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Induced Absolute Configuration of Achiral Tetradentate Ligands in Metal–Organic Frameworks for Circularly Polarized Luminescence

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chinese Journal of Chemistry 2024年第11期42卷 1260-1266页

作者： Hong-Ru Fu Dan-Dan Ren Kun Zhang Hong chen Xiaoyan Lu {1.-Rong Ding Lu-Fang Ma College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyangHenan471934 China College of Materials&Chemical Engineering China Three Gorges UniversityYichangHubei443002 China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian350002 China

The crystallization of chiral molecules is of great significance to understand the origin and evolution of hierarchical chirality and reveal the relationships between structural chirality and circularly polarized luminescence(CPL)***,we report two pairs of chiral metal–organic frameworks(MOFs)(DCF-1./LCF-1.,DCF-1./LCF-1.)by utilizing tetradentate ligands tetra(3-imidazoylphenyl)ethylene(TIPE)and 4,4'-[4',5.-bis[4-(4-pyridinyl)phenyl][1.1.:2',1.-terphenyl]-4,4”-diyl]bis[pyridine](TPPP)as *** can be observed that the spontaneous resolution of the achiral ligands is converted into the induced resolution,and the ligands form the absolute configuration by using enantiopure camphoric acid(cam)as chiral induced reagent(CIR).As a result,the racemate MOFs can be driven to generate absolute homochiral *** two achiral MOFs[Cd(D-cam)(TPPP)_(0.5.](AF-1.AF=achiral framework)and[Cd(L-cam)(TPPP)_(0.5.](AF-2)were *** position disorder of D/L-cam skeleton causes the generation of nonchiralization,further leading to disappearance of symmetry breaking of *** the perspective of structure,this is the first report which reveals the chiral transfer and nonchiralization between chiral induced agents and tetradentate ***,DCF-1. and LCF-1. show CPL with luminescence dissymmetry factor(glum)of–1.0×1.^(-2)and+9.2×1.^(–3),*** work provides the useful evidences to reveal the induced chiral crystallization and the construction of CPL-active crystalline materials.

关键词： Metal-organic frameworks Circularly polarized luminescence Chirality induction Spontaneous resolution Chirality transfer

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后生遗传修饰及其对动物克隆的影响

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生物工程学报 2003年第1期19卷 9-12页

作者：李文雍郁卫东陈清轩中国科学院遗传与发育生物学研究所

近年来 ,不断有新的哺乳动物和两栖类动物被成功克隆 ,但这并不能掩盖克隆效率过低和克隆动物异常的现实 ,为了解决这一问题 ,人们对克隆机理进行了大量研究。高度分化的体细胞核在去核的卵质中去分化和再程序化不完全是导致动物克隆失... 详细信息

近年来 ,不断有新的哺乳动物和两栖类动物被成功克隆 ,但这并不能掩盖克隆效率过低和克隆动物异常的现实 ,为了解决这一问题 ,人们对克隆机理进行了大量研究。高度分化的体细胞核在去核的卵质中去分化和再程序化不完全是导致动物克隆失败的主要原因 ,而去分化和再程序化不完全主要是由于基因组去甲基化不充分和过早再甲基化引起克隆胚中甲基化水平比正常胚中偏高所至 ,这可引起一些重要基因的异常表达 ,尤其是印记基因。这些机制的研究对提高克隆效率有着重要意义。

关键词：后生遗传修复动物克隆再程序化甲基化基因组印记

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A pilot study of the differentiated landscape of peripheral blood mononuclear cells from children with incomplete versus complete Kawasaki disease

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World Journal of Pediatrics 2024年第2期20卷 189-200页

作者： Shu-Na Sun Yan Zhou Xing Fu Yuan-Zheng Zheng Cao Xie Guo-You Qin Fang liu {1. Chu Feng Wang {1.g-Long liu qing-Tong Zhou De-Hua Yang Di Zhu Ming-Wei Wang Yong-Hao Gui Children's Hospital of Fudan University National Children's Medical CenterShanghai 201102China The National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Accuramed Technology(Shanghai)Ltd. Shanghai 200233China School of Pharmacy Fudan UniversityShanghai 201203China School of Public Health Fudan UniversityShanghai 200032China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources Sanya 572025China Department of Chemistry School of ScienceThe University of TokyoTokyo 113-0033Japan School of Pharmacy Hainan Medical UniversityHaikou 570288China

