, Beijing 1.0080, china State Key Laboratory of Reproductive biology Institute of Zoology the Chinese Academy of Sciences Beijing 100080 China

Inter-species nuclear transfer could be used to preserve North Goat (Capra ibex), an endan- gered species. We established the culture conditions for ibex-hirus reconstructed embryos and optimized the method for DNA extractions of a single cell and early cloned embryo. By using mitochondria-specific probes of ibex and hirus respectively we found that mitochondria of donor cells can co-exist with recipients in 1.cell and 2-cell stages of the reconstructed embryos but not in the following developmental stages.

关键词： Capra ibex cloned embryos nuclear transfer mitochondria PCR

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单个植入前胚胎mRNA差异显示方法的建立

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生物化学与生物物理进展 2003年第2期30卷 308-313页

作者：郁卫东杨立新李文雍刘桂生陈清轩中国科学院遗传与发育生物学研究所

在已有的研究基础上 ,优化和建立了单个植入前胚胎的mRNA差异显示 (singlepreimplantationembryodifferentialdisplaypolymerasechainraction ,SPEDDRT PCR) .以小鼠单个成熟的卵母细胞和单个的 2细胞期胚胎作为起始材料 ,比较二者之间... 详细信息

在已有的研究基础上 ,优化和建立了单个植入前胚胎的mRNA差异显示 (singlepreimplantationembryodifferentialdisplaypolymerasechainraction ,SPEDDRT PCR) .以小鼠单个成熟的卵母细胞和单个的 2细胞期胚胎作为起始材料 ,比较二者之间基因的表达差异 .选择在卵母细胞中不表达而在 2细胞期表达的差异片段 .进行GenBank检索和表达序列标签 (EST)库电子克隆 .与多胚研究方法一样 ,由线粒体编码的和 2细胞特异表达的NADH脱氢酶亚单位 2和ATPase 6证实了SPEDDRT PCR方法是可行而且可靠的 ,是一种需要材料极少。

关键词：植入前胚胎 mRNA 差异显示早期胚胎发育

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Design of hadronic calorimeter for DarkSHINE experiment

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Nuclear Science and Techniques 2024年第9期35卷 155-167页

作者： Zhen Wang Rui Yuan Han-qing {1. Jing chen Xiang chen Kim Siang Khaw Liang Li Shu Li Kun {1. Qi-Bin {1. Si-Yuan Song Tong Sun Xiao-Long Wang Yu-Feng Wang Hai-Jun Yang Jun-Hua Zhang Yu-Lei Zhang Zhi-Yu Zhao Chun-Xiang Zhu Xu-Liang Zhu Yi-Fan Zhu Tsung-Dao Lee institute Shanghai Jiao Tong University1 Lisuo RoadShanghai 201210China institute of Nuclear and Particle Physics School of Physics and Astronomy800 Dongchuan RoadShanghai 200240China Key Laboratory for Particle Astrophysics and Cosmology(MOE) Shanghai Key Laboratory for Particle Physics and Cosmology(SKLPPC)Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Fudan UniversityShanghai 200443China institute of Modern Physics Fudan UniversityShanghai 200443China

The sensitivity of the dark photon search through invisible decay final states in low-background experiments relies sig-nificantly on the neutron and muon veto efficiencies,which depend on the amount of material used and the design of the detector *** paper presents the optimized design of the hadronic calorimeter(HCAL)used in the DarkSHINE experiment,which is studied using a GEANT4-based simulation *** geometry is optimized by comparing a traditional design with uniform absorbers to one that uses different thicknesses at different locations on the detector,which enhances the efficiency of vetoing low-energy neutrons at the sub-GeV *** overall size and total amount of material used in the HCAL are optimized to be lower,owing to the load and budget requirements,whereas the overall performance is studied to satisfy the physical objectives.

关键词： Hadronic calorimeter GEANT4 simulation Neutron background Scintillation detector Dark photon

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Synthesis and characterization of tris(η~5-cyclopentadienyl-μ-carbonyliron)-μ_3.nitrosyl cluster:X-ray structure of[(η~5-C_5H_5)(μ-CO)Fe]_3.μ3.NO).C_4H_8O

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chinese Journal of Chemistry 1994年第2期12卷 123-128页

作者： SUN, Wen-Hua YANG, Shi-Yan WANG, Han-qing YUAN, Dong-Feng HOU, Zhi-Qiang chen, Yu-qingState Key Laboratory of Structural Chemistry and State Key Laboratory of Oxo Synthesis and SelectiveOxidation, Lanzhou {3. of Chemical Physics, chinese academy of sciences,Lanzhou , Gansu 73.000, chinaYU, Kai-Beichengdu Center of Analysis and Measurement, chinese academy of sciences, chengdu, sichuan 61004., china 1.tate Key Laboratory of Structural Chemistry and State Key Laboratory of Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou Gansu 730000 China2Chengdu Center of Analysis and Measurement Chinese Academy of Sciences Chengdu Sichuan 610041 China

Tris)(η 5-cyclopentadienyl-μ-carbonyl-iron)-μ3.nitrosyl cluster was obtained from the reaction of cyclopentadienyl dicarbonyliron dimer with nitrogen monoxide in xylene. The cluster was characterized by elemental analyses, IR, MS and 1. NMR. The crystal structure of [(η5-C5H5)(μ-CO)Fe]3.μ3.NO).C4H8O was determined by X-ray diffraction analysis. It crystallizes in the orthorhombic space group Pnma, a=9.053.2), 6=1..545(2), c=22.525(4) A, V=21.0.3.7) A3. Z=4,Dc=1.68 ***-3. structure solution and refinement based on 1.41.reflections with I > 3.0 (I) (MoKa, A=0.71.73.A) converged at R=0.0540. The infrared absorption band at 1.0}5 cm-1.of the μ3.NO in the cluster, which is red shifted, shows that μ3.NO is activated.

关键词： Nitrosyl complexes iron cluster NO activation.

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An ultrafast rechargeable hybrid potassium dual-ion capacitor based on carbon quantum dot@ultrathin carbon film cathode

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Rare Metals 2024年第10期43卷 5070-5081页

作者： Zhao-Meng liu Da Wang Shang-Zhuo Li {1.-Song Lai Dong-Run Yang Lu-Kang Zhao Jian-Jia Mu Xuan-chen Wang Xuan-Wen Gao Wen-Bin Luo institute for Energy Electrochemistry and Urban Mines Metallurgy School of MetallurgyNortheastern University Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai University

Ultrafast rechargeable hybrid potassium dualion capacitors （HPDICs） were designed by employing carbon quantum dot@ultrathin carbon film （CQD@CF） as the cathode *** designed CQD@CF is selfassembled by a simple catalytic graphitization route followed by an acid leaching *** special composite features a large adsorption interface,a remarkable anion hybrid storage capability and outstanding structure *** electrochemical performance of CQD@CF composite is fully tapped in a half-cell system at the operating voltage between 1.4 and 4.5 V,achieving an admirable specific discharge capacity of 1.8.5 mAh·g-1. 50 mA·g-1.an ultra-high capacity retention ratio of 97.97% after cycling 5000 times at 1.00 mA·g-1.nd a 96.1.%high capacity retention ratio after cycling 40,000 times at 5000 mA·g-1.***,with the support of ex situ TEM and XPS,the structural stability principle and anionic hybrid storage mechanism of CQD@CF electrode are investigated *** the full-cell system,HPDICs with the CQD@CF as cathode and nanographite powder as anode also present a 1.1.5 Wh·kg-1.igh energy density,a 5850 W·kg-1.ower density and a super-long cycle stability (90.2% capacity retention ratio after cycling 3.,000 times at 5000 mA·g-1..