Kawasaki disease(KD)is a disorder of immune *** prevalence of KD among 1.0,000 children aged 0-4 years was 71.9-1.0.0 in China,1.0.9-1.4.9 in Korea,and 1..1.21.3 in the USA[1..The most severe complication of KD is coronary artery lesions(CALs),including coronary dilatation and coronary aneurysms,which may even lead to myocardial ischemia,myocardial infarction,and sudden death.

关键词： coronary ischemia differentiated

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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi liu {1.-Yuan Qu Ying Lei Qi chen Yu-Xiu chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu Qiu-Sha Huang Hai-Xia Fu Yuan Kong Yue-Ying Li Qian-Fei Wang Xiao-Jun Huang Xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of chinese academy of sciences Beijing 100049China Peking-Tsinghua Center for Life sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25.and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1.and Th1. cell *** a platelet count of 30×1.^(9)L^(−1.as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

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A simple and effective method for fluoroalkylation——the addition of fluoroalkyl iodide to olefins in the presence of hydrogen peroxide

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chinese Journal of Chemistry 1991年第2期9卷 184-188页

作者： chen,{1.-Yun chen,Ming-Fang Shanghai institute of Organic Chemistry,chinese {5. of sciences,Shanghai 200032 Shanghai institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032

Addition of fluoroalkyl iodides to olefins in the presence of hydrogen peroxide(H_2O_(?)) in acetone,acetonitrile or ethanol gave the corresponding 1.1.adducts in good *** of fluoroalkyl iodide with diallyl ether(DAE)yielded tetrahydrofuran derivatives,p-Hydroquinone (p-HQ)can partly suppress the reaction.A radical initiation mechanism is proposed.

关键词： A simple and effective method for fluoroalkylation the addition of fluoroalkyl iodide to olefins in the presence of hydrogen peroxide

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Treatment with Vector-expressed Small Hairpin RNAs against Ki67 RNA-induced Cell Growth Inhibition and Apoptosis in Human Renal Carcinoma Cells

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Acta Biochimica et Biophysica Sinica 2006年第4期38卷 254-261页

作者： Jun-Nian ZHENG~(1.3*) Ya-Feng SUN~(2#) Dong-Sheng PEI~2 Jun-Jie liu~1.Teng-Xiang MA~3 Rui-Fa HAN~3 Wang LI~1.Dian-Bao ZHENG~1.Jia-Cun {1.~1.Xiao-qing SUN~1. 1.Laboratory of Urology,Affiliated Hospital of Xuzhou Medical College,Xuzhou 221.02,China 2 Research Center for Biochemistry and Molecular biology,Xuzhou Medical College,Xuzhou 221.02,China 3 {15. of Urology,Medical University of Tianjin,Tianjin 30021.,China LaboratoryofUrology AffiliatedHospitalofXuzhouMedicalCollegeXuzhou221002China ResearchCenterforBiochemistryandMolecularbiology XuzhouMedicalCollegeXuzhou221002China instituteofUrology MedicalUniversityofTianjin

Short hairpin RNAs (shRNAs) transcribed *** polymerase Ⅲ promoters can triggersequence-selective gene silencing in mammalian *** virtue of their excellent function in knocking downexpression of cancer-associated genes,shRNAs could be used as new therapeutic agents for *** of Ki67 in renal cancer has been correlated to a more aggressive tumor phenotype,inhibitionof Ki67 protein expression by means of shRNAs seems to be a promising approach for the therapy of *** this study,we constructed an expression plasmid encoding shRNAs against the Ki67 gene,namedpSilencerKi67,and transfected it into human renal carcinoma *** pSilencerKi67 was shown to signifi-cantly knock down the expression of the Ki67 gene in human renal carcinoma cells,resulting in inhibitingproliferation and inducing apoptotic cell death that can be maintained for at least *** findings offer thepromise of using vector-based shRNAs against Ki67 in renal cancer gene therapy.

关键词： Ki67 gene shRNAs renal cell carcinoma proliferation apoptosis

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仿驾驶员多目标决策自适应巡航鲁棒控制

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控制理论与应用 2018年第6期35卷 769-777页

作者：章军辉李庆陈大鹏中国科学院微电子研究所北京100029 中国科学院大学北京100049 中科院微电子研究所昆山分所江苏昆山215347

针对目前市场上自适应巡航(adaptive cruise control,ACC)用户使用率低与驾乘人员接受度差的问题,发展了一种多目标自适应巡航控制算法,基于模型预测控制(model predictive control,MPC)理论,综合协调动态追踪性、燃油经济性、驾乘舒适... 详细信息

针对目前市场上自适应巡航(adaptive cruise control,ACC)用户使用率低与驾乘人员接受度差的问题,发展了一种多目标自适应巡航控制算法,基于模型预测控制(model predictive control,MPC)理论,综合协调动态追踪性、燃油经济性、驾乘舒适性以及跟车安全性四项存在着一定冲突的控制目标,采用二次型性能指标以及线性不等式约束的形式,将纵向期望加速度决策问题转化成带约束的在线二次规划问题.引入误差修正项,建立闭环反馈校正机制,以补偿模型失配带来的预测误差,同时采用松弛向量法扩展求解可行域,规避了硬约束下二次规划非可行解问题.进一步,各工况下所强化的性能指标与约束空间不同,采用性能指标权重微校与约束空间边界松弛的策略,设计出3种工作模式ACC,以适应熟练驾驶群体的跟驰习惯.仿真结果表明,前车组合工况下,多模式多目标ACC控制能够实现各工作模式之间的无缝切换,并实现良好的期望跟车目的,从而增强ACC系统对复杂道路交通环境的适应性.

关键词：半自动驾驶自适应巡航控制模型预测控制松弛向量跟驰习惯

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Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in China: A Cross-sectional Survey

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Biomedical and Environmental sciences 2024年第3期37卷 254-265页

作者： SHAN Xiao Yun ZOU Yan HUANG Li Chun JIANG Shan ZHOU Wei Wen QIN Qiu Lan liu Chang {1. LUO Xiao Yan LU Jia Xi MAO De Qian LI Min YANG Zhen Yu YANG Li chen Key Laboratory of Trace Element Nutrition of National Health Committee National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 241001HunanChina Zhejiang Provincial Center for Disease Prevention and Control Hangzhou 310051ZhejiangChina Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning 530028GuangxiChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang 050021HebeiChina

Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are *** study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible relationships with VA,VD,and other factors in postpartum *** A total of 1.31. mothers(896 lactating and 41. non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this *** urinary iodine concentration(UIC),TSH,VA,and VD were *** The median UIC of total and lactating participants were 1.2.00µg/L and 1.9.95.g/L,*** median TSH,VA,and VD levels in all the participants were 1.89 mIU/L,0.44μg/mL,and 24.04 ng/mL,*** differences in the UIC were found between lactating and non-lactating *** and TSH levels were significantly different among the three *** rural UIC was higher than the urban *** mothers had a higher UIC and a higher prevalence of excessive *** UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient *** adjustment,no linear correlation was observed between UIC and VA/*** interaction was found between vitamins A/D and UIC on TSH *** The mothers in the present study had no iodine ***,area type,BMI,and VD may be related to the iodine status or TSH levels.