关键词： Anion hybrid storage mechanism Carbon quantum dots Potassium dual ion capacitor Ultrafast rechargeable Ultrathin carbon film

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The ERF transcription factor LTF1.activates DIR1.to control stereoselective synthesis of antiviral lignans and stress defense in Isatis indigotica roots

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Acta Pharmaceutica Sinica B 2024年第1期14卷 405-420页

作者： Ruibing chen Jian Yu Luyao Yu Liang Xiao Ying Xiao Junfeng chen Shouhong Gao Xianghui chen {3. Li Henan Zhang Wansheng chen Lei Zhang Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China Research and Development Center of chinese Medicine Resources and Biotechnology Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmacy Shanghai Changzheng HospitalNaval Medical UniversityShanghai 200003China School of Medicine Shanghai UniversityShanghai 200433China institute of Edible Fungi Shanghai Academy of Agricultural SciencesNational Engineering Research Center of Edible FungiKey Laboratory of Edible Fungi Resources and Utilization(South)Ministry of AgricultureShanghai 201403China College of Life sciences and Medicine Key Laboratory of Plant Secondary Metabolism and Regulation of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018China State Key Laboratory of Dao-di Herbs Beijing 100700China

Lignans are a powerful weapon for plants to resist stresses and have diverse bioactive functions to protect human *** the mechanisms of stereoselective biosynthesis and response to stresses of lignans is important for the guidance of plant ***,we identified the complete pathway to stereoselectively synthesize antiviral(-)-lariciresinol glucosides in Isatis indigotica roots,which consists of three-step sequential stereoselective enzymes DIR1.2,PLR,and ***1.was further identified as the key gene in respoJanuary 2024nse to stresses and was able to trigger stress defenses by mediating the elevation in lignan ***,the phytohormone-responsive ERF transcription factor LTF1.colocalized with DIR1.in the cell periphery of the vascular regions in mature roots and helped resist biotic and abiotic stresses by directly regulating the expression of *** systematic results suggest that DIR1.as the first common step of the lignan pathway cooperates with PLR and UGT71.2 to stereoselectively synthesize(-)-lariciresinol derived antiviral lignans in *** roots and is also a part of the LTF1.mediated regulatory network to resist *** conclusion,the LTF1.DIR1.module is an ideal engineering target to improve plant Defenses while increasing the content of valuable lignans in plants.

关键词： Lignans Stereoselective synthesis Stress resistance Dirigent protein ERF

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Two aquaporins,PIP1.1.and PIP2;1.mediate the uptake of neonicotinoid pesticides in plants

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Plant Communications 2024年第5期5卷 176-188页

作者： Qun Wan Yixin Li Jinjin cheng Ya Wang Jing Ge Tingli {1. Liya Ma Yong Li Jianan {1. Chunli Zhou Haocong Li Xing Sun Xiaolong chen qing X.Li Xiangyang Yu Key Laboratory of Food Quality and Safety of Jiangsu Province State Key Laboratory Breeding BaseNanjing 210014China institute of Food Safety and Nutrition Jiangsu Academy of Agricultural Sciences50 Zhongling StreetNanjing 210014China Jiangsu Provincial Key Construction Laboratory of Special Biomass Resource Utilization Nanjing Xiaozhuang University3601 Hongjin AvenueNanjing 211171China Department of Molecular Biosciences and Bioengineering University of Hawaii at ManoaHonoluluHI 96822USA

Neonicotinoids(NEOs),a large class of organic compounds,are a type of commonly used pesticide for crop *** uptake and accumulation in plants are prerequisites for their intra-and intercellular move-ments,transformation,and *** the molecular mechanisms that underpin NEO uptake by plants is crucial for effective application,which remains ***,we demonstrate that NEOs enter plant cells primarily through the transmembrane symplastic pathway and accumulate mainly in the *** plasma membrane intrinsic proteins discovered in Brassica rapa,BraPIP1.1.and BraPIP2;1.were found to encode aquaporins(AQPs)that are highly permeable to NEOs in different plant species and facilitate NEO subcellular diffusion and *** conserved transport function was further demonstrated in Xenopus laevis oocyte and yeast ***1.1.and BraPIP2;1.gene knockouts and interaction as-says suggested that their proteins can form functional *** of the potential of mean force indicated a negative correlation between NEO uptake and the energy barrier of BraPIP1.1.*** study shows that AQPs transport organic compounds with greater osmolarity than previously thought,providing new insight into the molecular mechanisms of organic compound uptake and facilitating innovations in systemic pesticides.

关键词： neonicotinoid aquaporin Brassica rapa plasma membrane uptake systemic pesticide

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