关键词： Median urinary iodine concentration Thyroid-stimulating hormone Vitamin A Vitamin D Postpartum women

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Enhanced detection of freeze‒thaw induced landslides in Zhidoi county(Tibetan Plateau,China)with Google Earth Engine and image fusion

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Advances in Climate Change Research 2024年第3期15卷 476-489页

作者： Jia-Hui YANG Yan-chen GAO Lang JIA Wen-Juan WANG {1.-Bai WU Francis ZVOMUYA Miles DYCK Hai-Long HE College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Department of Soil Science University of Manitob1Winnipeg MB R3T 2N2Canada Department of Renewable Resources University of Albert1Edmonton AB T6G 2H1Canad

Freeze‒thaw induced landslides(FTILs)in grasslands on the Tibetan Plateau are a geological disaster leading to soil *** landslides reduce biodiversity and intensify landscape fragmentation,which in turn are strengthen by the persistent climate change and increased anthropogenic ***,conventional techniques for mapping FTILs on a regional scale are impractical due to their labor-intensive,costly,and time-consuming *** study focuses on improving FTILs detection by implementing image fusion-based Google Earth Engine(GEE)and a random forest *** of multiple data sources,including texture features,index features,spectral features,slope,and vertical‒vertical polarization data,allow automatic detection of the spatial distribution characteristics of FTILs in Zhidoi county,which is located within the qinghai‒Tibet Engineering Corridor(QTEC).We employed statistical techniques to elucidate the mechanisms influencing FTILs *** enhanced method identifies two schemes that achieve high accuracy using a smaller training sample(scheme A:94.1.;scheme D:94.5.)compared to other methods(scheme B:5..0%;scheme C:95.8%).This methodology is effective in generating accurate results using only~1.%of the training sample size necessitated by other *** spatial distribution patterns of FTILs generated for{1.021.are similar to those obtained using various other training sample sources,with a primary concentration observed along the central region traversed by the *** results highlight the slope as the most crucial feature in the fusion images,accounting for 93%of FTILs occurring on gentle slopes ranging from 0°to 1.°.This study provides a theoretical framework and technological reference for the identification,monitoring,prevention and control of FTILs in *** developments hold the potential to benefit the management of grassland ecosystem,reduce economic losses,and promote grassland sustainability.

关键词： Permafrost degradation Random forest Thaw slump Spatial distribution Tibetan Plateau

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Fully sprayed MXene-based high-performance flexible piezoresistive sensor for image recognition

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Nano Materials Science 2024年第1期6卷 77-85页

作者： Zhi-Dong Zhang Xue-Feng Zhao qing-Chao Zhang Jie Liang Hui-Nan Zhang Tian-Sheng Zhang {1.-Yang Xue Key Laboratory of Instrumentation Science&Dynamic Measurement of Ministry of Education North University of ChinaTaiyuan030051People's Republic of China State Key Laboratory of ASIC and System Shanghai Institute of Intelligent Electronics&SystemsSchool of MicroelectronicsFudan UniversityShanghai200433People's Republic of China Shanxi Hosipital of Acupuncture and Moxibustion Taiyuan030006People's Republic of China

High-performance flexible pressure sensors provide comprehensive tactile perception and are applied in human activity monitoring,soft robotics,medical treatment,and human-computer ***,these flexible pressure sensors require extensive nano-architectural design and complicated manufacturing and are ***,a highly sensitive,flexible piezoresistive tactile sensor is designed and fabricated,consisting of three main parts:the randomly distributed microstructure on T-ZnOw/PDMS film as a top substrate,multilayer Ti_(3)C_(2)-MXene film as an intermediate conductive filler,and the few-layer Ti_(3)C_(2)-MXene nanosheetbased interdigital electrodes as the bottom *** MXene-based piezoresistive sensor with randomly distributed microstructure exhibits a high sensitivity over a broad pressure range(less than 1. kPa for 1.5.kPa^(-1.)and possesses an out-standing permanence of up to 5.00 ***,a 1.-pixel sensor array is designed,and its potential applications in visualizing pressure distribution and an example of tactile feedback are *** fully sprayed MXene-based pressure sensor,with high sensitivity and excellent durability,can be widely used in,electronic skin,intelligent robots,and many other emerging technologies.

关键词： Piezoresistive sensor Ti_(3)C_(2)-MXene T-ZnOw/PDMS film Randomly distributed microstructure

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